FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5165-5170

  Wu, Xinle ^a   Ge, Hongfei ^a   Lemon, Bryan ^a   Vonderfecht, Steven ^a   Weiszmann, Jennifer ^a   Hecht, Randy ^a   Gupte, Jamila ^a   Hager, Todd ^a   Wang, Zhulun ^a   Lindberg, Richard ^a   Li, Yang ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL TRUNCATION; ENERGY HOMEOSTASIS; FGF RECEPTORS; FIBROBLAST GROWTH FACTOR; HEPATOCELLULAR CARCINOMA; HEPATOCYTES; IN-VIVO; LIVER TUMORS; SIMILARITIES AND DIFFERENCES; TRANSGENIC MICE;

AMINO ACIDS; CELL CULTURE; GENE TRANSFER; GLUCOSE; ORGANIC ACIDS;

LIVER;

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GLUCOSE; HORMONE; LIPID; MUTANT PROTEIN; FGF19 PROTEIN, HUMAN; FGFR4 PROTEIN, HUMAN; FGFR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; GLUCOSE HOMEOSTASIS; IN VIVO STUDY; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER CELL; LIVER TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN 3T3; CELL TRANSFORMATION; GENE DELETION; GENETICS; HUMAN; LIVER CELL CARCINOMA; METABOLISM; MORTALITY;

MUS MUSCULUS;

3T3-L1 CELLS; AMINO ACID SEQUENCE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; FIBROBLAST GROWTH FACTORS; HEPATOCYTES; HUMANS; MICE; MICE, TRANSGENIC; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; SEQUENCE DELETION;

EID: 77949328590     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.068783     Document Type: Article

References (18)

1. Fukumoto, S. (2008) Endocr. J. 55, 23-31
2. Fukumoto, S., and Yamashita, T. (2007) Bone 40, 1190-1195
3. Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., and Kuro-o, M. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 7432-7437
4. Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., Gerard, R. D., Repa, J. J., Mangelsdorf, D. J., and Kliewer, S. A. (2005) Cell Metab. 2, 217-225
5. Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., and Stewart, T. A. (2002) Endocrinology 143, 1741-1747
6. Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M., Williams, P. M., Soriano, R., Corpuz, R., Moffat, B., Vandlen, R., Simmons, L., Foster, J., Stephan, J. P., Tsai, S. P., and Stewart, T. A. (2004) Endocrinology 145, 2594-2603
7. Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., Gromada, J., Brozinick, J. T., Hawkins, E. D., Wroblewski, V. J., Li, D. S., Mehrbod, F., Jaskunas, S. R., and Shanafelt, A. B. (2005) J. Clin. Invest. 115, 1627-1635
8. Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y. S., Lindberg, R. A., Chen, J. L., Jung, D. Y., Zhang, Z., Ko, H. J., Kim, J. K., and Véniant, M. M. (2009) Diabetes 58, 250-259
9. Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y. F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., and Etgen, G. J. (2007) Endocrinology 148, 774-781
10. Nicholes, K., Guillet, S., Tomlinson, E., Hillan, K., Wright, B., Frantz, G. D., Pham, T. A., Dillard-Telm, L., Tsai, S. P., Stephan, J. P., Stinson, J., Stewart, T., and French, D. M. (2002) Am. J. Pathol. 160, 2295-2307
11. Fausto, N. (1999) Sem. Liver Dis. 19, 243-252
12. Huang, X., Yang, C., Jin, C., Luo, Y., Wang, F., and McKeehan, W. L. (2009) Mol. Carcinogenesis 48, 553-562
13. Kurosu, H., and Kuro-O, M. (2009) Mol. Cell. Endocrinol. 299, 72-78
14. Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., and Kuro-o, M. (2007) J. Biol. Chem. 282, 26687-26695
15. Wu, X., Ge, H., Lemon, B., Weiszmann, J., Gupte, J., Hawkins, N., Li, X., Tang, J., Lindberg, R., and Li, Y. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 14379-14384
16. Wu, X., and Li, Y. (2009) Aging 1, 1023-1027
17. Wu, X., Lemon, B., Li, X., Gupte, J., Weiszmann, J., Stevens, J., Hawkins, N., Shen, W., Lindberg, R., Chen, J. L., Tian, H., and Li, Y. (2008) J. Biol. Chem. 283, 33304-33309
18. Lin, B. C., Wang, M., Blackmore, C., and Desnoyers, L. R. (2007) J. Biol. Chem. 282, 27277-27284