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Volumn 342, Issue 1, 2010, Pages 1-11

Hormone-like (endocrine) Fgfs: Their evolutionary history and roles in development, metabolism, and disease

Author keywords

Disease; Endocrine; Evolution; Fgf; Metabolism

Indexed keywords

ALPHA KLOTHO PROTEIN; BETA KLOTHO PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR 4; KLOTHO PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SOMATOMEDIN; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

EID: 77955814651     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-010-1024-2     Document Type: Short Survey
Times cited : (193)

References (81)
  • 1
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • ADHR Consortium. 10.1038/81664
    • ADHR Consortium 2000 Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 Nat Genet 26 345 348 10.1038/81664
    • (2000) Nat Genet , vol.26 , pp. 345-348
  • 2
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • 1:CAS:528:DC%2BD2sXmslOqsrY%3D 10.1016/j.cmet.2007.05.002 17550778
    • MK Badman P Pissios AR Kennedy G Koukos JS Flier E Maratos-Flier 2007 Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states Cell Metab 5 426 437 1:CAS:528:DC%2BD2sXmslOqsrY%3D 10.1016/j.cmet.2007.05.002 17550778
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 3
    • 70350322694 scopus 로고    scopus 로고
    • Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
    • 1:CAS:528:DC%2BD1MXhsVCht7nL 10.1210/en.2009-0532 19819944
    • MK Badman A Koester JS Flier A Kharitonenkov E Maratos-Flier 2009 Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis Endocrinology 150 4931 4940 1:CAS:528:DC%2BD1MXhsVCht7nL 10.1210/en.2009-0532 19819944
    • (2009) Endocrinology , vol.150 , pp. 4931-4940
    • Badman, M.K.1    Koester, A.2    Flier, J.S.3    Kharitonenkov, A.4    Maratos-Flier, E.5
  • 4
    • 61649100307 scopus 로고    scopus 로고
    • The FGF family: Biology, pathophysiology and therapy
    • 1:CAS:528:DC%2BD1MXisVShur4%3D 10.1038/nrd2792 19247306
    • A Beenken M Mohammadi 2009 The FGF family: biology, pathophysiology and therapy Nat Rev Drug Discov 8 235 253 1:CAS:528:DC%2BD1MXisVShur4%3D 10.1038/nrd2792 19247306
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 235-253
    • Beenken, A.1    Mohammadi, M.2
  • 5
    • 13544270218 scopus 로고    scopus 로고
    • An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia
    • 10.1093/hmg/ddi034 15590700
    • A Benet-Pagès P Orlik TM Strom B Lorenz-Depiereux 2005 An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia Hum Mol Genet 14 385 390 10.1093/hmg/ddi034 15590700
    • (2005) Hum Mol Genet , vol.14 , pp. 385-390
    • Benet-Pagès, A.1    Orlik, P.2    Strom, T.M.3    Lorenz-Depiereux, B.4
  • 6
    • 39449127028 scopus 로고    scopus 로고
    • Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus
    • 1:CAS:528:DC%2BD1cXjslCjsbw%3D 10.1055/s-2007-985148 17926232
    • WW Chen L Li GY Yang K Li XY Qi W Zhu Y Tang H Liu G Boden 2008 Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus Exp Clin Endocrinol Diabetes 116 65 68 1:CAS:528:DC%2BD1cXjslCjsbw%3D 10.1055/s-2007-985148 17926232
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , pp. 65-68
    • Chen, W.W.1    Li, L.2    Yang, G.Y.3    Li, K.4    Qi, X.Y.5    Zhu, W.6    Tang, Y.7    Liu, H.8    Boden, G.9
  • 9
    • 12844273414 scopus 로고    scopus 로고
    • Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders
    • 1:CAS:528:DC%2BD2MXisFCjsw%3D%3D 10.1007/s00109-004-0610-8 15599692
    • Y Frishberg O Topaz R Bergman D Behar D Fisher D Gordon G Richard E Sprecher 2005 Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders J Mol Med 83 33 38 1:CAS:528:DC%2BD2MXisFCjsw%3D%3D 10.1007/s00109-004-0610-8 15599692
    • (2005) J Mol Med , vol.83 , pp. 33-38
    • Frishberg, Y.1    Topaz, O.2    Bergman, R.3    Behar, D.4    Fisher, D.5    Gordon, D.6    Richard, G.7    Sprecher, E.8
  • 11
    • 69249231022 scopus 로고    scopus 로고
    • The role of bone in phosphate metabolism
    • 1:CAS:528:DC%2BD1MXhtVKlsrzN 10.1016/j.mce.2008.08.031 18822343
    • S Fukumoto 2009 The role of bone in phosphate metabolism Mol Cell Endocrinol 310 63 70 1:CAS:528:DC%2BD1MXhtVKlsrzN 10.1016/j.mce.2008.08.031 18822343
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 63-70
    • Fukumoto, S.1
  • 13
    • 18144380347 scopus 로고    scopus 로고
    • Fibroblast growth factor homologous factors: Evolution, structure, and function
    • 1:CAS:528:DC%2BD2MXjvVOnsL0%3D 10.1016/j.cytogfr.2005.02.002 15863036
    • M Goldfarb 2005 Fibroblast growth factor homologous factors: evolution, structure, and function Cytokine Growth Factor Rev 16 215 220 1:CAS:528:DC%2BD2MXjvVOnsL0%3D 10.1016/j.cytogfr.2005.02.002 15863036
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 215-220
    • Goldfarb, M.1
  • 15
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • 1:CAS:528:DC%2BD1MXht1OktrrI 10.1210/en.2009-0119 19589869
    • Y Hotta H Nakamura M Konishi Y Murata H Takagi S Matsumura K Inoue T Fushiki N Itoh 2009 Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver Endocrinology 150 4625 4633 1:CAS:528:DC%2BD1MXht1OktrrI 10.1210/en.2009-0119 19589869
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3    Murata, Y.4    Takagi, H.5    Matsumura, S.6    Inoue, K.7    Fushiki, T.8    Itoh, N.9
  • 16
    • 66649090939 scopus 로고    scopus 로고
    • Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression
    • 1:CAS:528:DC%2BD1MXmvVCqt7c%3D 10.1210/en.2008-0877 19213845
    • S Ichikawa AH Sorenson AM Austin DS Mackenzie TA Fritz A Moh SL Hui MJ Econs 2009 Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression Endocrinology 150 2543 2550 1:CAS:528: DC%2BD1MXmvVCqt7c%3D 10.1210/en.2008-0877 19213845
    • (2009) Endocrinology , vol.150 , pp. 2543-2550
    • Ichikawa, S.1    Sorenson, A.H.2    Austin, A.M.3    Mackenzie, D.S.4    Fritz, T.A.5    Moh, A.6    Hui, S.L.7    Econs, M.J.8
  • 20
    • 45649085226 scopus 로고    scopus 로고
    • Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    • 1:CAS:528:DC%2BD1cXotlymsro%3D 10.1016/j.cmet.2008.05.006 18585098
    • T Inagaki VY Lin R Goetz M Mohammadi DJ Mangelsdorf SA Kliewer 2008 Inhibition of growth hormone signaling by the fasting-induced hormone FGF21 Cell Metab 8 77 83 1:CAS:528:DC%2BD1cXotlymsro%3D 10.1016/j.cmet.2008.05.006 18585098
    • (2008) Cell Metab , vol.8 , pp. 77-83
    • Inagaki, T.1    Lin, V.Y.2    Goetz, R.3    Mohammadi, M.4    Mangelsdorf, D.J.5    Kliewer, S.A.6
  • 21
    • 0034333526 scopus 로고    scopus 로고
    • Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein
    • 1:CAS:528:DC%2BD3cXot12qtb0%3D 10.1016/S0925-4773(00)00439-1 11044614
    • S Ito S Kinoshita N Shiraishi S Nakagawa S Sekine T Fujimori YI Nabeshima 2000 Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein Mech Dev 98 115 119 1:CAS:528: DC%2BD3cXot12qtb0%3D 10.1016/S0925-4773(00)00439-1 11044614
    • (2000) Mech Dev , vol.98 , pp. 115-119
    • Ito, S.1    Kinoshita, S.2    Shiraishi, N.3    Nakagawa, S.4    Sekine, S.5    Fujimori, T.6    Nabeshima, Y.I.7
  • 22
    • 23644437321 scopus 로고    scopus 로고
    • Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho
    • 1:CAS:528:DC%2BD2MXntFCmtbs%3D 10.1172/JCI23076 16075061
    • S Ito T Fujimori A Furuya J Satoh Y Nabeshima Y Nabeshima 2005 Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho J Clin Invest 115 2202 2208 1:CAS:528:DC%2BD2MXntFCmtbs%3D 10.1172/JCI23076 16075061
    • (2005) J Clin Invest , vol.115 , pp. 2202-2208
    • Ito, S.1    Fujimori, T.2    Furuya, A.3    Satoh, J.4    Nabeshima, Y.5    Nabeshima, Y.6
  • 23
    • 35349007958 scopus 로고    scopus 로고
    • The Fgf families in humans, mice, and zebrafish: Their evolutional processes and roles in development, metabolism, and disease
    • 1:CAS:528:DC%2BD2sXhtl2jtLnJ 10.1248/bpb.30.1819 17917244
    • N Itoh 2007 The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease Biol Pharm Bull 30 1819 1825 1:CAS:528:DC%2BD2sXhtl2jtLnJ 10.1248/bpb.30.1819 17917244
    • (2007) Biol Pharm Bull , vol.30 , pp. 1819-1825
    • Itoh, N.1
  • 24
    • 36249024845 scopus 로고    scopus 로고
    • The zebrafish fgf family
    • 1:CAS:528:DC%2BD2sXht1yku7vE 10.1089/zeb.2007.0509 18041922
    • N Itoh M Konishi 2007 The zebrafish fgf family Zebrafish 4 179 186 1:CAS:528:DC%2BD2sXht1yku7vE 10.1089/zeb.2007.0509 18041922
    • (2007) Zebrafish , vol.4 , pp. 179-186
    • Itoh, N.1    Konishi, M.2
  • 25
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • 1:CAS:528:DC%2BD2cXotlajsLo%3D 10.1016/j.tig.2004.08.007 15475116
    • N Itoh DM Ornitz 2004 Evolution of the Fgf and Fgfr gene families Trends Genet 20 563 569 1:CAS:528:DC%2BD2cXotlajsLo%3D 10.1016/j.tig.2004.08.007 15475116
    • (2004) Trends Genet , vol.20 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 26
    • 38149134409 scopus 로고    scopus 로고
    • Functional evolutionary history of the mouse Fgf gene family
    • 1:CAS:528:DC%2BD1cXhvFGlu78%3D 10.1002/dvdy.21388 18058912
    • N Itoh DM Ornitz 2008 Functional evolutionary history of the mouse Fgf gene family Dev Dyn 237 18 27 1:CAS:528:DC%2BD1cXhvFGlu78%3D 10.1002/dvdy.21388 18058912
    • (2008) Dev Dyn , vol.237 , pp. 18-27
    • Itoh, N.1    Ornitz, D.M.2
  • 27
    • 70350093621 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice
    • 1:CAS:528:DC%2BD1MXhsVyhsbzK 10.1053/j.gastro.2009.07.064 19664632
    • CL Johnson JY Weston SA Chadi EN Fazio MW Huff A Kharitonenkov A Köester CL Pin 2009 Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice Gastroenterology 137 1795 1804 1:CAS:528:DC%2BD1MXhsVyhsbzK 10.1053/j.gastro.2009.07.064 19664632
    • (2009) Gastroenterology , vol.137 , pp. 1795-1804
    • Johnson, C.L.1    Weston, J.Y.2    Chadi, S.A.3    Fazio, E.N.4    Huff, M.W.5    Kharitonenkov, A.6    Köester, A.7    Pin, C.L.8
  • 28
    • 33745828096 scopus 로고    scopus 로고
    • Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation
    • 1:CAS:528:DC%2BD28XmsVagsbg%3D 10.1074/jbc.M602469200 16638743
    • K Kato C Jeanneau MA Tarp A Benet-Pagès B Lorenz-Depiereux EP Bennett U Mandel TM Strom H Clausen 2006 Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation J Biol Chem 281 18370 18377 1:CAS:528:DC%2BD28XmsVagsbg%3D 10.1074/jbc.M602469200 16638743
    • (2006) J Biol Chem , vol.281 , pp. 18370-18377
    • Kato, K.1    Jeanneau, C.2    Tarp, M.A.3    Benet-Pagès, A.4    Lorenz-Depiereux, B.5    Bennett, E.P.6    Mandel, U.7    Strom, T.M.8    Clausen, H.9
  • 29
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • 1:CAS:528:DyaK1MXjvVSntLo%3D 10.1172/JCI6223 10359558
    • S Kersten J Seydoux JM Peters FJ Gonzalez B Desvergne W Wahli 1999 Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting J Clin Invest 103 1489 1498 1:CAS:528:DyaK1MXjvVSntLo%3D 10.1172/JCI6223 10359558
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 30
    • 70449506753 scopus 로고    scopus 로고
    • FGFs and metabolism
    • 1:CAS:528:DC%2BD1MXhsVGqs7jN 10.1016/j.coph.2009.07.001 19683963
    • A Kharitonenkov 2009 FGFs and metabolism Curr Opin Pharmacol 9 805 810 1:CAS:528:DC%2BD1MXhsVGqs7jN 10.1016/j.coph.2009.07.001 19683963
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 805-810
    • Kharitonenkov, A.1
  • 31
    • 63849172657 scopus 로고    scopus 로고
    • FGF21: A novel prospect for the treatment of metabolic diseases
    • 1:CAS:528:DC%2BC3cXnt1Kiurk%3D 19337957
    • A Kharitonenkov AB Shanafelt 2009 FGF21: a novel prospect for the treatment of metabolic diseases Curr Opin Investig Drugs 10 359 364 1:CAS:528:DC%2BC3cXnt1Kiurk%3D 19337957
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 359-364
    • Kharitonenkov, A.1    Shanafelt, A.B.2
  • 34
    • 69549120039 scopus 로고    scopus 로고
    • Molecular pathology of the fibroblast growth factor family
    • 1:CAS:528:DC%2BD1MXhtFyqtL7P 10.1002/humu.21067 19621416
    • P Krejci J Prochazkova V Bryja A Kozubik WR Wilcox 2009 Molecular pathology of the fibroblast growth factor family Hum Mutat 30 1245 1255 1:CAS:528:DC%2BD1MXhtFyqtL7P 10.1002/humu.21067 19621416
    • (2009) Hum Mutat , vol.30 , pp. 1245-1255
    • Krejci, P.1    Prochazkova, J.2    Bryja, V.3    Kozubik, A.4    Wilcox, W.R.5
  • 35
    • 49649118142 scopus 로고    scopus 로고
    • Endocrine FGFs and Klothos: Emerging concepts
    • 1:CAS:528:DC%2BD1cXhtVeisrfL 10.1016/j.tem.2008.06.002 18692401
    • M Kuro-o 2008 Endocrine FGFs and Klothos: emerging concepts Trends Endocrinol Metab 19 239 245 1:CAS:528:DC%2BD1cXhtVeisrfL 10.1016/j.tem.2008.06. 002 18692401
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 239-245
    • Kuro-O, M.1
  • 37
    • 65549158690 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors as regulators of metabolic homeostasis
    • 1:CAS:528:DC%2BD1MXnsVSmtbg%3D 10.1002/biof.12 19319846
    • H Kurosu M Kuro-o 2009 Endocrine fibroblast growth factors as regulators of metabolic homeostasis Biofactors 35 52 60 1:CAS:528:DC%2BD1MXnsVSmtbg%3D 10.1002/biof.12 19319846
    • (2009) Biofactors , vol.35 , pp. 52-60
    • Kurosu, H.1    Kuro-O, M.2
  • 39
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • 1:CAS:528:DC%2BD2sXhtVWjsL3K 10.1074/jbc.M704165200 17623664
    • H Kurosu M Choi Y Ogawa AS Dickson R Goetz AV Eliseenkova M Mohammadi KP Rosenblatt SA Kliewer M Kuro-o 2007 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 J Biol Chem 282 26687 2695 1:CAS:528:DC%2BD2sXhtVWjsL3K 10.1074/jbc.M704165200 17623664
    • (2007) J Biol Chem , vol.282 , pp. 26687-22695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3    Dickson, A.S.4    Goetz, R.5    Eliseenkova, A.V.6    Mohammadi, M.7    Rosenblatt, K.P.8    Kliewer, S.A.9    Kuro-O, M.10
  • 40
    • 0344945402 scopus 로고    scopus 로고
    • Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    • 1:CAS:528:DC%2BD3sXpvFOqtLw%3D 10.1046/j.1523-1755.2003.00328.x 14633152
    • T Larsson U Nisbeth O Ljunggren H Jüppner KB Jonsson 2003 Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers Kidney Int 64 2272 2279 1:CAS:528:DC%2BD3sXpvFOqtLw%3D 10.1046/j.1523-1755.2003.00328.x 14633152
    • (2003) Kidney Int , vol.64 , pp. 2272-2279
    • Larsson, T.1    Nisbeth, U.2    Ljunggren, O.3    Jüppner, H.4    Jonsson, K.B.5
  • 41
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • 1:CAS:528:DyaK1MXltVOqs7k%3D 10.1073/pnas.96.13.7473 10377439
    • TC Leone CJ Weinheimer DP Kelly 1999 A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders Proc Natl Acad Sci USA 96 7473 7478 1:CAS:528:DyaK1MXltVOqs7k%3D 10.1073/pnas.96.13.7473 10377439
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 42
    • 52649142085 scopus 로고    scopus 로고
    • Pathogenic role of Fgf23 in Dmp1-null mice
    • 1:CAS:528:DC%2BD1cXhtVaktr3P 10.1152/ajpendo.90201.2008 18559986
    • S Liu J Zhou W Tang R Menard JQ Feng LD Quarles 2008 Pathogenic role of Fgf23 in Dmp1-null mice Am J Physiol Endocrinol Metab 295 E254 E261 1:CAS:528:DC%2BD1cXhtVaktr3P 10.1152/ajpendo.90201.2008 18559986
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Liu, S.1    Zhou, J.2    Tang, W.3    Menard, R.4    Feng, J.Q.5    Quarles, L.D.6
  • 44
    • 0030776762 scopus 로고    scopus 로고
    • A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1
    • 1:CAS:528:DyaK2sXmtleks7o%3D 9310317
    • JR McWhirter M Goulding JA Weiner J Chun C Murre 1997 A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1 Development 124 3221 3232 1:CAS:528:DyaK2sXmtleks7o%3D 9310317
    • (1997) Development , vol.124 , pp. 3221-3232
    • McWhirter, J.R.1    Goulding, M.2    Weiner, J.A.3    Chun, J.4    Murre, C.5
  • 45
    • 71849110508 scopus 로고    scopus 로고
    • Torpor induction in mammals: Recent discoveries fueling new ideas
    • 1:CAS:528:DC%2BD1MXhsVGrur3J 10.1016/j.tem.2009.09.005 19864159
    • RG Melvin MT Andrews 2009 Torpor induction in mammals: recent discoveries fueling new ideas Trends Endocrinol Metab 20 490 498 1:CAS:528: DC%2BD1MXhsVGrur3J 10.1016/j.tem.2009.09.005 19864159
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 490-498
    • Melvin, R.G.1    Andrews, M.T.2
  • 46
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: Processing, secretion and reception
    • 1:CAS:528:DC%2BD28Xht1Kgt7%2FM 10.1038/sj.onc.1210053 17143290
    • AJ Mikels R Nusse 2006 Wnts as ligands: processing, secretion and reception Oncogene 25 7461 7468 1:CAS:528:DC%2BD28Xht1Kgt7%2FM 10.1038/sj.onc.1210053 17143290
    • (2006) Oncogene , vol.25 , pp. 7461-7468
    • Mikels, A.J.1    Nusse, R.2
  • 47
    • 28244468141 scopus 로고    scopus 로고
    • Fgf19 regulated by Hh signaling is required for zebrafish forebrain development
    • 1:CAS:528:DC%2BD2MXht1OltbzI 10.1016/j.ydbio.2005.09.042 16256099
    • A Miyake Y Nakayama M Konishi N Itoh 2005 Fgf19 regulated by Hh signaling is required for zebrafish forebrain development Dev Biol 288 259 275 1:CAS:528:DC%2BD2MXht1OltbzI 10.1016/j.ydbio.2005.09.042 16256099
    • (2005) Dev Biol , vol.288 , pp. 259-275
    • Miyake, A.1    Nakayama, Y.2    Konishi, M.3    Itoh, N.4
  • 48
    • 34250223124 scopus 로고    scopus 로고
    • Physiology. Sister act
    • 1:CAS:528:DC%2BD2sXmsFyhtrk%3D 10.1126/science.1144837 17556573
    • DD Moore 2007 Physiology. Sister act Science 316 1436 1438 1:CAS:528:DC%2BD2sXmsFyhtrk%3D 10.1126/science.1144837 17556573
    • (2007) Science , vol.316 , pp. 1436-1438
    • Moore, D.D.1
  • 50
    • 63849189712 scopus 로고    scopus 로고
    • Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
    • 1:CAS:528:DC%2BD1MXhtFagtL%2FO 10.1111/j.1365-2265.2008.03502.x
    • M Mraz M Bartlova Z Lacinova D Michalsky M Kasalicky D Haluzikova M Matoulek I Dostalova V Humenanska M Haluzik 2009 Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity Clin Endocrinol 71 369 375 1:CAS:528:DC%2BD1MXhtFagtL%2FO 10.1111/j.1365-2265.2008.03502.x
    • (2009) Clin Endocrinol , vol.71 , pp. 369-375
    • Mraz, M.1    Bartlova, M.2    Lacinova, Z.3    Michalsky, D.4    Kasalicky, M.5    Haluzikova, D.6    Matoulek, M.7    Dostalova, I.8    Humenanska, V.9    Haluzik, M.10
  • 51
    • 37849028259 scopus 로고    scopus 로고
    • Fgf19 is required for zebrafish lens and retina development
    • 1:CAS:528:DC%2BD1cXlsFKhsg%3D%3D 10.1016/j.ydbio.2007.11.013 18089288
    • Y Nakayama A Miyake Y Nakagawa T Mido M Yoshikawa M Konishi N Itoh 2008 Fgf19 is required for zebrafish lens and retina development Dev Biol 313 752 766 1:CAS:528:DC%2BD1cXlsFKhsg%3D%3D 10.1016/j.ydbio.2007.11.013 18089288
    • (2008) Dev Biol , vol.313 , pp. 752-766
    • Nakayama, Y.1    Miyake, A.2    Nakagawa, Y.3    Mido, T.4    Yoshikawa, M.5    Konishi, M.6    Itoh, N.7
  • 52
    • 0033579972 scopus 로고    scopus 로고
    • Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain
    • 1:CAS:528:DyaK1MXnslOrtw%3D%3D 9931477
    • T Nishimura Y Utsunomiya M Hoshikawa H Ohuchi N Itoh 1999 Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain Biochim Biophys Acta 1444 148 151 1:CAS:528:DyaK1MXnslOrtw%3D%3D 9931477
    • (1999) Biochim Biophys Acta , vol.1444 , pp. 148-151
    • Nishimura, T.1    Utsunomiya, Y.2    Hoshikawa, M.3    Ohuchi, H.4    Itoh, N.5
  • 53
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • T Nishimura Y Nakatake M Konishi N Itoh 2000 Identification of a novel FGF, FGF-21, preferentially expressed in the liver Biochim Biophys Acta 492 203 206
    • (2000) Biochim Biophys Acta , vol.492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 55
    • 77952347202 scopus 로고    scopus 로고
    • FGF21 is dispensable for hypothermia induced by fasting in mice
    • 1:CAS:528:DC%2BC3cXns1Cju7w%3D 20424589
    • K Oishi K Sakamoto M Konishi Y Murata N Itoh H Sei 2010 FGF21 is dispensable for hypothermia induced by fasting in mice Neuro Endocrinol Lett 31 198 202 1:CAS:528:DC%2BC3cXns1Cju7w%3D 20424589
    • (2010) Neuro Endocrinol Lett , vol.31 , pp. 198-202
    • Oishi, K.1    Sakamoto, K.2    Konishi, M.3    Murata, Y.4    Itoh, N.5    Sei, H.6
  • 57
    • 70350348267 scopus 로고    scopus 로고
    • The FGF23-Klotho axis: Endocrine regulation of phosphate homeostasis
    • 1:CAS:528:DC%2BD1MXht1ymsL7E 10.1038/nrendo.2009.196 19844248
    • MS Razzaque 2009 The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis Nat Rev Endocrinol 5 611 619 1:CAS:528:DC%2BD1MXht1ymsL7E 10.1038/nrendo.2009.196 19844248
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 611-619
    • Razzaque, M.S.1
  • 58
    • 77949279533 scopus 로고    scopus 로고
    • Fibroblast growth factor 19 serum levels: Relation to renal function and metabolic parameters
    • 1:CAS:528:DC%2BC3cXltFShur4%3D 10.1055/s-0029-1243249 20013647
    • M Reiche A Bachmann U Lössner M Blüher M Stumvoll M Fasshauer 2010 Fibroblast growth factor 19 serum levels: relation to renal function and metabolic parameters Horm Metab Res 42 178 181 1:CAS:528:DC%2BC3cXltFShur4%3D 10.1055/s-0029-1243249 20013647
    • (2010) Horm Metab Res , vol.42 , pp. 178-181
    • Reiche, M.1    Bachmann, A.2    Lössner, U.3    Blüher, M.4    Stumvoll, M.5    Fasshauer, M.6
  • 59
    • 0036939056 scopus 로고    scopus 로고
    • Fgf genes in the basal chordate Ciona intestinalis
    • 1:CAS:528:DC%2BD38XpsV2msrw%3D 10.1007/s00427-002-0266-8 12373588
    • Y Satou KS Imai N Satoh 2002 Fgf genes in the basal chordate Ciona intestinalis Dev Genes Evol 212 432 438 1:CAS:528:DC%2BD38XpsV2msrw%3D 10.1007/s00427-002-0266-8 12373588
    • (2002) Dev Genes Evol , vol.212 , pp. 432-438
    • Satou, Y.1    Imai, K.S.2    Satoh, N.3
  • 60
    • 65449177586 scopus 로고    scopus 로고
    • High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    • 1:CAS:528:DC%2BD1MXkslWjsro%3D 10.1002/hep.22771 19185005
    • FG Schaap NA van der Gaag DJ Gouma PL Jansen 2009 High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis Hepatology 49 1228 1235 1:CAS:528:DC%2BD1MXkslWjsro%3D 10.1002/hep.22771 19185005
    • (2009) Hepatology , vol.49 , pp. 1228-1235
    • Schaap, F.G.1    Van Der Gaag, N.A.2    Gouma, D.J.3    Jansen, P.L.4
  • 61
    • 77249102583 scopus 로고    scopus 로고
    • The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance
    • 1:CAS:528:DC%2BC3cXjsFGgt7c%3D 10.1152/ajpgi.00322.2009 20093562
    • TC Schreuder HA Marsman M Lenicek JR van Werven AJ Nederveen PL Jansen FG Schaap 2010 The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance Am J Physiol Gastrointest Liver Physiol 298 G440 G445 1:CAS:528:DC%2BC3cXjsFGgt7c%3D 10.1152/ajpgi.00322.2009 20093562
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298
    • Schreuder, T.C.1    Marsman, H.A.2    Lenicek, M.3    Van Werven, J.R.4    Nederveen, A.J.5    Jansen, P.L.6    Schaap, F.G.7
  • 63
    • 1642416884 scopus 로고    scopus 로고
    • Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
    • 1:CAS:528:DC%2BD2cXhsFKhsbs%3D 14966565
    • T Shimada M Kakitani Y Yamazaki H Hasegawa Y Takeuchi T Fujita S Fukumoto K Tomizuka T Yamashita 2004 Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism J Clin Invest 113 561 568 1:CAS:528:DC%2BD2cXhsFKhsbs%3D 14966565
    • (2004) J Clin Invest , vol.113 , pp. 561-568
    • Shimada, T.1    Kakitani, M.2    Yamazaki, Y.3    Hasegawa, H.4    Takeuchi, Y.5    Fujita, T.6    Fukumoto, S.7    Tomizuka, K.8    Yamashita, T.9
  • 64
    • 41649109108 scopus 로고    scopus 로고
    • BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
    • 1:CAS:528:DC%2BD1cXkt1Cntr8%3D 10.1210/me.2007-0313 18187602
    • M Suzuki Y Uehara K Motomura-Matsuzaka J Oki Y Koyama M Kimura M Asada A Komi-Kuramochi S Oka T Imamura 2008 betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c Mol Endocrinol 22 1006 1014 1:CAS:528:DC%2BD1cXkt1Cntr8%3D 10.1210/me.2007-0313 18187602
    • (2008) Mol Endocrinol , vol.22 , pp. 1006-1014
    • Suzuki, M.1    Uehara, Y.2    Motomura-Matsuzaka, K.3    Oki, J.4    Koyama, Y.5    Kimura, M.6    Asada, M.7    Komi-Kuramochi, A.8    Oka, S.9    Imamura, T.10
  • 65
    • 27744534898 scopus 로고    scopus 로고
    • Functions and regulations of fibroblast growth factor signaling during embryonic development
    • 1:CAS:528:DC%2BD2MXht1GhtL%2FF 10.1016/j.ydbio.2005.09.011 16216232
    • B Thisse C Thisse 2005 Functions and regulations of fibroblast growth factor signaling during embryonic development Dev Biol 287 390 402 1:CAS:528:DC%2BD2MXht1GhtL%2FF 10.1016/j.ydbio.2005.09.011 16216232
    • (2005) Dev Biol , vol.287 , pp. 390-402
    • Thisse, B.1    Thisse, C.2
  • 66
    • 0032786770 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor-I in starvation and injury
    • 1:STN:280:DyaK1MzmvVCrtg%3D%3D 10.1111/j.1753-4887.1999.tb06939.x 10439629
    • JP Thissen LE Underwood JM Ketelslegers 1999 Regulation of insulin-like growth factor-I in starvation and injury Nutr Rev 57 167 176 1:STN:280:DyaK1MzmvVCrtg%3D%3D 10.1111/j.1753-4887.1999.tb06939.x 10439629
    • (1999) Nutr Rev , vol.57 , pp. 167-176
    • Thissen, J.P.1    Underwood, L.E.2    Ketelslegers, J.M.3
  • 68
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • 1:CAS:528:DC%2BD38XjtFOjsL0%3D 10.1210/en.143.5.1741 11956156
    • E Tomlinson L Fu L John B Hultgren X Huang M Renz JP Stephan SP Tsai L Powell-Braxton D French TA Stewart 2002 Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity Endocrinology 143 1741 1747 1:CAS:528:DC%2BD38XjtFOjsL0%3D 10.1210/en.143.5.1741 11956156
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3    Hultgren, B.4    Huang, X.5    Renz, M.6    Stephan, J.P.7    Tsai, S.P.8    Powell-Braxton, L.9    French, D.10    Stewart, T.A.11
  • 70
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • 1:CAS:528:DC%2BD3sXpvFCktr8%3D 10.1210/me.2003-0048 14528024
    • H Tsujikawa Y Kurotaki T Fujimori K Fukuda Y Nabeshima 2003 Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system Mol Endocrinol 17 2393 2403 1:CAS:528:DC%2BD3sXpvFCktr8%3D 10.1210/me.2003-0048 14528024
    • (2003) Mol Endocrinol , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.5
  • 71
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • 1:CAS:528:DC%2BD28Xht1OntbzF 10.1038/nature05315 17086194
    • I Urakawa Y Yamazaki T Shimada K Iijima H Hasegawa K Okawa T Fujita S Fukumoto T Yamashita 2006 Klotho converts canonical FGF receptor into a specific receptor for FGF23 Nature 444 770 774 1:CAS:528:DC%2BD28Xht1OntbzF 10.1038/nature05315 17086194
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5    Okawa, K.6    Fujita, T.7    Fukumoto, S.8    Yamashita, T.9
  • 72
    • 18544374140 scopus 로고    scopus 로고
    • Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract
    • 1:CAS:528:DC%2BD2MXltVWgs70%3D 10.1002/gene.20114 15789410
    • JW Vincentz JR McWhirter C Murre A Baldini Y Furuta 2005 Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract Genesis 41 192 201 1:CAS:528:DC%2BD2MXltVWgs70%3D 10.1002/gene.20114 15789410
    • (2005) Genesis , vol.41 , pp. 192-201
    • Vincentz, J.W.1    McWhirter, J.R.2    Murre, C.3    Baldini, A.4    Furuta, Y.5
  • 73
    • 33750587755 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
    • 1:CAS:528:DC%2BD28XpsVOrtL8%3D 10.2337/db05-1435 16936195
    • W Wente AM Efanov M Brenner A Kharitonenkov A Köster GE Sandusky S Sewing I Treinies H Zitzer J Gromada 2006 Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways Diabetes 55 2470 2478 1:CAS:528:DC%2BD28XpsVOrtL8%3D 10.2337/db05-1435 16936195
    • (2006) Diabetes , vol.55 , pp. 2470-2478
    • Wente, W.1    Efanov, A.M.2    Brenner, M.3    Kharitonenkov, A.4    Köster, A.5    Sandusky, G.E.6    Sewing, S.7    Treinies, I.8    Zitzer, H.9    Gromada, J.10
  • 74
    • 0035186837 scopus 로고    scopus 로고
    • Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23
    • 1:CAS:528:DC%2BD3MXpt1Kjsrs%3D 10.1046/j.1523-1755.2001.00064.x 11737582
    • KE White G Carn B Lorenz-Depiereux A Benet-Pages TM Strom MJ Econs 2001 Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23 Kidney Int 60 2079 2086 1:CAS:528:DC%2BD3MXpt1Kjsrs%3D 10.1046/j.1523-1755.2001. 00064.x 11737582
    • (2001) Kidney Int , vol.60 , pp. 2079-2086
    • White, K.E.1    Carn, G.2    Lorenz-Depiereux, B.3    Benet-Pages, A.4    Strom, T.M.5    Econs, M.J.6
  • 75
    • 33847259241 scopus 로고    scopus 로고
    • Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14
    • 1:CAS:528:DC%2BD2sXisVCnsbc%3D 10.1016/j.mcn.2006.11.020 17208450
    • M Xiao L Xu F Laezza K Yamada S Feng DM Ornitz 2007 Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14 Mol Cell Neurosci 34 366 377 1:CAS:528:DC%2BD2sXisVCnsbc%3D 10.1016/j.mcn.2006.11.020 17208450
    • (2007) Mol Cell Neurosci , vol.34 , pp. 366-377
    • Xiao, M.1    Xu, L.2    Laezza, F.3    Yamada, K.4    Feng, S.5    Ornitz, D.M.6
  • 77
    • 0034703619 scopus 로고    scopus 로고
    • Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
    • 1:CAS:528:DC%2BD3cXntlGit70%3D 10.1006/bbrc.2000.3696 11032749
    • T Yamashita M Yoshioka N Itoh 2000 Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain Biochem Biophys Res Commun 277 494 498 1:CAS:528: DC%2BD3cXntlGit70%3D 10.1006/bbrc.2000.3696 11032749
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 494-498
    • Yamashita, T.1    Yoshioka, M.2    Itoh, N.3
  • 78
    • 33744817641 scopus 로고    scopus 로고
    • Fgf21 is essential for haematopoiesis in zebrafish
    • 1:CAS:528:DC%2BD28Xlt1ahu7g%3D 16612391
    • H Yamauchi Y Hotta M Konishi A Miyake A Kawahara N Itoh 2006 Fgf21 is essential for haematopoiesis in zebrafish EMBO Rep 7 649 654 1:CAS:528:DC%2BD28Xlt1ahu7g%3D 16612391
    • (2006) EMBO Rep , vol.7 , pp. 649-654
    • Yamauchi, H.1    Hotta, Y.2    Konishi, M.3    Miyake, A.4    Kawahara, A.5    Itoh, N.6
  • 79
    • 0034685916 scopus 로고    scopus 로고
    • Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    • 1:CAS:528:DC%2BD3cXjsFamsb4%3D 10.1074/jbc.275.20.15482 10809780
    • C Yu F Wang M Kan C Jin RB Jones M Weinstein CX Deng WL McKeehan 2000 Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4 J Biol Chem 275 15482 15489 1:CAS:528: DC%2BD3cXjsFamsb4%3D 10.1074/jbc.275.20.15482 10809780
    • (2000) J Biol Chem , vol.275 , pp. 15482-15489
    • Yu, C.1    Wang, F.2    Kan, M.3    Jin, C.4    Jones, R.B.5    Weinstein, M.6    Deng, C.X.7    McKeehan, W.L.8
  • 80
    • 33744937606 scopus 로고    scopus 로고
    • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    • 1:CAS:528:DC%2BD28Xlt1Cktrc%3D 10.1074/jbc.M601252200 16597617
    • X Zhang OA Ibrahimi SK Olsen H Umemori M Mohammadi DM Ornitz 2006 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family J Biol Chem 281 15694 1700 1:CAS:528:DC%2BD28Xlt1Cktrc%3D 10.1074/jbc.M601252200 16597617
    • (2006) J Biol Chem , vol.281 , pp. 15694-21700
    • Zhang, X.1    Ibrahimi, O.A.2    Olsen, S.K.3    Umemori, H.4    Mohammadi, M.5    Ornitz, D.M.6
  • 81
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • 1:CAS:528:DC%2BD1cXlvVKjtL4%3D 10.2337/db07-1476 18252893
    • X Zhang DC Yeung M Karpisek D Stejskal ZG Zhou F Liu RL Wong WS Chow AW Tso KS Lam A Xu 2008 Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans Diabetes 57 1246 1253 1:CAS:528:DC%2BD1cXlvVKjtL4%3D 10.2337/db07-1476 18252893
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5    Liu, F.6    Wong, R.L.7    Chow, W.S.8    Tso, A.W.9    Lam, K.S.10    Xu, A.11


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