-
2
-
-
37049252376
-
Structural modifications of histones and their possible role in the regulation of RNA synthesis
-
Allfrey V. G., Mirsky A. E., Structural modifications of histones and their possible role in the regulation of RNA synthesis Science 1964 144 3618 559
-
(1964)
Science
, vol.144
, Issue.3618
, pp. 559
-
-
Allfrey, V.G.1
Mirsky, A.E.2
-
3
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
Lane A. A., Chabner B. A., Histone deacetylase inhibitors in cancer therapy Journal of Clinical Oncology 2009 27 32 5459 5468
-
(2009)
Journal of Clinical Oncology
, vol.27
, Issue.32
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
5
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W., Roeder R. G., Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 1997 90 4 595 606
-
(1997)
Cell
, vol.90
, Issue.4
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
6
-
-
0343484254
-
Regulation of E2F1 activity by acetylation
-
Martnez-Balbs M. A., Bauer U.-M., Nielsen S. J., Brehm A., Kouzarides T., Regulation of E2F1 activity by acetylation EMBO Journal 2000 19 4 662 671
-
(2000)
EMBO Journal
, vol.19
, Issue.4
, pp. 662-671
-
-
Martnez-Balbs, M.A.1
Bauer, U.-M.2
Nielsen, S.J.3
Brehm, A.4
Kouzarides, T.5
-
7
-
-
10044262126
-
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
-
Patel J. H., Du Y., Ard P. G., Phillips C., Carella B., Chen C.-J., Rakowski C., Chatterjee C., Lieberman P. M., Lane W. S., Blobel G. A., McMahon S. B., The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60 Molecular and Cellular Biology 2004 24 24 10826 10834
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.24
, pp. 10826-10834
-
-
Patel, J.H.1
Du, Y.2
Ard, P.G.3
Phillips, C.4
Carella, B.5
Chen, C.-J.6
Rakowski, C.7
Chatterjee, C.8
Lieberman, P.M.9
Lane, W.S.10
Blobel, G.A.11
McMahon, S.B.12
-
8
-
-
0035979737
-
Duration of nuclear NF-κB action regulated by reversible acetylation
-
Chen L.-F., Fischle W., Verdin E., Greene W. C., Duration of nuclear NF-κB action regulated by reversible acetylation Science 2001 293 5535 1653 1657
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1653-1657
-
-
Chen, L.-F.1
Fischle, W.2
Verdin, E.3
Greene, W.C.4
-
9
-
-
18744375998
-
Regulation and destabilization of HIF-1 by ARD1-mediated acetylation
-
Jeong J.-W., Bae M.-K., Ahn M.-Y., Kim S.-H., Sohn T.-K., Bae M.-H., Yoo M.-A., Song E. J., Lee K.-J., Kim K.-W., Regulation and destabilization of HIF-1 by ARD1-mediated acetylation Cell 2002 111 5 709 720
-
(2002)
Cell
, vol.111
, Issue.5
, pp. 709-720
-
-
Jeong, J.-W.1
Bae, M.-K.2
Ahn, M.-Y.3
Kim, S.-H.4
Sohn, T.-K.5
Bae, M.-H.6
Yoo, M.-A.7
Song, E.J.8
Lee, K.-J.9
Kim, K.-W.10
-
10
-
-
0242637101
-
Direct acetylation of the estrogen receptor hinge region by p300 regulates transactivation and hormone sensitivity
-
Wang C., Fu M., Angeletti R. H., Siconolfi-Baez L., Reutens A. T., Albanese C., Lisanti M. P., Katzenellenbogen B. S., Kato S., Hopp T., Fuqua S. A. W., Lopez G. N., Kushner P. J., Pestell R. G., Direct acetylation of the estrogen receptor hinge region by p300 regulates transactivation and hormone sensitivity Journal of Biological Chemistry 2001 276 21 18375 18383
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.21
, pp. 18375-18383
-
-
Wang, C.1
Fu, M.2
Angeletti, R.H.3
Siconolfi-Baez, L.4
Reutens, A.T.5
Albanese, C.6
Lisanti, M.P.7
Katzenellenbogen, B.S.8
Kato, S.9
Hopp, T.10
Fuqua, S.A.W.11
Lopez, G.N.12
Kushner, P.J.13
Pestell, R.G.14
-
11
-
-
0037135566
-
Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
-
Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N., Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor Journal of Biological Chemistry 2002 277 29 25904 25913
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.29
, pp. 25904-25913
-
-
Gaughan, L.1
Logan, I.R.2
Cook, S.3
Neal, D.E.4
Robson, C.N.5
-
12
-
-
12144286529
-
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
-
Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A., Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis Molecular Cell 2004 13 5 627 638
-
(2004)
Molecular Cell
, vol.13
, Issue.5
, pp. 627-638
-
-
Cohen, H.Y.1
Lavu, S.2
Bitterman, K.J.3
Hekking, B.4
Imahiyerobo, T.A.5
Miller, C.6
Frye, R.7
Ploegh, H.8
Kessler, B.M.9
Sinclair, D.A.10
-
13
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs J. J., Murphy P. J. M., Gaillard S., Zhao X., Wu J.-T., Nicchitta C. V., Yoshida M., Toft D. O., Pratt W. B., Yao T.-P., HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor Molecular Cell 2005 18 5 601 607
-
(2005)
Molecular Cell
, vol.18
, Issue.5
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.M.2
Gaillard, S.3
Zhao, X.4
Wu, J.-T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.-P.10
-
14
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan Z.-L., Guan Y.-J., Chatterjee D., Chin Y. E., Stat3 dimerization regulated by reversible acetylation of a single lysine residue Science 2005 307 5707 269 273
-
(2005)
Science
, vol.307
, Issue.5707
, pp. 269-273
-
-
Yuan, Z.-L.1
Guan, Y.-J.2
Chatterjee, D.3
Chin, Y.E.4
-
15
-
-
0037416151
-
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
-
Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., Matthias P., HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo EMBO Journal 2003 22 5 1168 1179
-
(2003)
EMBO Journal
, vol.22
, Issue.5
, pp. 1168-1179
-
-
Zhang, Y.1
Li, N.2
Caron, C.3
Matthias, G.4
Hess, D.5
Khochbin, S.6
Matthias, P.7
-
18
-
-
28644440158
-
Histone deacetylase inhibitors: Discovery and development as anticancer agents
-
Marks P. A., Dokmanovic M., Histone deacetylase inhibitors: discovery and development as anticancer agents Expert Opinion on Investigational Drugs 2005 14 12 1497 1511
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.12
, pp. 1497-1511
-
-
Marks, P.A.1
Dokmanovic, M.2
-
19
-
-
13844309711
-
Clinical development of histone deacetylase inhibitors as anticancer agents
-
Drummond D. C., Noble C. O., Kirpotin D. B., Guo Z., Scott G. K., Benz C. C., Clinical development of histone deacetylase inhibitors as anticancer agents Annual Review of Pharmacology and Toxicology 2005 45 495 528
-
(2005)
Annual Review of Pharmacology and Toxicology
, vol.45
, pp. 495-528
-
-
Drummond, D.C.1
Noble, C.O.2
Kirpotin, D.B.3
Guo, Z.4
Scott, G.K.5
Benz, C.C.6
-
20
-
-
18444414332
-
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
-
Lagger G., O'Carroll D., Rembold M., Khier H., Tischler J., Weitzer G., Schuettengruber B., Hauser C., Brunmeir R., Jenuwein T., Seiser C., Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression EMBO Journal 2002 21 11 2672 2681
-
(2002)
EMBO Journal
, vol.21
, Issue.11
, pp. 2672-2681
-
-
Lagger, G.1
O'Carroll, D.2
Rembold, M.3
Khier, H.4
Tischler, J.5
Weitzer, G.6
Schuettengruber, B.7
Hauser, C.8
Brunmeir, R.9
Jenuwein, T.10
Seiser, C.11
-
21
-
-
33847695362
-
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity
-
Trivedi C. M., Luo Y., Yin Z., Zhang M., Zhu W., Wang T., Floss T., Goettlicher M., Noppinger P. R., Wurst W., Ferrari V. A., Abrams C. S., Gruber P. J., Epstein J. A., Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 activity Nature Medicine 2007 13 3 324 331
-
(2007)
Nature Medicine
, vol.13
, Issue.3
, pp. 324-331
-
-
Trivedi, C.M.1
Luo, Y.2
Yin, Z.3
Zhang, M.4
Zhu, W.5
Wang, T.6
Floss, T.7
Goettlicher, M.8
Noppinger, P.R.9
Wurst, W.10
Ferrari, V.A.11
Abrams, C.S.12
Gruber, P.J.13
Epstein, J.A.14
-
22
-
-
42149162792
-
HDACs and HDAC inhibitors in colon cancer
-
Mariadason J. M., HDACs and HDAC inhibitors in colon cancer Epigenetics 2008 3 1 28 37
-
(2008)
Epigenetics
, vol.3
, Issue.1
, pp. 28-37
-
-
Mariadason, J.M.1
-
23
-
-
0036304760
-
Histone deacetylase inhibitors: A new class of potential therapeutic agents for cancer treatment
-
Richon V. M., O'Brien J. P., Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment Clinical Cancer Research 2002 8 3 662 664
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.3
, pp. 662-664
-
-
Richon, V.M.1
O'Brien, J.P.2
-
24
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
Yoo C. B., Jones P. A., Epigenetic therapy of cancer: past, present and future Nature Reviews Drug Discovery 2006 5 1 37 50
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.1
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
25
-
-
38449100788
-
Expression profile of class i histone deacetylases in human cancer tissues
-
Nakagawa M., Oda Y., Eguchi T., Aishima S., Yao T., Hosoi F., Basaki Y., Ono M., Kuwano M., Tanaka M., Tsuneyoshi M., Expression profile of class I histone deacetylases in human cancer tissues Oncology Reports 2007 18 4 769 774
-
(2007)
Oncology Reports
, vol.18
, Issue.4
, pp. 769-774
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
Aishima, S.4
Yao, T.5
Hosoi, F.6
Basaki, Y.7
Ono, M.8
Kuwano, M.9
Tanaka, M.10
Tsuneyoshi, M.11
-
26
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expressjon and gene-associated histone acetylation
-
Richon V. M., Sandhoff T. W., Rifkind R. A., Marks P. A., Histone deacetylase inhibitor selectively induces p21WAF1 expressjon and gene-associated histone acetylation Proceedings of the National Academy of Sciences of the United States of America 2000 97 18 10014 10019
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.18
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
27
-
-
0033822112
-
P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin e by the histone deacetylase inhibitor FR901228
-
Sandor V., Senderowicz A., Mertins S., Sackett D., Sausville E., Blagosklonny M. V., Bates S. E., P21-dependent G1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228 British Journal of Cancer 2000 83 6 817 825
-
(2000)
British Journal of Cancer
, vol.83
, Issue.6
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
Sackett, D.4
Sausville, E.5
Blagosklonny, M.V.6
Bates, S.E.7
-
28
-
-
27644556419
-
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
-
Zhao Y., Tan J., Zhuang L., Jiang X., Liu E. T., Yu Q., Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim Proceedings of the National Academy of Sciences of the United States of America 2005 102 44 16090 16095
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.44
, pp. 16090-16095
-
-
Zhao, Y.1
Tan, J.2
Zhuang, L.3
Jiang, X.4
Liu, E.T.5
Yu, Q.6
-
29
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A., Monestiroli S., Ronzoni S., Gelmetti V., Marchesi F., Viale A., Altucci L., Nervi C., Minucci S., Pelicci P. G., Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway Nature Medicine 2005 11 1 71 76
-
(2005)
Nature Medicine
, vol.11
, Issue.1
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
Altucci, L.7
Nervi, C.8
Minucci, S.9
Pelicci, P.G.10
-
30
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
Nebbioso A., Clarke N., Voltz E., Germain E., Ambrosino C., Bontempo P., Alvarez R., Schiavone E. M., Ferrara F., Bresciani F., Weisz A., De Lera A. R., Gronemeyer H., Altucci L., Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells Nature Medicine 2005 11 1 77 84
-
(2005)
Nature Medicine
, vol.11
, Issue.1
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
Alvarez, R.7
Schiavone, E.M.8
Ferrara, F.9
Bresciani, F.10
Weisz, A.11
De Lera, A.R.12
Gronemeyer, H.13
Altucci, L.14
-
31
-
-
31544466465
-
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis
-
Zhang Y., Adachi M., Kawamura R., Imai K., Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHA-induced apoptosis Cell Death and Differentiation 2006 13 1 129 140
-
(2006)
Cell Death and Differentiation
, vol.13
, Issue.1
, pp. 129-140
-
-
Zhang, Y.1
Adachi, M.2
Kawamura, R.3
Imai, K.4
-
32
-
-
0017767153
-
N-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells
-
Riggs M. G., Whittaker R. G., Neumann J. R., Ingram V. M., n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells Nature 1977 268 5619 462 464
-
(1977)
Nature
, vol.268
, Issue.5619
, pp. 462-464
-
-
Riggs, M.G.1
Whittaker, R.G.2
Neumann, J.R.3
Ingram, V.M.4
-
33
-
-
0020025385
-
Effects of sodium butyrate, a new pharmacological agent, on cells in culture
-
Kruh J., Effects of sodium butyrate, a new pharmacological agent, on cells in culture Molecular and Cellular Biochemistry 1982 42 2 65 82
-
(1982)
Molecular and Cellular Biochemistry
, vol.42
, Issue.2
, pp. 65-82
-
-
Kruh, J.1
-
34
-
-
0017886958
-
Sodium butyrate inhibits histone deacetylation in cultured cells
-
Candido E. P. M., Reeves R., Davie J. R., Sodium butyrate inhibits histone deacetylation in cultured cells Cell 1978 14 1 105 113
-
(1978)
Cell
, vol.14
, Issue.1
, pp. 105-113
-
-
Candido, E.P.M.1
Reeves, R.2
Davie, J.R.3
-
35
-
-
0017864644
-
The effect of sodium butyrate on histone modification
-
Sealy L., Chalkley R., The effect of sodium butyrate on histone modification Cell 1978 14 1 115 121
-
(1978)
Cell
, vol.14
, Issue.1
, pp. 115-121
-
-
Sealy, L.1
Chalkley, R.2
-
36
-
-
0017898940
-
Suppression of histone deacetylation in vivo and in vitro by sodium butyrate
-
Boffa L. C., Vidali G., Mann R. S., Allfrey V. G., Suppression of histone deacetylation in vivo and in vitro by sodium butyrate Journal of Biological Chemistry 1978 253 10 3364 3366
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.10
, pp. 3364-3366
-
-
Boffa, L.C.1
Vidali, G.2
Mann, R.S.3
Allfrey, V.G.4
-
37
-
-
0017900551
-
Expression of poly(adenosine diphosphate-ribose) polymerase activity in erythroleukemic mouse cells during cell cycle and erythropoietic differentiation
-
Rastl E., Swetly P., Expression of poly(adenosine diphosphate-ribose) polymerase activity in erythroleukemic mouse cells during cell cycle and erythropoietic differentiation Journal of Biological Chemistry 1978 253 12 4333 4340
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.12
, pp. 4333-4340
-
-
Rastl, E.1
Swetly, P.2
-
38
-
-
0034596309
-
Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
-
Marks P. A., Richon V. M., Rifkind R. A., Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells Journal of the National Cancer Institute 2000 92 15 1210 1216
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.15
, pp. 1210-1216
-
-
Marks, P.A.1
Richon, V.M.2
Rifkind, R.A.3
-
40
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
Marks P. A., Breslow R., Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug Nature Biotechnology 2007 25 1 84 90
-
(2007)
Nature Biotechnology
, vol.25
, Issue.1
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
41
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
Piekarz R. L., Frye R., Turner M., Wright J. J., Allen S. L., Kirschbaum M. H., Zain J., Prince H. M., Leonard J. P., Geskin L. J., Reeder C., Joske D., Figg W. D., Gardner E. R., Steinberg S. M., Jaffe E. S., Stetler-Stevenson M., Lade S., Fojo A. T., Bates S. E., Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma Journal of Clinical Oncology 2009 27 32 5410 5417
-
(2009)
Journal of Clinical Oncology
, vol.27
, Issue.32
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
Wright, J.J.4
Allen, S.L.5
Kirschbaum, M.H.6
Zain, J.7
Prince, H.M.8
Leonard, J.P.9
Geskin, L.J.10
Reeder, C.11
Joske, D.12
Figg, W.D.13
Gardner, E.R.14
Steinberg, S.M.15
Jaffe, E.S.16
Stetler-Stevenson, M.17
Lade, S.18
Fojo, A.T.19
Bates, S.E.20
more..
-
42
-
-
67650090545
-
Histone deacetylase inhibitors: Potential in cancer therapy
-
Marks P. A., Xu W.-S., Histone deacetylase inhibitors: potential in cancer therapy Journal of Cellular Biochemistry 2009 107 4 600 608
-
(2009)
Journal of Cellular Biochemistry
, vol.107
, Issue.4
, pp. 600-608
-
-
Marks, P.A.1
Xu, W.-S.2
-
43
-
-
0033561497
-
Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
-
Kim Y. B., Lee K.-H., Sugita K., Yoshida M., Horinouchi S., Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase Oncogene 1999 18 15 2461 2470
-
(1999)
Oncogene
, vol.18
, Issue.15
, pp. 2461-2470
-
-
Kim, Y.B.1
Lee, K.-H.2
Sugita, K.3
Yoshida, M.4
Horinouchi, S.5
-
44
-
-
77649171884
-
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
-
Tan J., Cang S., Ma Y., Petrillo R. L., Liu D., Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents Journal of Hematology and Oncology 2010 3, article 5
-
(2010)
Journal of Hematology and Oncology
, vol.35
-
-
Tan, J.1
Cang, S.2
Ma, Y.3
Petrillo, R.L.4
Liu, D.5
-
45
-
-
34547683194
-
Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous t-cell lymphoma
-
Olsen E. A., Kim Y. H., Kuzel T. M., Pacheco T. R., Foss F. M., Parker S., Frankel S. R., Chen C., Ricker J. L., Arduino J. M., Duvic M., Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous t-cell lymphoma Journal of Clinical Oncology 2007 25 21 3109 3115
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.21
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
Pacheco, T.R.4
Foss, F.M.5
Parker, S.6
Frankel, S.R.7
Chen, C.8
Ricker, J.L.9
Arduino, J.M.10
Duvic, M.11
-
46
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M., Talpur R., Ni X., Zhang C., Hazarika P., Kelly C., Chiao J. H., Reilly J. F., Ricker J. L., Richon V. M., Frankel S. R., Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL) Blood 2007 109 1 31 39
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
Chiao, J.H.7
Reilly, J.F.8
Ricker, J.L.9
Richon, V.M.10
Frankel, S.R.11
-
47
-
-
67651164712
-
Vorinostat provides prolonged safety and clinical benefit to patients with advanced cutaneous t-cell lymphoma (CTCL)
-
Olsen E., Duvic M., Breneman D., Vorinostat provides prolonged safety and clinical benefit to patients with advanced cutaneous t-cell lymphoma (CTCL) Journal of Clinical Oncology 2008 26
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Olsen, E.1
Duvic, M.2
Breneman, D.3
-
48
-
-
43049092663
-
Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma
-
Crump M., Coiffier B., Jacobsen E. D., Sun L., Ricker J. L., Xie H., Frankel S. R., Randolph S. S., Cheson B. D., Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma Annals of Oncology 2008 19 5 964 969
-
(2008)
Annals of Oncology
, vol.19
, Issue.5
, pp. 964-969
-
-
Crump, M.1
Coiffier, B.2
Jacobsen, E.D.3
Sun, L.4
Ricker, J.L.5
Xie, H.6
Frankel, S.R.7
Randolph, S.S.8
Cheson, B.D.9
-
49
-
-
77749333564
-
Phase 2 study of suberoylanilide hydroxamic acid (SAHA) in relapsed or refractory indolent non-Hodgkin's lymphoma: A California Cancer Consortium study
-
abstract no. 18515
-
Kirschbaum M., Zain J., Popplewell L., Phase 2 study of suberoylanilide hydroxamic acid (SAHA) in relapsed or refractory indolent non-Hodgkin's lymphoma: a California Cancer Consortium study Journal of Clinical Oncology 2007 25. abstract no. 18515
-
(2007)
Journal of Clinical Oncology
, vol.25
-
-
Kirschbaum, M.1
Zain, J.2
Popplewell, L.3
-
50
-
-
38949096781
-
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
-
Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W. G., Faderl S., Koller C., Morris G., Rosner G., Loboda A., Fantin V. R., Randolph S. S., Hardwick J. S., Reilly J. F., Chen C., Ricker J. L., Secrist J. P., Richon V. M., Frankel S. R., Kantarjian H. M., Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes Blood 2008 111 3 1060 1066
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1060-1066
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
Ferrajoli, A.4
Cortes, J.5
Wierda, W.G.6
Faderl, S.7
Koller, C.8
Morris, G.9
Rosner, G.10
Loboda, A.11
Fantin, V.R.12
Randolph, S.S.13
Hardwick, J.S.14
Reilly, J.F.15
Chen, C.16
Ricker, J.L.17
Secrist, J.P.18
Richon, V.M.19
Frankel, S.R.20
Kantarjian, H.M.21
more..
-
51
-
-
34250696097
-
Phase i and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
-
Ramalingam S. S., Parise R. A., Ramananthan R. K., Lagattuta T. F., Musguire L. A., Stoller R. G., Potter D. M., Argiris A. E., Zwiebel J. A., Egorin M. J., Belani C. P., Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies Clinical Cancer Research 2007 13 12 3605 3610
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3605-3610
-
-
Ramalingam, S.S.1
Parise, R.A.2
Ramananthan, R.K.3
Lagattuta, T.F.4
Musguire, L.A.5
Stoller, R.G.6
Potter, D.M.7
Argiris, A.E.8
Zwiebel, J.A.9
Egorin, M.J.10
Belani, C.P.11
-
52
-
-
73949140461
-
Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
-
Ramalingam S. S., Maitland M. L., Frankel P., Argiris A. E., Koczywas M., Gitlitz B., Thomas S., Espinoza-Delgado I., Vokes E. E., Gandara D. R., Belani C. P., Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer Journal of Clinical Oncology 2010 28 1 56 62
-
(2010)
Journal of Clinical Oncology
, vol.28
, Issue.1
, pp. 56-62
-
-
Ramalingam, S.S.1
Maitland, M.L.2
Frankel, P.3
Argiris, A.E.4
Koczywas, M.5
Gitlitz, B.6
Thomas, S.7
Espinoza-Delgado, I.8
Vokes, E.E.9
Gandara, D.R.10
Belani, C.P.11
-
53
-
-
72249110437
-
Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago phase 2 consortium
-
Bradley D., Rathkopf D., Dunn R., Stadler W. M., Liu G., Smith D. C., Pili R., Zwiebel J., Scher H., Hussain M., Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago phase 2 consortium Cancer 2009 115 23 5541 5549
-
(2009)
Cancer
, vol.115
, Issue.23
, pp. 5541-5549
-
-
Bradley, D.1
Rathkopf, D.2
Dunn, R.3
Stadler, W.M.4
Liu, G.5
Smith, D.C.6
Pili, R.7
Zwiebel, J.8
Scher, H.9
Hussain, M.10
-
54
-
-
50249095068
-
Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
-
Vansteenkiste J., Van Cutsem E., Dumez H., Chen C., Ricker J. L., Randolph S. S., Schffski P., Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer Investigational New Drugs 2008 26 5 483 488
-
(2008)
Investigational New Drugs
, vol.26
, Issue.5
, pp. 483-488
-
-
Vansteenkiste, J.1
Van Cutsem, E.2
Dumez, H.3
Chen, C.4
Ricker, J.L.5
Randolph, S.S.6
Schffski, P.7
-
55
-
-
38149140216
-
Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza , suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer
-
Blumenschein G. R. Jr., Kies M. S., Papadimitrakopoulou V. A., Lu C., Kumar A. J., Ricker J. L., Chiao J. H., Chen C., Frankel S. R., Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer Investigational New Drugs 2008 26 1 81 87
-
(2008)
Investigational New Drugs
, vol.26
, Issue.1
, pp. 81-87
-
-
Blumenschein Jr., G.R.1
Kies, M.S.2
Papadimitrakopoulou, V.A.3
Lu, C.4
Kumar, A.J.5
Ricker, J.L.6
Chiao, J.H.7
Chen, C.8
Frankel, S.R.9
-
56
-
-
77955292345
-
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor
-
ARTICLE E11208
-
Kachhap S. K., Rosmus N., Collis S. J., Kortenhorst M. S.Q., Wissing M. D., Hedayati M., Shabbeer S., Mendonca J., Deangelis J., Marchionni L., Lin J., Hti N., Nortier J. W. R., Deweese T. L., Hammers H., Carducci M. A., Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor PLoS ONE 2010 5 6, article e11208 1 12
-
(2010)
PLoS ONE
, vol.5
, Issue.6
, pp. 1-12
-
-
Kachhap, S.K.1
Rosmus, N.2
Collis, S.J.3
Kortenhorst, M.S.Q.4
Wissing, M.D.5
Hedayati, M.6
Shabbeer, S.7
Mendonca, J.8
Deangelis, J.9
Marchionni, L.10
Lin, J.11
Hti, N.12
Nortier, J.W.R.13
Deweese, T.L.14
Hammers, H.15
Carducci, M.A.16
-
57
-
-
77956341931
-
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
-
Miller K. M., Tjeertes J. V., Coates J., Legube G., Polo S. E., Britton S., Jackson S. P., Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining Nature Structural and Molecular Biology 2010 17 9 1144 1151
-
(2010)
Nature Structural and Molecular Biology
, vol.17
, Issue.9
, pp. 1144-1151
-
-
Miller, K.M.1
Tjeertes, J.V.2
Coates, J.3
Legube, G.4
Polo, S.E.5
Britton, S.6
Jackson, S.P.7
-
58
-
-
65449177752
-
Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status
-
Folkvord S., Ree A. H., Furre T., Halvorsen T., Flatmark K., Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status International Journal of Radiation Oncology, Biology, Physics 2009 74 2 546 552
-
(2009)
International Journal of Radiation Oncology, Biology, Physics
, vol.74
, Issue.2
, pp. 546-552
-
-
Folkvord, S.1
Ree, A.H.2
Furre, T.3
Halvorsen, T.4
Flatmark, K.5
-
59
-
-
77952310681
-
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: The Pelvic Radiation and Vorinostat (PRAVO) phase 1 study
-
Ree A. H., Dueland S., Folkvord S., Hole K. H., Seierstad T., Johansen M., Abrahamsen T. W., Flatmark K., Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study The Lancet Oncology 2010 11 5 459 464
-
(2010)
The Lancet Oncology
, vol.11
, Issue.5
, pp. 459-464
-
-
Ree, A.H.1
Dueland, S.2
Folkvord, S.3
Hole, K.H.4
Seierstad, T.5
Johansen, M.6
Abrahamsen, T.W.7
Flatmark, K.8
-
60
-
-
0036301281
-
Phase i trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
-
Sandor V., Bakke S., Robey R. W., Kang M. H., Blagosklonny M. V., Bender J., Brooks R., Piekarz R. L., Tucker E., Figg W. D., Chan K. K., Goldspiel B., Fojo A. T., Balcerzak S. P., Bates S. E., Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms Clinical Cancer Research 2002 8 3 718 728
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.3
, pp. 718-728
-
-
Sandor, V.1
Bakke, S.2
Robey, R.W.3
Kang, M.H.4
Blagosklonny, M.V.5
Bender, J.6
Brooks, R.7
Piekarz, R.L.8
Tucker, E.9
Figg, W.D.10
Chan, K.K.11
Goldspiel, B.12
Fojo, A.T.13
Balcerzak, S.P.14
Bates, S.E.15
-
61
-
-
19944432566
-
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
-
Byrd J. C., Marcucci G., Parthun M. R., Xiao J. J., Klisovic R. B., Moran M., Lin T. S., Liu S., Sklenar A. R., Davis M. E., Lucas D. M., Fischer B., Shank R., Tejaswi S. L., Binkley P., Wright J., Chan K. K., Grever M. R., A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia Blood 2005 105 3 959 967
-
(2005)
Blood
, vol.105
, Issue.3
, pp. 959-967
-
-
Byrd, J.C.1
Marcucci, G.2
Parthun, M.R.3
Xiao, J.J.4
Klisovic, R.B.5
Moran, M.6
Lin, T.S.7
Liu, S.8
Sklenar, A.R.9
Davis, M.E.10
Lucas, D.M.11
Fischer, B.12
Shank, R.13
Tejaswi, S.L.14
Binkley, P.15
Wright, J.16
Chan, K.K.17
Grever, M.R.18
-
62
-
-
33747065289
-
Phase i study of depsipeptide in pediatric patients with refractory solid tumors: A Children's Oncology Group report
-
Fouladi M., Furman W. L., Chin T., Freeman B. B. III, Dudkin L., Stewart C. F., Krailo M. D., Speights R., Ingle A. M., Houghton P. J., Wright J., Adamson P. C., Blaney S. M., Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group report Journal of Clinical Oncology 2006 24 22 3678 3685
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.22
, pp. 3678-3685
-
-
Fouladi, M.1
Furman, W.L.2
Chin, T.3
Freeman III, B.B.4
Dudkin, L.5
Stewart, C.F.6
Krailo, M.D.7
Speights, R.8
Ingle, A.M.9
Houghton, P.J.10
Wright, J.11
Adamson, P.C.12
Blaney, S.M.13
-
63
-
-
38949144400
-
Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (Romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
-
Klimek V. M., Fircanis S., Maslak P., Guernah I., Baum M., Wu N., Panageas K., Wright J. J., Pandolfi P. P., Nimer S. D., Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (Romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes Clinical Cancer Research 2008 14 3 826 832
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 826-832
-
-
Klimek, V.M.1
Fircanis, S.2
Maslak, P.3
Guernah, I.4
Baum, M.5
Wu, N.6
Panageas, K.7
Wright, J.J.8
Pandolfi, P.P.9
Nimer, S.D.10
-
64
-
-
40749101544
-
Clinical and molecular responses in lung cancer patients receiving Romidepsin
-
Schrump D. S., Fischette M. R., Nguyen D. M., Zhao M., Li X., Kunst T. F., Hancox A., Hong J. A., Chen G. A., Kruchin E., Wright J. J., Rosing D. R., Sparreboom A., Figg W. D., Steinberg S. M., Clinical and molecular responses in lung cancer patients receiving Romidepsin Clinical Cancer Research 2008 14 1 188 198
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.1
, pp. 188-198
-
-
Schrump, D.S.1
Fischette, M.R.2
Nguyen, D.M.3
Zhao, M.4
Li, X.5
Kunst, T.F.6
Hancox, A.7
Hong, J.A.8
Chen, G.A.9
Kruchin, E.10
Wright, J.J.11
Rosing, D.R.12
Sparreboom, A.13
Figg, W.D.14
Steinberg, S.M.15
-
65
-
-
33749049594
-
A phase II study of depsipeptide in refractory metastatic renal cell cancer
-
Stadler W. M., Margolin K., Ferber S., McCulloch W., Thompson J. A., A phase II study of depsipeptide in refractory metastatic renal cell cancer Clinical Genitourinary Cancer 2006 5 1 57 60
-
(2006)
Clinical Genitourinary Cancer
, vol.5
, Issue.1
, pp. 57-60
-
-
Stadler, W.M.1
Margolin, K.2
Ferber, S.3
McCulloch, W.4
Thompson, J.A.5
-
66
-
-
55749109580
-
Romidepsin (FK228), a histone heacetylase inhibitor: Final results of a phase II study in metastatic hormone refractory prostate cancer (HRPC)
-
abstract no. 15507
-
Parker C., Molife R., Karavasilis V., Romidepsin (FK228), a histone heacetylase inhibitor: final results of a phase II study in metastatic hormone refractory prostate cancer (HRPC) Journal of Clinical Oncology 2007 25. abstract no. 15507
-
(2007)
Journal of Clinical Oncology
, vol.25
-
-
Parker, C.1
Molife, R.2
Karavasilis, V.3
-
67
-
-
51649110503
-
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
-
Garcia-Manero G., Assouline S., Cortes J., Estrov Z., Kantarjian H., Yang H., Newsome W. M., Miller W. H. Jr., Rousseau C., Kalita A., Bonfils C., Dubay M., Patterson T.-A., Li Z., Besterman J. M., Reid G., Laille E., Martell R. E., Minden M., Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia Blood 2008 112 4 981 989
-
(2008)
Blood
, vol.112
, Issue.4
, pp. 981-989
-
-
Garcia-Manero, G.1
Assouline, S.2
Cortes, J.3
Estrov, Z.4
Kantarjian, H.5
Yang, H.6
Newsome, W.M.7
Miller Jr., W.H.8
Rousseau, C.9
Kalita, A.10
Bonfils, C.11
Dubay, M.12
Patterson, T.-A.13
Li, Z.14
Besterman, J.M.15
Reid, G.16
Laille, E.17
Martell, R.E.18
Minden, M.19
-
68
-
-
79251566809
-
Treatment of relapsed or refractory non-hodgkin lymphoma with the oral isotype-selective histone deacetylase inhibitor MGCD01013: Interim results from a phase II study
-
abstract no. 8528
-
Crump M., Andreadis C., Assouline S., Rizzieri D., Wedgwood A., Mclauglin P., Treatment of relapsed or refractory non-hodgkin lymphoma with the oral isotype-selective histone deacetylase inhibitor MGCD01013: interim results from a phase II study Journal of Clinical Oncology 2008 26. abstract no. 8528
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Crump, M.1
Andreadis, C.2
Assouline, S.3
Rizzieri, D.4
Wedgwood, A.5
McLauglin, P.6
-
69
-
-
66349133867
-
Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin Lymphoma (HL)
-
abstract no. 8507
-
Bociek R. G., Kuruvilla G., Pro B., Wedgwood A., Li Z., Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin Lymphoma (HL) Journal of Clinical Oncology 2008 26. abstract no. 8507
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Bociek, R.G.1
Kuruvilla, G.2
Pro, B.3
Wedgwood, A.4
Li, Z.5
-
70
-
-
42949154252
-
Phase i study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors
-
Siu L. L., Pili R., Duran I., Messersmith W. A., Chen E. X., Sullivan R., MacLean M., King S., Brown S., Reid G. K., Li Z., Kalita A. M., Laille E. J., Besterman J. M., Martell R. E., Carducci M. A., Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors Journal of Clinical Oncology 2008 26 12 1940 1947
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.12
, pp. 1940-1947
-
-
Siu, L.L.1
Pili, R.2
Duran, I.3
Messersmith, W.A.4
Chen, E.X.5
Sullivan, R.6
MacLean, M.7
King, S.8
Brown, S.9
Reid, G.K.10
Li, Z.11
Kalita, A.M.12
Laille, E.J.13
Besterman, J.M.14
Martell, R.E.15
Carducci, M.A.16
-
71
-
-
70350443118
-
Phase I/II: The oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors
-
abstract no. 4625
-
Hurwitz H., Nelson B., O'Dwyer P. J., Chiorean E. G., Gabrail N., Li Z., Phase I/II: the oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors Journal of Clinical Oncology 2008 26. abstract no. 4625
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Hurwitz, H.1
Nelson, B.2
O'Dwyer, P.J.3
Chiorean, E.G.4
Gabrail, N.5
Li, Z.6
-
72
-
-
33748063974
-
A phase i study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies
-
Giles F., Fischer T., Cortes J., Garcia-Manero G., Beck J., Ravandi F., Masson E., Rae P., Laird G., Sharma S., Kantarjian H., Dugan M., Albitar M., Bhalla K., A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies Clinical Cancer Research 2006 12 15 4628 4635
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.15
, pp. 4628-4635
-
-
Giles, F.1
Fischer, T.2
Cortes, J.3
Garcia-Manero, G.4
Beck, J.5
Ravandi, F.6
Masson, E.7
Rae, P.8
Laird, G.9
Sharma, S.10
Kantarjian, H.11
Dugan, M.12
Albitar, M.13
Bhalla, K.14
-
73
-
-
67651177148
-
Phase II study of oral panobinostat (LBH589), a potent pan-deacetylase inhibitor, in patients with refractory Cutaneous T-Cell Lymphoma (CTCL)
-
abstract no. 8555
-
Duvic M., Vanaclocha F., Bernengo M. G., Phase II study of oral panobinostat (LBH589), a potent pan-deacetylase inhibitor, in patients with refractory Cutaneous T-Cell Lymphoma (CTCL) Journal of Clinical Oncology 2008 26. abstract no. 8555
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Duvic, M.1
Vanaclocha, F.2
Bernengo, M.G.3
-
74
-
-
49349104503
-
A phase i clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia
-
Gimsing P., Hansen M., Knudsen L. M., Knoblauch P., Christensen I. J., Ooi C. E., Buhl-Jensen P., A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia European Journal of Haematology 2008 81 3 170 176
-
(2008)
European Journal of Haematology
, vol.81
, Issue.3
, pp. 170-176
-
-
Gimsing, P.1
Hansen, M.2
Knudsen, L.M.3
Knoblauch, P.4
Christensen, I.J.5
Ooi, C.E.6
Buhl-Jensen, P.7
-
75
-
-
38949146399
-
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors
-
Steele N. L., Plumb J. A., Vidal L., Tjrrnelund J., Knoblauch P., Rasmussen A., Chean E. O., Buhl-Jensen P., Brown R., Evans T. R. J., DeBono J. S., A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors Clinical Cancer Research 2008 14 3 804 810
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 804-810
-
-
Steele, N.L.1
Plumb, J.A.2
Vidal, L.3
Tjrrnelund, J.4
Knoblauch, P.5
Rasmussen, A.6
Chean, E.O.7
Buhl-Jensen, P.8
Brown, R.9
Evans, T.R.J.10
Debono, J.S.11
-
76
-
-
77952585540
-
Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours
-
Mackay H. J., Hirte H., Colgan T., Covens A., MacAlpine K., Grenci P., Wang L., Mason J., Pham P.-A., Tsao M.-S., Pan J., Zwiebel J., Oza A. M., Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours European Journal of Cancer 2010 46 9 1573 1579
-
(2010)
European Journal of Cancer
, vol.46
, Issue.9
, pp. 1573-1579
-
-
MacKay, H.J.1
Hirte, H.2
Colgan, T.3
Covens, A.4
MacAlpine, K.5
Grenci, P.6
Wang, L.7
Mason, J.8
Pham, P.-A.9
Tsao, M.-S.10
Pan, J.11
Zwiebel, J.12
Oza, A.M.13
-
77
-
-
34848883438
-
Phase i trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies
-
Kummar S., Gutierrez M., Gardner E. R., Donovan E., Hwang K., Eun J. C., Lee M.-J., Maynard K., Kalnitskiy M., Chen A., Melillo G., Ryan Q. C., Conley B., Figg W. D., Trepel J. B., Zwiebel J., Doroshow J. H., Murgo A. J., Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies Clinical Cancer Research 2007 13 18 5411 5417
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.18
, pp. 5411-5417
-
-
Kummar, S.1
Gutierrez, M.2
Gardner, E.R.3
Donovan, E.4
Hwang, K.5
Eun, J.C.6
Lee, M.-J.7
Maynard, K.8
Kalnitskiy, M.9
Chen, A.10
Melillo, G.11
Ryan, Q.C.12
Conley, B.13
Figg, W.D.14
Trepel, J.B.15
Zwiebel, J.16
Doroshow, J.H.17
Murgo, A.J.18
-
78
-
-
51649091668
-
A phase i and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas
-
Gore L., Rothenberg M. L., O'Bryant C. L., Schultz M. K., Sandler A. B., Coffin D., McCoy C., Schott A., Scholz C., Eckhardt S. G., A phase I and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas Clinical Cancer Research 2008 14 14 4517 4525
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.14
, pp. 4517-4525
-
-
Gore, L.1
Rothenberg, M.L.2
O'Bryant, C.L.3
Schultz, M.K.4
Sandler, A.B.5
Coffin, D.6
McCoy, C.7
Schott, A.8
Scholz, C.9
Eckhardt, S.G.10
-
79
-
-
77649102354
-
Phase i trial of 5-azacitidine (AC) and SNDX-275 in advanced lung cancer (NSCLC)
-
abstract no. 19036
-
Juergens R. A., Vendetti F., Coleman B., Sebree R. S., Rudek M. A., Belinsky S. A., Phase I trial of 5-azacitidine (AC) and SNDX-275 in advanced lung cancer (NSCLC) Journal of Clinical Oncology 2008 26. abstract no. 19036
-
(2008)
Journal of Clinical Oncology
, vol.26
-
-
Juergens, R.A.1
Vendetti, F.2
Coleman, B.3
Sebree, R.S.4
Rudek, M.A.5
Belinsky, S.A.6
-
80
-
-
26844505068
-
Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase i study
-
Chavez-Blanco A., Segura-Pacheco B., Perez-Cardenas E., Taja-Chayeb L., Cetina L., Candelaria M., Cantu D., Gonzalez-Fierro A., Garcia-Lopez P., Zambrano P., Perez-Plasencia C., Cabrera G., Trejo-Becerril C., Angeles E., Duenas-Gonzalez A., Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study Molecular Cancer 2005 4, article 22
-
(2005)
Molecular Cancer
, vol.422
-
-
Chavez-Blanco, A.1
Segura-Pacheco, B.2
Perez-Cardenas, E.3
Taja-Chayeb, L.4
Cetina, L.5
Candelaria, M.6
Cantu, D.7
Gonzalez-Fierro, A.8
Garcia-Lopez, P.9
Zambrano, P.10
Perez-Plasencia, C.11
Cabrera, G.12
Trejo-Becerril, C.13
Angeles, E.14
Duenas-Gonzalez, A.15
-
81
-
-
34447304130
-
Valproic acid (VPA) in patients with refractory advanced cancer: A dose escalating phase i clinical trial
-
Atmaca A., Al-Batran S.-E., Maurer A., Neumann A., Heinzel T., Hentsch B., Schwarz S. E., Hvelmann S., Gttlicher M., Knuth A., Jger E., Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial British Journal of Cancer 2007 97 2 177 182
-
(2007)
British Journal of Cancer
, vol.97
, Issue.2
, pp. 177-182
-
-
Atmaca, A.1
Al-Batran, S.-E.2
Maurer, A.3
Neumann, A.4
Heinzel, T.5
Hentsch, B.6
Schwarz, S.E.7
Hvelmann, S.8
Gttlicher, M.9
Knuth, A.10
Jger, E.11
-
82
-
-
34548395116
-
A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
-
Candelaria M., Gallardo-Rincn D., Arce C., Cetina L., Aguilar-Ponce J. L., Arrieta., Gonzlez-Fierro A., Chvez-Blanco A., de la Cruz-Hernndez E., Camargo M. F., Trejo-Becerril C., Prez-Crdenas E., Prez-Plasencia C., Taja-Chayeb L., Wegman-Ostrosky T., Revilla-Vazquez A., Dueas-Gonzlez A., A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors Annals of Oncology 2007 18 9 1529 1538
-
(2007)
Annals of Oncology
, vol.18
, Issue.9
, pp. 1529-1538
-
-
Candelaria, M.1
Gallardo-Rincn, D.2
Arce, C.3
Cetina, L.4
Aguilar-Ponce, J.L.5
Arrieta, .6
Gonzlez-Fierro, A.7
Chvez-Blanco, A.8
De La Cruz-Hernndez, E.9
Camargo, M.F.10
Trejo-Becerril, C.11
Prez-Crdenas, E.12
Prez-Plasencia, C.13
Taja-Chayeb, L.14
Wegman-Ostrosky, T.15
Revilla-Vazquez, A.16
Dueas-Gonzlez, A.17
-
83
-
-
29144481615
-
Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
-
Kuendgen A., Knipp S., Fox F., Strupp C., Hildebrandt B., Steidl C., Germing U., Haas R., Gattermann N., Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia Annals of Hematology 2005 84 supplement 1 61 66
-
(2005)
Annals of Hematology
, vol.84
, Issue.SUPPL. 1
, pp. 61-66
-
-
Kuendgen, A.1
Knipp, S.2
Fox, F.3
Strupp, C.4
Hildebrandt, B.5
Steidl, C.6
Germing, U.7
Haas, R.8
Gattermann, N.9
-
84
-
-
34948845116
-
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
-
Soriano A. O., Yang H., Faderl S., Estrov Z., Giles F., Ravandi F., Cortes J., Wierda W. G., Ouzounian S., Quezada A., Pierce S., Estey E. H., Issa J.-P. J., Kantarjian H. M., Garcia-Manero G., Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome Blood 2007 110 7 2302 2308
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2302-2308
-
-
Soriano, A.O.1
Yang, H.2
Faderl, S.3
Estrov, Z.4
Giles, F.5
Ravandi, F.6
Cortes, J.7
Wierda, W.G.8
Ouzounian, S.9
Quezada, A.10
Pierce, S.11
Estey, E.H.12
Issa, J.-P.J.13
Kantarjian, H.M.14
Garcia-Manero, G.15
-
85
-
-
33750530675
-
Phase 1/2 study of the combination of 5-aza- 2′ -deoxycytidine with valproic acid in patients with leukemia
-
Garcia-Manero G., Kantarjian H. M., Sanchez-Gonzalez B., Yang H., Rosner G., Verstovsek S., Rytting M., Wierda W. G., Ravandi F., Koller C., Xiao L., Faderl S., Estrov Z., Cortes J., O'Brien S., Estey E., Bueso-Ramos C., Fiorentino J., Jabbour E., Issa J.-P., Phase 1/2 study of the combination of 5-aza- 2′ -deoxycytidine with valproic acid in patients with leukemia Blood 2006 108 10 3271 3279
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3271-3279
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzalez, B.3
Yang, H.4
Rosner, G.5
Verstovsek, S.6
Rytting, M.7
Wierda, W.G.8
Ravandi, F.9
Koller, C.10
Xiao, L.11
Faderl, S.12
Estrov, Z.13
Cortes, J.14
O'Brien, S.15
Estey, E.16
Bueso-Ramos, C.17
Fiorentino, J.18
Jabbour, E.19
Issa, J.-P.20
more..
-
86
-
-
67349248619
-
Molecular classification of solid tumours: Towards pathway-driven therapeutics
-
Swanton C., Caldas C., Molecular classification of solid tumours: towards pathway-driven therapeutics British Journal of Cancer 2009 100 10 1517 1522
-
(2009)
British Journal of Cancer
, vol.100
, Issue.10
, pp. 1517-1522
-
-
Swanton, C.1
Caldas, C.2
-
87
-
-
77955270038
-
Combined proteasome and histone deacetylase inhibition: A promising synergy for patients with relapsed/refractory multiple myeloma
-
Jagannath S., Dimopoulos M. A., Lonial S., Combined proteasome and histone deacetylase inhibition: a promising synergy for patients with relapsed/refractory multiple myeloma Leukemia Research 2010 34 9 1111 1118
-
(2010)
Leukemia Research
, vol.34
, Issue.9
, pp. 1111-1118
-
-
Jagannath, S.1
Dimopoulos, M.A.2
Lonial, S.3
-
88
-
-
64749110754
-
Vorinostat plus Bortezomib for the treatment of relapsed/refractory multiple myeloma: Early clinical experience
-
abstract no. 871
-
Weber D., Badros A., Jagannath S., Vorinostat plus Bortezomib for the treatment of relapsed/refractory multiple myeloma: early clinical experience Blood 2008 112. abstract no. 871
-
(2008)
Blood
, vol.112
-
-
Weber, D.1
Badros, A.2
Jagannath, S.3
-
89
-
-
0036776260
-
A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy
-
Imanishi R., Ohtsuru A., Iwamatsu M., Iioka T., Namba H., Seto S., Yano K., Yamashita S., A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy Journal of Clinical Endocrinology and Metabolism 2002 87 10 4821 4824
-
(2002)
Journal of Clinical Endocrinology and Metabolism
, vol.87
, Issue.10
, pp. 4821-4824
-
-
Imanishi, R.1
Ohtsuru, A.2
Iwamatsu, M.3
Iioka, T.4
Namba, H.5
Seto, S.6
Yano, K.7
Yamashita, S.8
-
90
-
-
34250651294
-
Histone deacetylase inhibitors and demethylating agents: Clinical development of histone deacetylase inhibitors for cancer therapy
-
Piekarz R. L., Sackett D. L., Bates S. E., Histone deacetylase inhibitors and demethylating agents: clinical development of histone deacetylase inhibitors for cancer therapy Cancer Journal 2007 13 1 30 39
-
(2007)
Cancer Journal
, vol.13
, Issue.1
, pp. 30-39
-
-
Piekarz, R.L.1
Sackett, D.L.2
Bates, S.E.3
-
92
-
-
0011195924
-
Effect of infusion rate on the toxicity of depsipeptide (NCS-63-176) in Beagle Dogs
-
abstract no. 2193
-
Page J. G., Rodman L., Heath J. E., Tomaszeqski J. E., Smith A. C., Effect of infusion rate on the toxicity of depsipeptide (NCS-63-176) in Beagle Dogs Proceedings of the American Association for Cancer Research 1995 36. abstract no. 2193
-
(1995)
Proceedings of the American Association for Cancer Research
, vol.36
-
-
Page, J.G.1
Rodman, L.2
Heath, J.E.3
Tomaszeqski, J.E.4
Smith, A.C.5
-
93
-
-
0011218523
-
Comparison of toxicity of depsipeptide (NSC-630176) in dogs and rats
-
abstract no. 2549
-
Page J. G., Rodman L., Heath J. E., Thomaszewski J. E., Smith A. C., Comparison of toxicity of depsipeptide (NSC-630176) in dogs and rats Proceedings of the American Association for Cancer Research 1996 37. abstract no. 2549
-
(1996)
Proceedings of the American Association for Cancer Research
, vol.37
-
-
Page, J.G.1
Rodman, L.2
Heath, J.E.3
Thomaszewski, J.E.4
Smith, A.C.5
-
94
-
-
33745683507
-
Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma
-
Piekarz R. L., Frye A. R., Wright J. J., Steinberg S. M., Liewehr D. J., Rosing D. R., Sachdev V., Fojo T., Bates S. E., Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma Clinical Cancer Research 2006 12 12 3762 3773
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.12
, pp. 3762-3773
-
-
Piekarz, R.L.1
Frye, A.R.2
Wright, J.J.3
Steinberg, S.M.4
Liewehr, D.J.5
Rosing, D.R.6
Sachdev, V.7
Fojo, T.8
Bates, S.E.9
-
95
-
-
18644379905
-
A phase i trial of Depsipeptide (FR901228) in patients with advanced cancer
-
Marshall J. L., Rizvi N., Kauh J., Dahut W., Figuera M., Kang M. H., Figg W. D., Wainer I., Chaissang C., Zhaoyang Li M., Hawkins M. J., A phase I trial of Depsipeptide (FR901228) in patients with advanced cancer Journal of Experimental Therapeutics and Oncology 2002 2 6 325 332
-
(2002)
Journal of Experimental Therapeutics and Oncology
, vol.2
, Issue.6
, pp. 325-332
-
-
Marshall, J.L.1
Rizvi, N.2
Kauh, J.3
Dahut, W.4
Figuera, M.5
Kang, M.H.6
Figg, W.D.7
Wainer, I.8
Chaissang, C.9
Zhaoyang Li, M.10
Hawkins, M.J.11
-
96
-
-
67649985963
-
International multicenter Phase II study of the HDAC inhibitor (HDACi) depsipeptide (FK228) in cutaneous T-cell lymphoma (CTCL): Interim report
-
abstract no. 3062
-
Whittaker S., McCulloch W., Robak T., International multicenter Phase II study of the HDAC inhibitor (HDACi) depsipeptide (FK228) in cutaneous T-cell lymphoma (CTCL): interim report Journal of Clinical Oncology 2006 24. abstract no. 3062
-
(2006)
Journal of Clinical Oncology
, vol.24
-
-
Whittaker, S.1
McCulloch, W.2
Robak, T.3
-
97
-
-
67349227787
-
Isoform-specific histone deacetylase inhibitors: The next step?
-
Balasubramanian S., Verner E., Buggy J. J., Isoform-specific histone deacetylase inhibitors: the next step? Cancer Letters 2009 280 2 211 221
-
(2009)
Cancer Letters
, vol.280
, Issue.2
, pp. 211-221
-
-
Balasubramanian, S.1
Verner, E.2
Buggy, J.J.3
-
98
-
-
4544358659
-
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
-
Chang S., McKinsey T. A., Zhang C. L., Richardson J. A., Hill J. A., Olson E. N., Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development Molecular and Cellular Biology 2004 24 19 8467 8476
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.19
, pp. 8467-8476
-
-
Chang, S.1
McKinsey, T.A.2
Zhang, C.L.3
Richardson, J.A.4
Hill, J.A.5
Olson, E.N.6
-
99
-
-
55849084700
-
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
-
Montgomery R. L., Potthoff M. J., Haberland M., Qi X., Matsuzaki S., Humphries K. M., Richardson J. A., Bassel-Duby R., Olson E. N., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice Journal of Clinical Investigation 2008 118 11 3588 3597
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.11
, pp. 3588-3597
-
-
Montgomery, R.L.1
Potthoff, M.J.2
Haberland, M.3
Qi, X.4
Matsuzaki, S.5
Humphries, K.M.6
Richardson, J.A.7
Bassel-Duby, R.8
Olson, E.N.9
-
100
-
-
58049208190
-
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
-
Fotheringham S., Epping M. T., Stimson L., Khan O., Wood V., Pezzella F., Bernards R., La Thangue N. B., Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis Cancer Cell 2009 15 1 57 66
-
(2009)
Cancer Cell
, vol.15
, Issue.1
, pp. 57-66
-
-
Fotheringham, S.1
Epping, M.T.2
Stimson, L.3
Khan, O.4
Wood, V.5
Pezzella, F.6
Bernards, R.7
La Thangue, N.B.8
-
101
-
-
77950877402
-
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy
-
Khan O., Fotheringham S., Wood V., Stimson L., Zhang C., Pezzella F., Duvic M., Kerr D. J., La Thangue N. B., HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy Proceedings of the National Academy of Sciences of the United States of America 2010 107 14 6532 6537
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.14
, pp. 6532-6537
-
-
Khan, O.1
Fotheringham, S.2
Wood, V.3
Stimson, L.4
Zhang, C.5
Pezzella, F.6
Duvic, M.7
Kerr, D.J.8
La Thangue, N.B.9
|