Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

Science

Volumn 340, Issue 6134, 2013, Pages 857-861

  Lewis, Peter W ^a   Müller, Manuel M ^b   Koletsky, Matthew S ^a   Cordero, Francisco ^c   Lin, Shu ^d   Banaszynski, Laura A ^a   Garcia, Benjamin A ^d   Muir, Tom W ^b   Becher, Oren J ^c   Allis, C David ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR EZH2;

INHIBITION; METHYLATION; MUTATION; POLYMERASE CHAIN REACTION; TUMOR;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME INHIBITION; GAIN OF FUNCTION MUTATION; IN VITRO STUDY; IN VIVO STUDY; PONTINE GLIOMA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 84877785024     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1232245     Document Type: Article

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