-
1
-
-
84866985855
-
Targeting the TGF-b signalling pathway in disease
-
Akhurst RJ, Hata A. Targeting the TGF-b signalling pathway in disease. Nat Rev Drug Discov 11: 790–811, 2012
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 790-811
-
-
Akhurst, R.J.1
Hata, A.2
-
2
-
-
0036236158
-
Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose
-
Amiri F, Shaw S, Wang X, Tang J, Waller JL, Eaton DC, Marrero MB. Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose. Kidney Int 61: 1605–1616, 2002
-
(2002)
Kidney Int
, vol.61
, pp. 1605-1616
-
-
Amiri, F.1
Shaw, S.2
Wang, X.3
Tang, J.4
Waller, J.L.5
Eaton, D.C.6
Marrero, M.B.7
-
3
-
-
0032849010
-
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
-
Aramburu J, Yaffe MB, Lopez-Rodriguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285: 2129–2133, 1999
-
(1999)
Science
, vol.285
, pp. 2129-2133
-
-
Aramburu, J.1
Yaffe, M.B.2
Lopez-Rodriguez, C.3
Cantley, L.C.4
Hogan, P.G.5
Rao, A.6
-
4
-
-
33645732363
-
Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy
-
Awad AS, Huang L, Ye H, Duong ET, Bolton WK, Linden J, Okusa MD. Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. Am J Physiol Renal Physiol 290: F828–F837, 2006
-
(2006)
Am J Physiol Renal Physiol
, vol.290
, pp. F828-F837
-
-
Awad, A.S.1
Huang, L.2
Ye, H.3
Duong, E.T.4
Bolton, W.K.5
Linden, J.6
Okusa, M.D.7
-
5
-
-
1642277116
-
Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli
-
Banes AK, Shaw S, Jenkins J, Redd H, Amiri F, Pollock DM, Marrero MB. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol 286: F653–F659, 2004
-
(2004)
Am J Physiol Renal Physiol
, vol.286
, pp. F653-F659
-
-
Banes, A.K.1
Shaw, S.2
Jenkins, J.3
Redd, H.4
Amiri, F.5
Pollock, D.M.6
Marrero, M.B.7
-
6
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Green AR. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365: 1054–1061, 2005
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Green, A.R.13
-
7
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245–313, 2007
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
8
-
-
0038205926
-
Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat
-
Benigni A, Zoja C, Corna D, Zatelli C, Conti S, Campana M, Gagliardini E, Rottoli D, Zanchi C, Abbate M, Ledbetter S, Remuzzi G. Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J Am Soc Nephrol 14: 1816–1824, 2003
-
(2003)
J am Soc Nephrol
, vol.14
, pp. 1816-1824
-
-
Benigni, A.1
Zoja, C.2
Corna, D.3
Zatelli, C.4
Conti, S.5
Campana, M.6
Gagliardini, E.7
Rottoli, D.8
Zanchi, C.9
Abbate, M.10
Ledbetter, S.11
Remuzzi, G.12
-
9
-
-
63249092534
-
Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy
-
Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, Boucherot A, Neusser MA, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC, Kretzler M. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes 58: 469–477, 2009
-
(2009)
Diabetes
, vol.58
, pp. 469-477
-
-
Berthier, C.C.1
Zhang, H.2
Schin, M.3
Henger, A.4
Nelson, R.G.5
Yee, B.6
Boucherot, A.7
Neusser, M.A.8
Cohen, C.D.9
Carter-Su, C.10
Argetsinger, L.S.11
Rastaldi, M.P.12
Brosius, F.C.13
Kretzler, M.14
-
10
-
-
81155123707
-
Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes
-
Bertuccio C, Veron D, Aggarwal PK, Holzman L, Tufro A. Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes. J Biol Chem 286: 39,933–39,944, 2011
-
(2011)
J Biol Chem
, vol.286
, pp. 933-939
-
-
Bertuccio, C.1
Veron, D.2
Aggarwal, P.K.3
Holzman, L.4
Tufro, A.5
-
11
-
-
84888382854
-
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
-
Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, Atkins KB, Gyung Kang H, Henger A, Brakebusch C, Holzman LB, Kretzler M. Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury. Kidney Int 84: 920–930, 2013
-
(2013)
Kidney Int
, vol.84
, pp. 920-930
-
-
Blattner, S.M.1
Hodgin, J.B.2
Nishio, M.3
Wylie, S.A.4
Saha, J.5
Soofi, A.A.6
Vining, C.7
Randolph, A.8
Herbach, N.9
Wanke, R.10
Atkins, K.B.11
Gyung Kang, H.12
Henger, A.13
Brakebusch, C.14
Holzman, L.B.15
Kretzler, M.16
-
12
-
-
84919717887
-
Endothelin receptors, renal effects and blood pressure
-
Boesen EI. Endothelin receptors, renal effects and blood pressure. Curr Opin Pharmacol 21: 25–34, 2015
-
(2015)
Curr Opin Pharmacol
, vol.21
, pp. 25-34
-
-
Boesen, E.I.1
-
13
-
-
0035922441
-
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
-
Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345: 861–869, 2001
-
(2001)
N Engl J Med
, vol.345
, pp. 861-869
-
-
Brenner, B.M.1
Cooper, M.E.2
De Zeeuw, D.3
Keane, W.F.4
Mitch, W.E.5
Parving, H.H.6
Remuzzi, G.7
Snapinn, S.M.8
Zhang, Z.9
Shahinfar, S.10
-
14
-
-
84871763460
-
New targets for treatment of diabetic nephropathy: What we have learned from animal models
-
Brosius FC, 3rd, Alpers CE. New targets for treatment of diabetic nephropathy: what we have learned from animal models. Curr Opin Nephrol Hypertens 22: 17–25, 2013
-
(2013)
Curr Opin Nephrol Hypertens
, vol.22
, pp. 17-25
-
-
Brosius, F.C.1
Alpers, C.E.2
-
15
-
-
20044376702
-
The pathobiology of diabetic complications: A unifying mechanism
-
Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615–1625, 2005
-
(2005)
Diabetes
, vol.54
, pp. 1615-1625
-
-
Brownlee, M.1
-
16
-
-
84887479804
-
AKT2 is essential to maintain podocyte viability and function during chronic kidney disease
-
Canaud G, Bienaime F, Viau A, Treins C, Baron W, Nguyen C, Burtin M, Berissi S, Giannakakis K, Muda AO, Zschiedrich S, Huber TB, Friedlander G, Legendre C, Pontoglio M, Pende M, Terzi F. AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med 19: 1288–1296, 2013
-
(2013)
Nat Med
, vol.19
, pp. 1288-1296
-
-
Canaud, G.1
Bienaime, F.2
Viau, A.3
Treins, C.4
Baron, W.5
Nguyen, C.6
Burtin, M.7
Berissi, S.8
Giannakakis, K.9
Muda, A.O.10
Zschiedrich, S.11
Huber, T.B.12
Friedlander, G.13
Legendre, C.14
Pontoglio, M.15
Pende, M.16
Terzi, F.17
-
17
-
-
0037229517
-
Reversibility of established diabetic glomerulopathy by anti-TGF-b antibodies in db/db mice
-
Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Reversibility of established diabetic glomerulopathy by anti-TGF-b antibodies in db/db mice. Biochem Biophys Res Commun 300: 16–22, 2003
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 16-22
-
-
Chen, S.1
Iglesias-De La Cruz, M.C.2
Jim, B.3
Hong, S.W.4
Isono, M.5
Ziyadeh, F.N.6
-
18
-
-
7044260750
-
Podocytederived vascular endothelial growth factor mediates the stimulation of _3(IV) collagen production by transforming growth factor-_1 in mouse podocytes
-
Chen S, Kasama Y, Lee JS, Jim B, Marin M, Ziyadeh FN. Podocytederived vascular endothelial growth factor mediates the stimulation of _3(IV) collagen production by transforming growth factor-_1 in mouse podocytes. Diabetes 53: 2939–2949, 2004
-
(2004)
Diabetes
, vol.53
, pp. 2939-2949
-
-
Chen, S.1
Kasama, Y.2
Lee, J.S.3
Jim, B.4
Marin, M.5
Ziyadeh, F.N.6
-
19
-
-
84869220435
-
Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice
-
Cheng H, Wang H, Fan X, Paueksakon P, Harris RC. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int 82: 1176–1183, 2012
-
(2012)
Kidney Int
, vol.82
, pp. 1176-1183
-
-
Cheng, H.1
Wang, H.2
Fan, X.3
Paueksakon, P.4
Harris, R.C.5
-
20
-
-
77953854247
-
Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis
-
Cho SG, Du Q, Huang S, Dong Z. Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. Am J Physiol Renal Physiol 299: F199–F206, 2010
-
(2010)
Am J Physiol Renal Physiol
, vol.299
, pp. F199-F206
-
-
Cho, S.G.1
Du, Q.2
Huang, S.3
Dong, Z.4
-
21
-
-
0032712434
-
Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
-
Cooper ME, Vranes D, Youssef S, Stacker SA, Cox AJ, Rizkalla B, Casley DJ, Bach LA, Kelly DJ, Gilbert RE. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes 48: 2229–2239, 1999
-
(1999)
Diabetes
, vol.48
, pp. 2229-2239
-
-
Cooper, M.E.1
Vranes, D.2
Youssef, S.3
Stacker, S.A.4
Cox, A.J.5
Rizkalla, B.6
Casley, D.J.7
Bach, L.A.8
Kelly, D.J.9
Gilbert, R.E.10
-
22
-
-
0035461381
-
Overexpression of Cu2 /Zn2 superoxide dismutase protects against early diabetic glomerular injury in transgenic mice
-
Craven PA, Melhem MF, Phillips SL, DeRubertis FR. Overexpression of Cu2 /Zn2 superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes 50: 2114–2125, 2001
-
(2001)
Diabetes
, vol.50
, pp. 2114-2125
-
-
Craven, P.A.1
Melhem, M.F.2
Phillips, S.L.3
Derubertis, F.R.4
-
23
-
-
69849089270
-
Wnt/b- catenin signaling promotes podocyte dysfunction and albuminuria
-
Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y. Wnt/b- catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20: 1997–2008, 2009
-
(2009)
J am Soc Nephrol
, vol.20
, pp. 1997-2008
-
-
Dai, C.1
Stolz, D.B.2
Kiss, L.P.3
Monga, S.P.4
Holzman, L.B.5
Liu, Y.6
-
24
-
-
34547628176
-
Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia
-
Davis B, Dei Cas A, Long DA, White KE, Hayward A, Ku CH, Woolf AS, Bilous R, Viberti G, Gnudi L. Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia. J Am Soc Nephrol 18: 2320–2329, 2007
-
(2007)
J am Soc Nephrol
, vol.18
, pp. 2320-2329
-
-
Davis, B.1
Dei Cas, A.2
Long, D.A.3
White, K.E.4
Hayward, A.5
Ku, C.H.6
Woolf, A.S.7
Bilous, R.8
Viberti, G.9
Gnudi, L.10
-
25
-
-
0035034655
-
Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes
-
de Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 12: 993–1000, 2001
-
(2001)
J am Soc Nephrol
, vol.12
, pp. 993-1000
-
-
De Vriese, A.S.1
Tilton, R.G.2
Elger, M.3
Stephan, C.C.4
Kriz, W.5
Lameire, N.H.6
-
26
-
-
78149359262
-
Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): A randomised controlled trial
-
de Zeeuw D, Agarwal R, Amdahl M, Audhya P, Coyne D, Garimella T, Parving HH, Pritchett Y, Remuzzi G, Ritz E, Andress D. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet 376: 1543–1551, 2010
-
(2010)
Lancet
, vol.376
, pp. 1543-1551
-
-
De Zeeuw, D.1
Agarwal, R.2
Amdahl, M.3
Audhya, P.4
Coyne, D.5
Garimella, T.6
Parving, H.H.7
Pritchett, Y.8
Remuzzi, G.9
Ritz, E.10
Ress, D.11
-
27
-
-
84890946148
-
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease
-
de Zeeuw D, Akizawa T, Audhya P, Bakris GL, Chin M, Christ- Schmidt H, Goldsberry A, Houser M, Krauth M, Lambers Heerspink HJ, McMurray JJ, Meyer CJ, Parving HH, Remuzzi G, Toto RD, Vaziri ND, Wanner C, Wittes J, Wrolstad D, Chertow GM. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med 369: 2492–2503, 2013
-
(2013)
N Engl J Med
, vol.369
, pp. 2492-2503
-
-
De Zeeuw, D.1
Akizawa, T.2
Audhya, P.3
Bakris, G.L.4
Chin, M.5
Christ- Schmidt, H.6
Goldsberry, A.7
Houser, M.8
Krauth, M.9
Lambers Heerspink, H.J.10
McMurray, J.J.11
Meyer, C.J.12
Parving, H.H.13
Remuzzi, G.14
Toto, R.D.15
Vaziri, N.D.16
Wanner, C.17
Wittes, J.18
Wrolstad, D.19
Chertow, G.M.20
more..
-
28
-
-
84906540059
-
The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy
-
de Zeeuw D, Coll B, Andress D, Brennan JJ, Tang H, Houser M, Correa-Rotter R, Kohan D, Lambers Heerspink HJ, Makino H, Perkovic V, Pritchett Y, Remuzzi G, Tobe SW, Toto R, Viberti G, Parving HH. The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy. J Am Soc Nephrol 25: 1083–1093, 2014
-
(2014)
J am Soc Nephrol
, vol.25
, pp. 1083-1093
-
-
De Zeeuw, D.1
Coll, B.2
Ress, D.3
Brennan, J.J.4
Tang, H.5
Houser, M.6
Correa-Rotter, R.7
Kohan, D.8
Lambers Heerspink, H.J.9
Makino, H.10
Perkovic, V.11
Pritchett, Y.12
Remuzzi, G.13
Tobe, S.W.14
Toto, R.15
Viberti, G.16
Parving, H.H.17
-
29
-
-
66049093473
-
1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-_B pathway
-
Deb DK, Chen Y, Zhang Z, Zhang Y, Szeto FL, Wong KE, Kong J, Li YC. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-_B pathway. Am J Physiol Renal Physiol 296: F1212–F1218, 2009
-
(2009)
Am J Physiol Renal Physiol
, vol.296
, pp. F1212-F1218
-
-
Deb, D.K.1
Chen, Y.2
Zhang, Z.3
Zhang, Y.4
Szeto, F.L.5
Wong, K.E.6
Kong, J.7
Li, Y.C.8
-
30
-
-
77955875400
-
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
-
Deb DK, Sun T, Wong KE, Zhang Z, Ning G, Zhang Y, Kong J, Shi H, Chang A, Li YC. Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int 77: 1000–1009, 2010
-
(2010)
Kidney Int
, vol.77
, pp. 1000-1009
-
-
Deb, D.K.1
Sun, T.2
Wong, K.E.3
Zhang, Z.4
Ning, G.5
Zhang, Y.6
Kong, J.7
Shi, H.8
Chang, A.9
Li, Y.C.10
-
31
-
-
33846250366
-
Recombinant human anti-transforming growth factor b
-
1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 56: 323–333, 2007
-
(2007)
Arthritis Rheum
, vol.56
, pp. 323-333
-
-
Denton, C.P.1
Merkel, P.A.2
Furst, D.E.3
Khanna, D.4
Emery, P.5
Hsu, V.M.6
Silliman, N.7
Streisand, J.8
Powell, J.9
Akesson, A.10
Coppock, J.11
Hoogen, F.12
Herrick, A.13
Mayes, M.D.14
Veale, D.15
Haas, J.16
Ledbetter, S.17
Korn, J.H.18
Black, C.M.19
Seibold, J.R.20
more..
-
32
-
-
1442349987
-
Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: Evidence for reduced superoxide-nitric oxide interaction
-
DeRubertis FR, Craven PA, Melhem MF, Salah EM. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 53: 762–768, 2004
-
(2004)
Diabetes
, vol.53
, pp. 762-768
-
-
Derubertis, F.R.1
Craven, P.A.2
Melhem, M.F.3
Salah, E.M.4
-
33
-
-
84891784154
-
Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease
-
Dessapt-Baradez C, Woolf AS, White KE, Pan J, Huang JL, Hayward AA, Price KL, Kolatsi-Joannou M, Locatelli M, Diennet M, Webster Z, Smillie SJ, Nair V, Kretzler M, Cohen CD, Long DA, Gnudi L. Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease. J Am Soc Nephrol 25: 33–42, 2014
-
(2014)
J am Soc Nephrol
, vol.25
, pp. 33-42
-
-
Dessapt-Baradez, C.1
Woolf, A.S.2
White, K.E.3
Pan, J.4
Huang, J.L.5
Hayward, A.A.6
Price, K.L.7
Kolatsi-Joannou, M.8
Locatelli, M.9
Diennet, M.10
Webster, Z.11
Smillie, S.J.12
Nair, V.13
Kretzler, M.14
Cohen, C.D.15
Long, D.A.16
Gnudi, L.17
-
34
-
-
84887466140
-
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
-
Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest 123: 4888–4899, 2013
-
(2013)
J Clin Invest
, vol.123
, pp. 4888-4899
-
-
Dugan, L.L.1
You, Y.H.2
Ali, S.S.3
Diamond-Stanic, M.4
Miyamoto, S.5
Decleves, A.E.6
Reyev, A.7
Quach, T.8
Ly, S.9
Shekhtman, G.10
Nguyen, W.11
Chepetan, A.12
Le, T.P.13
Wang, L.14
Xu, M.15
Paik, K.P.16
Fogo, A.17
Viollet, B.18
Murphy, A.19
Brosius, F.20
Naviaux, R.K.21
Sharma, K.22
more..
-
35
-
-
84865592978
-
Amino acids and mTORC1: From lysosomes to disease
-
Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med 18: 524–533, 2012
-
(2012)
Trends Mol Med
, vol.18
, pp. 524-533
-
-
Efeyan, A.1
Zoncu, R.2
Sabatini, D.M.3
-
36
-
-
30944433984
-
Probucol delays progression of diabetic nephropathy
-
Endo K, Miyashita Y, Sasaki H, Ohira M, Saiki A, Koide N, Otsuka M, Oyama T, Takeyoshi M, Ito Y, Shirai K. Probucol delays progression of diabetic nephropathy. Diabetes Res Clin Pract 71: 156–163, 2006
-
(2006)
Diabetes Res Clin Pract
, vol.71
, pp. 156-163
-
-
Endo, K.1
Miyashita, Y.2
Sasaki, H.3
Ohira, M.4
Saiki, A.5
Koide, N.6
Otsuka, M.7
Oyama, T.8
Takeyoshi, M.9
Ito, Y.10
Shirai, K.11
-
37
-
-
33750331264
-
Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes
-
Epstein M, Williams GH, Weinberger M, Lewin A, Krause S, Mukherjee R, Patni R, Beckerman B. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol 1: 940–951, 2006
-
(2006)
Clin J am Soc Nephrol
, vol.1
, pp. 940-951
-
-
Epstein, M.1
Williams, G.H.2
Weinberger, M.3
Lewin, A.4
Krause, S.5
Mukherjee, R.6
Patni, R.7
Beckerman, B.8
-
38
-
-
40849130173
-
VEGF inhibition and renal thrombotic microangiopathy
-
Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358: 1129–1136, 2008
-
(2008)
N Engl J Med
, vol.358
, pp. 1129-1136
-
-
Eremina, V.1
Jefferson, J.A.2
Kowalewska, J.3
Hochster, H.4
Haas, M.5
Weisstuch, J.6
Richardson, C.7
Kopp, J.B.8
Kabir, M.G.9
Backx, P.H.10
Gerber, H.P.11
Ferrara, N.12
Barisoni, L.13
Alpers, C.E.14
Quaggin, S.E.15
-
39
-
-
0036789207
-
Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody
-
Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 51: 3090–3094, 2002
-
(2002)
Diabetes
, vol.51
, pp. 3090-3094
-
-
Flyvbjerg, A.1
Dagnaes-Hansen, F.2
De Vriese, A.S.3
Schrijvers, B.F.4
Tilton, R.G.5
Rasch, R.6
-
40
-
-
85015497707
-
Clinical advances in the development of novel VEGFR2 inhibitors
-
Fontanella C, Ongaro E, Bolzonello S, Guardascione M, Fasola G, Aprile G. Clinical advances in the development of novel VEGFR2 inhibitors. Ann Transl Med 2: 123, 2014
-
(2014)
Ann Transl Med
, vol.2
-
-
Fontanella, C.1
Ongaro, E.2
Bolzonello, S.3
Guardascione, M.4
Fasola, G.5
Aprile, G.6
-
41
-
-
0038623780
-
Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
-
Foster RR, Hole R, Anderson K, Satchell SC, Coward RJ, Mathieson PW, Gillatt DA, Saleem MA, Bates DO, Harper SJ. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol 284: F1263–F1273, 2003
-
(2003)
Am J Physiol Renal Physiol
, vol.284
, pp. F1263-F1273
-
-
Foster, R.R.1
Hole, R.2
Erson, K.3
Satchell, S.C.4
Coward, R.J.5
Mathieson, P.W.6
Gillatt, D.A.7
Saleem, M.A.8
Bates, D.O.9
Harper, S.J.10
-
42
-
-
84887467090
-
Combined angiotensin inhibition for the treatment of diabetic nephropathy
-
Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, Leehey DJ, McCullough PA, O’Connor T, Palevsky PM, Reilly RF, Seliger SL, Warren SR, Watnick S, Peduzzi P, Guarino P. Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 369: 1892–1903, 2013
-
(2013)
N Engl J Med
, vol.369
, pp. 1892-1903
-
-
Fried, L.F.1
Emanuele, N.2
Zhang, J.H.3
Brophy, M.4
Conner, T.A.5
Duckworth, W.6
Leehey, D.J.7
McCullough, P.A.8
O’Connor, T.9
Palevsky, P.M.10
Reilly, R.F.11
Seliger, S.L.12
Warren, S.R.13
Watnick, S.14
Peduzzi, P.15
Guarino, P.16
-
43
-
-
70350704811
-
Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes
-
Gagliardini E, Corna D, Zoja C, Sangalli F, Carrara F, Rossi M, Conti S, Rottoli D, Longaretti L, Remuzzi A, Remuzzi G, Benigni A. Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes. Am J Physiol Renal Physiol 297: F1448–F1456, 2009
-
(2009)
Am J Physiol Renal Physiol
, vol.297
, pp. F1448-F1456
-
-
Gagliardini, E.1
Corna, D.2
Zoja, C.3
Sangalli, F.4
Carrara, F.5
Rossi, M.6
Conti, S.7
Rottoli, D.8
Longaretti, L.9
Remuzzi, A.10
Remuzzi, G.11
Benigni, A.12
-
44
-
-
84893602212
-
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
-
Gao B, Doan A, Hybertson BM. The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clin Pharmacol Adv Applic 6: 19–34, 2014
-
(2014)
Clin Pharmacol Adv Applic
, vol.6
, pp. 19-34
-
-
Gao, B.1
Doan, A.2
Hybertson, B.M.3
-
45
-
-
73649124549
-
Chronic calcineurin inhibitor nephrotoxicity: Reflections on an evolving paradigm
-
Gaston RS. Chronic calcineurin inhibitor nephrotoxicity: reflections on an evolving paradigm. Clin J Am Soc Nephrol 4: 2029–2034, 2009
-
(2009)
Clin J am Soc Nephrol
, vol.4
, pp. 2029-2034
-
-
Gaston, R.S.1
-
46
-
-
0035946468
-
Chemokines control fat accumulation and leptin secretion by cultured human adipocytes
-
Gerhardt CC, Romero IA, Cancello R, Camoin L, Strosberg AD. Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 175: 81–92, 2001
-
(2001)
Mol Cell Endocrinol
, vol.175
, pp. 81-92
-
-
Gerhardt, C.C.1
Romero, I.A.2
Cancello, R.3
Camoin, L.4
Strosberg, A.D.5
-
48
-
-
33750919240
-
Wilcox CS. NADPH oxidases in the kidney
-
Gill PS, Wilcox CS. NADPH oxidases in the kidney. Antiox Redox Signal 8: 1597–1607, 2006
-
(2006)
Antiox Redox Signal
, vol.8
, pp. 1597-1607
-
-
Gill, P.S.1
-
49
-
-
79957881425
-
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
-
Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mor A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, Huber TB. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121: 2197–2209, 2011
-
(2011)
J Clin Invest
, vol.121
, pp. 2197-2209
-
-
Godel, M.1
Hartleben, B.2
Herbach, N.3
Liu, S.4
Zschiedrich, S.5
Lu, S.6
Debreczeni-Mor, A.7
Lindenmeyer, M.T.8
Rastaldi, M.P.9
Hartleben, G.10
Wiech, T.11
Fornoni, A.12
Nelson, R.G.13
Kretzler, M.14
Wanke, R.15
Pavenstadt, H.16
Kerjaschki, D.17
Cohen, C.D.18
Hall, M.N.19
Ruegg, M.A.20
Inoki, K.21
Walz, G.22
Huber, T.B.23
more..
-
50
-
-
0037215135
-
Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation
-
Gooch JL, Barnes JL, Garcia S, Abboud HE. Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation. Am J Physiol Renal Physiol 284: F144–F154, 2003
-
(2003)
Am J Physiol Renal Physiol
, vol.284
, pp. F144-F154
-
-
Gooch, J.L.1
Barnes, J.L.2
Garcia, S.3
Abboud, H.E.4
-
51
-
-
33751236177
-
Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus
-
Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology 147: 5363–5373, 2006
-
(2006)
Endocrinology
, vol.147
, pp. 5363-5373
-
-
Guo, C.1
Martinez-Vasquez, D.2
Mendez, G.P.3
Toniolo, M.F.4
Yao, T.M.5
Oestreicher, E.M.6
Kikuchi, T.7
Lapointe, N.8
Pojoga, L.9
Williams, G.H.10
Ricchiuti, V.11
Adler, G.K.12
-
52
-
-
0026549678
-
Increased plasma levels of endothelin in diabetic patients with hypertension
-
Haak T, Jungmann E, Felber A, Hillmann U, Usadel KH. Increased plasma levels of endothelin in diabetic patients with hypertension. Am J Hypertens 5: 161–166, 1992
-
(1992)
Am J Hypertens
, vol.5
, pp. 161-166
-
-
Haak, T.1
Jungmann, E.2
Felber, A.3
Hillmann, U.4
Usadel, K.H.5
-
53
-
-
84906712847
-
Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?
-
Hall ET, Bhalla V. Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease? Diabetes 63: 2904–2905, 2014
-
(2014)
Diabetes
, vol.63
, pp. 2904-2905
-
-
Hall, E.T.1
Bhalla, V.2
-
54
-
-
33646366660
-
Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
-
Han SY, Kim CH, Kim HS, Jee YH, Song HK, Lee MH, Han KH, Kim HK, Kang YS, Han JY, Kim YS, Cha DR. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. J Am Soc Nephrol 17: 1362–1372, 2006
-
(2006)
J am Soc Nephrol
, vol.17
, pp. 1362-1372
-
-
Han, S.Y.1
Kim, C.H.2
Kim, H.S.3
Jee, Y.H.4
Song, H.K.5
Lee, M.H.6
Han, K.H.7
Kim, H.K.8
Kang, Y.S.9
Han, J.Y.10
Kim, Y.S.11
Cha, D.R.12
-
55
-
-
84878002397
-
Orally administered chemokine receptor CCR2 Antagonist CCX140-B in Type 2 diabetes: A pilot double-blind, randomized clinical trial
-
Hanefeld M. Orally administered chemokine receptor CCR2 Antagonist CCX140-B in Type 2 diabetes: a pilot double-blind, randomized clinical trial. J Diabetes Metab 3: 225, 2012
-
(2012)
J Diabetes Metab
, vol.3
-
-
Hanefeld, M.1
-
56
-
-
84883709817
-
AMPK: A target for drugs and natural products with effects on both diabetes and cancer
-
Hardie DG. AMPK: a target for drugs and natural products with effects on both diabetes and cancer. Diabetes 62: 2164–2172, 2013
-
(2013)
Diabetes
, vol.62
, pp. 2164-2172
-
-
Hardie, D.G.1
-
58
-
-
26944452881
-
Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinasesignal transducers and activators of transcription pathway in renal cells
-
Hernandez-Vargas P, Lopez-Franco O, Sanjuan G, Ruperez M, Ortiz-Munoz G, Suzuki Y, Aguado-Roncero P, Perez-Tejerizo G, Blanco J, Egido J, Ruiz-Ortega M, Gomez-Guerrero C. Suppressors of cytokine signaling regulate angiotensin II-activated Janus kinasesignal transducers and activators of transcription pathway in renal cells. J Am Soc Nephrol 16: 1673–1683, 2005
-
(2005)
J am Soc Nephrol
, vol.16
, pp. 1673-1683
-
-
Hernandez-Vargas, P.1
Lopez-Franco, O.2
Sanjuan, G.3
Ruperez, M.4
Ortiz-Munoz, G.5
Suzuki, Y.6
Aguado-Roncero, P.7
Perez-Tejerizo, G.8
Blanco, J.9
Egido, J.10
Ruiz-Ortega, M.11
Gomez-Guerrero, C.12
-
59
-
-
1842411863
-
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension
-
Hocher B, Thone-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T, Bauer C, Neumayer HH, Schleuning WD, Theuring F. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest 99: 1380–1389, 1997
-
(1997)
J Clin Invest
, vol.99
, pp. 1380-1389
-
-
Hocher, B.1
Thone-Reineke, C.2
Rohmeiss, P.3
Schmager, F.4
Slowinski, T.5
Burst, V.6
Siegmund, F.7
Quertermous, T.8
Bauer, C.9
Neumayer, H.H.10
Schleuning, W.D.11
Theuring, F.12
-
60
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin, and NFAT
-
Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17: 2205–2232, 2003
-
(2003)
Genes Dev
, vol.17
, pp. 2205-2232
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
Rao, A.4
-
61
-
-
0037018145
-
NFAT: Ubiquitous regulator of cell differentiation and adaptation
-
Horsley V, Pavlath GK. NFAT: ubiquitous regulator of cell differentiation and adaptation. J Cell Biol 156: 771–774, 2002
-
(2002)
J Cell Biol
, vol.156
, pp. 771-774
-
-
Horsley, V.1
Pavlath, G.K.2
-
62
-
-
79957927211
-
Guan KL. MTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
-
Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Ruegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest 121: 2181–2196, 2011
-
(2011)
J Clin Invest
, vol.121
, pp. 2181-2196
-
-
Inoki, K.1
Mori, H.2
Wang, J.3
Suzuki, T.4
Hong, S.5
Yoshida, S.6
Blattner, S.M.7
Ikenoue, T.8
Ruegg, M.A.9
Hall, M.N.10
Kwiatkowski, D.J.11
Rastaldi, M.P.12
Huber, T.B.13
Kretzler, M.14
Holzman, L.B.15
Wiggins, R.C.16
-
63
-
-
84920025605
-
Metformin in patients with type 2 diabetes and kidney disease: A systematic review
-
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK. Metformin in patients with type 2 diabetes and kidney disease: a systematic review. J Am Med Assoc 312: 2668–2675, 2014
-
(2014)
J am Med Assoc
, vol.312
, pp. 2668-2675
-
-
Inzucchi, S.E.1
Lipska, K.J.2
Mayo, H.3
Bailey, C.J.4
McGuire, D.K.5
-
64
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, Hall MN. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122–1128, 2004
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
65
-
-
79957880117
-
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
-
Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, Quaggin SE. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 121: 2278–2289, 2011
-
(2011)
J Clin Invest
, vol.121
, pp. 2278-2289
-
-
Jeansson, M.1
Gawlik, A.2
Erson, G.3
Li, C.4
Kerjaschki, D.5
Henkelman, M.6
Quaggin, S.E.7
-
66
-
-
77951199503
-
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
-
Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, Zhang DD. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59: 850–860, 2010
-
(2010)
Diabetes
, vol.59
, pp. 850-860
-
-
Jiang, T.1
Huang, Z.2
Lin, Y.3
Zhang, Z.4
Fang, D.5
Zhang, D.D.6
-
67
-
-
77958102050
-
CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
-
Kang YS, Lee MH, Song HK, Ko GJ, Kwon OS, Lim TK, Kim SH, Han SY, Han KH, Lee JE, Han JY, Kim HK, Cha DR. CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kidney Int 78: 883–894, 2010
-
(2010)
Kidney Int
, vol.78
, pp. 883-894
-
-
Kang, Y.S.1
Lee, M.H.2
Song, H.K.3
Ko, G.J.4
Kwon, O.S.5
Lim, T.K.6
Kim, S.H.7
Han, S.Y.8
Han, K.H.9
Lee, J.E.10
Han, J.Y.11
Kim, H.K.12
Cha, D.R.13
-
68
-
-
84951906215
-
Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: A multicenter, randomized clinical trial
-
Kato S, Maruyama S, Makino H, Wada J, Ogawa D, Uzu T, Araki H, Koya D, Kanasaki K, Oiso Y, Goto M, Nishiyama A, Kobori H, Imai E, Ando M, Matsuo S. Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial. Clin Exp Nephrol 1–9, 2015
-
(2015)
Clin Exp Nephrol
, pp. 1-9
-
-
Kato, S.1
Maruyama, S.2
Makino, H.3
Wada, J.4
Ogawa, D.5
Uzu, T.6
Araki, H.7
Koya, D.8
Kanasaki, K.9
Oiso, Y.10
Goto, M.11
Nishiyama, A.12
Kobori, H.13
Imai, E.14
O, M.15
Matsuo, S.16
-
69
-
-
0034021275
-
Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (MRen-2)27 rat
-
Kelly DJ, Skinner SL, Gilbert RE, Cox AJ, Cooper ME, Wilkinson- Berka JL. Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat. Kidney Int 57: 1882–1894, 2000
-
(2000)
Kidney Int
, vol.57
, pp. 1882-1894
-
-
Kelly, D.J.1
Skinner, S.L.2
Gilbert, R.E.3
Cox, A.J.4
Cooper, M.E.5
Wilkinson- Berka, J.L.6
-
70
-
-
84867814558
-
Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin
-
2012
-
Kim J, Shon E, Kim CS, Kim JS. Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin. Exp Diabetes Res 2012: 210821, 2012
-
(2012)
Exp Diabetes Res
-
-
Kim, J.1
Shon, E.2
Kim, C.S.3
Kim, J.S.4
-
71
-
-
79953295959
-
Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy
-
Kohan DE, Pritchett Y, Molitch M, Wen S, Garimella T, Audhya P, Andress DL. Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy. J Am Soc Nephrol 22: 763–772, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 763-772
-
-
Kohan, D.E.1
Pritchett, Y.2
Molitch, M.3
Wen, S.4
Garimella, T.5
Audhya, P.6
Ress, D.L.7
-
72
-
-
78751672175
-
Regulation of blood pressure and salt homeostasis by endothelin
-
Kohan DE, Rossi NF, Inscho EW, Pollock DM. Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev 91: 1–77, 2011
-
(2011)
Physiol Rev
, vol.91
, pp. 1-77
-
-
Kohan, D.E.1
Rossi, N.F.2
Inscho, E.W.3
Pollock, D.M.4
-
73
-
-
0035057565
-
Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes
-
Komers R, Lindsley JN, Oyama TT, Schutzer WE, Reed JF, Mader SL, Anderson S. Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. J Clin Invest 107: 889–898, 2001
-
(2001)
J Clin Invest
, vol.107
, pp. 889-898
-
-
Komers, R.1
Lindsley, J.N.2
Oyama, T.T.3
Schutzer, W.E.4
Reed, J.F.5
Mader, S.L.6
Erson, S.7
-
74
-
-
0042867404
-
Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats
-
Koya D, Hayashi K, Kitada M, Kashiwagi A, Kikkawa R, Haneda M. Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J Am Soc Nephrol 14: S250–S253, 2003
-
(2003)
J am Soc Nephrol
, vol.14
, pp. S250-S253
-
-
Koya, D.1
Hayashi, K.2
Kitada, M.3
Kashiwagi, A.4
Kikkawa, R.5
Haneda, M.6
-
75
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352: 1789–1790, 2005
-
(2005)
N Engl J Med
, vol.352
, pp. 1789-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
76
-
-
58149343883
-
Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice
-
Ku CH, White KE, Dei Cas A, Hayward A, Webster Z, Bilous R, Marshall S, Viberti G, Gnudi L. Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice. Diabetes 57: 2824–2833, 2008
-
(2008)
Diabetes
, vol.57
, pp. 2824-2833
-
-
Ku, C.H.1
White, K.E.2
Dei Cas, A.3
Hayward, A.4
Webster, Z.5
Bilous, R.6
Marshall, S.7
Viberti, G.8
Gnudi, L.9
-
77
-
-
33845317604
-
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
-
Kuwahara K, Wang Y, McAnally J, Richardson JA, Bassel-Duby R, Hill JA, Olson EN. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 116: 3114–3126, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 3114-3126
-
-
Kuwahara, K.1
Wang, Y.2
McAnally, J.3
Richardson, J.A.4
Bassel-Duby, R.5
Hill, J.A.6
Olson, E.N.7
-
78
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 149: 274–293, 2012
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
79
-
-
0346103700
-
A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice
-
Lee HT, Gallos G, Nasr SH, Emala CW. A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 15: 102–111, 2004
-
(2004)
J am Soc Nephrol
, vol.15
, pp. 102-111
-
-
Lee, H.T.1
Gallos, G.2
Nasr, S.H.3
Emala, C.W.4
-
80
-
-
33846677486
-
Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes
-
Lee S, Kim W, Moon SO, Sung MJ, Kim DH, Kang KP, Jang KY, Lee SY, Park BH, Koh GY, Park SK. Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Nephrol Dial Transpl 22: 396–408, 2007
-
(2007)
Nephrol Dial Transpl
, vol.22
, pp. 396-408
-
-
Lee, S.1
Kim, W.2
Moon, S.O.3
Sung, M.J.4
Kim, D.H.5
Kang, K.P.6
Jang, K.Y.7
Lee, S.Y.8
Park, B.H.9
Koh, G.Y.10
Park, S.K.11
-
81
-
-
70350710165
-
Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions
-
Lee SH, Yoo TH, Nam BY, Kim DK, Li JJ, Jung DS, Kwak SJ, Ryu DR, Han SH, Lee JE, Moon SJ, Han DS, Kang SW. Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions. Am J Physiol Renal Physiol 297: F1381–F1390, 2009
-
(2009)
Am J Physiol Renal Physiol
, vol.297
, pp. F1381-F1390
-
-
Lee, S.H.1
Yoo, T.H.2
Nam, B.Y.3
Kim, D.K.4
Li, J.J.5
Jung, D.S.6
Kwak, S.J.7
Ryu, D.R.8
Han, S.H.9
Lee, J.E.10
Moon, S.J.11
Han, D.S.12
Kang, S.W.13
-
82
-
-
84906542664
-
Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis
-
Lenoir O, Milon M, Virsolvy A, Henique C, Schmitt A, Masse JM, Kotelevtsev Y, Yanagisawa M, Webb DJ, Richard S, Tharaux PL. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol 25: 1050–1062, 2014
-
(2014)
J am Soc Nephrol
, vol.25
, pp. 1050-1062
-
-
Lenoir, O.1
Milon, M.2
Virsolvy, A.3
Henique, C.4
Schmitt, A.5
Masse, J.M.6
Kotelevtsev, Y.7
Yanagisawa, M.8
Webb, D.J.9
Richard, S.10
Tharaux, P.L.11
-
83
-
-
0027517659
-
The effect of angiotensin- converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
-
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin- converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 329: 1456–1462, 1993
-
(1993)
N Engl J Med
, vol.329
, pp. 1456-1462
-
-
Lewis, E.J.1
Hunsicker, L.G.2
Bain, R.P.3
Rohde, R.D.4
-
84
-
-
0035922447
-
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
-
Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345: 851–860, 2001
-
(2001)
N Engl J Med
, vol.345
, pp. 851-860
-
-
Lewis, E.J.1
Hunsicker, L.G.2
Clarke, W.R.3
Berl, T.4
Pohl, M.A.5
Lewis, J.B.6
Ritz, E.7
Atkins, R.C.8
Rohde, R.9
Raz, I.10
-
85
-
-
84874985656
-
NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression
-
Li R, Zhang L, Shi W, Zhang B, Liang X, Liu S, Wang W. NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression. Exp Cell Res 319: 992–1000, 2013
-
(2013)
Exp Cell Res
, vol.319
, pp. 992-1000
-
-
Li, R.1
Zhang, L.2
Shi, W.3
Zhang, B.4
Liang, X.5
Liu, S.6
Wang, W.7
-
86
-
-
0036073755
-
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
-
Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110: 229–238, 2002
-
(2002)
J Clin Invest
, vol.110
, pp. 229-238
-
-
Li, Y.C.1
Kong, J.2
Wei, M.3
Chen, Z.F.4
Liu, S.Q.5
Cao, L.P.6
-
87
-
-
80051978747
-
Use of metformin in the setting of mild-to-moderate renal insufficiency
-
Lipska KJ, Bailey CJ, Inzucchi SE. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34: 1431–1437, 2011
-
(2011)
Diabetes Care
, vol.34
, pp. 1431-1437
-
-
Lipska, K.J.1
Bailey, C.J.2
Inzucchi, S.E.3
-
88
-
-
33646352217
-
Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
-
Lloberas N, Cruzado JM, Franquesa M, Herrero-Fresneda I, Torras J, Alperovich G, Rama I, Vidal A, Grinyo JM. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 17: 1395–1404, 2006
-
(2006)
J am Soc Nephrol
, vol.17
, pp. 1395-1404
-
-
Lloberas, N.1
Cruzado, J.M.2
Franquesa, M.3
Herrero-Fresneda, I.4
Torras, J.5
Alperovich, G.6
Rama, I.7
Vidal, A.8
Grinyo, J.M.9
-
89
-
-
84888643463
-
Transforming growth factor-beta and the progression of renal disease
-
Loeffler I, Wolf G. Transforming growth factor-beta and the progression of renal disease. Nephrol Dial Transpl 29 Suppl 1: i37–i45, 2014
-
(2014)
Nephrol Dial Transpl
, vol.29
, pp. i37-i45
-
-
Loeffler, I.1
Wolf, G.2
-
90
-
-
0036834582
-
Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy
-
Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, Bosch J, Dagenais G, Mann JF, Gerstein HC. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 25: 1919–1927, 2002
-
(2002)
Diabetes Care
, vol.25
, pp. 1919-1927
-
-
Lonn, E.1
Yusuf, S.2
Hoogwerf, B.3
Pogue, J.4
Yi, Q.5
Zinman, B.6
Bosch, J.7
Dagenais, G.8
Mann, J.F.9
Gerstein, H.C.10
-
91
-
-
79952455513
-
Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome
-
Luo ZF, Qi W, Feng B, Mu J, Zeng W, Guo YH, Pang Q, Ye ZL, Liu L, Yuan FH. Prevention of diabetic nephropathy in rats through enhanced renal antioxidative capacity by inhibition of the proteasome. Life Sci 88: 512–520, 2011
-
(2011)
Life Sci
, vol.88
, pp. 512-520
-
-
Luo, Z.F.1
Qi, W.2
Feng, B.3
Mu, J.4
Zeng, W.5
Guo, Y.H.6
Pang, Q.7
Ye, Z.L.8
Liu, L.9
Yuan, F.H.10
-
92
-
-
77955735519
-
Epidemiology of type 1 diabetes
-
Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ. Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 39: 481–497, 2010
-
(2010)
Endocrinol Metab Clin North Am
, vol.39
, pp. 481-497
-
-
Maahs, D.M.1
West, N.A.2
Lawrence, J.M.3
Mayer-Davis, E.J.4
-
93
-
-
77949877308
-
Avosentan for overt diabetic nephropathy
-
Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G. Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21: 527–535, 2010
-
(2010)
J am Soc Nephrol
, vol.21
, pp. 527-535
-
-
Mann, J.F.1
Green, D.2
Jamerson, K.3
Ruilope, L.M.4
Kuranoff, S.J.5
Littke, T.6
Viberti, G.7
-
94
-
-
49149087718
-
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (The ONTARGET study): A multicentre, randomised, double-blind, controlled trial
-
Mann JF, Schmieder RE, McQueen M, Dyal L, Schumacher H, Pogue J, Wang X, Maggioni A, Budaj A, Chaithiraphan S, Dickstein K, Keltai M, Metsarinne K, Oto A, Parkhomenko A, Piegas LS, Svendsen TL, Teo KK, Yusuf S. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372: 547–553, 2008
-
(2008)
Lancet
, vol.372
, pp. 547-553
-
-
Mann, J.F.1
Schmieder, R.E.2
McQueen, M.3
Dyal, L.4
Schumacher, H.5
Pogue, J.6
Wang, X.7
Maggioni, A.8
Budaj, A.9
Chaithiraphan, S.10
Dickstein, K.11
Keltai, M.12
Metsarinne, K.13
Oto, A.14
Parkhomenko, A.15
Piegas, L.S.16
Svendsen, T.L.17
Teo, K.K.18
Yusuf, S.19
-
95
-
-
33645744364
-
Role of the JAK/STAT signaling pathway in diabetic nephropathy
-
Marrero MB, Banes-Berceli AK, Stern DM, Eaton DC. Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol Renal Physiol 290: F762–F768, 2006
-
(2006)
Am J Physiol Renal Physiol
, vol.290
, pp. F762-F768
-
-
Marrero, M.B.1
Banes-Berceli, A.K.2
Stern, D.M.3
Eaton, D.C.4
-
96
-
-
78650920801
-
Vascular endothelial growth factor (VEGF) in the pathogenesis of diabetic nephropathy of type 1 diabetes mellitus
-
Mironidou-Tzouveleki M, Tsartsalis S, Tomos C. Vascular endothelial growth factor (VEGF) in the pathogenesis of diabetic nephropathy of type 1 diabetes mellitus. Curr Drug Targets 12: 107–114, 2011
-
(2011)
Curr Drug Targets
, vol.12
, pp. 107-114
-
-
Mironidou-Tzouveleki, M.1
Tsartsalis, S.2
Tomos, C.3
-
97
-
-
1042302788
-
Nephropathy in diabetes
-
Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW. Nephropathy in diabetes. Diabetes Care 27 Suppl 1: S79–S83, 2004
-
(2004)
Diabetes Care
, vol.27
, pp. S79-S83
-
-
Molitch, M.E.1
Defronzo, R.A.2
Franz, M.J.3
Keane, W.F.4
Mogensen, C.E.5
Parving, H.H.6
Steffes, M.W.7
-
98
-
-
65649120747
-
The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential
-
Mori H, Inoki K, Masutani K, Wakabayashi Y, Komai K, Nakagawa R, Guan KL, Yoshimura A. The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential. Biochem Biophys Res Commun 384: 471–475, 2009
-
(2009)
Biochem Biophys Res Commun
, vol.384
, pp. 471-475
-
-
Mori, H.1
Inoki, K.2
Masutani, K.3
Wakabayashi, Y.4
Komai, K.5
Nakagawa, R.6
Guan, K.L.7
Yoshimura, A.8
-
99
-
-
66149096223
-
Inhibiting the calcineurin-NFAT (Nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity
-
Mulero MC, Aubareda A, Orzaez M, Messeguer J, Serrano-Candelas E, Martinez-Hoyer S, Messeguer A, Perez-Paya E, Perez-Riba M. Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J Biol Chem 284: 9394–9401, 2009
-
(2009)
J Biol Chem
, vol.284
, pp. 9394-9401
-
-
Mulero, M.C.1
Aubareda, A.2
Orzaez, M.3
Messeguer, J.4
Serrano-Candelas, E.5
Martinez-Hoyer, S.6
Messeguer, A.7
Perez-Paya, E.8
Perez-Riba, M.9
-
100
-
-
84908207626
-
Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: A systematic review and meta-analysis
-
Murakami N, Riella LV, Funakoshi T. Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis. Am J Transplant 14: 2317–2327, 2014
-
(2014)
Am J Transplant
, vol.14
, pp. 2317-2327
-
-
Murakami, N.1
Riella, L.V.2
Funakoshi, T.3
-
101
-
-
78650522881
-
Endothelial dysfunction as a potential contributor in diabetic nephropathy
-
Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MB, Kosugi T, Li Q. Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol 7: 36–44, 2011
-
(2011)
Nat Rev Nephrol
, vol.7
, pp. 36-44
-
-
Nakagawa, T.1
Tanabe, K.2
Croker, B.P.3
Johnson, R.J.4
Grant, M.B.5
Kosugi, T.6
Li, Q.7
-
102
-
-
2342526607
-
A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
-
Noguchi H, Matsushita M, Okitsu T, Moriwaki A, Tomizawa K, Kang S, Li ST, Kobayashi N, Matsumoto S, Tanaka K, Tanaka N, Matsui H. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 10: 305–309, 2004
-
(2004)
Nat Med
, vol.10
, pp. 305-309
-
-
Noguchi, H.1
Matsushita, M.2
Okitsu, T.3
Moriwaki, A.4
Tomizawa, K.5
Kang, S.6
Li, S.T.7
Kobayashi, N.8
Matsumoto, S.9
Tanaka, K.10
Tanaka, N.11
Matsui, H.12
-
103
-
-
84862207240
-
Three decades of Wnts: A personal perspective on how a scientific field developed
-
Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 31: 2670–2684, 2012
-
(2012)
EMBO J
, vol.31
, pp. 2670-2684
-
-
Nusse, R.1
Varmus, H.2
-
104
-
-
33646107369
-
VEGF receptor signalling—in control of vascular function
-
Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling—in control of vascular function. Nat Rev Mol Cell Biol 7: 359–371, 2006
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 359-371
-
-
Olsson, A.K.1
Dimberg, A.2
Kreuger, J.3
Claesson-Welsh, L.4
-
105
-
-
0032076542
-
Jak2 is essential for signaling through a variety of cytokine receptors
-
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93: 385–395, 1998
-
(1998)
Cell
, vol.93
, pp. 385-395
-
-
Parganas, E.1
Wang, D.2
Stravopodis, D.3
Topham, D.J.4
Marine, J.C.5
Teglund, S.6
Vanin, E.F.7
Bodner, S.8
Colamonici, O.R.9
Van Deursen, J.M.10
Grosveld, G.11
Ihle, J.N.12
-
106
-
-
84869492851
-
Cardiorenal end points in a trial of aliskiren for type 2 diabetes
-
Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai AS, Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 367: 2204–2213, 2012
-
(2012)
N Engl J Med
, vol.367
, pp. 2204-2213
-
-
Parving, H.H.1
Brenner, B.M.2
McMurray, J.J.3
De Zeeuw, D.4
Haffner, S.M.5
Solomon, S.D.6
Chaturvedi, N.7
Persson, F.8
Desai, A.S.9
Nicolaides, M.10
Richard, A.11
Xiang, Z.12
Brunel, P.13
Pfeffer, M.A.14
-
107
-
-
0035922444
-
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
-
Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 345: 870–878, 2001
-
(2001)
N Engl J Med
, vol.345
, pp. 870-878
-
-
Parving, H.H.1
Lehnert, H.2
Brochner-Mortensen, J.3
Gomis, R.4
Ersen, S.5
Arner, P.6
-
108
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 358: 2433–2446, 2008
-
(2008)
N Engl J Med
, vol.358
, pp. 2433-2446
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
Lewis, E.J.4
Hollenberg, N.K.5
-
109
-
-
84867795201
-
Increased expression of the glucoseresponsive gene, RCAN1, causes hypoinsulinemia, beta-cell dysfunction, and diabetes
-
Peiris H, Raghupathi R, Jessup CF, Zanin MP, Mohanasundaram D, Mackenzie KD, Chataway T, Clarke JN, Brealey J, Coates PT, Pritchard MA, Keating DJ. Increased expression of the glucoseresponsive gene, RCAN1, causes hypoinsulinemia, beta-cell dysfunction, and diabetes. Endocrinology 153: 5212–5221, 2012
-
(2012)
Endocrinology
, vol.153
, pp. 5212-5221
-
-
Peiris, H.1
Raghupathi, R.2
Jessup, C.F.3
Zanin, M.P.4
Mohanasundaram, D.5
Mackenzie, K.D.6
Chataway, T.7
Clarke, J.N.8
Brealey, J.9
Coates, P.T.10
Pritchard, M.A.11
Keating, D.J.12
-
110
-
-
79954582442
-
Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD
-
Pergola PE, Krauth M, Huff JW, Ferguson DA, Ruiz S, Meyer CJ, Warnock DG. Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD. Am J Nephrol 33: 469–476, 2011
-
(2011)
Am J Nephrol
, vol.33
, pp. 469-476
-
-
Pergola, P.E.1
Krauth, M.2
Huff, J.W.3
Ferguson, D.A.4
Ruiz, S.5
Meyer, C.J.6
Warnock, D.G.7
-
111
-
-
79960855656
-
Bardoxolone methyl and kidney function in CKD with type 2 diabetes
-
Pergola PE, Raskin P, Toto RD, Meyer CJ, Huff JW, Grossman EB, Krauth M, Ruiz S, Audhya P, Christ-Schmidt H, Wittes J, Warnock DG. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med 365: 327–336, 2011
-
(2011)
N Engl J Med
, vol.365
, pp. 327-336
-
-
Pergola, P.E.1
Raskin, P.2
Toto, R.D.3
Meyer, C.J.4
Huff, J.W.5
Grossman, E.B.6
Krauth, M.7
Ruiz, S.8
Audhya, P.9
Christ-Schmidt, H.10
Wittes, J.11
Warnock, D.G.12
-
112
-
-
79957840666
-
Aliskiren in combination with losartan reduces albuminuria independent of baseline blood pressure in patients with type 2 diabetes and nephropathy
-
Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH. Aliskiren in combination with losartan reduces albuminuria independent of baseline blood pressure in patients with type 2 diabetes and nephropathy. Clin J Am Soc Nephrol 6: 1025–1031, 2011
-
(2011)
Clin J am Soc Nephrol
, vol.6
, pp. 1025-1031
-
-
Persson, F.1
Lewis, J.B.2
Lewis, E.J.3
Rossing, P.4
Hollenberg, N.K.5
Parving, H.H.6
-
113
-
-
84931264834
-
Adenosine A a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress
-
Persson P, Friederich-Persson M, Fasching A, Hansell P, Inagi R, Palm F. Adenosine A a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress. Acta Physiol (Oxf) 214: 311–318, 2015
-
(2015)
Acta Physiol (Oxf)
, vol.214
, pp. 311-318
-
-
Persson, P.1
Friederich-Persson, M.2
Fasching, A.3
Hansell, P.4
Inagi, R.5
Palm, F.6
-
114
-
-
84920262044
-
Reduced adenosine A2A receptormediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration
-
Persson P, Hansell P, Palm F. Reduced adenosine A2A receptormediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration. Kidney Int 87: 109–115, 2015
-
(2015)
Kidney Int
, vol.87
, pp. 109-115
-
-
Persson, P.1
Hansell, P.2
Palm, F.3
-
115
-
-
33645469407
-
Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure
-
Pfab T, Thone-Reineke C, Theilig F, Lange I, Witt H, Maser-Gluth C, Bader M, Stasch JP, Ruiz P, Bachmann S, Yanagisawa M, Hocher B. Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol 17: 1082–1089, 2006
-
(2006)
J am Soc Nephrol
, vol.17
, pp. 1082-1089
-
-
Pfab, T.1
Thone-Reineke, C.2
Theilig, F.3
Lange, I.4
Witt, H.5
Maser-Gluth, C.6
Bader, M.7
Stasch, J.P.8
Ruiz, P.9
Bachmann, S.10
Yanagisawa, M.11
Hocher, B.12
-
116
-
-
80053234606
-
FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin
-
Qi XM, Wu YG, Liang C, Zhang P, Dong J, Ren KJ, Zhang W, Fang F, Shen JJ. FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin. Int Immunopharmacol 11: 1613–1619, 2011
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 1613-1619
-
-
Qi, X.M.1
Wu, Y.G.2
Liang, C.3
Zhang, P.4
Dong, J.5
Ren, K.J.6
Zhang, W.7
Fang, F.8
Shen, J.J.9
-
117
-
-
68149178848
-
Pirfenidone is renoprotective in diabetic kidney disease
-
RamachandraRao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S, Shaw MA, Sharma K. Pirfenidone is renoprotective in diabetic kidney disease. J Am Soc Nephrol 20: 1765–1785, 2009
-
(2009)
J am Soc Nephrol
, vol.20
, pp. 1765-1785
-
-
Ramachandrarao, S.P.1
Zhu, Y.2
Ravasi, T.3
McGowan, T.A.4
Toh, I.5
Dunn, S.R.6
Okada, S.7
Shaw, M.A.8
Sharma, K.9
-
118
-
-
84887441963
-
Akt2 relaxes podocytes in chronic kidney disease
-
Reiser J. Akt2 relaxes podocytes in chronic kidney disease. Nat Med 19: 1212–1213, 2013
-
(2013)
Nat Med
, vol.19
, pp. 1212-1213
-
-
Reiser, J.1
-
119
-
-
84867160764
-
Bardoxolone methyl decreases megalin and activates nrf2 in the kidney
-
Reisman SA, Chertow GM, Hebbar S, Vaziri ND, Ward KW, Meyer CJ. Bardoxolone methyl decreases megalin and activates nrf2 in the kidney. J Am Soc Nephrol 23: 1663–1673, 2012
-
(2012)
J am Soc Nephrol
, vol.23
, pp. 1663-1673
-
-
Reisman, S.A.1
Chertow, G.M.2
Hebbar, S.3
Vaziri, N.D.4
Ward, K.W.5
Meyer, C.J.6
-
120
-
-
78149277201
-
Endothelin- 1 increases glomerular permeability and inflammation independent of blood pressure in the rat
-
Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM. Endothelin- 1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension 56: 942–949, 2010
-
(2010)
Hypertension
, vol.56
, pp. 942-949
-
-
Saleh, M.A.1
Boesen, E.I.2
Pollock, J.S.3
Savin, V.J.4
Pollock, D.M.5
-
121
-
-
84858234310
-
Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy
-
Sanchez-Nino MD, Bozic M, Cordoba-Lanus E, Valcheva P, Gracia O, Ibarz M, Fernandez E, Navarro-Gonzalez JF, Ortiz A, Valdivielso JM. Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy. Am J Physiol Renal Physiol 302: F647–F657, 2012
-
(2012)
Am J Physiol Renal Physiol
, vol.302
, pp. F647-F657
-
-
Sanchez-Nino, M.D.1
Bozic, M.2
Cordoba-Lanus, E.3
Valcheva, P.4
Gracia, O.5
Ibarz, M.6
Fernandez, E.7
Navarro-Gonzalez, J.F.8
Ortiz, A.9
Valdivielso, J.M.10
-
122
-
-
84865013186
-
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
-
Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S, Niezychowski W. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 367: 616–624, 2012
-
(2012)
N Engl J Med
, vol.367
, pp. 616-624
-
-
Sandborn, W.J.1
Ghosh, S.2
Panes, J.3
Vranic, I.4
Su, C.5
Rousell, S.6
Niezychowski, W.7
-
123
-
-
84937787230
-
U.S. Renal Data System 2014 Annual Data Report. Epidemiology of kidney disease in the United States
-
Saran R, Li Y, Robinson B, Ayanian J, Balkrishnan R, Bragg- Gresham J, Chen JT, Cope E, Gipson D, He K, Herman W, Heung M, Hirth RA, Jacobsen SS, Kalantar-Zadeh K, Kovesdy CP, Leichtman AB, Lu Y, Molnar MZ, Morgenstern H, Nallamothu B, O’Hare AM, Pisoni R, Plattner B, Port FK, Rao P, Rhee CM, Schaubel DE, Selewski DT, Shahinian V, Sim JJ, Song P, Streja E, Kurella Tamura M, Tentori F, Eggers PW, Agodoa LY, Abbott KC. U.S. Renal Data System 2014 Annual Data Report. Epidemiology of kidney disease in the United States. Am J Kidney Dis 65: A7, 2015
-
(2015)
Am J Kidney Dis
, vol.65
-
-
Saran, R.1
Li, Y.2
Robinson, B.3
Ayanian, J.4
Balkrishnan, R.5
Bragg- Gresham, J.6
Chen, J.T.7
Cope, E.8
Gipson, D.9
He, K.10
Herman, W.11
Heung, M.12
Hirth, R.A.13
Jacobsen, S.S.14
Kalantar-Zadeh, K.15
Kovesdy, C.P.16
Leichtman, A.B.17
Lu, Y.18
Molnar, M.Z.19
Morgenstern, H.20
Nallamothu, B.21
O’Hare, A.M.22
Pisoni, R.23
Plattner, B.24
Port, F.K.25
Rao, P.26
Rhee, C.M.27
Schaubel, D.E.28
Selewski, D.T.29
Shahinian, V.30
Sim, J.J.31
Song, P.32
Streja, E.33
Kurella Tamura, M.34
Tentori, F.35
Eggers, P.W.36
Agodoa, L.Y.37
Abbott, K.C.38
more..
-
124
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22: 159–168, 2006
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
125
-
-
0038809142
-
Monocyte chemoattractant protein 1 in obesity and insulin resistance
-
Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 100: 7265–7270, 2003
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7265-7270
-
-
Sartipy, P.1
Loskutoff, D.J.2
-
126
-
-
85027957604
-
An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
-
Sayyed SG, Ryu M, Kulkarni OP, Schmid H, Lichtnekert J, Gruner S, Green L, Mattei P, Hartmann G, Anders HJ. An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes. Kidney Int 80: 68–78, 2011
-
(2011)
Kidney Int
, vol.80
, pp. 68-78
-
-
Sayyed, S.G.1
Ryu, M.2
Kulkarni, O.P.3
Schmid, H.4
Lichtnekert, J.5
Gruner, S.6
Green, L.7
Mattei, P.8
Hartmann, G.9
Ers, H.J.10
-
127
-
-
32844467281
-
Beneficial impact of spironolactone in diabetic nephropathy
-
Schjoedt KJ, Rossing K, Juhl TR, Boomsma F, Rossing P, Tarnow L, Parving HH. Beneficial impact of spironolactone in diabetic nephropathy. Kidney Int 68: 2829–2836, 2005
-
(2005)
Kidney Int
, vol.68
, pp. 2829-2836
-
-
Schjoedt, K.J.1
Rossing, K.2
Juhl, T.R.3
Boomsma, F.4
Rossing, P.5
Tarnow, L.6
Parving, H.H.7
-
128
-
-
33746566456
-
Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
-
Schjoedt KJ, Rossing K, Juhl TR, Boomsma F, Tarnow L, Rossing P, Parving HH. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int 70: 536–542, 2006
-
(2006)
Kidney Int
, vol.70
, pp. 536-542
-
-
Schjoedt, K.J.1
Rossing, K.2
Juhl, T.R.3
Boomsma, F.4
Tarnow, L.5
Rossing, P.6
Parving, H.H.7
-
129
-
-
2442707596
-
The role of vascular endothelial growth factor (VEGF) in renal pathophysiology
-
Schrijvers BF, Flyvbjerg A, De Vriese AS. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 65: 2003–2017, 2004
-
(2004)
Kidney Int
, vol.65
, pp. 2003-2017
-
-
Schrijvers, B.F.1
Flyvbjerg, A.2
De Vriese, A.S.3
-
130
-
-
79957670746
-
Pirfenidone for diabetic nephropathy
-
Sharma K, Ix JH, Mathew AV, Cho M, Pflueger A, Dunn SR, Francos B, Sharma S, Falkner B, McGowan TA, Donohue M, Ramachandrarao S, Xu R, Fervenza FC, Kopp JB. Pirfenidone for diabetic nephropathy. J Am Soc Nephrol 22: 1144–1151, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 1144-1151
-
-
Sharma, K.1
Ix, J.H.2
Mathew, A.V.3
Cho, M.4
Pflueger, A.5
Dunn, S.R.6
Francos, B.7
Sharma, S.8
Falkner, B.9
McGowan, T.A.10
Donohue, M.11
Ramachandrarao, S.12
Xu, R.13
Fervenza, F.C.14
Kopp, J.B.15
-
131
-
-
0029924637
-
Neutralization of TGF-b by anti-TGF-b antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
-
Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-b by anti-TGF-b antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45: 522–530, 1996
-
(1996)
Diabetes
, vol.45
, pp. 522-530
-
-
Sharma, K.1
Jin, Y.2
Guo, J.3
Ziyadeh, F.N.4
-
132
-
-
43049095682
-
Adiponectin regulates albuminuria and podocyte function in mice
-
Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645–1656, 2008
-
(2008)
J Clin Invest
, vol.118
, pp. 1645-1656
-
-
Sharma, K.1
Ramachandrarao, S.2
Qiu, G.3
Usui, H.K.4
Zhu, Y.5
Dunn, S.R.6
Ouedraogo, R.7
Hough, K.8
McCue, P.9
Chan, L.10
Falkner, B.11
Goldstein, B.J.12
-
133
-
-
0029076281
-
Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-b as a key mediator
-
Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-b as a key mediator. Diabetes 44: 1139–1146, 1995
-
(1995)
Diabetes
, vol.44
, pp. 1139-1146
-
-
Sharma, K.1
Ziyadeh, F.N.2
-
134
-
-
0036171986
-
Calcineurin as a multifunctional regulator
-
Shibasaki F, Hallin U, Uchino H. Calcineurin as a multifunctional regulator. J Biochem 131: 1–15, 2002
-
(2002)
J Biochem
, vol.131
, pp. 1-15
-
-
Shibasaki, F.1
Hallin, U.2
Uchino, H.3
-
135
-
-
67949083425
-
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2
-
Shin N, Baribaud F, Wang K, Yang G, Wynn R, Covington MB, Feldman P, Gallagher KB, Leffet LM, Lo YY, Wang A, Xue CB, Newton RC, Scherle PA. Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2. Biochem Biophys Res Commun 387: 251–255, 2009
-
(2009)
Biochem Biophys Res Commun
, vol.387
, pp. 251-255
-
-
Shin, N.1
Baribaud, F.2
Wang, K.3
Yang, G.4
Wynn, R.5
Covington, M.B.6
Feldman, P.7
Gallagher, K.B.8
Leffet, L.M.9
Lo, Y.Y.10
Wang, A.11
Xue, C.B.12
Newton, R.C.13
Scherle, P.A.14
-
136
-
-
77957861954
-
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling
-
Sison K, Eremina V, Baelde H, Min W, Hirashima M, Fantus IG, Quaggin SE. Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 21: 1691–1701, 2010
-
(2010)
J am Soc Nephrol
, vol.21
, pp. 1691-1701
-
-
Sison, K.1
Eremina, V.2
Baelde, H.3
Min, W.4
Hirashima, M.5
Fantus, I.G.6
Quaggin, S.E.7
-
137
-
-
33645808515
-
Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: Prevention by lipoic acid treatment
-
Siu B, Saha J, Smoyer WE, Sullivan KA, Brosius FC, 3rd. Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment. BMC Nephrol 7: 6, 2006
-
(2006)
BMC Nephrol
, vol.7
-
-
Siu, B.1
Saha, J.2
Smoyer, W.E.3
Sullivan, K.A.4
Brosius, F.C.5
-
138
-
-
84868015376
-
Vegfa protects the glomerular microvasculature in diabetes
-
Sivaskandarajah GA, Jeansson M, Maezawa Y, Eremina V, Baelde HJ, Quaggin SE. Vegfa protects the glomerular microvasculature in diabetes. Diabetes 61: 2958–2966, 2012
-
(2012)
Diabetes
, vol.61
, pp. 2958-2966
-
-
Sivaskandarajah, G.A.1
Jeansson, M.2
Maezawa, Y.3
Eremina, V.4
Baelde, H.J.5
Quaggin, S.E.6
-
139
-
-
80051580160
-
Oxidative stress and diabetic kidney disease
-
Stanton RC. Oxidative stress and diabetic kidney disease. Curr Diabetes Rep 11: 330–336, 2011
-
(2011)
Curr Diabetes Rep
, vol.11
, pp. 330-336
-
-
Stanton, R.C.1
-
140
-
-
84871918476
-
The GPCR Network: A large-scale collaboration to determine human GPCR structure and function
-
Stevens RC, Cherezov V, Katritch V, Abagyan R, Kuhn P, Rosen H, Wuthrich K. The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov 12: 25–34, 2013
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 25-34
-
-
Stevens, R.C.1
Cherezov, V.2
Katritch, V.3
Abagyan, R.4
Kuhn, P.5
Rosen, H.6
Wuthrich, K.7
-
141
-
-
84858008133
-
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
-
Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W Jr., Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 18: 396–404, 2012
-
(2012)
Nat Med
, vol.18
, pp. 396-404
-
-
Sugimoto, H.1
Lebleu, V.S.2
Bosukonda, D.3
Keck, P.4
Taduri, G.5
Bechtel, W.6
Okada, H.7
Carlson, W.8
Bey, P.9
Rusckowski, M.10
Tampe, B.11
Tampe, D.12
Kanasaki, K.13
Zeisberg, M.14
Kalluri, R.15
-
142
-
-
33644783770
-
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
-
Susztak K, Raff AC, Schiffer M, Bottinger EP. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55: 225–233, 2006
-
(2006)
Diabetes
, vol.55
, pp. 225-233
-
-
Susztak, K.1
Raff, A.C.2
Schiffer, M.3
Bottinger, E.P.4
-
143
-
-
0344443732
-
Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice
-
Takahashi K, Mizuarai S, Araki H, Mashiko S, Ishihara A, Kanatani A, Itadani H, Kotani H. Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J Biol Chem 278: 46,654–46,660, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 654-746
-
-
Takahashi, K.1
Mizuarai, S.2
Araki, H.3
Mashiko, S.4
Ishihara, A.5
Kanatani, A.6
Itadani, H.7
Kotani, H.8
-
145
-
-
0027976053
-
Dipyridamole prevents diabetes-induced alterations of kidney function in rats
-
Vallon V, Osswald H. Dipyridamole prevents diabetes-induced alterations of kidney function in rats. Naunyn-Schmiedeberg’s Arch Pharmacol 349: 217–222, 1994
-
(1994)
Naunyn-Schmiedeberg’s Arch Pharmacol
, vol.349
, pp. 217-222
-
-
Vallon, V.1
Osswald, H.2
-
146
-
-
79954632427
-
Podocyte vascular endothelial growth factor (Vegf(1)(6)(4)) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes
-
Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A. Podocyte vascular endothelial growth factor (Vegf(1)(6)(4)) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 54: 1227–1241, 2011
-
(2011)
Diabetologia
, vol.54
, pp. 1227-1241
-
-
Veron, D.1
Bertuccio, C.A.2
Marlier, A.3
Reidy, K.4
Garcia, A.M.5
Jimenez, J.6
Velazquez, H.7
Kashgarian, M.8
Moeckel, G.W.9
Tufro, A.10
-
147
-
-
77955870854
-
Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease
-
Veron D, Reidy KJ, Bertuccio C, Teichman J, Villegas G, Jimenez J, Shen W, Kopp JB, Thomas DB, Tufro A. Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease. Kidney Int 77: 989–999, 2010
-
(2010)
Kidney Int
, vol.77
, pp. 989-999
-
-
Veron, D.1
Reidy, K.J.2
Bertuccio, C.3
Teichman, J.4
Villegas, G.5
Jimenez, J.6
Shen, W.7
Kopp, J.B.8
Thomas, D.B.9
Tufro, A.10
-
148
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, Catalano JV, Deininger M, Miller C, Silver RT, Talpaz M, Winton EF, Harvey JH Jr, Arcasoy MO, Hexner E, Lyons RM, Paquette R, Raza A, Vaddi K, Erickson-Viitanen S, Koumenis IL, Sun W, Sandor V, Kantarjian HM. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 366: 799–807, 2012
-
(2012)
N Engl J Med
, vol.366
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
Levy, R.S.4
Gupta, V.5
Dipersio, J.F.6
Catalano, J.V.7
Deininger, M.8
Miller, C.9
Silver, R.T.10
Talpaz, M.11
Winton, E.F.12
Harvey, J.H.13
Arcasoy, M.O.14
Hexner, E.15
Lyons, R.M.16
Paquette, R.17
Raza, A.18
Vaddi, K.19
Erickson-Viitanen, S.20
Koumenis, I.L.21
Sun, W.22
Sandor, V.23
Kantarjian, H.M.24
more..
-
149
-
-
79953298958
-
Next-generation mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy
-
Wander SA, Hennessy BT, Slingerland JM. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest 121: 1231–1241, 2011
-
(2011)
J Clin Invest
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
150
-
-
79960972131
-
Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo
-
Wang L, Chang JH, Paik SY, Tang Y, Eisner W, Spurney RF. Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. Mol Endocrinol 25: 1376–1386, 2011
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1376-1386
-
-
Wang, L.1
Chang, J.H.2
Paik, S.Y.3
Tang, Y.4
Eisner, W.5
Spurney, R.F.6
-
151
-
-
84862777971
-
Mechanisms of the proteinuria induced by Rho GTPases
-
Wang L, Ellis MJ, Gomez JA, Eisner W, Fennell W, Howell DN, Ruiz P, Fields TA, Spurney RF. Mechanisms of the proteinuria induced by Rho GTPases. Kidney Int 81: 1075–1085, 2012
-
(2012)
Kidney Int
, vol.81
, pp. 1075-1085
-
-
Wang, L.1
Ellis, M.J.2
Gomez, J.A.3
Eisner, W.4
Fennell, W.5
Howell, D.N.6
Ruiz, P.7
Fields, T.A.8
Spurney, R.F.9
-
152
-
-
55749103377
-
Gq-dependent signaling upregulates COX2 in glomerular podocytes
-
Wang L, Flannery PJ, Rosenberg PB, Fields TA, Spurney RF. Gq-dependent signaling upregulates COX2 in glomerular podocytes. J Am Soc Nephrol 19: 2108–2118, 2008
-
(2008)
J am Soc Nephrol
, vol.19
, pp. 2108-2118
-
-
Wang, L.1
Flannery, P.J.2
Rosenberg, P.B.3
Fields, T.A.4
Spurney, R.F.5
-
153
-
-
0037648482
-
Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy
-
Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 63: 2037–2049, 2003
-
(2003)
Kidney Int
, vol.63
, pp. 2037-2049
-
-
Wang, S.1
Chen, Q.2
Simon, T.C.3
Strebeck, F.4
Chaudhary, L.5
Morrissey, J.6
Liapis, H.7
Klahr, S.8
Hruska, K.A.9
-
154
-
-
33748062324
-
Renal bone morphogenetic protein-7 protects against diabetic nephropathy
-
Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17: 2504–2512, 2006
-
(2006)
J am Soc Nephrol
, vol.17
, pp. 2504-2512
-
-
Wang, S.1
De Caestecker, M.2
Kopp, J.3
Mitu, G.4
Lapage, J.5
Hirschberg, R.6
-
155
-
-
84863023552
-
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
-
Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Chang BH, Schumacker PT, Danesh FR. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 15: 186–200, 2012
-
(2012)
Cell Metab
, vol.15
, pp. 186-200
-
-
Wang, W.1
Wang, Y.2
Long, J.3
Wang, J.4
Haudek, S.B.5
Overbeek, P.6
Chang, B.H.7
Schumacker, P.T.8
Danesh, F.R.9
-
156
-
-
0036894194
-
Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in TGF-b and fibronectin synthesis in mesangial cells
-
Wang X, Shaw S, Amiri F, Eaton DC, Marrero MB. Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in TGF-b and fibronectin synthesis in mesangial cells. Diabetes 51: 3505–3509, 2002
-
(2002)
Diabetes
, vol.51
, pp. 3505-3509
-
-
Wang, X.1
Shaw, S.2
Amiri, F.3
Eaton, D.C.4
Marrero, M.B.5
-
157
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 29: 1235–1243, 2008
-
(2008)
Carcinogenesis
, vol.29
, pp. 1235-1243
-
-
Wang, X.J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
Chen, W.7
Yi, X.8
Zheng, W.9
Wondrak, G.T.10
Wong, P.K.11
Zhang, D.D.12
-
158
-
-
84870501767
-
Vitamin D receptor signaling in podocytes protects against diabetic nephropathy
-
Wang Y, Deb DK, Zhang Z, Sun T, Liu W, Yoon D, Kong J, Chen Y, Chang A, Li YC. Vitamin D receptor signaling in podocytes protects against diabetic nephropathy. J Am Soc Nephrol 23: 1977–1986, 2012
-
(2012)
J am Soc Nephrol
, vol.23
, pp. 1977-1986
-
-
Wang, Y.1
Deb, D.K.2
Zhang, Z.3
Sun, T.4
Liu, W.5
Yoon, D.6
Kong, J.7
Chen, Y.8
Chang, A.9
Li, Y.C.10
-
159
-
-
77957868187
-
Activation of NFAT signaling in podocytes causes glomerulosclerosis
-
Wang Y, Jarad G, Tripathi P, Pan M, Cunningham J, Martin DR, Liapis H, Miner JH, Chen F. Activation of NFAT signaling in podocytes causes glomerulosclerosis. J Am Soc Nephrol 21: 1657–1666, 2010
-
(2010)
J am Soc Nephrol
, vol.21
, pp. 1657-1666
-
-
Wang, Y.1
Jarad, G.2
Tripathi, P.3
Pan, M.4
Cunningham, J.5
Martin, D.R.6
Liapis, H.7
Miner, J.H.8
Chen, F.9
-
160
-
-
33747867785
-
Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy
-
Wang Y, Zhou J, Minto AW, Hack BK, Alexander JJ, Haas M, Li YC, Heilig CW, Quigg RJ. Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int 70: 882–891, 2006
-
(2006)
Kidney Int
, vol.70
, pp. 882-891
-
-
Wang, Y.1
Zhou, J.2
Minto, A.W.3
Hack, B.K.4
Alexander, J.J.5
Haas, M.6
Li, Y.C.7
Heilig, C.W.8
Quigg, R.J.9
-
161
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115–124, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
Lemieux, J.4
Slaymaker, S.5
Vaddi, K.6
Charo, I.7
Leibel, R.L.8
Ferrante, A.W.9
-
162
-
-
62149126622
-
Avosentan reduces albumin excretion in diabetics with macroalbuminuria
-
Wenzel RR, Littke T, Kuranoff S, Jurgens C, Bruck H, Ritz E, Philipp T, Mitchell A. Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Nephrol 20: 655–664, 2009
-
(2009)
J am Soc Nephrol
, vol.20
, pp. 655-664
-
-
Wenzel, R.R.1
Littke, T.2
Kuranoff, S.3
Jurgens, C.4
Bruck, H.5
Ritz, E.6
Philipp, T.7
Mitchell, A.8
-
163
-
-
84875019579
-
CC chemokine receptors and chronic inflammation—therapeutic opportunities and pharmacological challenges
-
White GE, Iqbal AJ, Greaves DR. CC chemokine receptors and chronic inflammation—therapeutic opportunities and pharmacological challenges. Pharmacol Rev 65: 47–89, 2013
-
(2013)
Pharmacol Rev
, vol.65
, pp. 47-89
-
-
White, G.E.1
Iqbal, A.J.2
Greaves, D.R.3
-
164
-
-
39149114408
-
Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits
-
Winiarska K, Malinska D, Szymanski K, Dudziak M, Bryla J. Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits. Biochimie 90: 450–459, 2008
-
(2008)
Biochimie
, vol.90
, pp. 450-459
-
-
Winiarska, K.1
Malinska, D.2
Szymanski, K.3
Dudziak, M.4
Bryla, J.5
-
165
-
-
33847280286
-
T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
-
Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115: 1029–1038, 2007
-
(2007)
Circulation
, vol.115
, pp. 1029-1038
-
-
Wu, H.1
Ghosh, S.2
Perrard, X.D.3
Feng, L.4
Garcia, G.E.5
Perrard, J.L.6
Sweeney, J.F.7
Peterson, L.E.8
Chan, L.9
Smith, C.W.10
Ballantyne, C.M.11
-
166
-
-
33748561167
-
Cross-talk between calcium and reactive oxygen species signaling
-
Yan Y, Wei CL, Zhang WR, Cheng HP, Liu J. Cross-talk between calcium and reactive oxygen species signaling. Acta Pharmacol Sin 27: 821–826, 2006
-
(2006)
Acta Pharmacol Sin
, vol.27
, pp. 821-826
-
-
Yan, Y.1
Wei, C.L.2
Zhang, W.R.3
Cheng, H.P.4
Liu, J.5
-
167
-
-
84868550831
-
Inhibitors/antagonists of TGF-b system in kidney fibrosis
-
Yanagita M. Inhibitors/antagonists of TGF-b system in kidney fibrosis. Nephrol Dial Transpl 27: 3686–3691, 2012
-
(2012)
Nephrol Dial Transpl
, vol.27
, pp. 3686-3691
-
-
Yanagita, M.1
-
168
-
-
34447127566
-
Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders
-
Yu H, van Berkel TJ, Biessen EA. Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders. Cardiovasc Drug Rev 25: 175–187, 2007
-
(2007)
Cardiovasc Drug Rev
, vol.25
, pp. 175-187
-
-
Yu, H.1
Van Berkel, T.J.2
Biessen, E.A.3
-
169
-
-
35648976022
-
1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter
-
Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, Cohen R, Klopot A, Zhang Z, Li YC. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem 282: 29,821–29,830, 2007
-
(2007)
J Biol Chem
, vol.282
, pp. 821-829
-
-
Yuan, W.1
Pan, W.2
Kong, J.3
Zheng, W.4
Szeto, F.L.5
Wong, K.E.6
Cohen, R.7
Klopot, A.8
Zhang, Z.9
Li, Y.C.10
-
170
-
-
42049107348
-
Telmisartan, ramipril, or both in patients at high risk for vascular events
-
Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 358: 1547–1559, 2008
-
(2008)
N Engl J Med
, vol.358
, pp. 1547-1559
-
-
Yusuf, S.1
Teo, K.K.2
Pogue, J.3
Dyal, L.4
Copland, I.5
Schumacher, H.6
Dagenais, G.7
Sleight, P.8
Erson, C.9
-
171
-
-
77958140054
-
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer
-
Zhang DD. The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer. Antiox Redox Signal 13: 1623–1626, 2010
-
(2010)
Antiox Redox Signal
, vol.13
, pp. 1623-1626
-
-
Zhang, D.D.1
-
172
-
-
84883255760
-
NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice
-
Zhang L, Li R, Shi W, Liang X, Liu S, Ye Z, Yu C, Chen Y, Zhang B, Wang W, Lai Y, Ma J, Li Z, Tan X. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol 170: 426–439, 2013
-
(2013)
Br J Pharmacol
, vol.170
, pp. 426-439
-
-
Zhang, L.1
Li, R.2
Shi, W.3
Liang, X.4
Liu, S.5
Ye, Z.6
Yu, C.7
Chen, Y.8
Zhang, B.9
Wang, W.10
Lai, Y.11
Ma, J.12
Li, Z.13
Tan, X.14
-
173
-
-
69449097895
-
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: Strong synergism with AT1 receptor antagonist
-
Zhang Y, Deb DK, Kong J, Ning G, Wang Y, Li G, Chen Y, Zhang Z, Strugnell S, Sabbagh Y, Arbeeny C, Li YC. Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist. Am J Physiol Renal Physiol 297: F791–F801, 2009
-
(2009)
Am J Physiol Renal Physiol
, vol.297
, pp. F791-F801
-
-
Zhang, Y.1
Deb, D.K.2
Kong, J.3
Ning, G.4
Wang, Y.5
Li, G.6
Chen, Y.7
Zhang, Z.8
Strugnell, S.9
Sabbagh, Y.10
Arbeeny, C.11
Li, Y.C.12
-
174
-
-
37549046405
-
Renoprotective role of the vitamin D receptor in diabetic nephropathy
-
Zhang Z, Sun L, Wang Y, Ning G, Minto AW, Kong J, Quigg RJ, Li YC. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int 73: 163–171, 2008
-
(2008)
Kidney Int
, vol.73
, pp. 163-171
-
-
Zhang, Z.1
Sun, L.2
Wang, Y.3
Ning, G.4
Minto, A.W.5
Kong, J.6
Quigg, R.J.7
Li, Y.C.8
-
175
-
-
57349185929
-
Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase
-
Zhang Z, Zhang Y, Ning G, Deb DK, Kong J, Li YC. Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc Nat Acad Sci USA 105: 15,896–15,901, 2008
-
(2008)
Proc Nat Acad Sci USA
, vol.105
, pp. 896-915
-
-
Zhang, Z.1
Zhang, Y.2
Ning, G.3
Deb, D.K.4
Kong, J.5
Li, Y.C.6
-
176
-
-
84924090632
-
Multiple genes of the renin-angiotensin system are novel targets of Wnt/b-catenin signaling
-
Zhou L, Li Y, Hao S, Zhou D, Tan RJ, Nie J, Hou FF, Kahn M, Liu Y. Multiple genes of the renin-angiotensin system are novel targets of Wnt/b-catenin signaling. J Am Soc Nephrol 26: 107–120, 2015
-
(2015)
J am Soc Nephrol
, vol.26
, pp. 107-120
-
-
Zhou, L.1
Li, Y.2
Hao, S.3
Zhou, D.4
Tan, R.J.5
Nie, J.6
Hou, F.F.7
Kahn, M.8
Liu, Y.9
-
177
-
-
80052333245
-
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis
-
Zhu L, Jiang R, Aoudjit L, Jones N, Takano T. Activation of RhoA in podocytes induces focal segmental glomerulosclerosis. J Am Soc Nephrol 22: 1621–1630, 2011
-
(2011)
J am Soc Nephrol
, vol.22
, pp. 1621-1630
-
-
Zhu, L.1
Jiang, R.2
Aoudjit, L.3
Jones, N.4
Takano, T.5
-
178
-
-
33846638744
-
Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis
-
Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 49: 186–193, 2007
-
(2007)
Am J Kidney Dis
, vol.49
, pp. 186-193
-
-
Zhu, X.1
Wu, S.2
Dahut, W.L.3
Parikh, C.R.4
-
179
-
-
0034608948
-
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
-
Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Nat Acad Sci USA 97: 8015–8020, 2000.
-
(2000)
Proc Nat Acad Sci USA
, vol.97
, pp. 8015-8020
-
-
Ziyadeh, F.N.1
Hoffman, B.B.2
Han, D.C.3
Iglesias-De La Cruz, M.C.4
Hong, S.W.5
Isono, M.6
Chen, S.7
McGowan, T.A.8
Sharma, K.9
|