Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2

Biochemical and Biophysical Research Communications

Volumn 387, Issue 2, 2009, Pages 251-255

  Shin, Niu ^a   Baribaud, Frédéric ^a   Wang, Kathy ^a   Yang, Genjie ^a   Wynn, Rich ^a   Covington, Maryanne B ^a   Feldman, Patricia ^a   Gallagher, Karen B ^a   Leffet, Lynn M ^a   Lo, Yvonne Y ^a   Wang, Anlai ^a   Xue, Chu Biao ^a   Newton, Robert C ^a   Scherle, Peggy A ^a  

^a Experimental Station   (United States)

Author keywords

Antagonist; Binding affinity; Ca++ flux; CCR2; Chemokines; INCB3344; Inflammation; MCP 1; Whole blood assay

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; INCB 3344; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD; CHEMOTAXIS; DISSOCIATION CONSTANT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MONOCYTE; PRIORITY JOURNAL;

BIOLOGICAL ASSAY; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOTAXIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; HUMANS; LEUKOCYTES, MONONUCLEAR; PHOSPHORYLATION; PYRROLIDINES; RECEPTORS, CCR2;

RODENTIA;

EID: 67949083425     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.135     Document Type: Article

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