-
1
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
2
-
-
0027378582
-
Role for DNA methylation in genomic imprinting
-
Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362-365 (1993).
-
(1993)
Nature
, vol.366
, pp. 362-365
-
-
Li, E.1
Beard, C.2
Jaenisch, R.3
-
3
-
-
0031467130
-
X-chromosome inactivation in mammals
-
Heard, E., Clerc, P. & Avner, P. X-chromosome inactivation in mammals. Annu. Rev. Genet. 31, 571-610 (1997).
-
(1997)
Annu. Rev. Genet
, vol.31
, pp. 571-610
-
-
Heard, E.1
Clerc, P.2
Avner, P.3
-
4
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
Egger, G., Liang, G., Aparicio, A. & Jones, P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429, 457-463 (2004).
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
5
-
-
0033822364
-
Large-scale human promoter mapping using CpG islands
-
Ioshikhes, I.P. & Zhang, M.Q. Large-scale human promoter mapping using CpG islands. Nat. Genet. 26, 61-63 (2000).
-
(2000)
Nat. Genet
, vol.26
, pp. 61-63
-
-
Ioshikhes, I.P.1
Zhang, M.Q.2
-
6
-
-
32344450824
-
Genomic DNA methylation: The mark and its mediators
-
Klose, R.J. & Bird, A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31, 89-97 (2006).
-
(2006)
Trends Biochem. Sci
, vol.31
, pp. 89-97
-
-
Klose, R.J.1
Bird, A.P.2
-
7
-
-
0026583975
-
Repression of genes by DNA methylation depends on CpG density and promoter strength: Evidence for involvement of a methyl-CpG binding protein
-
Boyes, J. & Bird, A. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J. 11, 327-333 (1992).
-
(1992)
EMBO J
, vol.11
, pp. 327-333
-
-
Boyes, J.1
Bird, A.2
-
8
-
-
0028106737
-
Dependence of transcriptional repression on CpG methylation density
-
Hsieh, C.L. Dependence of transcriptional repression on CpG methylation density. Mol. Cell. Biol. 14, 5487-5494 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 5487-5494
-
-
Hsieh, C.L.1
-
9
-
-
0027689976
-
Dynamics of DNA methylation during development
-
Brandeis, M., Ariel, M. & Cedar, H. Dynamics of DNA methylation during development. Bioessays 15, 709-713 (1993).
-
(1993)
Bioessays
, vol.15
, pp. 709-713
-
-
Brandeis, M.1
Ariel, M.2
Cedar, H.3
-
10
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 6-21
-
-
Bird, A.1
-
11
-
-
0036613432
-
Role for DNA methylation in the control of cell type specific maspin expression
-
Futscher, B.W. et al. Role for DNA methylation in the control of cell type specific maspin expression. Nat. Genet. 31, 175-179 (2002).
-
(2002)
Nat. Genet
, vol.31
, pp. 175-179
-
-
Futscher, B.W.1
-
12
-
-
14744267496
-
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression
-
Song, F. et al. Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc. Natl. Acad. Sci. USA 102, 3336-3341 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3336-3341
-
-
Song, F.1
-
13
-
-
0032901199
-
Cytosine methylation and mammalian development
-
Walsh, C.P. & Bestor, T.H. Cytosine methylation and mammalian development. Genes Dev. 13, 26-34 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 26-34
-
-
Walsh, C.P.1
Bestor, T.H.2
-
14
-
-
0032906457
-
DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation
-
Warnecke, P.M. & Clark, S.J. DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation. Mol. Cell. Biol. 19, 164-172 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 164-172
-
-
Warnecke, P.M.1
Clark, S.J.2
-
15
-
-
0035875049
-
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
-
Smiraglia, D.J. et al. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies. Hum. Mol. Genet. 10, 1413-1419 (2001).
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 1413-1419
-
-
Smiraglia, D.J.1
-
16
-
-
0018185292
-
Molecular basis of base substitution hotspots in Escherichia coli
-
Coulondre, C., Miller, J.H., Farabaugh, P.J. & Gilbert, W. Molecular basis of base substitution hotspots in Escherichia coli. Nature 274, 775-780 (1978).
-
(1978)
Nature
, vol.274
, pp. 775-780
-
-
Coulondre, C.1
Miller, J.H.2
Farabaugh, P.J.3
Gilbert, W.4
-
17
-
-
0028358421
-
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA
-
Shen, J.C., Rideout, W.M., III. & Jones, P.A. The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res. 22, 972-976 (1994).
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 972-976
-
-
Shen, J.C.1
Rideout III, W.M.2
Jones, P.A.3
-
18
-
-
0033575886
-
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
-
Hendrich, B., Hardeland, U., Ng, H.H., Jiricny, J. & Bird, A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 401, 301-304 (1999).
-
(1999)
Nature
, vol.401
, pp. 301-304
-
-
Hendrich, B.1
Hardeland, U.2
Ng, H.H.3
Jiricny, J.4
Bird, A.5
-
19
-
-
0027383758
-
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells
-
Neddermann, P. & Jiricny, J. The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. J. Biol. Chem. 268, 21218-21224 (1993).
-
(1993)
J. Biol. Chem
, vol.268
, pp. 21218-21224
-
-
Neddermann, P.1
Jiricny, J.2
-
20
-
-
32044455298
-
Large-scale structure of genomic methylation patterns
-
Rollins, R.A. et al. Large-scale structure of genomic methylation patterns. Genome Res. 16, 157-163 (2006).
-
(2006)
Genome Res
, vol.16
, pp. 157-163
-
-
Rollins, R.A.1
-
21
-
-
31944432339
-
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
-
Saxonov, S., Berg, P. & Brutlag, D.L. A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc. Natl. Acad. Sci. USA 103, 1412-1417 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1412-1417
-
-
Saxonov, S.1
Berg, P.2
Brutlag, D.L.3
-
22
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber, M. et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet. 37, 853-862 (2005).
-
(2005)
Nat. Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
-
23
-
-
0037133565
-
Comprehensive analysis of CpG islands in human chromosomes 21 and 22
-
Takai, D. & Jones, P.A. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc. Natl. Acad. Sci. USA 99, 3740-3745 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3740-3745
-
-
Takai, D.1
Jones, P.A.2
-
24
-
-
0023216891
-
CpG islands in vertebrate genomes
-
Gardiner-Garden, M. & Frommer, M. CpG islands in vertebrate genomes. J. Mol. Biol. 196, 261-282 (1987).
-
(1987)
J. Mol. Biol
, vol.196
, pp. 261-282
-
-
Gardiner-Garden, M.1
Frommer, M.2
-
25
-
-
23844519339
-
A high-resolution map of active promoters in the human genome
-
Kim, T.H. et al. A high-resolution map of active promoters in the human genome. Nature 436, 876-880 (2005).
-
(2005)
Nature
, vol.436
, pp. 876-880
-
-
Kim, T.H.1
-
26
-
-
15044366201
-
Methylation of histones: Playing memory with DNA
-
Peters, A.H. & Schubeler, D. Methylation of histones: playing memory with DNA. Curr. Opin. Cell Biol. 17, 230-238 (2005).
-
(2005)
Curr. Opin. Cell Biol
, vol.17
, pp. 230-238
-
-
Peters, A.H.1
Schubeler, D.2
-
27
-
-
2642570305
-
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
-
Schubeler, D. et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev. 18, 1263-1271 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 1263-1271
-
-
Schubeler, D.1
-
28
-
-
4644300141
-
Bayesian Markov chain Monte Carlo sequence analysis reveals varying neutral substitution patterns in mammalian evolution
-
Hwang, D.G. & Green, P. Bayesian Markov chain Monte Carlo sequence analysis reveals varying neutral substitution patterns in mammalian evolution. Proc. Natl. Acad. Sci. USA 101, 13994-14001 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13994-14001
-
-
Hwang, D.G.1
Green, P.2
-
29
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su, A.I. et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 101, 6062-6067 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6062-6067
-
-
Su, A.I.1
-
30
-
-
33745845526
-
The human cumulus-oocyte complex gene-expression profile
-
Assou, S. et al. The human cumulus-oocyte complex gene-expression profile. Hum. Reprod. 21, 1705-1719 (2006).
-
(2006)
Hum. Reprod
, vol.21
, pp. 1705-1719
-
-
Assou, S.1
-
31
-
-
4344711733
-
Frequent nonrandom activation of germ-line genes in human cancer
-
Koslowski, M. et al. Frequent nonrandom activation of germ-line genes in human cancer. Cancer Res. 64, 5988-5993 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 5988-5993
-
-
Koslowski, M.1
-
32
-
-
0025836937
-
DNA hypomethylation and germ cell-specific expression of testis-specific H2B histone gene
-
Choi, Y.C. & Chae, C.B. DNA hypomethylation and germ cell-specific expression of testis-specific H2B histone gene. J. Biol. Chem. 266, 20504-20511 (1991).
-
(1991)
J. Biol. Chem
, vol.266
, pp. 20504-20511
-
-
Choi, Y.C.1
Chae, C.B.2
-
33
-
-
0033761974
-
Testis-specific histone H1t gene is hypermethylated in nongerminal cells in the mouse
-
Singal, R. et al. Testis-specific histone H1t gene is hypermethylated in nongerminal cells in the mouse. Biol. Reprod. 63, 1237-1244 (2000).
-
(2000)
Biol. Reprod
, vol.63
, pp. 1237-1244
-
-
Singal, R.1
-
34
-
-
0034458963
-
Genomic targeting of methylated DNA: Influence of methylation on transcription, replication, chromatin structure, and histone acetylation
-
Schubeler, D. et al. Genomic targeting of methylated DNA: influence of methylation on transcription, replication, chromatin structure, and histone acetylation. Mol. Cell. Biol. 20, 9103-9112 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 9103-9112
-
-
Schubeler, D.1
-
35
-
-
33751505540
-
DNA methylation profiling of human chromosomes 6, 20 and 22
-
Eckhardt, F. et al. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet. 38, 1378-1385 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 1378-1385
-
-
Eckhardt, F.1
-
36
-
-
33645777446
-
CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
-
Bock, C. et al. CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet 2, e26 (2006).
-
(2006)
PLoS Genet
, vol.2
-
-
Bock, C.1
-
37
-
-
8644278033
-
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein
-
Ayton, P.M., Chen, E.H. & Cleary, M.L. Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol. Cell. Biol. 24, 10470-10478 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 10470-10478
-
-
Ayton, P.M.1
Chen, E.H.2
Cleary, M.L.3
-
38
-
-
29244438472
-
CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
-
Lee, J.H. & Skalnik, D.G. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. J. Biol. Chem. 280, 41725-41731 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 41725-41731
-
-
Lee, J.H.1
Skalnik, D.G.2
-
39
-
-
14644406272
-
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping
-
Roh, T.Y., Cuddapah, S. & Zhao, K. Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev. 19, 542-552 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 542-552
-
-
Roh, T.Y.1
Cuddapah, S.2
Zhao, K.3
-
40
-
-
0028940587
-
Gene number, noise reduction and biological complexity
-
Bird, A.P. Gene number, noise reduction and biological complexity. Trends Genet. 11, 94-100 (1995).
-
(1995)
Trends Genet
, vol.11
, pp. 94-100
-
-
Bird, A.P.1
-
41
-
-
33749396836
-
DNA methylation is a primary mechanism for silencing post-migratory primordial germ cell genes in both germ cell and somatic cell lineages
-
Maatouk, D.M. et al. DNA methylation is a primary mechanism for silencing post-migratory primordial germ cell genes in both germ cell and somatic cell lineages. Development 133, 3411-3418 (2006).
-
(2006)
Development
, vol.133
, pp. 3411-3418
-
-
Maatouk, D.M.1
-
42
-
-
20144379783
-
A role for E2F6 in the restriction of male-germ-cell-specific gene expression
-
Pohlers, M. et al. A role for E2F6 in the restriction of male-germ-cell-specific gene expression. Curr. Biol. 15, 1051-1057 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 1051-1057
-
-
Pohlers, M.1
-
43
-
-
2442654138
-
Promoter-dependent mechanism leading to selective hypomethylation within the 5′ region of gene MAGE-A1 in tumor cells
-
De Smet, C., Loriot, A. & Boon, T. Promoter-dependent mechanism leading to selective hypomethylation within the 5′ region of gene MAGE-A1 in tumor cells. Mol. Cell. Biol. 24, 4781-4790 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 4781-4790
-
-
De Smet, C.1
Loriot, A.2
Boon, T.3
-
44
-
-
0035735265
-
Computational identification of promoters and first exons in the human genome
-
Davuluri, R.V., Grosse, I. & Zhang, M.Q. Computational identification of promoters and first exons in the human genome. Nat. Genet. 29, 412-417 (2001).
-
(2001)
Nat. Genet
, vol.29
, pp. 412-417
-
-
Davuluri, R.V.1
Grosse, I.2
Zhang, M.Q.3
-
45
-
-
15244353967
-
X-inactivation profile reveals extensive variability in X-linked gene expression in females
-
Carrel, L. & Willard, H.F. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434, 400-404 (2005).
-
(2005)
Nature
, vol.434
, pp. 400-404
-
-
Carrel, L.1
Willard, H.F.2
-
46
-
-
0038692119
-
Human housekeeping genes are compact
-
Eisenberg, E. & Levanon, E.Y. Human housekeeping genes are compact. Trends Genet. 19, 362-365 (2003).
-
(2003)
Trends Genet
, vol.19
, pp. 362-365
-
-
Eisenberg, E.1
Levanon, E.Y.2
-
47
-
-
23144464171
-
Cancer/testis antigens, gametogenesis and cancer
-
Simpson, A.J., Caballero, O.L., Jungbluth, A., Chen, Y.T. & Old, L.J. Cancer/testis antigens, gametogenesis and cancer. Nat. Rev. Cancer 5, 615-625 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 615-625
-
-
Simpson, A.J.1
Caballero, O.L.2
Jungbluth, A.3
Chen, Y.T.4
Old, L.J.5
-
48
-
-
0038492517
-
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
-
Li, Z. et al. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc. Natl. Acad. Sci. USA 100, 8164-8169 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8164-8169
-
-
Li, Z.1
-
49
-
-
0031172451
-
Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses
-
Riesewijk, A.M. et al. Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses. Genomics 42, 236-244 (1997).
-
(1997)
Genomics
, vol.42
, pp. 236-244
-
-
Riesewijk, A.M.1
-
50
-
-
0842263778
-
The multicoloured world of promoter recognition complexes
-
Muller, F. & Tora, L. The multicoloured world of promoter recognition complexes. EMBO J. 23, 2-8 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 2-8
-
-
Muller, F.1
Tora, L.2
|