Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes

Diabetes

Volumn 48, Issue 11, 1999, Pages 2229-2239

  Cooper, Mark E ^a,c   Vranes, Dimitria ^a   Youssef, Sherif ^a   Stacker, Steven A ^b   Cox, Alison J ^a   Rizkalla, Bishoy ^a   Casley, David J ^a   Bach, Leon A ^a   Kelly, Darren J ^a   Gilbert, Richard E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c AUSTIN HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

STREPTOZOCIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; NORTHERN BLOTTING; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BLOTTING, NORTHERN; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; LYMPHOKINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032712434     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.11.2229     Document Type: Article

References (65)

1. Ferrara N, Davissmyth T: The biology of vascular endothelial growth factor. Endocrine Rev 18:4-25, 1997
2. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT: Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A 90:7533-7537, 1993
3. Oelrichs RB, Reid HH, Bernard O, Ziemiecki A, Wilks AF: NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo. Oncogene 8:11-18, 1993
4. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13:9-22, 1999
5. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH: Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995, 1994
6. Monacci WT, Merrill MJ, Oldfield EH: Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J Physiol 264:995-1002, 1993
7. Brenchley PE: VEGF/VPF: a modulator of microvascular function with potential roles in glomerular pathophysiology. J Nephrol 9:10-17, 1996
8. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N: Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89:244-253, 1992
9. Simon M, Rockl W, Hornig C, Grone EF, Theis H, Weich HA, Fuchs E, Yayon A, Grone HJ: Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [I-125] VEGF binding sites. J Am Soc Nephrol 9:1032-1044, 1998
10. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480-1487, 1994
11. Adamis AP, Miller JW, Bernal MT, Damico DJ, Folkman J, Yeo TK, Yeo KT: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthal 118:445-450, 1994
12. Hammes H-P, Lin J, Bretzel RG, Brownlee M, Breier G: Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes 47:401-406, 1998
13. Gilbert RE, Vranes D, Berka JL, Kelly DJ, Cox A, Wu LL, Stacker SA, Cooper ME: Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Lab Invest 78:1017-1027, 1998
14. Gilbert RE, Tsalamandris C, Allen TJ, Colville D, Jerums G: Early nephropathy predicts vision-threatening retinal disease in patients with Type I diabetes mellitus. J Am Soc Nephrol 9:85-89, 1998
15. Del Prete D, Anglani F, Ceol M, D'Angelo A, Forino M, Vianeelo D, Baggio B, Gambaro G: Molecular biology of diabetic glomerulosclerosis. Nephrol Dial Transpl 13 (Suppl. 8):20-25, 1998
16. Cooper ME: Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet 352:213-219, 1998
17. Schmidt FH: Enzymatic determination of glucose and fructose simultaneously. Klin Woch 39:1244-1247, 1961
18. Bunag RD: Validation in awake rats of a tail-cuff method for measuring systolic pressure. J Appl Physiol 34:279-282, 1973
19. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidium thiocynate-phenol-chlorofonn extraction. Anal Biochem 162:156-159, 1987
20. Gilbert RE, Cox A, Wu LL, Allen TJ, Hulthen L, Jerums G, Cooper ME: Expression of transforming growth factor-β1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition. Diabetes 47:414-122, 1998
21. Baskin DG, Stahl WL: Fundamentals of quantitative autoradiography by computer densitometry for in situ hybridisation with emphasis on 33P. J Histochem Cytochem 41:1767-1776, 1993
22. Wookey PJ, Tikellis C, Du HC, Qin HF, Sexton PM, Cooper ME: Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin. Am J Physiol 39:F289-F294, 1996
23. Wu LL, Cox A, Roe CJ, Dziadek M, Cooper ME, Gilbert RE: Secreted protein acidic and rich in cysteine expression after subtotal nephrectomy and blockade of the renin-angiotensin system. J Am Soc Nephrol 8:1373-1382, 1997
24. 131I-labelled human growth hormone of high specific radioactivity. Biochem J 89:114-123, 1963
25. Dean R, Zhuo JL, Alcorn D, Casley D, Mendelsohn FAO: Cellular localization of endothelin receptor subtypes in the rat kidney following in vitro labelling. Clin Exp Pharmacol Physiol 23:524-531, 1996
26. Harris PJ, Cooper ME, Hiranyachattada S, Berka JL, Kelly DJ, Nobes M, Wookey PJ: Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney. Am J Physiol 272:F13-F21, 1997
27. Snedecor GW, Cochran WG: Statistical Methods. 7th ed. Ames, Iowa, Iowa State University Press, 1980, p. 228-236
28. Simon M, Grone HJ, Johren O, Kullmer J, Plate KH, Risau W, Fuchs E: Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol 268:F240-F250, 1995
29. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW: The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5:1806-1814, 1991
30. Seifert RA, Alpers CE, Bowen-Pope DF: Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney. Kidney Int 54:731-746, 1998
31. Zhuo JL, Dean R, Maric C, Aldred PG, Harris P, Alcorn D, Mendelsohn FAO: Localization and interactions of vasoactive peptide receptors in renomedullary interstitial cells of the kidney. Kidney Int 54:S22-S28, 1998
32. Keyt BA, Nguyen HV, Berleau LT, Duarte CM, Park J, Chen H, Ferrara N: Identification of vascular endothelial growth factor determinants for binding kdr and flt-1 receptors: generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem 271:5638-5646, 1996
33. Williams B: A potential role for angiotensin II-induced vascular endothelial growth factor expression in the pathogenesis of diabetic nephropathy? Miner Electrolyte Metab 24:400-405, 1998
34. Takahashi T, Shirasawa T, Miyake K, Yahagi Y, Maruyama N, Kasahara N, Kawamura T, Matsumura O, Mitarai T, Sakai O: Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells. Biochem Biophys Res Commun 209:218-226, 1995
35. Kee N, McTavish AJ, Papillon J, Cybulsky AV: Receptor protein tyrosine kinases in perinatal developing rat kidney. Kidney Int 52:309-317, 1997
36. Williams B, Gallacher B, Patel H, Orme C: Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 46:1497-1503, 1997
37. Aiello LP, Bursell S-E, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LEH, King GL: Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes 46:1473-1480, 1997
38. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell S-E, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:728-731, 1996
39. Bucala R, Vlassara H: Advanced glycosylation end products in diabetic renal and vascular disease. Am J Kidney Dis 26:875-888, 1995
40. Hirata C, Nakano K, Nakamura N, Kitagawa Y, Shigeta H, Hasegawa G, Ogata M, Ikeda T, Sawa H, Nakamura K, Ienaga K, Obayashi H, Kondo M: Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells. Biochem Biophys Res Commun 236:712-715, 1997
41. Lu M, Kuroki M, Amano S, Tolentino M, Keough K, Kim I, Bucala R, Adamis AP: Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest 101:1219-1224, 1998
42. Gruden G, Thomas S, Burt D, Lane S, Chusney G, Sacks S, Viberti GC: Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc Natl Acad Sci U S A 94:12112-12116, 1997
43. Williams B, Baker AQ, Gallacher B, Lodwick D: Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells. Hypertension 25:913-917, 1995
44. Williams B, Quinnbaker A, Gallacher B: Serum and platelet-derived growth factor-induced expression of vascular permeability factor mRNA by human vascular smooth muscle cells in vitro. Clin Sci 88:141-147, 1995
45. Stavri GT, Zachary IC, Baskerville PA, Martin JF, Erusalimsky JD: Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells: synergistic interaction with hypoxia. Circulation 92:11-14, 1995
46. Stavri GT, Hong Y, Zachary IC, Breier G, Baskerville PA, Yla HS, Risau W, Martin JF, Erusalimsky JD: Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells. FEBS Lett 358:311-315, 1995
47. Natarajan R, Bai W, Lanting L, Gonzales N, Nadler J: Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am J Physiol 42:H2224-H2231, 1997
48. Mandriota SJ, Menoud PA, Pepper MS: Transforming growth factor β-1 downregulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J Biol Chem 271:11500-11505, 1996
49. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K: Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269:6271-6274, 1994
50. Gilbert RE, Wilkinson-Berka JL, Johnson DW, Cox A, Soulis T, Wu LL, Kelly DJ, Jerums G, Pollock CA, Cooper ME: Renal expression of transforming growth factor-β inducible gene-h3 (β-ig-h3) in normal and diabetic rats. Kidney Int 54:1052-1062, 1998
51. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA: Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A 90:1814-1818, 1993
52. Vigstrup J, Mogensen CE: Proliferative diabetic retinopathy: at risk patients identified by early detection of microalbuminuria. Acta Ophthalmol (Copenh) 63:530-534, 1985
53. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC: Failure of blood-island formation and vasculogenesis in flk-1-deficient mice. Nature 376:62-66, 1995
54. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380:439-442, 1996
55. Kitamoto Y, Tokunaga H, Tomita K: Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J Clin Invest 99:2351-2357, 1997
56. Grone HJ, Simon M, Grone EF: Expression of vascular endothelial growth factor in renal vascular disease and renal allografts. J Pathol 177:259-267, 1995
57. Klanke B, Simon M, Rockl W, Weich HA, Stolte H, Grone HJ: Effects of vascular endothelial growth factor (VEGF) vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney. Nephrol Dial Transplant 13:875-885, 1998
58. Parving HH, Kastrup J, Smidt UM: Reduced transcapillary escape of albumin during acute blood pressure-lowering in type 1 (insulin-dependent) diabetic patients with nephropathy. Diabetologia 28:797-801, 1985
59. Roberts WG, Palade GE: Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108:2369-2379, 1995
60. Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR: Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest 99:2192-2202, 1997
61. Stephan CC, Chang KC, Lejeune W, Erichsen D, Bjercke RJ, Rege A, Biediger RJ, Kogan TP, Brock TA, Williamson JR, Tilton RG: Role for heparin-binding growth factors in glucose-induced vascular dysfunction. Diabetes 47:1771-1778, 1998
62. Østerby R, Asplund J, Bangstad HJ, Nyberg G, Rudberg S, Viberti G, Walker JD: Neovascularization at the vascular pole region in diabetic glomerulopathy. Nephrol Dial Transplant 14:348-352, 1999
63. Nyengaard JR, Rasch R: The impact of experimental diabetes mellitus in rats on glomerular capillary number and sizes. Diabetologia 36:189-194, 1993
64. Min W, Yamanaka N: Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy. Virchows Arch A Pathol Anat Histopathol 423:201-207, 1993
65. Vranes D, Dilley RJ, Cooper ME: Vascular changes in the diabetic kidney: effects of ACE inhibition. J Diabetes Complications 9:296-300, 1995