Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: Relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 1, 2013, Pages

  Lee, Paul ^a   Brychta, Robert J ^a   Linderman, Joyce ^a   Smith, Sheila ^a   Chen, Kong Y ^a   Celi, Francesco S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FIBROBLAST GROWTH FACTOR 21; GLYCEROL;

ADIPOSE TISSUE; ADULT; AGE; AREA UNDER THE CURVE; ARTICLE; CALORIMETER; CIRCADIAN RHYTHM; COLD EXPOSURE; CONTROLLED STUDY; CROSSOVER PROCEDURE; ENERGY EXPENDITURE; FAT MASS; FATTY ACID BLOOD LEVEL; FEMALE; GENDER; GLYCEROL TISSUE LEVEL; HUMAN; HUMAN EXPERIMENT; INTERVENTION STUDY; LEAN BODY WEIGHT; LIPOLYSIS; MALE; METABOLIC REGULATION; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THERMOGENESIS; TISSUE LEVEL;

ADULT; CIRCADIAN RHYTHM; COLD TEMPERATURE; CROSS-OVER STUDIES; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; LIPOLYSIS; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; SINGLE-BLIND METHOD; THERMOGENESIS; YOUNG ADULT;

ANIMALIA;

EID: 84872070199     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3107     Document Type: Article

References (19)

1. Adams AC, Kharitonenkov A 2012 FGF21: the center of a transcriptional nexus in metabolic regulation. Curr Diabetes Rev 8:285-293
2. Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J 2006 Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 55:2470-2478
3. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB 2005 FGF-21 as a novel metabolic regulator. J Clin Invest 115:1627-1635
4. Potthoff MJ, Kliewer SA, Mangelsdorf DJ 2012 Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev 26:312-324
5. Cantó C, Auwerx J 2012 Cell biology. FGF21 takes a fat bite. Science 336:675-676
6. Chartoumpekis DV, Habeos IG, Ziros PG, Psyrogiannis AI, Kyriazopoulou VE, Papavassiliou AG 2011 Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol Med 17:736-740
7. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM 2012 FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26:271-281
8. Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F 2011 Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 286:12983-12990
9. Celi FS, Brychta RJ, Linderman JD, Butler PW, Alberobello AT, Smith S, Courville AB, Lai EW, Costello R, Skarulis MC, Csako G, Remaley A, Pacak K, Chen KY 2010 Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults. Eur J Endocrinol 163:863-872
10. Chau MD, Gao J, Yang Q, Wu Z, Gromada J 2010 Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway. Proc Natl Acad Sci USA 107:12553-12558
11. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA 2007 Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell Metab 5:415-425
12. Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Rydén M 2008 FGF21 attenuates lipolysis in human adipocytes: a possible link to improved insulin sensitivity. FEBS Lett 582:1725-1730
13. Yu H, Xia F, Lam KS, Wang Y, Bao Y, Zhang J, Gu Y, Zhou P, Lu J, Jia W, Xu A 2011 Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem 57:691-700
14. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E 2007 Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5:426-437
15. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P 2009 Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518-1525
16. Lee P, Zhao JT, Swarbrick MM, Gracie G, Bova R, Greenfield JR, Freund J, Ho KK 2011 High prevalence of brown adipose tissue in adult humans. J Clin Endocrinol Metab 96:2450-2455
17. Lee P, Swarbrick MM, Zhao JT, Ho KK 2011 Inducible brown adipogenesis of supraclavicular fat in adult humans. Endocrinology 152:3597-3602
18. Cinti S 2009 Transdifferentiation properties of adipocytes in the adipose organ. Am J Physiol Endocrinol Metab 297:E977-E986
19. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM 2012 Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366-376