Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli

American Journal of Physiology - Renal Physiology

Volumn 286, Issue 4 55-4, 2004, Pages

  Banes, Amy K ^a   Shaw, Séan ^a   Jenkins, John ^a   Redd, Heather ^a   Amiri, Farhad ^a   Pollock, David M ^a   Marrero, Mario B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Glomerular mesangial cells; Janus kinase signal transducers and activators of transcription pathway

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HUMAN INSULIN; INSULIN; JANUS KINASE 2; LINPLANT; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERGLYCEMIA; IN VIVO STUDY; MALE; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; SUSTAINED RELEASE PREPARATION; WESTERN BLOTTING;

EID: 1642277116     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00163.2003     Document Type: Article

References (17)

1. A receptor blockade attenuates the hypertension but not the renal dysfunction in DOCA-salt rats. Am J Physiol Regul Integr Comp Physiol 275: R245-R252, 1998.
2. Amiri F and Garcia R. Renal angiotensin II receptors and protein kinase C in diabetic rats: effects of insulin and ACE inhibition. Am J Physiol Renal Physiol 278: F603-F612, 2000.
3. Amiri F, Shaw S, Wang X, Tang J, Waller JL, Eaton DC, and Marrero MB. Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose. Kidney Int 61: 1605-1616, 2002.
4. Amiri F, Venema VJ, Wnag X, Ju H, Venema RC, and Marrero MB. Hyperglycemia enhances angiotensin II-induced Janus-activated kinase/ STAT signaling in vascular smooth muscle cells. J Biol Chem 274: 32382-32386, 1999.
5. Anderson S, Blouch K, Bialek J, Deckert M, Parving HH, and Meyers BD. Glomerular permselectivity in early stages of overt diabetic nephropathy. Kindey Int 58: 2129-2137, 2000.
6. Anderson S, Tarnow L, Rossing P, Hansen BV, and Parving HH. Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy. Kidney Int 57: 601-606, 2000.
7. Bartoli M, Gu X, Tsai NT, Venema RC, Brooks SE, Marrero MB, and Caldwell RB. Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. J Biol Chem 275: 33189-33192, 2000.
8. Darnell JE Jr. STATs and gene regulation. Science 277: 1630-1635, 1997.
9. De Gasparo M, Catt KJ, Inagami T, Wright JW, and Unger T. International Union of Pharmacology XXIII. The angiotensin II receptors. Pharmacol Rev 52: 415-472, 2000.
10. El-Adawi H, Deng L, Tramontano A, Smith S, Mascareno E, Ganguly K, Castillo R, and El-Sherif N. The functional role of the JAK-STAT pathway in post-infarction remodeling. Cardiovasc Res 57: 129-138, 2003.
11. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, and Bernstein KE. Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle proliferation. J Biol Chem 272: 24684-24690, 1997.
12. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, and Bernstein KE. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375: 247-250, 1995.
13. Marrero MB, Venema VJ, Ju H, Eaton DC, and Venema RC. Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. Am J Physiol Cell Physiol 275: C1216-C1223, 1998.
14. Pollock DM and Rekito A. Hypertensive response to chronic NO synthase inhibition is different in Sprague-Dawley rats from two suppliers. Am J Physiol Regul Integr Comp Physiol 275: R1719-R1723, 1998.
15. Ruff-Jamison S, Zhong Z, Wen Z, Chen K, Darnell JE Jr, and Cohen S. Epidermal growth factor and lipopolysaccharide activate STAT3 transcription factor in mouse liver. J Biol Chem 269: 21933-21935, 1994.
16. Wang X, Shaw S, Amiri F, Eaton DC, and Marrero MB. Inhibition of the JAK/STAT signaling pathway prevents the high glucose-induced increase in TGF-β and fibronectin synthesis in mesangial cells. Diabetes 51: 3505-3509, 2002.
17. Zor T and Selinger Z. Linerization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies. Anal Biochem 236: 302-308, 1996.