-
2
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
3
-
-
0032960181
-
Cancer epigenetics comes of age
-
Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21:163-7.
-
(1999)
Nat Genet
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
4
-
-
0028875205
-
Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
-
Gonzalez-Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995;55:4531-5.
-
(1995)
Cancer Res
, vol.55
, pp. 4531-4535
-
-
Gonzalez-Zulueta, M.1
Bender, C.M.2
Yang, A.S.3
-
5
-
-
0024365892
-
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
-
Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 1989;83:155-8.
-
(1989)
Hum Genet
, vol.83
, pp. 155-158
-
-
Greger, V.1
Passarge, E.2
Hopping, W.3
Messmer, E.4
Horsthemke, B.5
-
6
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 1994;91:9700-4.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
-
7
-
-
0025891856
-
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene
-
Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM, Dryja TP. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet 1991;48:880-8.
-
(1991)
Am J Hum Genet
, vol.48
, pp. 880-888
-
-
Sakai, T.1
Toguchida, J.2
Ohtani, N.3
Yandell, D.W.4
Rapaport, J.M.5
Dryja, T.P.6
-
8
-
-
0027496294
-
Imprinting of human H19: Allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching
-
Zhang Y, Shields T, Crenshaw T, Hao Y, Moulton T, Tycko B. Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching. Am J Hum Genet 1993;53:113-24.
-
(1993)
Am J Hum Genet
, vol.53
, pp. 113-124
-
-
Zhang, Y.1
Shields, T.2
Crenshaw, T.3
Hao, Y.4
Moulton, T.5
Tycko, B.6
-
9
-
-
21044439177
-
Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
-
Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res 2005;11:3604-8.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3604-3608
-
-
Kaminskas, E.1
Farrell, A.2
Abraham, S.3
-
10
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006;5:37-50.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
11
-
-
0013773866
-
5-Azacytidine, a new, highly effective cancerostatic
-
Sorm F, Piskala A, Cihak A, Vesely J. 5-Azacytidine, a new, highly effective cancerostatic. Experientia 1964;20:202-3.
-
(1964)
Experientia
, vol.20
, pp. 202-203
-
-
Sorm, F.1
Piskala, A.2
Cihak, A.3
Vesely, J.4
-
12
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:85-93.
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
13
-
-
0020308438
-
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA
-
Taylor SM, Jones PA. Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA. J Mol Biol 1982;162:679-92.
-
(1982)
J Mol Biol
, vol.162
, pp. 679-692
-
-
Taylor, S.M.1
Jones, P.A.2
-
14
-
-
0017801980
-
Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine
-
Beisler JA. Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine. J Med Chem 1978;21:204-8.
-
(1978)
J Med Chem
, vol.21
, pp. 204-208
-
-
Beisler, J.A.1
-
15
-
-
1642499364
-
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
-
Cheng JC, Weisenberger DJ, Gonzales FA, et al. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 2004;24:1270-8.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1270-1278
-
-
Cheng, J.C.1
Weisenberger, D.J.2
Gonzales, F.A.3
-
18
-
-
10744224687
-
Functional properties of subunit interactions in human cytidine deaminase
-
Vincenzetti S, De Sanctis G, Costanzi S, et al. Functional properties of subunit interactions in human cytidine deaminase. Protein Eng 2003;16:1055-61.
-
(2003)
Protein Eng
, vol.16
, pp. 1055-1061
-
-
Vincenzetti, S.1
De Sanctis, G.2
Costanzi, S.3
-
19
-
-
0037420191
-
Inhibition of DNA methylation and reactivation of silenced genes by zebularine
-
Cheng JC, Matsen CB, Gonzales FA, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 2003;95:399-409.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 399-409
-
-
Cheng, J.C.1
Matsen, C.B.2
Gonzales, F.A.3
-
20
-
-
0033563083
-
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
-
Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV, Laird PW. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res 1999;59:2302-6.
-
(1999)
Cancer Res
, vol.59
, pp. 2302-2306
-
-
Eads, C.A.1
Danenberg, K.D.2
Kawakami, K.3
Saltz, L.B.4
Danenberg, P.V.5
Laird, P.W.6
-
21
-
-
0036314920
-
Quantitative methylation analysis using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE)
-
Gonzalgo ML, Jones PA. Quantitative methylation analysis using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE). Methods 2002;27:128-33.
-
(2002)
Methods
, vol.27
, pp. 128-133
-
-
Gonzalgo, M.L.1
Jones, P.A.2
-
22
-
-
33749403746
-
Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting
-
Gal-Yam EN, Jeong S, Tanay A, Egger G, Lee AS, Jones PA. Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting. PLoS Genet 2006;2:e160.
-
(2006)
PLoS Genet
, vol.2
-
-
Gal-Yam, E.N.1
Jeong, S.2
Tanay, A.3
Egger, G.4
Lee, A.S.5
Jones, P.A.6
-
23
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;1:686-92.
-
(1995)
Nat Med
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
-
24
-
-
2342557977
-
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
-
Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004;32:e38.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Yang, A.S.1
Estecio, M.R.2
Doshi, K.3
Kondo, Y.4
Tajara, E.H.5
Issa, J.P.6
-
25
-
-
0021722919
-
DNA methylation in 5-aza-2′-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells
-
Flatau E, Gonzales FA, Michalowsky LA, Jones PA. DNA methylation in 5-aza-2′-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells. Mol Cell Biol 1984;4:2098-102.
-
(1984)
Mol Cell Biol
, vol.4
, pp. 2098-2102
-
-
Flatau, E.1
Gonzales, F.A.2
Michalowsky, L.A.3
Jones, P.A.4
-
26
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies
-
Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004;103:1635-40.
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
-
27
-
-
0000418476
-
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
-
Santi DV, Norment A, Garrett CE. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A 1984;81:6993-7.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 6993-6997
-
-
Santi, D.V.1
Norment, A.2
Garrett, C.E.3
-
28
-
-
0036965821
-
Zebularine: A novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
-
Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ, Hornby DP. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 2002;321:591-9.
-
(2002)
J Mol Biol
, vol.321
, pp. 591-599
-
-
Zhou, L.1
Cheng, X.2
Connolly, B.A.3
Dickman, M.J.4
Hurd, P.J.5
Hornby, D.P.6
-
29
-
-
0033582720
-
Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone
-
Hurd PJ, Whitmarsh AJ, Baldwin GS, et al. Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. J Mol Biol 1999;286:389-401.
-
(1999)
J Mol Biol
, vol.286
, pp. 389-401
-
-
Hurd, P.J.1
Whitmarsh, A.J.2
Baldwin, G.S.3
-
30
-
-
0020629104
-
Kinetics of deamination of 5-aza-2′-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside
-
Chabot GG, Bouchard J, Momparler RL. Kinetics of deamination of 5-aza-2′-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside. Biochem Pharmacol 1983;32:1327-8.
-
(1983)
Biochem Pharmacol
, vol.32
, pp. 1327-1328
-
-
Chabot, G.G.1
Bouchard, J.2
Momparler, R.L.3
-
31
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006;5:471-84.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
32
-
-
0034939942
-
Phosphorodiamidate morpholino oligomers: Favorable properties for sequence-specific gene inactivation
-
Iversen PL. Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation. Curr Opin Mol Ther 2001;3:235-8.
-
(2001)
Curr Opin Mol Ther
, vol.3
, pp. 235-238
-
-
Iversen, P.L.1
-
34
-
-
0024449939
-
Partial protection of oncogene, anti-sense oligodeoxynucleotides against serum nuclease degradation using terminal methyl-phosphonate groups
-
Tidd DM, Warenius HM. Partial protection of oncogene, anti-sense oligodeoxynucleotides against serum nuclease degradation using terminal methyl-phosphonate groups. Br J Cancer 1989;60:343-50.
-
(1989)
Br J Cancer
, vol.60
, pp. 343-350
-
-
Tidd, D.M.1
Warenius, H.M.2
-
35
-
-
2442761730
-
Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection
-
Barry ME, Pinto-Gonzalez D, Orson FM, McKenzie GJ, Petry GR, Barry MA. Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum Gene Ther 1999;10:2461-80.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 2461-2480
-
-
Barry, M.E.1
Pinto-Gonzalez, D.2
Orson, F.M.3
McKenzie, G.J.4
Petry, G.R.5
Barry, M.A.6
-
36
-
-
0009574065
-
Studies on acid deoxyribonuclease. Ii. Isolation and characterization of spleen-acid deoxyribonuclease
-
Bernardi G, Griffe M. Studies on acid deoxyribonuclease. Ii. Isolation and characterization of spleen-acid deoxyribonuclease. Biochemistry 1964;3:1419-26.
-
(1964)
Biochemistry
, vol.3
, pp. 1419-1426
-
-
Bernardi, G.1
Griffe, M.2
-
37
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995;374:546-9.
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
-
38
-
-
0035885126
-
Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
-
Gursel I, Gursel M, Ishii KJ, Klinman DM. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J Immunol 2001;167:3324-8.
-
(2001)
J Immunol
, vol.167
, pp. 3324-3328
-
-
Gursel, I.1
Gursel, M.2
Ishii, K.J.3
Klinman, D.M.4
-
39
-
-
0037600638
-
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues
-
Gait MJ. Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues. Cell Mol Life Sci 2003;60:844-53.
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 844-853
-
-
Gait, M.J.1
-
40
-
-
0026839585
-
Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker
-
Geselowitz DA, Neckers LM. Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker. Antisense Res Dev 1992;2:17-25.
-
(1992)
Antisense Res Dev
, vol.2
, pp. 17-25
-
-
Geselowitz, D.A.1
Neckers, L.M.2
-
41
-
-
0030975358
-
Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein
-
Benimetskaya L, Loike JD, Khaled Z, et al. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein. Nat Med 1997;3:414-20.
-
(1997)
Nat Med
, vol.3
, pp. 414-420
-
-
Benimetskaya, L.1
Loike, J.D.2
Khaled, Z.3
-
42
-
-
0028864495
-
Bovine serum albumin is a major oligonucleotide-binding protein found on the surface of cultured cells
-
Geselowitz DA, Neckers LM. Bovine serum albumin is a major oligonucleotide-binding protein found on the surface of cultured cells. Antisense Res Dev 1995;5:213-7.
-
(1995)
Antisense Res Dev
, vol.5
, pp. 213-217
-
-
Geselowitz, D.A.1
Neckers, L.M.2
-
43
-
-
0000407290
-
Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors?
-
Yakubov LA, Deeva EA, Zarytova VF, et al. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? Proc Natl Acad Sci U S A 1989;86:6454-8.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 6454-6458
-
-
Yakubov, L.A.1
Deeva, E.A.2
Zarytova, V.F.3
-
44
-
-
0032539676
-
Identification and characterization of a cell membrane nucleic acid channel
-
Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE. Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci U S A 1998;95:1921-6.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 1921-1926
-
-
Hanss, B.1
Leal-Pinto, E.2
Bruggeman, L.A.3
Copeland, T.D.4
Klotman, P.E.5
-
45
-
-
1842870143
-
Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma
-
Yano Y, Hayashi Y, Sano K, et al. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma. Int J Mol Med 2003;12:763-6.
-
(2003)
Int J Mol Med
, vol.12
, pp. 763-766
-
-
Yano, Y.1
Hayashi, Y.2
Sano, K.3
-
46
-
-
33746629480
-
-
Menniti FS, Faraci WS, Schmidt CJ. Phosphodiesterases in the CNS: targets for drug development. Nat Rev Drug Discov 2006;5:660-70.
-
Menniti FS, Faraci WS, Schmidt CJ. Phosphodiesterases in the CNS: targets for drug development. Nat Rev Drug Discov 2006;5:660-70.
-
-
-
-
47
-
-
0036729478
-
Cyclic nucleotide research: Still expanding after half a century
-
Beavo JA, Brunton LL. Cyclic nucleotide research: still expanding after half a century. Nat Rev Mol Cell Biol 2002;3:710-8.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 710-718
-
-
Beavo, J.A.1
Brunton, L.L.2
-
48
-
-
1242308248
-
cAMP detection methods in HTS: Selecting the best from the rest
-
Williams C. cAMP detection methods in HTS: selecting the best from the rest. Nat Rev Drug Discov 2004;3:125-35.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 125-135
-
-
Williams, C.1
|