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Volumn 6, Issue NOV, 2015, Pages

Fibroblast growth factor 21 analogs for treating metabolic disorders

Author keywords

Antibody; Beta Klotho; Diabetes; FGF19; FGF21; FGFR1; Obesity; Therapy

Indexed keywords

ADIPONECTIN; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR 4; MONOCLONAL ANTIBODY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCOUPLING PROTEIN 1;

EID: 84949776698     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2015.00168     Document Type: Review
Times cited : (53)

References (109)
  • 1
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    • Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem (2011) 149:121-30. doi: 10.1093/jb/mvq121
    • (2011) J Biochem , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 2
    • 84885136779 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors, developmental corruption and malignant disease
    • Kelleher FC, O'Sullivan H, Smyth E, McDermott R, Viterbo A. Fibroblast growth factor receptors, developmental corruption and malignant disease. Carcinogenesis (2013) 34:2198-205. doi:10.1093/carcin/bgt254
    • (2013) Carcinogenesis , vol.34 , pp. 2198-2205
    • Kelleher, F.C.1    O'Sullivan, H.2    Smyth, E.3    McDermott, R.4    Viterbo, A.5
  • 3
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • Itoh N, Ornitz DM. Evolution of the Fgf and Fgfr gene families. Trends Genet (2004) 20:563-9. doi:10.1016/j.tig.2004.08.007
    • (2004) Trends Genet , vol.20 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 4
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta (2000) 1492:203-6. doi:10.1016/S0167-4781(00)00067-1
    • (2000) Biochim Biophys Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 5
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 5:415-25. doi:10.1016/j.cmet.2007.05.003
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5    Parameswara, V.6
  • 8
    • 41649109108 scopus 로고    scopus 로고
    • BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    • Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, Kimura M, et al. BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol (2008) 22:1006-14. doi:10.1210/me.2007-0313
    • (2008) Mol Endocrinol , vol.22 , pp. 1006-1014
    • Suzuki, M.1    Uehara, Y.2    Motomura-Matsuzaka, K.3    Oki, J.4    Koyama, Y.5    Kimura, M.6
  • 9
    • 77955814651 scopus 로고    scopus 로고
    • Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease
    • Itoh N. Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Cell Tissue Res (2010) 342:1-11. doi:10.1007/s00441-010-1024-2
    • (2010) Cell Tissue Res , vol.342 , pp. 1-11
    • Itoh, N.1
  • 10
    • 79955590366 scopus 로고    scopus 로고
    • Hormone-like fibroblast growth factors and metabolic regulation
    • Long YC, Kharitonenkov A. Hormone-like fibroblast growth factors and metabolic regulation. Biochim Biophys Acta (2011) 1812:791-5. doi:10.1016/j.bbadis.2011.04.002
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 791-795
    • Long, Y.C.1    Kharitonenkov, A.2
  • 11
    • 70350322694 scopus 로고    scopus 로고
    • Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
    • Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology (2009) 150:4931-40. doi:10.1210/en.2009-0532
    • (2009) Endocrinology , vol.150 , pp. 4931-4940
    • Badman, M.K.1    Koester, A.2    Flier, J.S.3    Kharitonenkov, A.4    Maratos-Flier, E.5
  • 13
    • 63849189712 scopus 로고    scopus 로고
    • Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
    • Mraz M, Bartlova M, Lacinova Z, Michalsky D, Kasalicky M, Haluzikova D, et al. Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. Clin Endocrinol (2009) 71:369-75. doi:10.1111/j.1365-2265.2008.03502.x
    • (2009) Clin Endocrinol , vol.71 , pp. 369-375
    • Mraz, M.1    Bartlova, M.2    Lacinova, Z.3    Michalsky, D.4    Kasalicky, M.5    Haluzikova, D.6
  • 14
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes (2008) 57:1246-53. doi:10.2337/db07-1476
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5    Liu, F.6
  • 15
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care (2009) 32:1542-6. doi:10.2337/dc09-0684
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 16
    • 84862928486 scopus 로고    scopus 로고
    • Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes
    • Xiao Y, Xu A, Law LS, Chen C, Li H, Li X, et al. Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes. J Clin Endocrinol Metab (2012) 97:E54-8. doi:10.1210/jc.2011-1930
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E54-E58
    • Xiao, Y.1    Xu, A.2    Law, L.S.3    Chen, C.4    Li, H.5    Li, X.6
  • 17
    • 66749106885 scopus 로고    scopus 로고
    • Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects
    • Li H, Bao Y, Xu A, Pan X, Lu J, Wu H, et al. Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects. J Clin Endocrinol Metab (2009) 94:2151-6. doi:10.1210/jc.2008-2331
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2151-2156
    • Li, H.1    Bao, Y.2    Xu, A.3    Pan, X.4    Lu, J.5    Wu, H.6
  • 18
    • 77956519052 scopus 로고    scopus 로고
    • Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
    • Yilmaz Y, Eren F, Yonal O, Kurt R, Aktas B, Celikel CA, et al. Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. Eur J Clin Invest (2010) 40:887-92. doi:10.1111/j.1365-2362.2010.02338.x
    • (2010) Eur J Clin Invest , vol.40 , pp. 887-892
    • Yilmaz, Y.1    Eren, F.2    Yonal, O.3    Kurt, R.4    Aktas, B.5    Celikel, C.A.6
  • 19
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol (2010) 53:934-40. doi:10.1016/j.jhep.2010.05.018
    • (2010) J Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3    Fan, J.4    Zhou, J.5    Wang, X.6
  • 20
    • 78650850911 scopus 로고    scopus 로고
    • Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile
    • Lin Z, Wu Z, Yin X, Liu Y, Yan X, Lin S, et al. Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PLoS One (2010) 5:e15534. doi:10.1371/journal.pone.0015534
    • (2010) PLoS One , vol.5
    • Lin, Z.1    Wu, Z.2    Yin, X.3    Liu, Y.4    Yan, X.5    Lin, S.6
  • 21
    • 84883118811 scopus 로고    scopus 로고
    • Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease
    • Shen Y, Ma X, Zhou J, Pan X, Hao Y, Zhou M, et al. Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease. Cardiovasc Diabetol (2013) 12:124. doi:10.1186/1475-2840-12-124
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 124
    • Shen, Y.1    Ma, X.2    Zhou, J.3    Pan, X.4    Hao, Y.5    Zhou, M.6
  • 22
    • 84885039863 scopus 로고    scopus 로고
    • Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors
    • Chow WS, Xu A, Woo YC, Tso AW, Cheung SC, Fong CH, et al. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Arterioscler Thromb Vasc Biol (2013) 33:2454-9. doi:10.1161/ATVBAHA.113.301599
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 2454-2459
    • Chow, W.S.1    Xu, A.2    Woo, Y.C.3    Tso, A.W.4    Cheung, S.C.5    Fong, C.H.6
  • 23
    • 84899587333 scopus 로고    scopus 로고
    • Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction
    • Hindricks J, Ebert T, Bachmann A, Kralisch S, Lossner U, Kratzsch J, et al. Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction. Clin Endocrinol (2014) 80:918-24. doi:10.1111/cen.12380
    • (2014) Clin Endocrinol , vol.80 , pp. 918-924
    • Hindricks, J.1    Ebert, T.2    Bachmann, A.3    Kralisch, S.4    Lossner, U.5    Kratzsch, J.6
  • 24
    • 79954525448 scopus 로고    scopus 로고
    • Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese
    • Lin Z, Zhou Z, Liu Y, Gong Q, Yan X, Xiao J, et al. Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. PLoS One (2011) 6:e18398. doi:10.1371/journal.pone.0018398
    • (2011) PLoS One , vol.6
    • Lin, Z.1    Zhou, Z.2    Liu, Y.3    Gong, Q.4    Yan, X.5    Xiao, J.6
  • 25
    • 84872070199 scopus 로고    scopus 로고
    • Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis
    • Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, Celi FS. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab (2013) 98:E98-102. doi:10.1210/jc.2012-3107
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E98-E102
    • Lee, P.1    Brychta, R.J.2    Linderman, J.3    Smith, S.4    Chen, K.Y.5    Celi, F.S.6
  • 27
    • 74049108945 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: from pharmacology to physiology
    • Kliewer SA, Mangelsdorf DJ. Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr (2010) 91:254S-7S. doi:10.3945/ajcn.2009.28449B
    • (2010) Am J Clin Nutr , vol.91 , pp. 254S-257S
    • Kliewer, S.A.1    Mangelsdorf, D.J.2
  • 28
    • 79952103793 scopus 로고    scopus 로고
    • FGF21 reloaded: challenges of a rapidly growing field
    • Kharitonenkov A, Larsen P. FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab (2011) 22:81-6. doi:10.1016/j.tem.2010.11.003
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 81-86
    • Kharitonenkov, A.1    Larsen, P.2
  • 29
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
    • Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev (2012) 26:312-24. doi:10.1101/gad.184788.111
    • (2012) Genes Dev , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 30
    • 84870568785 scopus 로고    scopus 로고
    • Circulating fibroblast growth factors as metabolic regulators - a critical appraisal
    • Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators - a critical appraisal. Cell Metab (2012) 16:693-705. doi:10.1016/j.cmet.2012.11.001
    • (2012) Cell Metab , vol.16 , pp. 693-705
    • Angelin, B.1    Larsson, T.E.2    Rudling, M.3
  • 31
    • 84897109882 scopus 로고    scopus 로고
    • Inventing new medicines: the FGF21 story
    • Kharitonenkov A, Adams AC. Inventing new medicines: the FGF21 story. Mol Metab (2014) 3:221-9. doi:10.1016/j.molmet.2013.12.003
    • (2014) Mol Metab , vol.3 , pp. 221-229
    • Kharitonenkov, A.1    Adams, A.C.2
  • 32
    • 84901496215 scopus 로고    scopus 로고
    • Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome
    • Zhang J, Li Y. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. Drug Discov Today (2014) 19:579-89. doi:10.1016/j.drudis.2013.10.021
    • (2014) Drug Discov Today , vol.19 , pp. 579-589
    • Zhang, J.1    Li, Y.2
  • 33
    • 84901821975 scopus 로고    scopus 로고
    • FGF21-based pharmacotherapy - potential utility for metabolic disorders
    • Gimeno RE, Moller DE. FGF21-based pharmacotherapy - potential utility for metabolic disorders. Trends Endocrinol Metab (2014) 25:303-11. doi:10.1016/j.tem.2014.03.001
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 303-311
    • Gimeno, R.E.1    Moller, D.E.2
  • 34
    • 84920483737 scopus 로고    scopus 로고
    • Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
    • Owen BM, Mangelsdorf DJ, Kliewer SA. Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Trends Endocrinol Metab (2015) 26:22-9. doi:10.1016/j.tem.2014.10.002
    • (2015) Trends Endocrinol Metab , vol.26 , pp. 22-29
    • Owen, B.M.1    Mangelsdorf, D.J.2    Kliewer, S.A.3
  • 36
    • 84865741904 scopus 로고    scopus 로고
    • BetaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
    • Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, et al. BetaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab (2012) 16:387-93. doi:10.1016/j.cmet.2012.08.002
    • (2012) Cell Metab , vol.16 , pp. 387-393
    • Ding, X.1    Boney-Montoya, J.2    Owen, B.M.3    Bookout, A.L.4    Coate, K.C.5    Mangelsdorf, D.J.6
  • 37
    • 84881508008 scopus 로고    scopus 로고
    • The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    • Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife (2012) 1:e00065. doi:10.7554/eLife.00065
    • (2012) Elife , vol.1
    • Zhang, Y.1    Xie, Y.2    Berglund, E.D.3    Coate, K.C.4    He, T.T.5    Katafuchi, T.6
  • 39
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes (2009) 58:250-9. doi:10.2337/db08-0392
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3    Stanislaus, S.4    Chen, M.5    Sivits, G.6
  • 40
    • 69249093921 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
    • Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, et al. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology (2009) 150:4084-93. doi:10.1210/en.2009-0221
    • (2009) Endocrinology , vol.150 , pp. 4084-4093
    • Berglund, E.D.1    Li, C.Y.2    Bina, H.A.3    Lynes, S.E.4    Michael, M.D.5    Shanafelt, A.B.6
  • 41
    • 70350455732 scopus 로고    scopus 로고
    • Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models - association with liver and adipose tissue effects
    • Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models - association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab (2009) 297:E1105-14. doi:10.1152/ajpendo.00348.2009
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E1105-E1114
    • Xu, J.1    Stanislaus, S.2    Chinookoswong, N.3    Lau, Y.Y.4    Hager, T.5    Patel, J.6
  • 43
    • 43549110007 scopus 로고    scopus 로고
    • FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity
    • Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Ryden M. FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. FEBS Lett (2008) 582:1725-30. doi:10.1016/j.febslet.2008.04.038
    • (2008) FEBS Lett , vol.582 , pp. 1725-1730
    • Arner, P.1    Pettersson, A.2    Mitchell, P.J.3    Dunbar, J.D.4    Kharitonenkov, A.5    Ryden, M.6
  • 44
    • 70349472910 scopus 로고    scopus 로고
    • Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
    • Li X, Ge H, Weiszmann J, Hecht R, Li YS, Veniant MM, et al. Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett (2009) 583:3230-4. doi:10.1016/j.febslet.2009.09.012
    • (2009) FEBS Lett , vol.583 , pp. 3230-3234
    • Li, X.1    Ge, H.2    Weiszmann, J.3    Hecht, R.4    Li, Y.S.5    Veniant, M.M.6
  • 45
    • 84877272187 scopus 로고    scopus 로고
    • An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
    • Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 17:790-7. doi:10.1016/j.cmet.2013.03.019
    • (2013) Cell Metab , vol.17 , pp. 790-797
    • Holland, W.L.1    Adams, A.C.2    Brozinick, J.T.3    Bui, H.H.4    Miyauchi, Y.5    Kusminski, C.M.6
  • 46
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 17:779-89. doi:10.1016/j.cmet.2013.04.005
    • (2013) Cell Metab , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3    Lin, S.4    Hoo, R.C.5    Konishi, M.6
  • 47
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev (1998) 12:3182-94. doi:10.1101/gad.12.20.3182
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6
  • 48
    • 84863637593 scopus 로고    scopus 로고
    • FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
    • Veniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, et al. FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One (2012) 7:e40164. doi:10.1371/journal.pone.0040164
    • (2012) PLoS One , vol.7
    • Veniant, M.M.1    Hale, C.2    Helmering, J.3    Chen, M.M.4    Stanislaus, S.5    Busby, J.6
  • 49
    • 84870359606 scopus 로고    scopus 로고
    • Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
    • Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Sci Transl Med (2012) 4:162ra153. doi:10.1126/scitranslmed.3004690
    • (2012) Sci Transl Med , vol.4
    • Foltz, I.N.1    Hu, S.2    King, C.3    Wu, X.4    Yang, C.5    Wang, W.6
  • 50
    • 84905679771 scopus 로고    scopus 로고
    • The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
    • Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, et al. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab (2013) 2:31. doi:10.1016/j.molmet.2012.08.007
    • (2013) Mol Metab , vol.2 , pp. 31
    • Adams, A.C.1    Yang, C.2    Coskun, T.3    Cheng, C.C.4    Gimeno, R.E.5    Luo, Y.6
  • 51
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem (2007) 282:26687-95. doi:10.1074/jbc.M704165200
    • (2007) J Biol Chem , vol.282 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3    Dickson, A.S.4    Goetz, R.5    Eliseenkova, A.V.6
  • 52
    • 79960726293 scopus 로고    scopus 로고
    • Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
    • Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology (2011) 152:2996-3004. doi:10.1210/en.2011-0281
    • (2011) Endocrinology , vol.152 , pp. 2996-3004
    • Fisher, F.M.1    Estall, J.L.2    Adams, A.C.3    Antonellis, P.J.4    Bina, H.A.5    Flier, J.S.6
  • 53
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 26:271-81. doi:10.1101/gad.177857.111
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5    Verdeguer, F.6
  • 55
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem (2011) 286:12983-90. doi:10.1074/jbc.M110.215889
    • (2011) J Biol Chem , vol.286 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3    Gonzalez, F.J.4    Giralt, M.5    Mampel, T.6
  • 57
    • 84930579383 scopus 로고    scopus 로고
    • Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue
    • Veniant MM, Sivits G, Helmering J, Komorowski R, Lee J, Fan W, et al. Pharmacologic effects of FGF21 are independent of the "browning" of white adipose tissue. Cell Metab (2015) 21:731-8. doi:10.1016/j.cmet.2015.04.019
    • (2015) Cell Metab , vol.21 , pp. 731-738
    • Veniant, M.M.1    Sivits, G.2    Helmering, J.3    Komorowski, R.4    Lee, J.5    Fan, W.6
  • 58
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab (2007) 5:426-37. doi:10.1016/j.cmet.2007.05.002
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 60
    • 84910003771 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target
    • Liu WY, Huang S, Shi KQ, Zhao CC, Chen LL, Braddock M, et al. The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target. Expert Opin Ther Targets (2014) 18:1305-13. doi:10.1517/14728222.2014.944898
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 1305-1313
    • Liu, W.Y.1    Huang, S.2    Shi, K.Q.3    Zhao, C.C.4    Chen, L.L.5    Braddock, M.6
  • 61
    • 84908291960 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets
    • 1073-83.e6
    • Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, et al. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology (2014) 147:1073-83.e6. doi:10.1053/j.gastro.2014.07.044
    • (2014) Gastroenterology , vol.147
    • Fisher, F.M.1    Chui, P.C.2    Nasser, I.A.3    Popov, Y.4    Cunniff, J.C.5    Lundasen, T.6
  • 62
    • 84861571519 scopus 로고    scopus 로고
    • Association between serum fibroblast growth factor 21 and diabetic nephropathy
    • Jian WX, Peng WH, Jin J, Chen XR, Fang WJ, Wang WX, et al. Association between serum fibroblast growth factor 21 and diabetic nephropathy. Metabolism (2012) 61:853-9. doi:10.1016/j.metabol.2011.10.012
    • (2012) Metabolism , vol.61 , pp. 853-859
    • Jian, W.X.1    Peng, W.H.2    Jin, J.3    Chen, X.R.4    Fang, W.J.5    Wang, W.X.6
  • 63
    • 84883151328 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice
    • Kim HW, Lee JE, Cha JJ, Hyun YY, Kim JE, Lee MH, et al. Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice. Endocrinology (2013) 154:3366-76. doi:10.1210/en.2012-2276
    • (2013) Endocrinology , vol.154 , pp. 3366-3376
    • Kim, H.W.1    Lee, J.E.2    Cha, J.J.3    Hyun, Y.Y.4    Kim, J.E.5    Lee, M.H.6
  • 65
    • 84862797612 scopus 로고    scopus 로고
    • Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques
    • An SY, Lee MS, Yi SA, Ha ES, Han SJ, Kim HJ, et al. Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques. Diabetes Res Clin Pract (2012) 96:196-203. doi:10.1016/j.diabres.2012.01.004
    • (2012) Diabetes Res Clin Pract , vol.96 , pp. 196-203
    • An, S.Y.1    Lee, M.S.2    Yi, S.A.3    Ha, E.S.4    Han, S.J.5    Kim, H.J.6
  • 66
    • 84934929950 scopus 로고    scopus 로고
    • Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes
    • Xiao Y, Liu L, Xu A, Zhou P, Long Z, Tu Y, et al. Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol (2015) 14:72. doi:10.1186/s12933-015-0229-9
    • (2015) Cardiovasc Diabetol , vol.14 , pp. 72
    • Xiao, Y.1    Liu, L.2    Xu, A.3    Zhou, P.4    Long, Z.5    Tu, Y.6
  • 68
    • 84922915157 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
    • Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Pocher N, et al. Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. J Lipid Res (2014) 55:2229-41. doi:10.1194/jlr.M044784
    • (2014) J Lipid Res , vol.55 , pp. 2229-2241
    • Brahma, M.K.1    Adam, R.C.2    Pollak, N.M.3    Jaeger, D.4    Zierler, K.A.5    Pocher, N.6
  • 69
    • 84891684837 scopus 로고    scopus 로고
    • High glucose represses beta-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling
    • So WY, Cheng Q, Chen L, Evans-Molina C, Xu A, Lam KS, et al. High glucose represses beta-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling. Diabetes (2013) 62:3751-9. doi:10.2337/db13-0645
    • (2013) Diabetes , vol.62 , pp. 3751-3759
    • So, W.Y.1    Cheng, Q.2    Chen, L.3    Evans-Molina, C.4    Xu, A.5    Lam, K.S.6
  • 70
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, Holland WL, et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab (2013) 18:333-40. doi:10.1016/j.cmet.2013.08.005
    • (2013) Cell Metab , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3    Glass, L.C.4    Deeg, M.A.5    Holland, W.L.6
  • 71
    • 84879187565 scopus 로고    scopus 로고
    • LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys
    • Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Myers SR, et al. LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys. PLoS One (2013) 8:e65763. doi:10.1371/journal.pone.0065763
    • (2013) PLoS One , vol.8
    • Adams, A.C.1    Halstead, C.A.2    Hansen, B.C.3    Irizarry, A.R.4    Martin, J.A.5    Myers, S.R.6
  • 73
    • 57749105436 scopus 로고    scopus 로고
    • C-terminal tail of FGF19 determines its specificity toward klotho co-receptors
    • Wu X, Lemon B, Li X, Gupte J, Weiszmann J, Stevens J, et al. C-terminal tail of FGF19 determines its specificity toward klotho co-receptors. J Biol Chem (2008) 283:33304-9. doi:10.1074/jbc.M803319200
    • (2008) J Biol Chem , vol.283 , pp. 33304-33309
    • Wu, X.1    Lemon, B.2    Li, X.3    Gupte, J.4    Weiszmann, J.5    Stevens, J.6
  • 74
    • 57849155278 scopus 로고    scopus 로고
    • FGF21 N-and C-termini play different roles in receptor interaction and activation
    • Yie J, Hecht R, Patel J, Stevens J, Wang W, Hawkins N, et al. FGF21 N-and C-termini play different roles in receptor interaction and activation. FEBS Lett (2009) 583:19-24. doi:10.1016/j.febslet.2008.11.023
    • (2009) FEBS Lett , vol.583 , pp. 19-24
    • Yie, J.1    Hecht, R.2    Patel, J.3    Stevens, J.4    Wang, W.5    Hawkins, N.6
  • 76
    • 84870278211 scopus 로고    scopus 로고
    • Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
    • Hecht R, Li YS, Sun J, Belouski E, Hall M, Hager T, et al. Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes. PLoS One (2012) 7:e49345. doi:10.1371/journal.pone.0049345
    • (2012) PLoS One , vol.7
    • Hecht, R.1    Li, Y.S.2    Sun, J.3    Belouski, E.4    Hall, M.5    Hager, T.6
  • 77
    • 84861355961 scopus 로고    scopus 로고
    • Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands
    • Goetz R, Ohnishi M, Ding X, Kurosu H, Wang L, Akiyoshi J, et al. Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands. Mol Cell Biol (2012) 32:1944-54. doi:10.1128/MCB.06603-11
    • (2012) Mol Cell Biol , vol.32 , pp. 1944-1954
    • Goetz, R.1    Ohnishi, M.2    Ding, X.3    Kurosu, H.4    Wang, L.5    Akiyoshi, J.6
  • 79
    • 79958126904 scopus 로고    scopus 로고
    • A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol
    • Huang Z, Wang H, Lu M, Sun C, Wu X, Tan Y, et al. A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol. PLoS One (2011) 6:e20669. doi:10.1371/journal.pone.0020669
    • (2011) PLoS One , vol.6
    • Huang, Z.1    Wang, H.2    Lu, M.3    Sun, C.4    Wu, X.5    Tan, Y.6
  • 80
    • 84879389894 scopus 로고    scopus 로고
    • Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
    • Xu J, Bussiere J, Yie J, Sickmier A, An P, Belouski E, et al. Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation. Bioconjug Chem (2013) 24:915-25. doi:10.1021/bc300603k
    • (2013) Bioconjug Chem , vol.24 , pp. 915-925
    • Xu, J.1    Bussiere, J.2    Yie, J.3    Sickmier, A.4    An, P.5    Belouski, E.6
  • 81
    • 84863011453 scopus 로고    scopus 로고
    • FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
    • Mu J, Pinkstaff J, Li Z, Skidmore L, Li N, Myler H, et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes (2012) 61:505-12. doi:10.2337/db11-0838
    • (2012) Diabetes , vol.61 , pp. 505-512
    • Mu, J.1    Pinkstaff, J.2    Li, Z.3    Skidmore, L.4    Li, N.5    Myler, H.6
  • 82
    • 84874616515 scopus 로고    scopus 로고
    • Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities
    • Hager T, Spahr C, Xu J, Salimi-Moosavi H, Hall M. Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities. Anal Chem (2013) 85:2731-8. doi:10.1021/ac303203y
    • (2013) Anal Chem , vol.85 , pp. 2731-2738
    • Hager, T.1    Spahr, C.2    Xu, J.3    Salimi-Moosavi, H.4    Hall, M.5
  • 83
    • 84865442538 scopus 로고    scopus 로고
    • Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    • Veniant MM, Komorowski R, Chen P, Stanislaus S, Winters K, Hager T, et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology (2012) 153:4192-203. doi:10.1210/en.2012-1211
    • (2012) Endocrinology , vol.153 , pp. 4192-4203
    • Veniant, M.M.1    Komorowski, R.2    Chen, P.3    Stanislaus, S.4    Winters, K.5    Hager, T.6
  • 84
    • 84880426480 scopus 로고    scopus 로고
    • Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
    • Huang J, Ishino T, Chen G, Rolzin P, Osothprarop TF, Retting K, et al. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody. J Pharmacol Exp Ther (2013) 346:270-80. doi:10.1124/jpet.113.204420
    • (2013) J Pharmacol Exp Ther , vol.346 , pp. 270-280
    • Huang, J.1    Ishino, T.2    Chen, G.3    Rolzin, P.4    Osothprarop, T.F.5    Retting, K.6
  • 85
    • 84906826372 scopus 로고    scopus 로고
    • Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
    • Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, et al. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature (2014) 513:436-9. doi:10.1038/nature13540
    • (2014) Nature , vol.513 , pp. 436-439
    • Suh, J.M.1    Jonker, J.W.2    Ahmadian, M.3    Goetz, R.4    Lackey, D.5    Osborn, O.6
  • 86
    • 84859519165 scopus 로고    scopus 로고
    • Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities
    • Wu X, Li Y. Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities. Adv Exp Med Biol (2012) 728:195-213. doi:10.1007/978-1-4614-0887-1_13
    • (2012) Adv Exp Med Biol , vol.728 , pp. 195-213
    • Wu, X.1    Li, Y.2
  • 87
    • 77949328590 scopus 로고    scopus 로고
    • FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
    • Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem (2010) 285:5165-70. doi:10.1074/jbc.M109.068783
    • (2010) J Biol Chem , vol.285 , pp. 5165-5170
    • Wu, X.1    Ge, H.2    Lemon, B.3    Vonderfecht, S.4    Weiszmann, J.5    Hecht, R.6
  • 88
    • 79952803104 scopus 로고    scopus 로고
    • FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
    • Wu AL, Coulter S, Liddle C, Wong A, Eastham-Anderson J, French DM, et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS One (2011) 6:e17868. doi:10.1371/journal.pone.0017868
    • (2011) PLoS One , vol.6
    • Wu, A.L.1    Coulter, S.2    Liddle, C.3    Wong, A.4    Eastham-Anderson, J.5    French, D.M.6
  • 89
    • 84866171951 scopus 로고    scopus 로고
    • Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
    • French DM, Lin BC, Wang M, Adams C, Shek T, Hotzel K, et al. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models. PLoS One (2012) 7:e36713. doi:10.1371/journal.pone.0036713
    • (2012) PLoS One , vol.7
    • French, D.M.1    Lin, B.C.2    Wang, M.3    Adams, C.4    Shek, T.5    Hotzel, K.6
  • 90
    • 77956293010 scopus 로고    scopus 로고
    • Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
    • Wu X, Ge H, Lemon B, Vonderfecht S, Baribault H, Weiszmann J, et al. Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19). Proc Natl Acad Sci U S A (2010) 107:14158-63. doi:10.1073/pnas.1009427107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14158-14163
    • Wu, X.1    Ge, H.2    Lemon, B.3    Vonderfecht, S.4    Baribault, H.5    Weiszmann, J.6
  • 91
    • 84863379532 scopus 로고    scopus 로고
    • Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism
    • Ge H, Baribault H, Vonderfecht S, Lemon B, Weiszmann J, Gardner J, et al. Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism. PLoS One (2012) 7:e33603. doi:10.1371/journal.pone.0033603
    • (2012) PLoS One , vol.7
    • Ge, H.1    Baribault, H.2    Vonderfecht, S.3    Lemon, B.4    Weiszmann, J.5    Gardner, J.6
  • 92
    • 84922726981 scopus 로고    scopus 로고
    • A nontumorigenic variant of FGF19 treats cholestatic liver diseases
    • Luo J, Ko B, Elliott M, Zhou M, Lindhout DA, Phung V, et al. A nontumorigenic variant of FGF19 treats cholestatic liver diseases. Sci Transl Med (2014) 6:247ra100. doi:10.1126/scitranslmed.3009098
    • (2014) Sci Transl Med , vol.6
    • Luo, J.1    Ko, B.2    Elliott, M.3    Zhou, M.4    Lindhout, D.A.5    Phung, V.6
  • 93
    • 84861047531 scopus 로고    scopus 로고
    • A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
    • Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, et al. A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature (2012) 485:391-4. doi:10.1038/nature10998
    • (2012) Nature , vol.485 , pp. 391-394
    • Jonker, J.W.1    Suh, J.M.2    Atkins, A.R.3    Ahmadian, M.4    Li, P.5    Whyte, J.6
  • 94
    • 84862777904 scopus 로고    scopus 로고
    • A unique FGF23 with the ability to activate FGFR signaling through both alphaKlotho and betaKlotho
    • Wu X, Weiszmann J, Ge H, Baribault H, Stevens J, Hawkins N, et al. A unique FGF23 with the ability to activate FGFR signaling through both alphaKlotho and betaKlotho. J Mol Biol (2012) 418:82-9. doi:10.1016/j.jmb.2012.02.027
    • (2012) J Mol Biol , vol.418 , pp. 82-89
    • Wu, X.1    Weiszmann, J.2    Ge, H.3    Baribault, H.4    Stevens, J.5    Hawkins, N.6
  • 95
    • 84865258676 scopus 로고    scopus 로고
    • Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
    • Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, et al. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem (2012) 287:29134-46. doi:10.1074/jbc.M112.342980
    • (2012) J Biol Chem , vol.287 , pp. 29134-29146
    • Goetz, R.1    Ohnishi, M.2    Kir, S.3    Kurosu, H.4    Wang, L.5    Pastor, J.6
  • 96
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 444:770-4. doi:10.1038/nature05315
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5    Okawa, K.6
  • 98
    • 83655165300 scopus 로고    scopus 로고
    • Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
    • Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 3:113ra126. doi:10.1126/scitranslmed.3002669
    • (2011) Sci Transl Med , vol.3
    • Wu, A.L.1    Kolumam, G.2    Stawicki, S.3    Chen, Y.4    Li, J.5    Zavala-Solorio, J.6
  • 99
    • 84913580271 scopus 로고    scopus 로고
    • Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms
    • Lelliott CJ, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, et al. Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms. PLoS One (2014) 9:e112109. doi:10.1371/journal.pone.0112109
    • (2014) PLoS One , vol.9
    • Lelliott, C.J.1    Ahnmark, A.2    Admyre, T.3    Ahlstedt, I.4    Irving, L.5    Keyes, F.6
  • 100
    • 84874338054 scopus 로고    scopus 로고
    • Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia
    • Wu AL, Feng B, Chen MZ, Kolumam G, Zavala-Solorio J, Wyatt SK, et al. Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS One (2013) 8:e57322. doi:10.1371/journal.pone.0057322
    • (2013) PLoS One , vol.8
    • Wu, A.L.1    Feng, B.2    Chen, M.Z.3    Kolumam, G.4    Zavala-Solorio, J.5    Wyatt, S.K.6
  • 101
    • 84876452595 scopus 로고    scopus 로고
    • FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-klotho bispecific protein
    • Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, et al. FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-klotho bispecific protein. PLoS One (2013) 8:e61432. doi:10.1371/journal.pone.0061432
    • (2013) PLoS One , vol.8
    • Smith, R.1    Duguay, A.2    Bakker, A.3    Li, P.4    Weiszmann, J.5    Thomas, M.R.6
  • 102
    • 84951573603 scopus 로고    scopus 로고
    • Sustained brown fat stimulation and insulin sensitization by a humanized bispecific antibody agonist for fibroblast growth factor receptor 1/βKlotho complex
    • Kolumam G, Chen MZ, Tong R, Zavala-Solorio J, Kates L, van Bruggen N, et al. Sustained brown fat stimulation and insulin sensitization by a humanized bispecific antibody agonist for fibroblast growth factor receptor 1/βKlotho complex. EBioMedicine (2015) 2:730-43. doi:10.1016/j.ebiom.2015.05.028
    • (2015) EBioMedicine , vol.2 , pp. 730-743
    • Kolumam, G.1    Chen, M.Z.2    Tong, R.3    Zavala-Solorio, J.4    Kates, L.5    van Bruggen, N.6
  • 103
  • 104
    • 84864388774 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
    • Wu S, Levenson A, Kharitonenkov A, De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem (2012) 287:26060-7. doi:10.1074/jbc.M112.343707
    • (2012) J Biol Chem , vol.287 , pp. 26060-26067
    • Wu, S.1    Levenson, A.2    Kharitonenkov, A.3    De Luca, F.4
  • 105
    • 84863116228 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
    • Wei W, Dutchak PA, Wang X, Ding X, Wang X, Bookout AL, et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A (2012) 109:3143-8. doi:10.1073/pnas.1200797109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3143-3148
    • Wei, W.1    Dutchak, P.A.2    Wang, X.3    Ding, X.4    Wang, X.5    Bookout, A.L.6
  • 106
    • 84883778996 scopus 로고    scopus 로고
    • FGF21 regulates metabolism and circadian behavior by acting on the nervous system
    • Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, et al. FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 19:1147-52. doi:10.1038/nm.3249
    • (2013) Nat Med , vol.19 , pp. 1147-1152
    • Bookout, A.L.1    de Groot, M.H.2    Owen, B.M.3    Lee, S.4    Gautron, L.5    Lawrence, H.L.6
  • 107
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
    • Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones. Cell (2012) 148:556-67. doi:10.1016/j.cell.2011.11.062
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6
  • 108
    • 84883763046 scopus 로고    scopus 로고
    • FGF21 contributes to neuroendocrine control of female reproduction
    • Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, et al. FGF21 contributes to neuroendocrine control of female reproduction. Nat Med (2013) 19:1153-6. doi:10.1038/nm.3250
    • (2013) Nat Med , vol.19 , pp. 1153-1156
    • Owen, B.M.1    Bookout, A.L.2    Ding, X.3    Lin, V.Y.4    Atkin, S.D.5    Gautron, L.6
  • 109
    • 84885484874 scopus 로고    scopus 로고
    • Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
    • Camacho RC, Zafian PT, Achanfuo-Yeboah J, Manibusan A, Berger JP. Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice. Eur J Pharmacol (2013) 715:41-5. doi:10.1016/j.ejphar.2013.06.023
    • (2013) Eur J Pharmacol , vol.715 , pp. 41-45
    • Camacho, R.C.1    Zafian, P.T.2    Achanfuo-Yeboah, J.3    Manibusan, A.4    Berger, J.P.5


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