메뉴 건너뛰기




Volumn 18, Issue 11, 2014, Pages 1305-1313

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: A novel predictor and therapeutic target

Author keywords

Alcoholic liver disease; Endoplasmic reticulum stress; Fibroblast growth factor 21; Fibroblast growth factor 21 resistance; Hepatocellular carcinoma; Nonalcoholic fatty liver disease; Pathogenesis; Therapeutic target; Viral hepatitis

Indexed keywords

BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR 21; INSULIN; FIBROBLAST GROWTH FACTOR;

EID: 84910003771     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.944898     Document Type: Review
Times cited : (27)

References (79)
  • 1
    • 47949111205 scopus 로고    scopus 로고
    • Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states
    • Muise ES, Azzolina B, Kuo DW, et al. Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol Pharmacol 2008;74(2):403-12
    • (2008) Mol Pharmacol , vol.74 , Issue.2 , pp. 403-412
    • Muise, E.S.1    Azzolina, B.2    Kuo, D.W.3
  • 2
    • 84901463912 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: A promising therapeutic target in obesity-related diseases
    • Cheung BM, Deng H. Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases. Expert Rev Cardiovasc Ther 2014;12(6):659-66
    • (2014) Expert Rev Cardiovasc Ther , vol.12 , Issue.6 , pp. 659-666
    • Cheung, B.M.1    Deng, H.2
  • 3
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 2000;1492(1):203-6
    • (2000) Biochim Biophys Acta , vol.1492 , Issue.1 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 4
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 2011;286(15):12983-90
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3
  • 5
    • 80052036925 scopus 로고    scopus 로고
    • Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
    • Oishi K, Konishi M, Murata Y, Itoh N. Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice. Biochem Biophys Res Commun 2011;412(2):396-400
    • (2011) Biochem Biophys Res Commun , vol.412 , Issue.2 , pp. 396-400
    • Oishi, K.1    Konishi, M.2    Murata, Y.3    Itoh, N.4
  • 6
    • 34247565954 scopus 로고    scopus 로고
    • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
    • Goetz R, Beenken A, Ibrahimi OA, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol 2007;27(9):3417-28
    • (2007) Mol Cell Biol , vol.27 , Issue.9 , pp. 3417-3428
    • Goetz, R.1    Beenken, A.2    Ibrahimi, O.A.3
  • 7
    • 61649100307 scopus 로고    scopus 로고
    • The FGF family: Biology, pathophysiology and therapy
    • Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009;8(3):235-53
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.3 , pp. 235-253
    • Beenken, A.1    Mohammadi, M.2
  • 8
    • 84865741904 scopus 로고    scopus 로고
    • betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism
    • Ding X, Boney-Montoya J, Owen BM, et al. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 2012;16(3):387-93
    • (2012) Cell Metab , vol.16 , Issue.3 , pp. 387-393
    • Ding, X.1    Boney-Montoya, J.2    Owen, B.M.3
  • 9
    • 84870359606 scopus 로고    scopus 로고
    • Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex
    • Foltz IN, Hu S, King C, et al. Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho/FGFR1c receptor complex. Sci Transl Med 2012;4(162):162ra153
    • (2012) Sci Transl Med , vol.4 , Issue.162 , pp. 162ra153
    • Foltz, I.N.1    Hu, S.2    King, C.3
  • 10
    • 34249697012 scopus 로고    scopus 로고
    • BetaKlotho is required for metabolic activity of fibroblast growth factor 21
    • Ogawa Y, Kurosu H, Yamamoto M, et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA 2007;104(18):7432-7
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.18 , pp. 7432-7437
    • Ogawa, Y.1    Kurosu, H.2    Yamamoto, M.3
  • 11
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • Potthoff MJ, Inagaki T, Satapati S, et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA 2009;106(26):10853-8
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.26 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3
  • 12
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009;58(1):250-9
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3
  • 13
    • 82455162662 scopus 로고    scopus 로고
    • Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking
    • Wu C, Gilroy R, Taylor R, et al. Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking. Hepatology 2011;54(6):1966-74
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 1966-1974
    • Wu, C.1    Gilroy, R.2    Taylor, R.3
  • 14
    • 84876074055 scopus 로고    scopus 로고
    • Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
    • Yang C, Lu W, Lin T, et al. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol 2013;13:67
    • (2013) BMC Gastroenterol , vol.13 , pp. 67
    • Yang, C.1    Lu, W.2    Lin, T.3
  • 15
    • 84892162004 scopus 로고    scopus 로고
    • Stressed liver and muscle call on adipocytes with FGF21
    • Luo Y, McKeehan WL. Stressed liver and muscle call on adipocytes with FGF21. Front Endocrinol (Lausanne) 2013;4:194
    • (2013) Front Endocrinol (Lausanne) , vol.4 , pp. 194
    • Luo, Y.1    McKeehan, W.L.2
  • 16
    • 79952103793 scopus 로고    scopus 로고
    • FGF21 reloaded: Challenges of a rapidly growing field
    • Kharitonenkov A, Larsen P. FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab 2011;22(3):81-6
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.3 , pp. 81-86
    • Kharitonenkov, A.1    Larsen, P.2
  • 17
    • 74049108945 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: From pharmacology to physiology
    • Kliewer SA, Mangelsdorf DJ. Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr 2010;91(1):254s-7s
    • (2010) Am J Clin Nutr , vol.91 , Issue.1 , pp. 254s-7s
    • Kliewer, S.A.1    Mangelsdorf, D.J.2
  • 18
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: Pathogenesis and new therapeutic targets
    • Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011;141(5):1572-85
    • (2011) Gastroenterology , vol.141 , Issue.5 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 20
    • 33847008303 scopus 로고    scopus 로고
    • Genetics of alcoholic liver disease and nonalcoholic fatty liver disease
    • Wilfred de Alwis NM, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis 2007;27(1):44-54
    • (2007) Semin Liver Dis , vol.27 , Issue.1 , pp. 44-54
    • Wilfred De Alwis, N.M.1    Day, C.P.2
  • 21
    • 0042847330 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    • Fischer M, You M, Matsumoto M, Crabb DW. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 2003;278(30):27997-8004
    • (2003) J Biol Chem , vol.278 , Issue.30 , pp. 27997-28004
    • Fischer, M.1    You, M.2    Matsumoto, M.3    Crabb, D.W.4
  • 22
    • 0028869502 scopus 로고
    • Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease
    • Wan YJ, Morimoto M, Thurman RG, et al. Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life Sci 1995;56(5):307-17
    • (1995) Life Sci , vol.56 , Issue.5 , pp. 307-317
    • Wan, Y.J.1    Morimoto, M.2    Thurman, R.G.3
  • 23
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007;5(6):426-37
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3
  • 24
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5(6):415-25.
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3
  • 26
    • 67650263853 scopus 로고    scopus 로고
    • Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    • Mai K, Andres J, Biedasek K, et al. Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes 2009;58(7):1532-8
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1532-1538
    • Mai, K.1    Andres, J.2    Biedasek, K.3
  • 28
    • 33846418834 scopus 로고    scopus 로고
    • The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    • Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 2007;148(2):774-81
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 774-781
    • Kharitonenkov, A.1    Wroblewski, V.J.2    Koester, A.3
  • 29
    • 57349098220 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 corrects obesity in mice
    • Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 2008;149(12):6018-27
    • (2008) Endocrinology , vol.149 , Issue.12 , pp. 6018-6027
    • Coskun, T.1    Bina, H.A.2    Schneider, M.A.3
  • 30
    • 84900791017 scopus 로고    scopus 로고
    • Serum and hepatic fibroblast growth factor 21 (FGF-21) levels are increased in subjects with severe acute alcoholic hepatitis and in mice exposed to chronic-binge alcohol by decreased transcriptional suppression
    • abstract
    • Feng W, Liu Y, Zhao C, et al. Serum and hepatic fibroblast growth factor 21 (FGF-21) levels are increased in subjects with severe acute alcoholic hepatitis and in mice exposed to chronic-binge alcohol by decreased transcriptional suppression (abstract). Hepatology 2013;58(S1):480A
    • (2013) Hepatology , vol.58 , Issue.S1 , pp. 480A
    • Feng, W.1    Liu, Y.2    Zhao, C.3
  • 31
    • 84900821567 scopus 로고    scopus 로고
    • Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: Pathophysiology, translational relevance, and challenges
    • Mathews S, Xu M, Wang H, et al. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 2014;306(10):G819-23
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , Issue.10 , pp. G819-G823
    • Mathews, S.1    Xu, M.2    Wang, H.3
  • 32
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43(2 Suppl 1):S99-S112
    • (2006) Hepatology , vol.43 , Issue.2 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 33
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • Hamaguchi M, Kojima T, Takeda N, et al. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 2005;143(10):722-8
    • (2005) Ann Intern Med , vol.143 , Issue.10 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 34
    • 84928351417 scopus 로고    scopus 로고
    • Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children
    • Epub ahead of print
    • Malespin M, Sleesman B, Lau A, et al. Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children. J Clin Gastroenterol 2014. [Epub ahead of print]
    • (2014) J Clin Gastroenterol
    • Malespin, M.1    Sleesman, B.2    Lau, A.3
  • 35
    • 0037021505 scopus 로고    scopus 로고
    • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    • Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002;288(21):2709-16
    • (2002) JAMA , vol.288 , Issue.21 , pp. 2709-2716
    • Lakka, H.M.1    Laaksonen, D.E.2    Lakka, T.A.3
  • 36
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010;51(5):1820-32
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 37
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129(1):113-21
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 38
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: A follow-up study for up to 20 years
    • Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, et al. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009;58(11):1538-44
    • (2009) Gut , vol.58 , Issue.11 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3
  • 39
    • 68949111875 scopus 로고    scopus 로고
    • Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease
    • Milner KL, van der Poorten D, Xu A, et al. Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease. Hepatology 2009;49(6):1926-34
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1926-1934
    • Milner, K.L.1    Van Der Poorten, D.2    Xu, A.3
  • 40
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study
    • Feldstein AE, Wieckowska A, Lopez AR, et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology 2009;50(4):1072-8
    • (2009) Hepatology , vol.50 , Issue.4 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3
  • 41
    • 84874117479 scopus 로고    scopus 로고
    • High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China
    • Li H, Dong K, Fang Q, et al. High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. J Hepatol 2013;58(3):557-63
    • (2013) J Hepatol , vol.58 , Issue.3 , pp. 557-563
    • Li, H.1    Dong, K.2    Fang, Q.3
  • 42
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay J, Chui PC, Gopalakrishnan GS, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 2010;139(2):456-63
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 43
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol 2010;53(5):934-40
    • (2010) J Hepatol , vol.53 , Issue.5 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3
  • 44
    • 78049297991 scopus 로고    scopus 로고
    • Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    • Fisher FM, Chui PC, Antonellis PJ, et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010;59(11):2781-9
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2781-2789
    • Fisher, F.M.1    Chui, P.C.2    Antonellis, P.J.3
  • 45
    • 79151469687 scopus 로고    scopus 로고
    • Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease
    • Gaemers IC, Stallen JM, Kunne C, et al. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim Biophys Acta 2011;1812(4):447-58
    • (2011) Biochim Biophys Acta , vol.1812 , Issue.4 , pp. 447-458
    • Gaemers, I.C.1    Stallen, J.M.2    Kunne, C.3
  • 46
    • 79959509827 scopus 로고    scopus 로고
    • Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery
    • Jansen PL, van Werven J, Aarts E, et al. Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery. Dig Dis 2011;29(1):48-51
    • (2011) Dig Dis , vol.29 , Issue.1 , pp. 48-51
    • Jansen, P.L.1    Van Werven, J.2    Aarts, E.3
  • 47
    • 39449127028 scopus 로고    scopus 로고
    • Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus
    • Chen WW, Li L, Yang GY, et al. Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2008;116(1):65-8
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , Issue.1 , pp. 65-68
    • Chen, W.W.1    Li, L.2    Yang, G.Y.3
  • 48
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X, Yeung DC, Karpisek M, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008;57(5):1246-53
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3
  • 49
    • 57949116523 scopus 로고    scopus 로고
    • Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content
    • Fabbrini E, deHaseth D, Deivanayagam S, et al. Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) 2009;17(1):25-9
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.1 , pp. 25-29
    • Fabbrini, E.1    DeHaseth, D.2    Deivanayagam, S.3
  • 50
    • 84897382346 scopus 로고    scopus 로고
    • Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats
    • Li S, Meng F, Liao X, et al. Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS One 2014;9(1):e86724
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86724
    • Li, S.1    Meng, F.2    Liao, X.3
  • 51
    • 84874664386 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
    • Schaap FG, Kremer AE, Lamers WH, et al. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie 2013;95(4):692-9
    • (2013) Biochimie , vol.95 , Issue.4 , pp. 692-699
    • Schaap, F.G.1    Kremer, A.E.2    Lamers, W.H.3
  • 52
    • 84891324421 scopus 로고    scopus 로고
    • The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease
    • Lake AD, Novak P, Hardwick RN, et al. The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. Toxicol Sci 2014;137(1):26-35
    • (2014) Toxicol Sci , vol.137 , Issue.1 , pp. 26-35
    • Lake, A.D.1    Novak, P.2    Hardwick, R.N.3
  • 53
    • 84894234845 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
    • Zhang XQ, Xu CF, Yu CH, et al. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol 2014;20(7):1768-76
    • (2014) World J Gastroenterol , vol.20 , Issue.7 , pp. 1768-1776
    • Zhang, X.Q.1    Xu, C.F.2    Yu, C.H.3
  • 55
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol 2011;54(4):795-809
    • (2011) J Hepatol , vol.54 , Issue.4 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 56
    • 84895168540 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activation and excess energy burning in hepatocarcinogenesis
    • Misra P, Reddy JK. Peroxisome proliferator-activated receptor-alpha activation and excess energy burning in hepatocarcinogenesis. Biochimie 2014;98:63-74
    • (2014) Biochimie , vol.98 , pp. 63-74
    • Misra, P.1    Reddy, J.K.2
  • 57
    • 82455212124 scopus 로고    scopus 로고
    • Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial
    • Samson SL, Sathyanarayana P, Jogi M, et al. Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. Diabetologia 2011;54(12):3093-100
    • (2011) Diabetologia , vol.54 , Issue.12 , pp. 3093-3100
    • Samson, S.L.1    Sathyanarayana, P.2    Jogi, M.3
  • 58
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003;362(9399):1907-17
    • (2003) Lancet , vol.362 , Issue.9399 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 59
    • 33845380799 scopus 로고    scopus 로고
    • Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis
    • Huang X, Yu C, Jin C, et al. Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Mol Carcinog 2006;45(12):934-42
    • (2006) Mol Carcinog , vol.45 , Issue.12 , pp. 934-942
    • Huang, X.1    Yu, C.2    Jin, C.3
  • 60
    • 84904764170 scopus 로고    scopus 로고
    • Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice
    • El-Ashmawy NE, El-Bahrawy HA, Shamloula MM, El-Feky OA. Biochemical/metabolic changes associated with hepatocellular carcinoma development in mice. Tumour Biol 2014;35(6):5459-66
    • (2014) Tumour Biol , vol.35 , Issue.6 , pp. 5459-5466
    • El-Ashmawy, N.E.1    El-Bahrawy, H.A.2    Shamloula, M.M.3    El-Feky, O.A.4
  • 61
    • 77949328590 scopus 로고    scopus 로고
    • FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation
    • Wu X, Ge H, Lemon B, et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem 2010;285(8):5165-70
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5165-5170
    • Wu, X.1    Ge, H.2    Lemon, B.3
  • 62
    • 2542505481 scopus 로고    scopus 로고
    • Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
    • Fu L, John LM, Adams SH, et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 2004;145(6):2594-603
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2594-2603
    • Fu, L.1    John, L.M.2    Adams, S.H.3
  • 63
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson E, Fu L, John L, et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 2002;143(5):1741-7
    • (2002) Endocrinology , vol.143 , Issue.5 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3
  • 64
    • 84866752981 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Natural history, current management, and emerging tools
    • Tinkle CL, Haas-Kogan D. Hepatocellular carcinoma: natural history, current management, and emerging tools. Biologics 2012;6:207-19
    • (2012) Biologics , vol.6 , pp. 207-219
    • Tinkle, C.L.1    Haas-Kogan, D.2
  • 65
    • 84911476407 scopus 로고    scopus 로고
    • Should we consider patients with coexistent hepatitis B or C infection for orthotopic heart transplantation?
    • Sekar B, Newton PJ, Williams SG, Shaw SM. Should we consider patients with coexistent hepatitis B or C infection for orthotopic heart transplantation? J Transplant 2013;2013:748578
    • (2013) J Transplant , vol.2013 , pp. 748578
    • Sekar, B.1    Newton, P.J.2    Williams, S.G.3    Shaw, S.M.4
  • 66
    • 84865706218 scopus 로고    scopus 로고
    • Serum FGF21 and RBP4 levels in patients with chronic hepatitis C
    • Kukla M, Berdowska A, Stygar D, et al. Serum FGF21 and RBP4 levels in patients with chronic hepatitis C. Scand J Gastroenterol 2012;47(8-9):1037-47
    • (2012) Scand J Gastroenterol , vol.47 , Issue.8-9 , pp. 1037-1047
    • Kukla, M.1    Berdowska, A.2    Stygar, D.3
  • 67
    • 68549086862 scopus 로고    scopus 로고
    • Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation
    • Li S, Ye L, Yu X, et al. Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation. Virology 2009;391(2):257-64
    • (2009) Virology , vol.391 , Issue.2 , pp. 257-264
    • Li, S.1    Ye, L.2    Yu, X.3
  • 68
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A, Wychowski C, Lin C, et al. Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol 1993;67(3):1385-95
    • (1993) J Virol , vol.67 , Issue.3 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3
  • 69
    • 84881378339 scopus 로고    scopus 로고
    • APRI, the FIB-4 score, and Forn's index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B
    • Ucar F, Sezer S, Ginis Z, et al. APRI, the FIB-4 score, and Forn's index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B. Eur J Gastroenterol Hepatol 2013;25(9):1076-81
    • (2013) Eur J Gastroenterol Hepatol , vol.25 , Issue.9 , pp. 1076-1081
    • Ucar, F.1    Sezer, S.2    Ginis, Z.3
  • 70
    • 56649112801 scopus 로고    scopus 로고
    • Diagnosis of nonalcoholic fatty liver disease: Invasive versus noninvasive
    • Wieckowska A, Feldstein AE. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis 2008;28(4):386-95
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 386-395
    • Wieckowska, A.1    Feldstein, A.E.2
  • 71
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • Matteoni CA, Younossi ZM, Gramlich T, et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999;116(6):1413-19
    • (1999) Gastroenterology , vol.116 , Issue.6 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 72
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions
    • Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94(9):2467-74
    • (1999) Am J Gastroenterol , vol.94 , Issue.9 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3
  • 73
    • 33748498921 scopus 로고    scopus 로고
    • The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis
    • Palmentieri B, de Sio I, La Mura V, et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis 2006;38(7):485-9
    • (2006) Dig Liver Dis , vol.38 , Issue.7 , pp. 485-489
    • Palmentieri, B.1    De Sio, I.2    La Mura, V.3
  • 74
    • 33750312195 scopus 로고    scopus 로고
    • Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease
    • Guha IN, Parkes J, Roderick PR, et al. Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. Gut 2006;55(11):1650-60
    • (2006) Gut , vol.55 , Issue.11 , pp. 1650-1660
    • Guha, I.N.1    Parkes, J.2    Roderick, P.R.3
  • 75
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121(1):91-100
    • (2001) Gastroenterology , vol.121 , Issue.1 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 76
    • 33646468226 scopus 로고    scopus 로고
    • Obesity is the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease: A cross-sectional case-control study
    • Lee S, Jin Kim Y, Yong Jeon T, et al. Obesity is the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease: a cross-sectional case-control study. Scand J Gastroenterol 2006;41(5):566-72
    • (2006) Scand J Gastroenterol , vol.41 , Issue.5 , pp. 566-572
    • Lee, S.1    Jin Kim, Y.2    Yong Jeon, T.3
  • 77
    • 84873376793 scopus 로고    scopus 로고
    • The central role of the non alcoholic fatty liver disease in metabolic syndrome
    • Hurjui DM, Nita O, Graur LI, et al. The central role of the non alcoholic fatty liver disease in metabolic syndrome. Rev Med Chir Soc Med Nat Iasi 2012;116(2):425-31
    • (2012) Rev Med Chir Soc Med Nat Iasi , vol.116 , Issue.2 , pp. 425-431
    • Hurjui, D.M.1    Nita, O.2    Graur, L.I.3
  • 78
    • 84894377590 scopus 로고    scopus 로고
    • Therapeutic effect of fibroblast growth factor 21 on NAFLD in MSG-iR mice and its mechanism
    • Zhu SL, Zhang ZY, Ren GP, et al. [Therapeutic effect of fibroblast growth factor 21 on NAFLD in MSG-iR mice and its mechanism]. Yao Xue Xue Bao 2013;48(12):1778-84
    • (2013) Yao Xue Xue Bao , vol.48 , Issue.12 , pp. 1778-1784
    • Zhu, S.L.1    Zhang, Z.Y.2    Ren, G.P.3
  • 79
    • 84879468929 scopus 로고    scopus 로고
    • Association between serum atypical fibroblast growth factors 21 and 19 and pediatric nonalcoholic fatty liver disease
    • Alisi A, Ceccarelli S, Panera N, et al. Association between serum atypical fibroblast growth factors 21 and 19 and pediatric nonalcoholic fatty liver disease. PLoS One 2013;8(6):e67160
    • (2013) PLoS One , vol.8 , Issue.6 , pp. e67160
    • Alisi, A.1    Ceccarelli, S.2    Panera, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.