Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

Clinical Endocrinology

Volumn 71, Issue 3, 2009, Pages 369-375

  Mraz, M ^a   Bartlova, M ^a   Lacinova, Z ^a   Michalsky, D ^a   Kasalicky, M ^a   Haluzikova, D ^a   Matoulek, M ^a   Dostalova, I ^a   Humenanska, V ^b   Haluzik, M ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Biovendor   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FENOFIBRATE; FIBROBLAST GROWTH FACTOR 21; INSULIN; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ANTHROPOMETRY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; LOW CALORY DIET; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

ADIPONECTIN; ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; HUMANS; LEPTIN; LIVER; MIDDLE AGED; OBESITY; PROCETOFEN;

EID: 63849189712     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03502.x     Document Type: Article

References (27)

1. Kharitonenkov, A., Shiyanova, T.L., Koester, A. et al. (2005) FGF-21 as a novel metabolic regulator. Journal of Clinical Investigation, 115, 1627 1635.
2. Eswarakumar, V.P., Lax, I. Schlessinger, J. (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine and Growth Factor Review, 16, 139 149.
3. Fu, X.B., Li, X.K., Wang, T. et al. (2004) Enhanced anti-apoptosis and gut epithelium protection function of acidic fibroblast growth factor after cancelling of its mitogenic activity. World Journal of Gastroenterology, 10, 3590 3596.
4. Itoh, N. Ornitz, D.M. (2004) Evolution of the Fgf and Fgfr gene families. Trends in Genetics, 20, 563 569.
5. Kharitonenkov, A., Wroblewski, V.J., Koester, A. et al. (2007) The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology, 148, 774 781.
6. Tomlinson, E., Fu, L., John, L. et al. (2002) Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology, 143, 1741 1747.
7. Wente, W., Efanov, A.M., Brenner, M. et al. (2006) Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes, 55, 2470 2478.
8. Badman, M.K., Pissios, P., Kennedy, A.R. et al. (2007) Hepatic fibroblast growth factor 21 is regulated by PPAR-α and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metabolism, 5, 426 437.
9. Inagaki, T., Choi, M., Moschetta, A. et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabolism, 2, 217 225.
10. Lundasen, T., Hunt, M.C., Nilsson, L.M. et al. (2007) PPAR-α is a key regulator of hepatic FGF21. Biochemical and Biophysical Research Communications, 360, 437 440.
11. Kharitonenkov, A. Shanafelt, A.B. (2008) Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases. BioDrugs, 22, 37 44.
12. Zhang, X., Yeung, D.C., Karpisek, M. et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes, 57, 1246 1253.
13. Chen, W.W., Li, L., Yang, G.Y. et al. (2008) Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Molecular and Cellular Endocrinology, 116, 65 68.
14. Anderlova, K., Dolezalova, R., Housova, J. et al. (2007) Influence of PPAR-α agonist fenofibrate on insulin sensitivity and selected adipose tissue-derived hormones in obese women with type 2 diabetes. Physiological Research, 56, 579 586.
15. Dolinkova, M., Dostalova, I., Lacinova, Z. et al. (2008) The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Molecular and Cellular Endocrinology, 291, 63 70.
16. Matthews, D.R., Hosker, J.P., Rudenski, A.S. et al. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412 419.
17. Haluzik, M. Haluzikova, D. (2006) The role of resistin in obesity-induced insulin resistance. Current Opinion in Investigational Drugs, 7, 306 311.
18. Havel, P.J. (2002) Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Current Opinions in Lipidology, 13, 51 59.
19. Housa, D., Housova, J., Vernerova, Z. et al. (2006) Adipocytokines and cancer. Physiological Research, 55, 233 244.
20. Trujillo, M.E. Scherer, P.E. (2005) Adiponectin - journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. Journal of Internal Medicine, 257, 167 175.
21. Zhang, Y., Proenca, R., Maffei, M. et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425 432.
22. Moyers, J.S., Shiyanova, T.L., Mehrbod, F. et al. (2007) Molecular determinants of FGF-21 activity-synergy and cross-talk with PPAR-γ signaling. Journal of Cellular Physiology, 210, 1 6.
23. Lefebvre, P., Chinetti, G., Fruchart, J.C. et al. (2006) Sorting out the roles of PPAR-α in energy metabolism and vascular homeostasis. Journal of Clinical Investigation, 116, 571 580.
24. Inagaki, T., Dutchak, P., Zhao, G. et al. (2007) Endocrine regulation of the fasting response by PPAR-α-mediated induction of fibroblast growth factor 21. Cell Metabolism, 5, 415 425.
25. Dostalova, I., Kavalkova, P., Haluzikova, D. et al. (2008) Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 93, 3627 3632.
26. Nishimura, T., Nakatake, Y., Konishi, M. et al. (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochimica et Biophysica Acta, 1492, 203 206.
27. Muise, E.S., Azzolina, B., Kuo, D.W. et al. (2008) Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Molecular Pharmacology, 74, 403 412.