Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes

American Journal of Physiology - Renal Physiology

Volumn 284, Issue 6 53-6, 2003, Pages

  Foster, Rebecca R ^a   Hole, Rachel ^a   Anderson, Karen ^a   Satchell, Simon C ^a   Coward, Richard J ^a   Mathieson, Peter W ^a   Gillatt, David A ^b   Saleem, Moin A ^a   Bates, David O ^a   Harper, Steven J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Cell survival; Glomerulus; Immunogold; Intracellular calcium

Indexed keywords

CALCIUM ION; NEUROPILIN 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB;

ADULT; AGED; ARTICLE; AUTOCRINE EFFECT; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOGOLD LABELING; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0038623780     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00276.2002     Document Type: Article

References (41)

1. Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, and Mercurio AM. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 61: 5736-5740, 2001.
2. Bailey E, Bottomley MJ, Westwell S, Pringle JH, Furness PN, Feehally J, Brenchley PE, and Harper SJ. Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by nonisotopic in situ hybridisation. J Clin Pathol 52: 735-738, 1999.
3. Bates DO. The chronic effect of vascular endothelial growth factor on individually perfused frog mesenteric microvessels. J Physiol 513: 225-233, 1998.
4. Bates DO, Cui T-G, Doughty JM, Winkler M, Sugiono M, Shields JD, Peat D, Gillatt DA, and Harper SJ. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down regulated in renal cell carcinoma. Cancer Res 62: 1-9, 2002.
5. Bates DO and Curry FE. Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am J Physiol Heart Circ Physiol 271: H2520-H2528, 1996.
6. 2+-dependent pathway. Am J Physiol Heart Circ Physiol 273: H687-H694, 1997.
7. Brenchley PE. A modulator of microvascular function with potential roles in glomerular epithelial cells. Clin Sci (Colch) 101: 439, 1996.
8. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
9. Feng D, Nagy JA, Brekken RA, Pettersson A, Manseau EJ, Pyne K, Mulligan R, Thorpe PE, Dvorak HF, and Dvorak AM. Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors. J Histochem Cytochem 48: 545-556, 2000.
10. Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 280: C1358-C1366, 2001.
11. Fornoni A, Li H, Foschi A, Striker GE, and Striker LJ. Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis. Am J Pathol 158: 275-280, 2001.
12. Fuh G, Garcia KC, and de Vos AM. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J Biol Chem 275: 26690-26695, 2000.
13. Furness PN, Hall LL, Shaw JA, and Pringle JH. Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome. Nephrol Dial Transplant 14: 1234-1237, 1999.
14. Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, and Klagsbrun M. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity. PNAS 97: 2573-2578, 2000.
15. Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, and Ferrara N. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417: 954-958, 2002.
16. Gluzman-Poltorak Z, Cohen T, Herzog Y, and Neufeld G. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165. J Biol Chem 275: 29922, 2000.
17. Harper SJ, Xing CY, Whittle C, Parry R, Gillatt DA, Peat D, and Mathieson PW. Expression of neuropilin by human glomerular epithelial cells in vitro and in vivo. Clin Sci (Colch) 101: 439-466, 2001.
18. Houck KA, Ferrara N, Winer J, Cachianes G, Li, B, and Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814, 1991.
19. Jingjing L, Xue Y, Agarwal N, and Roque RS. Human Muller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor. Invest Ophthalmol Vis Sci 40: 752-759, 1999.
20. Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, and Tryggvason K. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998.
21. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res 60: 3807-3812, 2000.
22. Mundel P and Kriz W. Structure and function of podocytes: an update. Anat Embryol (Berl) 192: 385-397, 1995.
23. Neufeld G, Cohen T, Shraga N, Lange T, Kessler O, and Herzog Y. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc Med 12: 13-19, 2002.
24. Nitschke R, Henger A, Ricken S, Gloy J, Muller V, Greger R, and Pavenstadt H. Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus. Kidney Int 57: 41-49, 2000.
25. Ostendorf T, Kunter U, Eitner F, Loos A, Regele H, Kerjaschki D, Henninger DD, Janjic N, and Floege J. VEGF(165) mediates glomerular endothelial repair. J Clin Invest 104: 913-923, 1999.
26. Parry RG, Gillespie KM, and Mathieson PW. Effects of type 2 cytokines on glomerular epithelial cells. Exp Nephrol 9: 275-283, 2001.
27. Pocock TM and Bates DO. In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries. J Physiol 534: 479-488, 2001.
28. i. Am J Physiol Heart Circ Physiol 279: H1625-H1634, 2000.
29. Poltorak Z, Cohen T, Sivan R, Kandelis Y, Spira G, Vlodavsky I, Keshet E, and Neufeld G. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272: 7151-7158, 1997.
30. Roberts WG and Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108: 2369-2379, 1995.
31. Rudiger F, Greger R, Nitschke R, Henger A, Mundel P, and Pavenstadt H. Polycations induce calcium signaling in glomerular podocytes. Kidney Int 56: 1700-1709, 1999.
32. Saleem MA, O'Hare MJ, Reiser J, Coward RJ, Inward CD, Farren T, Xing CY, Ni L, Mathieson PW, and Mundel P. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13: 630-638, 2002.
33. Satchell SC, Harper SJ, Tooke JE, Kerjaschki D, Saleem MA, and Mathieson PW. Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor. J Am Soc Nephrol 13: 544-550, 2002.
34. Simon M, Rockl W, Hornig C, Grone EF, Theis H, Weich HA, Fuchs E, Yayon A, and Grone HJ. Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [125I]VEGF binding sites. J Am Soc Nephrol 9: 1032-1044, 1998.
35. Soker S, Gollamudi-Payne S, Fidder H, Charmahelli H, and Klagsbrun M. Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165. J Biol Chem 272: 31582-31588, 1997.
36. Soker S, Takashima S, Miao HQ, Neufeld G, and Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745, 1998.
37. Suga S, Kim YG, Joly A, Puchacz E, Kang DH, Jefferson JA, Abraham JA, Hughes J, Johnson RJ, and Schreiner GF. Vascular endothelial growth factor (VEGF121) protects rats from renal infarction in thrombotic microangiopathy. Kidney Int 60: 1297-1308, 2001.
38. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, and Yancopoulos GD. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6: 460-463, 2000.
39. Webb NJ, Watson CJ, Roberts IS, Bottomley MJ, Jones CA, Lewis MA, Postlethwaite RJ, and Brenchley PE. Circulating vascular endothelial growth factor is not increased during relapses of steroid-sensitive nephrotic syndrome. Kidney Int 55: 1063-1071, 1999.
40. Whittle C, Gillespie K, Harrison R, Mathieson PW, and Harper SJ. Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant. Clin Sci (Colch) 97: 303-312, 1999.
41. Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rosel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister GD, Schirner M, Thierauch KH, Schneider MR, Drevs J, Martiny-Baron G, and Totzke F. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factorinduced responses and tumor growth after oral administration. Cancer Res 60: 2178-2189, 2000.