Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice

FEBS Letters

Volumn 583, Issue 19, 2009, Pages 3230-3234

  Li, Xiaofan ^a   Ge, Hongfei ^a   Weiszmann, Jennifer ^a   Hecht, Randy ^a   Li, Yue sheng ^a   Véniant, Murielle M ^a   Xu, Jing ^a   Wu, Xinle ^a   Lindberg, Richard ^a   Li, Yang ^a  

^a AMGEN INC   (United States)

Author keywords

Klotho; FGF21; Fibroblast growth factor receptor; Free fatty acid; Glucose; Lipolysis

Indexed keywords

FATTY ACID; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HORMONE INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LIPOLYSIS; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; FIBROBLAST GROWTH FACTORS; INJECTIONS, SUBCUTANEOUS; LIPASE; LIPOLYSIS; MICE; MICE, INBRED STRAINS;

MUS;

EID: 70349472910     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.09.012     Document Type: Article

References (19)

1. Kharitonenkov A., et al. FGF-21 as a novel metabolic regulator. J. Clin. Invest. 115 (2005) 1627-1635
2. Badman M.K., Pissios P., Kennedy A.R., Koukos G., Flier J.S., and Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 5 (2007) 426-437
3. Xu J., et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58 (2008) 250-259
4. Coskun T., Bina H.A., Schneider M.A., Dunbar J.D., Hu C.C., Chen Y., Moller D.E., and Kharitonenkov A. FGF21 corrects obesity in mice. Endocrinology 149 (2008) 6018-6027
5. Kharitonenkov A., et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148 (2007) 774-781
6. Ogawa Y., et al. BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc. Natl. Acad. Sci. USA 104 (2007) 7432-7437
7. Suzuki M., et al. {beta}Klotho is required for FGF21 signaling through FGFR1c and FGFR3c. Mol. Endocrinol. 22 (2008) 1006-1014
8. Kharitonenkov A., et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho. J. Cell Physiol. 215 (2008) 1-7
9. Ge H., Li X., Weiszmann J., Wang P., Baribault H., Chen J.L., Tian H., and Li Y. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 149 (2008) 4519-4526
10. Wu X., et al. Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc. Natl. Acad. Sci. USA 106 (2009) 14379-14384
11. Inagaki T., et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 5 (2007) 41525
12. Arner P., Pettersson A., Mitchell P.J., Dunbar J.D., Kharitonenkov A., and Ryden M. FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. FEBS Lett. 582 (2008) 1725-1730
13. Boden G., Chen X., Capulong E., and Mozzoli M. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50 (2001) 810-816
14. Boden G. Free fatty acids (FFA), a link between obesity and insulin resistance. Front. Biosci. 3 (1998) d169-d175
15. Arner P. Insulin resistance in type 2 diabetes: role of fatty acids. Diabetes Metab. Res. Rev. 18 Suppl. 2 (2002) S5-S9
16. Boden G., Chen X., and Stein T.P. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 280 (2001) E23-E30
17. Xu J., et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58 (2009) 250-259
18. Segerlantz M., Bramnert M., Manhem P., Laurila E., and Groop L.C. Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults. J. Clin. Endocrinol. Metab. 86 (2001) 5813-5818
19. Berglund, E.D., Li, C.Y., Bina, H.A., Lynes, S.G., Michael, M.D., Shanafelt, A.B., Kharitonenkov, A. and Wasserman, D.H. (in press) Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology 150, 4084-4093.