-
1
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
T. Inagaki et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 Cell Metab. 5 2007 415 425
-
(2007)
Cell Metab.
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
-
2
-
-
67649823642
-
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
-
M.J. Potthoff et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response Proc. Natl. Acad. Sci. U. S. A. 106 2009 10853 10858
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 10853-10858
-
-
Potthoff, M.J.1
-
3
-
-
84863012459
-
Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
-
P.A. Dutchak et al. Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones Cell 148 2012 556 567
-
(2012)
Cell
, vol.148
, pp. 556-567
-
-
Dutchak, P.A.1
-
4
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
A. Kharitonenkov et al. FGF-21 as a novel metabolic regulator J. Clin. Invest. 115 2005 1627 1635
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1627-1635
-
-
Kharitonenkov, A.1
-
5
-
-
33846418834
-
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
-
A. Kharitonenkov et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21 Endocrinology 148 2007 774 781
-
(2007)
Endocrinology
, vol.148
, pp. 774-781
-
-
Kharitonenkov, A.1
-
6
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
T. Coskun et al. Fibroblast growth factor 21 corrects obesity in mice Endocrinology 149 2008 6018 6027
-
(2008)
Endocrinology
, vol.149
, pp. 6018-6027
-
-
Coskun, T.1
-
7
-
-
61649127208
-
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
-
J. Xu et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice Diabetes 58 2009 250 259
-
(2009)
Diabetes
, vol.58
, pp. 250-259
-
-
Xu, J.1
-
8
-
-
0035081241
-
Fibroblast growth factors
-
REVIEWS3005
-
D.M. Ornitz, and N. Itoh Fibroblast growth factors Genome Biol. 2 2001 REVIEWS3005
-
(2001)
Genome Biol.
, vol.2
-
-
Ornitz, D.M.1
Itoh, N.2
-
9
-
-
0031317928
-
Fibroblast growth factors and their receptors
-
Z. Galzie et al. Fibroblast growth factors and their receptors Biochem. Cell Biol. 75 1997 669 685
-
(1997)
Biochem. Cell Biol.
, vol.75
, pp. 669-685
-
-
Galzie, Z.1
-
10
-
-
0034597752
-
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
-
H. Ohuchi et al. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development Biochem. Biophys. Res. Commun. 277 2000 643 649
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.277
, pp. 643-649
-
-
Ohuchi, H.1
-
11
-
-
0035694459
-
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
-
A. Bhushan et al. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis Development 128 2001 5109 5117
-
(2001)
Development
, vol.128
, pp. 5109-5117
-
-
Bhushan, A.1
-
12
-
-
0034697007
-
Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes
-
M. Konishi et al. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes J. Biol. Chem. 275 2000 12119 12122
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12119-12122
-
-
Konishi, M.1
-
13
-
-
84870568785
-
Circulating fibroblast growth factors as metabolic regulators - A critical appraisal
-
B. Angelin et al. Circulating fibroblast growth factors as metabolic regulators - a critical appraisal Cell Metab. 16 2012 693 705
-
(2012)
Cell Metab.
, vol.16
, pp. 693-705
-
-
Angelin, B.1
-
14
-
-
34247565954
-
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
-
R. Goetz et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members Mol. Cell Biol. 27 2007 3417 3428
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 3417-3428
-
-
Goetz, R.1
-
15
-
-
69249093921
-
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity
-
E.D. Berglund et al. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity Endocrinology 150 2009 4084 4093
-
(2009)
Endocrinology
, vol.150
, pp. 4084-4093
-
-
Berglund, E.D.1
-
16
-
-
70350455732
-
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models - Association with liver and adipose tissue effects
-
J. Xu et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models - association with liver and adipose tissue effects Am. J. Physiol. Endocrinol. Metab. 297 2009 1105 1114
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
, pp. 1105-1114
-
-
Xu, J.1
-
17
-
-
84865741904
-
BetaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
-
X. Ding et al. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism Cell Metab. 16 2012 387 393
-
(2012)
Cell Metab.
, vol.16
, pp. 387-393
-
-
Ding, X.1
-
18
-
-
84881508008
-
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
-
Y. Zhang et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice Elife 1 2012 e00065
-
(2012)
Elife
, vol.1
, pp. 00065
-
-
Zhang, Y.1
-
19
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
M.K. Badman et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states Cell Metab. 5 2007 426 437
-
(2007)
Cell Metab.
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
-
20
-
-
34447265235
-
PPARalpha is a key regulator of hepatic FGF21
-
T. Lundasen et al. PPARalpha is a key regulator of hepatic FGF21 Biochem. Biophys. Res. Commun. 360 2007 437 440
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.360
, pp. 437-440
-
-
Lundasen, T.1
-
21
-
-
0033305213
-
Peroxisome proliferator-activated receptors: Nuclear control of metabolism
-
B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr. Rev. 20 1999 649 688
-
(1999)
Endocr. Rev.
, vol.20
, pp. 649-688
-
-
Desvergne, B.1
Wahli, W.2
-
22
-
-
45649085226
-
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
-
T. Inagaki et al. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21 Cell Metab. 8 2008 77 83
-
(2008)
Cell Metab.
, vol.8
, pp. 77-83
-
-
Inagaki, T.1
-
23
-
-
84864388774
-
Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
-
S. Wu et al. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate J. Biol. Chem. 287 2012 26060 26067
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 26060-26067
-
-
Wu, S.1
-
24
-
-
47949111205
-
Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
-
E.S. Muise et al. Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states Mol. Pharmacol. 74 2008 403 412
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 403-412
-
-
Muise, E.S.1
-
25
-
-
37549052177
-
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
-
H. Wang et al. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes Mol. Cell Biol. 28 2008 188 200
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 188-200
-
-
Wang, H.1
-
26
-
-
48349146527
-
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
-
X. Zhang et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans Diabetes 57 2008 1246 1253
-
(2008)
Diabetes
, vol.57
, pp. 1246-1253
-
-
Zhang, X.1
-
27
-
-
80052036925
-
Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
-
K. Oishi et al. Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice Biochem. Biophys. Res. Commun. 412 2011 396 400
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.412
, pp. 396-400
-
-
Oishi, K.1
-
28
-
-
33845407972
-
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling
-
J.S. Moyers et al. Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling J. Cell. Physiol. 210 2007 1 6
-
(2007)
J. Cell. Physiol.
, vol.210
, pp. 1-6
-
-
Moyers, J.S.1
-
29
-
-
84863116228
-
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma
-
W. Wei et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma Proc. Natl. Acad. Sci. U. S. A. 109 2012 3143 3148
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 3143-3148
-
-
Wei, W.1
-
30
-
-
84883260199
-
Fibroblast growth factor 21 is not required for the antidiabetic actions of thiazolidinediones
-
A.C. Adams et al. Fibroblast growth factor 21 is not required for the antidiabetic actions of thiazolidinediones Mol. Metabolism 2 2013 205 214
-
(2013)
Mol. Metabolism
, vol.2
, pp. 205-214
-
-
Adams, A.C.1
-
31
-
-
84872057896
-
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
-
K.H. Kim et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine Nat. Med. 19 2013 83 92
-
(2013)
Nat. Med.
, vol.19
, pp. 83-92
-
-
Kim, K.H.1
-
32
-
-
0034640103
-
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
-
A.N. Plotnikov et al. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity Cell 101 2000 413 424
-
(2000)
Cell
, vol.101
, pp. 413-424
-
-
Plotnikov, A.N.1
-
33
-
-
0027344852
-
Structural and functional diversity in the FGF receptor multigene family
-
D.E. Johnson, and L.T. Williams Structural and functional diversity in the FGF receptor multigene family Adv. Cancer Res. 60 1993 1 41
-
(1993)
Adv. Cancer Res.
, vol.60
, pp. 1-41
-
-
Johnson, D.E.1
Williams, L.T.2
-
34
-
-
0025001394
-
Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor
-
R. Flaumenhaft et al. Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor J. Cell Biol. 111 1990 1651 1659
-
(1990)
J. Cell Biol.
, vol.111
, pp. 1651-1659
-
-
Flaumenhaft, R.1
-
35
-
-
58349115748
-
The Klotho gene family as a regulator of endocrine fibroblast growth factors
-
H. Kurosu, and O.M. Kuro The Klotho gene family as a regulator of endocrine fibroblast growth factors Mol. Cell. Endocrinol. 299 2009 72 78
-
(2009)
Mol. Cell. Endocrinol.
, vol.299
, pp. 72-78
-
-
Kurosu, H.1
Kuro, O.M.2
-
36
-
-
55249119775
-
The Klotho gene family and the endocrine fibroblast growth factors
-
H. Kurosu, and M. Kuro-o The Klotho gene family and the endocrine fibroblast growth factors Curr. Opin. Nephrol. Hypertens. 17 2008 368 372
-
(2008)
Curr. Opin. Nephrol. Hypertens.
, vol.17
, pp. 368-372
-
-
Kurosu, H.1
Kuro-O, M.2
-
37
-
-
35748973876
-
Co-receptor requirements for fibroblast growth factor-19 signaling
-
X. Wu et al. Co-receptor requirements for fibroblast growth factor-19 signaling J. Biol. Chem. 282 2007 29069 29072
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29069-29072
-
-
Wu, X.1
-
38
-
-
34249697012
-
BetaKlotho is required for metabolic activity of fibroblast growth factor 21
-
Y. Ogawa et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21 Proc. Natl. Acad. Sci. U. S. A. 104 2007 7432 7437
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 7432-7437
-
-
Ogawa, Y.1
-
39
-
-
34848869695
-
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
-
H. Kurosu et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 J. Biol. Chem. 282 2007 26687 26695
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26687-26695
-
-
Kurosu, H.1
-
40
-
-
39149091423
-
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho
-
A. Kharitonenkov et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho J. Cell. Physiol. 215 2008 1 7
-
(2008)
J. Cell. Physiol.
, vol.215
, pp. 1-7
-
-
Kharitonenkov, A.1
-
41
-
-
41649109108
-
BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
-
M. Suzuki et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c Mol. Endocrinol. 22 2008 1006 1014
-
(2008)
Mol. Endocrinol.
, vol.22
, pp. 1006-1014
-
-
Suzuki, M.1
-
42
-
-
57749105436
-
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
-
X. Wu et al. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors J. Biol. Chem. 283 2008 33304 33309
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33304-33309
-
-
Wu, X.1
-
43
-
-
76549112800
-
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
-
K. Tomiyama et al. Relevant use of Klotho in FGF19 subfamily signaling system in vivo Proc. Natl. Acad. Sci. U. S. A. 107 2010 1666 1671
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 1666-1671
-
-
Tomiyama, K.1
-
44
-
-
84870272334
-
FGF21 requires betaklotho to act in vivo
-
A.C. Adams et al. FGF21 requires betaklotho to act in vivo PLoS One 7 2012 e49977
-
(2012)
PLoS One
, vol.7
, pp. 49977
-
-
Adams, A.C.1
-
45
-
-
57849155278
-
FGF21 N- and C-termini play different roles in receptor interaction and activation
-
J. Yie et al. FGF21 N- and C-termini play different roles in receptor interaction and activation FEBS Lett. 583 2009 19 24
-
(2009)
FEBS Lett.
, vol.583
, pp. 19-24
-
-
Yie, J.1
-
46
-
-
62149139387
-
Different roles of N- and C-termini in the functional activity of FGF21
-
R. Micanovic et al. Different roles of N- and C-termini in the functional activity of FGF21 J. Cell. Physiol. 219 2009 227 234
-
(2009)
J. Cell. Physiol.
, vol.219
, pp. 227-234
-
-
Micanovic, R.1
-
47
-
-
77949328590
-
FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
-
X. Wu et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation J. Biol. Chem. 285 2010 5165 5170
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 5165-5170
-
-
Wu, X.1
-
48
-
-
84863379532
-
Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism
-
H. Ge et al. Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism PLoS One 7 2012 e33603
-
(2012)
PLoS One
, vol.7
, pp. 33603
-
-
Ge, H.1
-
49
-
-
83655165300
-
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
-
A.L. Wu et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1 Sci. Transl. Med. 3 2011 113ra126
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Wu, A.L.1
-
50
-
-
84870359606
-
Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
-
I.N. Foltz et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex Sci. Transl. Med. 4 2012 162ra153
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Foltz, I.N.1
-
51
-
-
84905679771
-
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
-
A.C. Adams et al. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue Mol. Metabolism 2 2013 31
-
(2013)
Mol. Metabolism
, vol.2
, pp. 31
-
-
Adams, A.C.1
-
52
-
-
84867898251
-
Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress
-
C. Yang et al. Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress Nutr. Metab. (Lond.) 9 2012 94
-
(2012)
Nutr. Metab. (Lond.)
, vol.9
, pp. 94
-
-
Yang, C.1
-
53
-
-
77957376253
-
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse
-
K. Fon Tacer et al. Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse Mol. Endocrinol. 24 2010 2050 2064
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 2050-2064
-
-
Fon Tacer, K.1
-
54
-
-
79952803104
-
FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
-
A.L. Wu et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways PLoS One 6 2011 e17868
-
(2011)
PLoS One
, vol.6
, pp. 17868
-
-
Wu, A.L.1
-
55
-
-
0029102375
-
Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat
-
Z. Hu et al. Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat Cell Growth Differ. 6 1995 1019 1025
-
(1995)
Cell Growth Differ.
, vol.6
, pp. 1019-1025
-
-
Hu, Z.1
-
56
-
-
70349324370
-
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
-
Y. Hotta et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver Endocrinology 150 2009 4625 4633
-
(2009)
Endocrinology
, vol.150
, pp. 4625-4633
-
-
Hotta, Y.1
-
57
-
-
84877272187
-
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
-
W.L. Holland et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice Cell Metab. 17 2013 790 797
-
(2013)
Cell Metab.
, vol.17
, pp. 790-797
-
-
Holland, W.L.1
-
58
-
-
84877260638
-
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
-
Z. Lin et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice Cell Metab. 17 2013 779 789
-
(2013)
Cell Metab.
, vol.17
, pp. 779-789
-
-
Lin, Z.1
-
59
-
-
33750587755
-
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
-
W. Wente et al. Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways Diabetes 55 2006 2470 2478
-
(2006)
Diabetes
, vol.55
, pp. 2470-2478
-
-
Wente, W.1
-
60
-
-
84891684837
-
High glucose represses beta-Klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: Involvement of peroxisome proliferator-activated receptor gamma signaling
-
[Epub ahead of print]
-
So, W.Y. et al. (2013) High glucose represses beta-Klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor gamma signaling. Diabetes [Epub ahead of print].
-
(2013)
Diabetes
-
-
So, W.Y.1
-
61
-
-
36148970418
-
The fasting polypeptide FGF21 can enter brain from blood
-
H. Hsuchou et al. The fasting polypeptide FGF21 can enter brain from blood Peptides 28 2007 2382 2386
-
(2007)
Peptides
, vol.28
, pp. 2382-2386
-
-
Hsuchou, H.1
-
62
-
-
80755168936
-
Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: Relationship with plasma FGF21 and body adiposity
-
B.K. Tan et al. Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity Diabetes 60 2011 2758 2762
-
(2011)
Diabetes
, vol.60
, pp. 2758-2762
-
-
Tan, B.K.1
-
63
-
-
77954277205
-
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats
-
D.A. Sarruf et al. Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats Diabetes 59 2010 1817 1824
-
(2010)
Diabetes
, vol.59
, pp. 1817-1824
-
-
Sarruf, D.A.1
-
64
-
-
84879666287
-
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
-
A. Planavila et al. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice Nat. Commun. 4 2013 2019
-
(2013)
Nat. Commun.
, vol.4
, pp. 2019
-
-
Planavila, A.1
-
65
-
-
43549110007
-
FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity
-
P. Arner et al. FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity FEBS Lett. 582 2008 1725 1730
-
(2008)
FEBS Lett.
, vol.582
, pp. 1725-1730
-
-
Arner, P.1
-
66
-
-
70349472910
-
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
-
X. Li et al. Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice FEBS Lett. 583 2009 3230 3234
-
(2009)
FEBS Lett.
, vol.583
, pp. 3230-3234
-
-
Li, X.1
-
67
-
-
84863012022
-
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
-
F.M. Fisher et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis Genes Dev. 26 2012 271 281
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
-
68
-
-
0032532152
-
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
-
I. Shimomura et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy Genes Dev. 12 1998 3182 3194
-
(1998)
Genes Dev.
, vol.12
, pp. 3182-3194
-
-
Shimomura, I.1
-
69
-
-
84863637593
-
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
-
M. Veniant et al. FGF21 promotes metabolic homeostasis via white adipose and leptin in mice PLoS One 7 2012 e40164
-
(2012)
PLoS One
, vol.7
, pp. 40164
-
-
Veniant, M.1
-
70
-
-
80054696665
-
Therapeutic utilities of fibroblast growth factor 19
-
X. Wu, and Y. Li Therapeutic utilities of fibroblast growth factor 19 Expert Opin. Ther. Targets 15 2011 1307 1316
-
(2011)
Expert Opin. Ther. Targets
, vol.15
, pp. 1307-1316
-
-
Wu, X.1
Li, Y.2
-
71
-
-
0018692485
-
Renal filtration, transport, and metabolism of low-molecular-weight proteins: A review
-
T. Maack et al. Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review Kidney Int. 16 1979 251 270
-
(1979)
Kidney Int.
, vol.16
, pp. 251-270
-
-
Maack, T.1
-
72
-
-
84879389894
-
Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
-
J. Xu et al. Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation Bioconjug. Chem. 24 2013 915 925
-
(2013)
Bioconjug. Chem.
, vol.24
, pp. 915-925
-
-
Xu, J.1
-
73
-
-
79958126904
-
A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol
-
Z. Huang et al. A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol PLoS One 6 2011 e20669
-
(2011)
PLoS One
, vol.6
, pp. 20669
-
-
Huang, Z.1
-
74
-
-
84863011453
-
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
-
J. Mu et al. FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents Diabetes 61 2012 505 512
-
(2012)
Diabetes
, vol.61
, pp. 505-512
-
-
Mu, J.1
-
75
-
-
79959370195
-
Optimized clinical performance of growth hormone with an expanded genetic code
-
H. Cho et al. Optimized clinical performance of growth hormone with an expanded genetic code Proc. Natl. Acad. Sci. U. S. A. 108 2011 9060 9065
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 9060-9065
-
-
Cho, H.1
-
76
-
-
0031946518
-
Short communication: Renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins
-
A. Bendele et al. Short communication: renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins Toxicol. Sci. 42 1998 152 157
-
(1998)
Toxicol. Sci.
, vol.42
, pp. 152-157
-
-
Bendele, A.1
-
77
-
-
84894408706
-
Cytoplasmic vacuoles in renal tubular epithelium of mice given polyethylene glycol (PEG) conjugated protein are reduced by altering PEG size and conformation
-
B. Bolon et al. Cytoplasmic vacuoles in renal tubular epithelium of mice given polyethylene glycol (PEG) conjugated protein are reduced by altering PEG size and conformation Toxicologist 60 2001 376
-
(2001)
Toxicologist
, vol.60
, pp. 376
-
-
Bolon, B.1
-
78
-
-
84870278211
-
Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
-
R. Hecht et al. Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes PLoS One 7 2012 e49345
-
(2012)
PLoS One
, vol.7
, pp. 49345
-
-
Hecht, R.1
-
79
-
-
84874616515
-
Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: Application to various FGF21 modalities
-
T. Hager et al. Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities Anal. Chem. 85 2013 2731 2738
-
(2013)
Anal. Chem.
, vol.85
, pp. 2731-2738
-
-
Hager, T.1
-
80
-
-
84865442538
-
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
-
M. Veniant et al. Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys Endocrinology 153 2012 4192 4203
-
(2012)
Endocrinology
, vol.153
, pp. 4192-4203
-
-
Veniant, M.1
-
81
-
-
84880426480
-
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
-
J. Huang et al. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody J. Pharmacol. Exp. Ther. 346 2013 270 280
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.346
, pp. 270-280
-
-
Huang, J.1
-
82
-
-
84877047337
-
A novel approach to improve the function of FGF21
-
R. Smith et al. A novel approach to improve the function of FGF21 BioDrugs 27 2013 159 166
-
(2013)
BioDrugs
, vol.27
, pp. 159-166
-
-
Smith, R.1
-
83
-
-
84861355961
-
Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands
-
R. Goetz et al. Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands Mol. Cell. Biol. 32 2012 1944 1954
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 1944-1954
-
-
Goetz, R.1
-
84
-
-
84874903440
-
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
-
A. Kharitonenkov et al. Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 PLoS One 8 2013 e58575
-
(2013)
PLoS One
, vol.8
, pp. 58575
-
-
Kharitonenkov, A.1
-
85
-
-
84866089922
-
Optimization and characterization of a novel FGF21 mutant
-
X.L. Ye et al. [Optimization and characterization of a novel FGF21 mutant] Yao Xue Xue Bao 47 2012 897 903
-
(2012)
Yao Xue Xue Bao
, vol.47
, pp. 897-903
-
-
Ye, X.L.1
-
86
-
-
84859519165
-
Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities
-
X. Wu, and Y. Li Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities Adv. Exp. Med. Biol. 728 2012 195 213
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 195-213
-
-
Wu, X.1
Li, Y.2
-
87
-
-
2542505481
-
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
-
L. Fu et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes Endocrinology 145 2004 2594 2603
-
(2004)
Endocrinology
, vol.145
, pp. 2594-2603
-
-
Fu, L.1
-
88
-
-
77956293010
-
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
-
X. Wu et al. Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19) Proc. Natl. Acad. Sci. U. S. A. 107 2010 14158 14163
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 14158-14163
-
-
Wu, X.1
-
89
-
-
0036086285
-
A mouse model of hepatocellular carcinoma: Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
-
K. Nicholes et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice Am. J. Pathol. 160 2002 2295 2307
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 2295-2307
-
-
Nicholes, K.1
-
90
-
-
84866171951
-
Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
-
D.M. French et al. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models PLoS One 7 2012 e36713
-
(2012)
PLoS One
, vol.7
, pp. 36713
-
-
French, D.M.1
-
91
-
-
70149120326
-
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
-
X. Wu et al. Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice Proc. Natl. Acad. Sci. U. S. A. 106 2009 14379 14384
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 14379-14384
-
-
Wu, X.1
-
92
-
-
84859528536
-
Physiology of FGF15/19
-
S.A. Jones Physiology of FGF15/19 Adv. Exp. Med. Biol. 728 2012 171 182
-
(2012)
Adv. Exp. Med. Biol.
, vol.728
, pp. 171-182
-
-
Jones, S.A.1
-
93
-
-
84863338708
-
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
-
C. Yang et al. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB PLoS One 7 2012 e33870
-
(2012)
PLoS One
, vol.7
, pp. 33870
-
-
Yang, C.1
-
94
-
-
84859097478
-
Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys
-
R. Pai et al. Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys Toxicol. Sci. 126 2012 446 456
-
(2012)
Toxicol. Sci.
, vol.126
, pp. 446-456
-
-
Pai, R.1
-
95
-
-
34047260591
-
FGF23 is a hormone-regulating phosphate metabolism - Unique biological characteristics of FGF23
-
S. Fukumoto, and T. Yamashita FGF23 is a hormone-regulating phosphate metabolism - unique biological characteristics of FGF23 Bone 40 2007 1190 1195
-
(2007)
Bone
, vol.40
, pp. 1190-1195
-
-
Fukumoto, S.1
Yamashita, T.2
-
96
-
-
33845631059
-
Klotho converts canonical FGF receptor into a specific receptor for FGF23
-
I. Urakawa et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23 Nature 444 2006 770 774
-
(2006)
Nature
, vol.444
, pp. 770-774
-
-
Urakawa, I.1
-
97
-
-
33646578195
-
Regulation of fibroblast growth factor-23 signaling by Klotho
-
H. Kurosu et al. Regulation of fibroblast growth factor-23 signaling by Klotho J. Biol. Chem. 281 2006 6120 6123
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6120-6123
-
-
Kurosu, H.1
-
98
-
-
84862777904
-
A unique FGF23 with the ability to activate FGFR signaling through both alphaKlotho and betaKlotho
-
X. Wu et al. A unique FGF23 with the ability to activate FGFR signaling through both alphaKlotho and betaKlotho J. Mol. Biol. 418 2012 82 89
-
(2012)
J. Mol. Biol.
, vol.418
, pp. 82-89
-
-
Wu, X.1
-
99
-
-
84865258676
-
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor
-
R. Goetz et al. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor J. Biol. Chem. 287 2012 29134 29146
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29134-29146
-
-
Goetz, R.1
-
100
-
-
85044708724
-
Receptor antibodies as novel therapeutics for diabetes
-
S. Ussar et al. Receptor antibodies as novel therapeutics for diabetes Sci. Transl. Med. 3 2011 113ps47
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Ussar, S.1
-
101
-
-
84874338054
-
Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia
-
A.L. Wu et al. Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia PLoS One 8 2013 e57322
-
(2013)
PLoS One
, vol.8
, pp. 57322
-
-
Wu, A.L.1
-
102
-
-
2542482608
-
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex
-
N.J. Harmer et al. Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex J. Mol. Biol. 339 2004 821 834
-
(2004)
J. Mol. Biol.
, vol.339
, pp. 821-834
-
-
Harmer, N.J.1
-
103
-
-
84862782796
-
Understanding the physical interactions in the FGF21/FGFR/beta-Klotho complex: Structural requirements and implications in FGF21 signaling
-
J. Yie et al. Understanding the physical interactions in the FGF21/FGFR/beta-Klotho complex: structural requirements and implications in FGF21 signaling Chem. Biol. Drug Des. 79 2012 398 410
-
(2012)
Chem. Biol. Drug Des.
, vol.79
, pp. 398-410
-
-
Yie, J.1
-
104
-
-
79953843347
-
The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21
-
J. Gupte et al. The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21 J. Mol. Biol. 408 2011 491 502
-
(2011)
J. Mol. Biol.
, vol.408
, pp. 491-502
-
-
Gupte, J.1
-
105
-
-
84876452595
-
FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-Klotho bispecific protein
-
R. Smith et al. FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/beta-Klotho bispecific protein PLoS One 8 2013 e61432
-
(2013)
PLoS One
, vol.8
, pp. 61432
-
-
Smith, R.1
|