메뉴 건너뛰기




Volumn 19, Issue 6, 2015, Pages 1098-1106

Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial

Author keywords

Albuminuria; Diabetic nephropathy; Randomized study; Spironolactone

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMIDAPRIL; IRBESARTAN; LISINOPRIL; LOSARTAN; OLMESARTAN; PERINDOPRIL; SPIRONOLACTONE; TELMISARTAN; TEMOCAPRIL; VALSARTAN; ALDOSTERONE; MINERALOCORTICOID ANTAGONIST;

EID: 84951906215     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-015-1106-2     Document Type: Article
Times cited : (51)

References (38)
  • 1
    • 84951905727 scopus 로고    scopus 로고
    • IDF Diabetes Altas, 6 ed. Brussels
    • International Diabetes Federation (2013) IDF Diabetes Altas, 6 ed. Brussels. pp 29–49.
    • (2013) pp 29–49
  • 2
    • 84891790939 scopus 로고    scopus 로고
    • Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions
    • COI: 1:CAS:528:DC%2BC3sXhvV2itL3F, PID: 24264395
    • Nathan DM, Bayless M, Cleary P, Genuth S, Gubitosi-Klug R, Lachin JM, et al. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes. 2013;62(12):3976–86. doi:10.2337/db13-1093.
    • (2013) Diabetes. , vol.62 , Issue.12 , pp. 3976-3986
    • Nathan, D.M.1    Bayless, M.2    Cleary, P.3    Genuth, S.4    Gubitosi-Klug, R.5    Lachin, J.M.6
  • 3
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • COI: 1:CAS:528:DC%2BD38Xhtlymtg%3D%3D, PID: 11742409
    • Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782–7. doi:10.1038/414782a.
    • (2001) Nature. , vol.414 , Issue.6865 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 4
    • 28544438949 scopus 로고    scopus 로고
    • Predictors of diabetic end-stage renal disease in Japan
    • Iseki K. Predictors of diabetic end-stage renal disease in Japan. Nephrol Carlton. 2005;10(Suppl):S2–6. doi:10.1111/j.1440-1797.2005.00447.x.
    • (2005) Nephrol Carlton , vol.10 , pp. S2-S6
    • Iseki, K.1
  • 5
    • 84862957795 scopus 로고    scopus 로고
    • Overview of regular dialysis treatment in Japan (as of 31 December 2009)
    • PID: 22248195
    • Nakai S, Iseki K, Itami N, Ogata S, Kazama JJ, Kimata N, et al. Overview of regular dialysis treatment in Japan (as of 31 December 2009). Ther Apher Dial. 2012;16(1):11–53. doi:10.1111/j.1744-9987.2011.01050.x.
    • (2012) Ther Apher Dial. , vol.16 , Issue.1 , pp. 11-53
    • Nakai, S.1    Iseki, K.2    Itami, N.3    Ogata, S.4    Kazama, J.J.5    Kimata, N.6
  • 6
    • 44649162402 scopus 로고    scopus 로고
    • Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) study
    • COI: 1:CAS:528:DC%2BD1cXos12jurY%3D, PID: 18633177
    • Makino H, Haneda M, Babazono T, Moriya T, Ito S, Iwamoto Y, et al. Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) study. Hypertens Res. 2008;31(4):657–64. doi:10.1291/hypres.31.657.
    • (2008) Hypertens Res. , vol.31 , Issue.4 , pp. 657-664
    • Makino, H.1    Haneda, M.2    Babazono, T.3    Moriya, T.4    Ito, S.5    Iwamoto, Y.6
  • 7
    • 34249746896 scopus 로고    scopus 로고
    • Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXmtlKhsL0%3D, PID: 17360976
    • Araki S, Haneda M, Koya D, Hidaka H, Sugimoto T, Isono M, et al. Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with type 2 diabetes. Diabetes. 2007;56(6):1727–30. doi:10.2337/db06-1646.
    • (2007) Diabetes. , vol.56 , Issue.6 , pp. 1727-1730
    • Araki, S.1    Haneda, M.2    Koya, D.3    Hidaka, H.4    Sugimoto, T.5    Isono, M.6
  • 8
    • 47649091344 scopus 로고    scopus 로고
    • Microvascular disease: what does the UKPDS tell us about diabetic nephropathy?
    • PID: 18717975
    • Bilous R. Microvascular disease: what does the UKPDS tell us about diabetic nephropathy? Diabet Med. 2008;25(Suppl 2):25–9. doi:10.1111/j.1464-5491.2008.02496.x.
    • (2008) Diabet Med. , vol.25 , pp. 25-29
    • Bilous, R.1
  • 9
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXht1Wgt7nK, PID: 18784090
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577–89. doi:10.1056/NEJMoa0806470.
    • (2008) N Engl J Med. , vol.359 , Issue.15 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 10
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD3MXntlelsLY%3D, PID: 11565519
    • Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001;345(12):870–8. doi:10.1056/NEJMoa011489.
    • (2001) N Engl J Med. , vol.345 , Issue.12 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Brochner-Mortensen, J.3    Gomis, R.4    Andersen, S.5    Arner, P.6
  • 11
    • 34249899918 scopus 로고    scopus 로고
    • Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXntlWkt7g%3D, PID: 17389334
    • Makino H, Haneda M, Babazono T, Moriya T, Ito S, Iwamoto Y, et al. Prevention of transition from incipient to overt nephropathy with telmisartan in patients with type 2 diabetes. Diabetes Care. 2007;30(6):1577–8. doi:10.2337/dc06-1998.
    • (2007) Diabetes Care. , vol.30 , Issue.6 , pp. 1577-1578
    • Makino, H.1    Haneda, M.2    Babazono, T.3    Moriya, T.4    Ito, S.5    Iwamoto, Y.6
  • 12
    • 0035922443 scopus 로고    scopus 로고
    • Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease
    • COI: 1:STN:280:DC%2BD3MrhvVWgtw%3D%3D, PID: 11565535
    • Chrysostomou A, Becker G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N Engl J Med. 2001;345(12):925–6. doi:10.1056/NEJM200109203451215.
    • (2001) N Engl J Med. , vol.345 , Issue.12 , pp. 925-926
    • Chrysostomou, A.1    Becker, G.2
  • 13
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD1MXhs1Witb3P, PID: 19926893
    • Mehdi UF, Adams-Huet B, Raskin P, Vega GL, Toto RD. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol. 2009;20(12):2641–50. doi:10.1681/ASN.2009070737.
    • (2009) J Am Soc Nephrol. , vol.20 , Issue.12 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3    Vega, G.L.4    Toto, R.D.5
  • 14
    • 32844467281 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD28XhslWjuw%3D%3D, PID: 16316360
    • Schjoedt KJ, Rossing K, Juhl TR, Boomsma F, Rossing P, Tarnow L, et al. Beneficial impact of spironolactone in diabetic nephropathy. Kidney Int. 2005;68(6):2829–36. doi:10.1111/j.1523-1755.2005.00756.x.
    • (2005) Kidney Int. , vol.68 , Issue.6 , pp. 2829-2836
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3    Boomsma, F.4    Rossing, P.5    Tarnow, L.6
  • 15
    • 24144495285 scopus 로고    scopus 로고
    • Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study
    • COI: 1:CAS:528:DC%2BD2MXhtVGntrzO, PID: 16123474
    • Rossing K, Schjoedt KJ, Smidt UM, Boomsma F, Parving HH. Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study. Diabetes Care. 2005;28(9):2106–12.
    • (2005) Diabetes Care. , vol.28 , Issue.9 , pp. 2106-2112
    • Rossing, K.1    Schjoedt, K.J.2    Smidt, U.M.3    Boomsma, F.4    Parving, H.H.5
  • 16
    • 33845302661 scopus 로고    scopus 로고
    • Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease
    • COI: 1:CAS:528:DC%2BD28Xht1Kju7bL, PID: 17035949
    • Bianchi S, Bigazzi R, Campese VM. Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int. 2006;70(12):2116–23. doi:10.1038/sj.ki.5001854.
    • (2006) Kidney Int. , vol.70 , Issue.12 , pp. 2116-2123
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 17
    • 40149090641 scopus 로고    scopus 로고
    • Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker
    • COI: 1:CAS:528:DC%2BD1cXltl2ntbo%3D, PID: 18360019
    • Furumatsu Y, Nagasawa Y, Tomida K, Mikami S, Kaneko T, Okada N, et al. Effect of renin-angiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker. Hypertens Res. 2008;31(1):59–67. doi:10.1291/hypres.31.59.
    • (2008) Hypertens Res. , vol.31 , Issue.1 , pp. 59-67
    • Furumatsu, Y.1    Nagasawa, Y.2    Tomida, K.3    Mikami, S.4    Kaneko, T.5    Okada, N.6
  • 18
    • 80051469912 scopus 로고    scopus 로고
    • Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy
    • COI: 1:CAS:528:DC%2BC3MXptFCksL4%3D, PID: 21670416
    • Konishi Y, Nishiyama A, Morikawa T, Kitabayashi C, Shibata M, Hamada M, et al. Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy. Hypertension. 2011;58(2):205–11. doi:10.1161/HYPERTENSIONAHA.110.166843.
    • (2011) Hypertension. , vol.58 , Issue.2 , pp. 205-211
    • Konishi, Y.1    Nishiyama, A.2    Morikawa, T.3    Kitabayashi, C.4    Shibata, M.5    Hamada, M.6
  • 19
    • 65549111017 scopus 로고    scopus 로고
    • Revised equations for estimated GFR from serum creatinine in Japan
    • COI: 1:CAS:528:DC%2BD1MXnslKku7c%3D, PID: 19339088
    • Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53(6):982–92. doi:10.1053/j.ajkd.2008.12.034.
    • (2009) Am J Kidney Dis. , vol.53 , Issue.6 , pp. 982-992
    • Matsuo, S.1    Imai, E.2    Horio, M.3    Yasuda, Y.4    Tomita, K.5    Nitta, K.6
  • 20
    • 84872311750 scopus 로고    scopus 로고
    • GFR estimation using standardized serum cystatin C in Japan
    • COI: 1:CAS:528:DC%2BC38XhtF2itb3L, PID: 22892396
    • Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S. GFR estimation using standardized serum cystatin C in Japan. Am J Kidney Dis. 2013;61(2):197–203. doi:10.1053/j.ajkd.2012.07.007.
    • (2013) Am J Kidney Dis. , vol.61 , Issue.2 , pp. 197-203
    • Horio, M.1    Imai, E.2    Yasuda, Y.3    Watanabe, T.4    Matsuo, S.5
  • 21
    • 84869057325 scopus 로고    scopus 로고
    • Urinary neutrophil gelatinase-associated lipocalin levels in comparison with glomerular filtration rate for evaluation of renal function in patients with diabetic chronic kidney disease
    • PID: 22950063
    • Woo KS, Choi JL, Kim BR, Kim JE, An WS, Han JY. Urinary neutrophil gelatinase-associated lipocalin levels in comparison with glomerular filtration rate for evaluation of renal function in patients with diabetic chronic kidney disease. Diabetes Metab J. 2012;36(4):307–13. doi:10.4093/dmj.2012.36.4.307.
    • (2012) Diabetes Metab J. , vol.36 , Issue.4 , pp. 307-313
    • Woo, K.S.1    Choi, J.L.2    Kim, B.R.3    Kim, J.E.4    An, W.S.5    Han, J.Y.6
  • 22
    • 27744529624 scopus 로고    scopus 로고
    • Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats
    • COI: 1:CAS:528:DC%2BD2MXms1egs7o%3D, PID: 15888567
    • Kobori H, Ozawa Y, Suzaki Y, Nishiyama A. Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. J Am Soc Nephrol. 2005;16(7):2073–80. doi:10.1681/ASN.2004080676.
    • (2005) J Am Soc Nephrol. , vol.16 , Issue.7 , pp. 2073-2080
    • Kobori, H.1    Ozawa, Y.2    Suzaki, Y.3    Nishiyama, A.4
  • 23
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review
    • PID: 18215698
    • Bomback AS, Kshirsagar AV, Amamoo MA, Klemmer PJ. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis. 2008;51(2):199–211. doi:10.1053/j.ajkd.2007.10.040.
    • (2008) Am J Kidney Dis. , vol.51 , Issue.2 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Amamoo, M.A.3    Klemmer, P.J.4
  • 24
    • 84874521311 scopus 로고    scopus 로고
    • Renoprotective effects of mineralocorticoid receptor blockers in patients with proteinuric kidney diseases
    • COI: 1:CAS:528:DC%2BC3sXislOks7s%3D, PID: 23222416
    • Morales E, Millet VG, Rojas-Rivera J, Huerta A, Gutierrez E, Gutierrez-Solis E, et al. Renoprotective effects of mineralocorticoid receptor blockers in patients with proteinuric kidney diseases. Nephrol Dial Transplant. 2013;28(2):405–12. doi:10.1093/ndt/gfs429.
    • (2013) Nephrol Dial Transplant. , vol.28 , Issue.2 , pp. 405-412
    • Morales, E.1    Millet, V.G.2    Rojas-Rivera, J.3    Huerta, A.4    Gutierrez, E.5    Gutierrez-Solis, E.6
  • 25
    • 84890086278 scopus 로고    scopus 로고
    • Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC3sXhslajur%2FN, PID: 24009294
    • Esteghamati A, Noshad S, Jarrah S, Mousavizadeh M, Khoee SH, Nakhjavani M. Long-term effects of addition of mineralocorticoid receptor antagonist to angiotensin II receptor blocker in patients with diabetic nephropathy: a randomized clinical trial. Nephrol Dial Transplant. 2013;28(11):2823–33. doi:10.1093/ndt/gft281.
    • (2013) Nephrol Dial Transplant. , vol.28 , Issue.11 , pp. 2823-2833
    • Esteghamati, A.1    Noshad, S.2    Jarrah, S.3    Mousavizadeh, M.4    Khoee, S.H.5    Nakhjavani, M.6
  • 26
    • 33750274950 scopus 로고    scopus 로고
    • Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function
    • PID: 17053552
    • van den Meiracker AH, Baggen RG, Pauli S, Lindemans A, Vulto AG, Poldermans D, et al. Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function. J Hypertens. 2006;24(11):2285–92. doi:10.1097/01.hjh.0000249708.44016.5c.
    • (2006) J Hypertens. , vol.24 , Issue.11 , pp. 2285-2292
    • van den Meiracker, A.H.1    Baggen, R.G.2    Pauli, S.3    Lindemans, A.4    Vulto, A.G.5    Poldermans, D.6
  • 27
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • COI: 1:CAS:528:DyaK1MXmtVyrurk%3D, PID: 10471456
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341(10):709–17. doi:10.1056/NEJM199909023411001.
    • (1999) N Engl J Med. , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6
  • 28
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD38Xps1Ohu74%3D, PID: 12511531
    • Sato A, Hayashi K, Naruse M, Saruta T. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension. 2003;41(1):64–8.
    • (2003) Hypertension. , vol.41 , Issue.1 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3    Saruta, T.4
  • 29
    • 36349036058 scopus 로고    scopus 로고
    • Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus
    • COI: 1:CAS:528:DC%2BD2sXhsVSgur7K, PID: 18047925
    • Yoneda T, Takeda Y, Usukura M, Oda N, Takata H, Yamamoto Y, et al. Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus. Am J Hypertens. 2007;20(12):1329–33. doi:10.1016/j.amjhyper.2007.09.001.
    • (2007) Am J Hypertens. , vol.20 , Issue.12 , pp. 1329-1333
    • Yoneda, T.1    Takeda, Y.2    Usukura, M.3    Oda, N.4    Takata, H.5    Yamamoto, Y.6
  • 30
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
    • COI: 1:CAS:528:DC%2BD1cXhsVWgsr7L, PID: 19029984
    • Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, et al. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nature medicine. 2008;14(12):1370–6. doi:10.1038/nm.1879.
    • (2008) Nature medicine. , vol.14 , Issue.12 , pp. 1370-1376
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3    Kawarazaki, W.4    Kurihara, H.5    Tanaka, H.6
  • 31
    • 77249109990 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats
    • COI: 1:CAS:528:DC%2BC3cXivFCjsb8%3D, PID: 19940106
    • Nishiyama A, Kobori H, Konishi Y, Morikawa T, Maeda I, Okumura M, et al. Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats. The Journal of pharmacology and experimental therapeutics. 2010;332(3):1072–80. doi:10.1124/jpet.109.158113.
    • (2010) The Journal of pharmacology and experimental therapeutics. , vol.332 , Issue.3 , pp. 1072-1080
    • Nishiyama, A.1    Kobori, H.2    Konishi, Y.3    Morikawa, T.4    Maeda, I.5    Okumura, M.6
  • 32
    • 84891130376 scopus 로고    scopus 로고
    • Eplerenone-mediated aldosterone blockade prevents renal fibrosis by reducing renal inflammation, interstitial cell proliferation and oxidative stress
    • COI: 1:CAS:528:DC%2BC3sXitVSqtLvO, PID: 24296802
    • Chen H, Sun F, Zhong X, Shao Y, Yoshimura A, Liu Y. Eplerenone-mediated aldosterone blockade prevents renal fibrosis by reducing renal inflammation, interstitial cell proliferation and oxidative stress. Kidney Blood Press Res. 2013;37(6):557–66. doi:10.1159/000355736.
    • (2013) Kidney Blood Press Res , vol.37 , Issue.6 , pp. 557-566
    • Chen, H.1    Sun, F.2    Zhong, X.3    Shao, Y.4    Yoshimura, A.5    Liu, Y.6
  • 33
    • 84876798791 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade reduced oxidative stress in renal transplant recipients: a double-blind, randomized pilot study
    • COI: 1:CAS:528:DC%2BC3sXpsVGlurk%3D, PID: 23635604
    • Ojeda-Cervantes M, Barrera-Chimal J, Alberu J, Perez-Villalva R, Morales-Buenrostro LE, Bobadilla NA. Mineralocorticoid receptor blockade reduced oxidative stress in renal transplant recipients: a double-blind, randomized pilot study. Am J Nephrol. 2013;37(5):481–90. doi:10.1159/000350539.
    • (2013) Am J Nephrol. , vol.37 , Issue.5 , pp. 481-490
    • Ojeda-Cervantes, M.1    Barrera-Chimal, J.2    Alberu, J.3    Perez-Villalva, R.4    Morales-Buenrostro, L.E.5    Bobadilla, N.A.6
  • 34
    • 0025732119 scopus 로고
    • The renal tubulointerstitium in diabetes mellitus
    • COI: 1:STN:280:DyaK3M3oslantA%3D%3D, PID: 2062033
    • Ziyadeh FN, Goldfarb S. The renal tubulointerstitium in diabetes mellitus. Kidney Int. 1991;39(3):464–75.
    • (1991) Kidney Int. , vol.39 , Issue.3 , pp. 464-475
    • Ziyadeh, F.N.1    Goldfarb, S.2
  • 35
    • 4644245230 scopus 로고    scopus 로고
    • Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DC%2BD2cXpsVShurg%3D, PID: 15458443
    • Fujisawa G, Okada K, Muto S, Fujita N, Itabashi N, Kusano E, et al. Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats. Kidney Int. 2004;66(4):1493–502. doi:10.1111/j.1523-1755.2004.00913.x.
    • (2004) Kidney Int. , vol.66 , Issue.4 , pp. 1493-1502
    • Fujisawa, G.1    Okada, K.2    Muto, S.3    Fujita, N.4    Itabashi, N.5    Kusano, E.6
  • 36
    • 33847203614 scopus 로고    scopus 로고
    • Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis
    • COI: 1:CAS:528:DC%2BD2sXhvF2isLY%3D, PID: 17213874
    • Kramer AB, van der Meulen EF, Hamming I, van Goor H, Navis G. Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. Kidney Int. 2007;71(5):417–24. doi:10.1038/sj.ki.5002075.
    • (2007) Kidney Int. , vol.71 , Issue.5 , pp. 417-424
    • Kramer, A.B.1    van der Meulen, E.F.2    Hamming, I.3    van Goor, H.4    Navis, G.5
  • 37
    • 84894106381 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: an emerging paradigm in diabetic nephropathy: a systematic review
    • COI: 1:CAS:528:DC%2BC3sXhvF2rsr3N
    • Mavrakanas TA, Gariani K, Martin PY. Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitor or angiotensin II receptor blocker treatment: an emerging paradigm in diabetic nephropathy: a systematic review. Eur J Int Med. 2014;25(2):173–6. doi:10.1016/j.ejim.2013.11.007.
    • (2014) Eur J Int Med. , vol.25 , Issue.2 , pp. 173-176
    • Mavrakanas, T.A.1    Gariani, K.2    Martin, P.Y.3
  • 38
    • 20844460800 scopus 로고    scopus 로고
    • Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    • COI: 1:CAS:528:DC%2BD2MXis1Grtrc%3D, PID: 15698420
    • Wolf G, Ritz E. Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications. Kidney Int. 2005;67(3):799–812. doi:10.1111/j.1523-1755.2005.00145.x.
    • (2005) Kidney Int. , vol.67 , Issue.3 , pp. 799-812
    • Wolf, G.1    Ritz, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.