Inhibitors of histone demethylases

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3625-3636

  Lohse, Brian ^a   Kristensen, Jesper L ^a   Kristensen, Line H ^a   Agger, Karl ^b   Helin, Kristian ^b   Gajhede, Michael ^a   Clausen, Rasmus P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Epigenetics; HDM; Histone demethylases; Inhibitors; LSD1

Indexed keywords

2 METHOXY DERIVATIVE; 2,4 PYRIDINEDICARBOXYLIC ACID; AZIRIDINE; BAICALEIN; BENZYL DERIVATIVE; BENZYLSULFIDE DERIVATIVE; BETA LAPACHONE; CARBIDOPA; CYCLOPROPYL DERIVATIVE; DIMETHYL ESTER DERIVATIVE; DOPAMINE; FENOLDOPAM; HISTONE DEACETYLASE INHIBITOR; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE INHIBITOR; HYDROXAMIC ACID; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; LYSINE SPECIFIC DEMETHYLASE 2 INHIBITOR; MYRICETIN; OXIDOREDUCTASE INHIBITOR; OXYGENASE INHIBITOR; PARGYLINE; PEPTIDE DERIVATIVE; PHENETHYL DERIVATIVE; PHENYLSULFIDE DERIVATIVE; PHENYLZENE; PYRIMIDINE DERIVATIVE; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

ARTICLE; CANCER GROWTH; DEMETHYLATION; DRUG DESIGN; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENE OVEREXPRESSION; HIGH THROUGHPUT SCREENING; HISTONE METHYLATION; HUMAN; IC 50; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PROTEIN PROCESSING;

ANIMALS; BINDING SITES; ENZYME ACTIVATION; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HUMANS; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SUBSTRATE SPECIFICITY;

EID: 79958273993     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.046     Document Type: Article

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