Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: Application to various FGF21 modalities

Analytical Chemistry

Volumn 85, Issue 5, 2013, Pages 2731-2738

  Hager, Todd ^a   Spahr, Chris ^a   Xu, Jing ^a   Salimi Moosavi, Hossein ^a   Hall, Michael ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ATTACHMENT; DRUG CANDIDATES; DRUG DEVELOPMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH-THROUGHPUT; HIGHER RESOLUTION; IN-VIVO; INTEGRATED APPROACH; LIGAND BINDING; NOVEL PROTEINS; PROTEIN THERAPEUTICS;

BIOCONVERSION; LIGANDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OPTIMIZATION; POLYETHYLENE GLYCOLS;

PROTEINS;

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 21; LIGAND;

ARTICLE; BIOTRANSFORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY;

BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTORS; HUMANS; LIGANDS; MASS SPECTROMETRY;

EID: 84874616515     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac303203y     Document Type: Article

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