Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Ge, Hongfei ^a   Baribault, Helene ^a   Vonderfecht, Steven ^a   Lemon, Bryan ^a   Weiszmann, Jennifer ^a   Gardner, Jonitha ^a   Lee, Ki Jeong ^a   Gupte, Jamila ^a   Mookherjee, Paramita ^b   Wang, Minghan ^a   Sheng, Jackie ^a   Wu, Xinle ^a   Li, Yang ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA KLOTHO PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 19-7; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 1C; KLOTHO PROTEIN; LEPTIN; UNCLASSIFIED DRUG; FGFR1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR 15, MOUSE; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SPECIFICITY; ENERGY METABOLISM; GLUCOSE METABOLISM; LIPID METABOLISM; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PROTEIN FUNCTION; REGULATORY MECHANISM; ADENO ASSOCIATED VIRUS; ANIMAL; CELL LINE; GENE VECTOR; GENETICS; GLUCOSE TOLERANCE TEST; LIVER; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DEPENDOVIRUS; FIBROBLAST GROWTH FACTORS; GENETIC VECTORS; GLUCOSE; GLUCOSE TOLERANCE TEST; LIVER; MALE; MICE; PROTEIN BINDING; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION;

EID: 84863379532     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033603     Document Type: Article

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