메뉴 건너뛰기




Volumn 81, Issue 11, 2012, Pages 1075-1085

Mechanisms of the proteinuria induced by Rho GTPases

Author keywords

cell signaling; glomerular disease; podocyte

Indexed keywords

ACTIN; MESSENGER RNA; NEPHRIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SYNAPTOPODIN;

EID: 84862777971     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.472     Document Type: Article
Times cited : (131)

References (54)
  • 1
    • 0034126357 scopus 로고    scopus 로고
    • Getting a foothold in nephrotic syndrome
    • DOI 10.1038/74139
    • Somlo S, Mundel P. Getting a foothold in nephrotic syndrome. Nat Genet 2000; 24: 333-335. (Pubitemid 30187426)
    • (2000) Nature Genetics , vol.24 , Issue.4 , pp. 333-335
    • Somlo, S.1    Mundel, P.2
  • 2
    • 0035210580 scopus 로고    scopus 로고
    • Caught flat-footed: Podocyte damage and the molecular bases of focal glomerulosclerosis
    • DOI 10.1172/JCI200114629
    • Kerjaschki D. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 2001; 108: 1583-1587. (Pubitemid 33144868)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.11 , pp. 1583-1587
    • Kerjaschki, D.1
  • 5
    • 33744969296 scopus 로고    scopus 로고
    • Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling
    • Asanuma K, Yanagida-Asanuma E, Faul C et al. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol 2006; 8: 485-491.
    • (2006) Nat Cell Biol , vol.8 , pp. 485-491
    • Asanuma, K.1    Yanagida-Asanuma, E.2    Faul, C.3
  • 6
    • 43749116673 scopus 로고    scopus 로고
    • HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein
    • Lu TC, He JC, Wang ZH et al. HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem 2008; 283: 8173-8182.
    • (2008) J Biol Chem , vol.283 , pp. 8173-8182
    • Lu, T.C.1    He, J.C.2    Zh, W.3
  • 7
    • 0034213327 scopus 로고    scopus 로고
    • Rho GTPases and their effector proteins
    • DOI 10.1042/0264-6021:3480241
    • Bishop AL, Hall A. Rho GTPases and their effector proteins. Biochem J 2000; 348(Part 2): 241-255. (Pubitemid 30345195)
    • (2000) Biochemical Journal , vol.348 , Issue.2 , pp. 241-255
    • Bishop, A.L.1    Hall, A.2
  • 9
    • 10944244704 scopus 로고    scopus 로고
    • Rho signalling at a glance
    • DOI 10.1242/jcs.01582
    • Schwartz M. Rho signalling at a glance. J Cell Sci 2004; 117: 5457-5458. (Pubitemid 40012192)
    • (2004) Journal of Cell Science , vol.117 , Issue.23 , pp. 5457-5458
    • Schwartz, M.1
  • 10
    • 12344329603 scopus 로고    scopus 로고
    • Rho signaling in vascular diseases
    • DOI 10.1124/mi.4.6.8
    • Seasholtz TM, Brown JH. RHO SIGNALING in vascular diseases. Mol Interv 2004; 4: 348-357. (Pubitemid 40124382)
    • (2004) Molecular Interventions , vol.4 , Issue.6 , pp. 348-357
    • Seasholtz, T.M.1    Brown, J.H.2
  • 11
    • 0344514708 scopus 로고    scopus 로고
    • Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats
    • DOI 10.1046/j.1523-1755.2003.00300.x
    • Kanda T, Wakino S, Hayashi K et al. Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. Kidney Int 2003; 64: 2009-2019. (Pubitemid 37449535)
    • (2003) Kidney International , vol.64 , Issue.6 , pp. 2009-2019
    • Kanda, T.1    Wakino, S.2    Hayashi, K.3    Homma, K.4    Ozawa, Y.5    Saruta, T.6
  • 13
    • 31544433970 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic strategies of chronic renal injury: Renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis
    • DOI 10.1254/jphs.FMJ05003X5
    • Nishikimi T, Matsuoka H. Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis. J Pharmacol Sci 2006; 100: 22-28. (Pubitemid 43161610)
    • (2006) Journal of Pharmacological Sciences , vol.100 , Issue.1 , pp. 22-28
    • Nishikimi, T.1    Matsuoka, H.2
  • 16
    • 33645455275 scopus 로고    scopus 로고
    • Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling
    • Shibata S, Nagase M, Fujita T. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 2006; 17: 754-764.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 754-764
    • Shibata, S.1    Nagase, M.2    Fujita, T.3
  • 17
    • 67651089825 scopus 로고    scopus 로고
    • Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy
    • Sakurai N, Kuroiwa T, Ikeuchi H et al. Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy. Nephrol Dial Transplant 2009; 24: 2378-2383.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2378-2383
    • Sakurai, N.1    Kuroiwa, T.2    Ikeuchi, H.3
  • 18
    • 40449099586 scopus 로고    scopus 로고
    • Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, fasudil, through podocyte protection and prevention of leukocyte migration
    • DOI 10.2353/ajpath.2008.070196
    • Hidaka T, Suzuki Y, Yamashita M et al. Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am J Pathol 2008; 172: 603-614. (Pubitemid 351354534)
    • (2008) American Journal of Pathology , vol.172 , Issue.3 , pp. 603-614
    • Hidaka, T.1    Suzuki, Y.2    Yamashita, M.3    Shibata, T.4    Tanaka, Y.5    Horikoshi, S.6    Tomino, Y.7
  • 19
    • 58149269398 scopus 로고    scopus 로고
    • Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats
    • Koshikawa S, Nishikimi T, Inaba C et al. Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. J Hypertens 2008; 26: 1837-1848.
    • (2008) J Hypertens , vol.26 , pp. 1837-1848
    • Koshikawa, S.1    Nishikimi, T.2    Inaba, C.3
  • 20
    • 80052333245 scopus 로고    scopus 로고
    • Activation of RhoA in podocytes induces focal segmental glomerulosclerosis
    • Zhu L, Jiang R, Aoudjit L et al. Activation of RhoA in podocytes induces focal segmental glomerulosclerosis. J Am Soc Nephrol 2011; 22: 1621-1630.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1621-1630
    • Zhu, L.1    Jiang, R.2    Aoudjit, L.3
  • 21
    • 0031898727 scopus 로고    scopus 로고
    • Inducible gene expression in the nervous system of transgenic mice
    • DOI 10.1146/annurev.neuro.21.1.377
    • Gingrich JR, Roder J. Inducible gene expression in the nervous system of transgenic mice. Annu Rev Neurosci 1998; 21: 377-405. (Pubitemid 28150668)
    • (1998) Annual Review of Neuroscience , vol.21 , pp. 377-405
    • Gingrich, J.R.1    Roder, J.2
  • 23
    • 0034857627 scopus 로고    scopus 로고
    • TAT-mediated protein transduction into mammalian cells
    • DOI 10.1006/meth.2001.1186
    • Becker-Hapak M, McAllister SS, Dowdy SF. TAT-mediated protein transduction into mammalian cells. Methods 2001; 24: 247-256. (Pubitemid 32846431)
    • (2001) Methods , vol.24 , Issue.3 , pp. 247-256
    • Becker-Hapak, M.1    McAllister, S.S.2    Dowdy, S.F.3
  • 24
    • 0030816323 scopus 로고    scopus 로고
    • Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes
    • DOI 10.1083/jcb.139.1.193
    • Mundel P, Heid HW, Mundel TM et al. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 1997; 139: 193-204. (Pubitemid 27444091)
    • (1997) Journal of Cell Biology , vol.139 , Issue.1 , pp. 193-204
    • Mundel, P.1    Heid, H.W.2    Mundel, T.M.3    Kruger, M.4    Reiser, J.5    Kriz, W.6
  • 25
    • 34147093748 scopus 로고    scopus 로고
    • Rho kinase in the regulation of cell death and survival
    • DOI 10.1007/s00005-007-0009-7
    • Shi J, Wei L. Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) 2007; 55: 61-75. (Pubitemid 46559196)
    • (2007) Archivum Immunologiae et Therapiae Experimentalis , vol.55 , Issue.2 , pp. 61-75
    • Shi, J.1    Wei, L.2
  • 26
    • 39349104907 scopus 로고    scopus 로고
    • Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes
    • DOI 10.1038/sj.ki.5002691, PII 5002691
    • Zhu J, Sun N, Aoudjit L et al. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 2008; 73: 556-566. (Pubitemid 351264104)
    • (2008) Kidney International , vol.73 , Issue.5 , pp. 556-566
    • Zhu, J.1    Sun, N.2    Aoudjit, L.3    Li, H.4    Kawachi, H.5    Lemay, S.6    Takano, T.7
  • 30
    • 0035164681 scopus 로고    scopus 로고
    • The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death
    • Putaala H, Soininen R, Kilpelainen P et al. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 2001; 10: 1-8. (Pubitemid 32051561)
    • (2001) Human Molecular Genetics , vol.10 , Issue.1 , pp. 1-8
    • Putaala, H.1    Soininen, R.2    Kilpelainen, P.3    Wartiovaara, J.4    Tryggvason, K.5
  • 32
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: A unifying view of glomerular diseases
    • DOI 10.1038/sj.ki.5002222, PII 5002222
    • Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007; 71: 1205-1214. (Pubitemid 46884251)
    • (2007) Kidney International , vol.71 , Issue.12 , pp. 1205-1214
    • Wiggins, R.C.1
  • 36
    • 0033807362 scopus 로고    scopus 로고
    • Nephrin in experimental glomerular disease
    • Luimula P, Ahola H, Wang SX et al. Nephrin in experimental glomerular disease. Kidney Int 2000; 58: 1461-1468.
    • (2000) Kidney Int , vol.58 , pp. 1461-1468
    • Luimula, P.1    Ahola, H.2    Wang, S.X.3
  • 38
    • 43049142649 scopus 로고    scopus 로고
    • Beneficial effects of the rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis
    • DOI 10.1159/000121531
    • Wang L, Ellis MJ, Fields TA et al. Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. Kidney Blood Press Res 2008; 31: 111-121. (Pubitemid 351630068)
    • (2008) Kidney and Blood Pressure Research , vol.31 , Issue.2 , pp. 111-121
    • Wang, L.1    Ellis, M.J.2    Fields, T.A.3    Howell, D.N.4    Spurney, R.F.5
  • 40
    • 0032929050 scopus 로고    scopus 로고
    • The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV- associated nephropathy
    • Barisoni L, Kriz W, Mundel P et al. The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999; 10: 51-61. (Pubitemid 29034942)
    • (1999) Journal of the American Society of Nephrology , vol.10 , Issue.1 , pp. 51-61
    • Barisoni, L.1    Kriz, W.2    Mundel, P.3    D'Agati, V.4
  • 41
    • 58149361842 scopus 로고    scopus 로고
    • Signaling in regulation of podocyte phenotypes
    • Chuang PY, He JC. Signaling in regulation of podocyte phenotypes. Nephron Physiol 2009; 111: p9-p15.
    • (2009) Nephron Physiol , vol.111
    • Chuang, P.Y.1    He, J.C.2
  • 42
    • 33646401549 scopus 로고    scopus 로고
    • Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization
    • Verma R, Kovari I, Soofi A et al. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 2006; 116: 1346-1359.
    • (2006) J Clin Invest , vol.116 , pp. 1346-1359
    • Verma, R.1    Kovari, I.2    Soofi, A.3
  • 43
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte's response to injury: Role in proteinuria and glomerulosclerosis
    • DOI 10.1038/sj.ki.5000410, PII 5000410
    • Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006; 69: 2131-2147. (Pubitemid 43882099)
    • (2006) Kidney International , vol.69 , Issue.12 , pp. 2131-2147
    • Shankland, S.J.1
  • 44
    • 0035175276 scopus 로고    scopus 로고
    • Synaptopodin expression in idiopathic nephrotic syndrome of childhood
    • DOI 10.1046/j.1523-1755.2001.00472.x
    • Srivastava T, Garola RE, Whiting JM et al. Synaptopodin expression in idiopathic nephrotic syndrome of childhood. Kidney Int 2001; 59: 118-125. (Pubitemid 32055220)
    • (2001) Kidney International , vol.59 , Issue.1 , pp. 118-125
    • Srivastava, T.1    Garola, R.E.2    Whiting, J.M.3    Alon, U.S.4
  • 45
    • 33644783770 scopus 로고    scopus 로고
    • Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • DOI 10.2337/diabetes.55.1.225
    • Susztak K, Raff AC, Schiffer M et al. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225-233. (Pubitemid 43343319)
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 225-233
    • Susztak, K.1    Raff, A.C.2    Schiffer, M.3    Bottinger, E.P.4
  • 47
    • 20044362239 scopus 로고    scopus 로고
    • From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy
    • DOI 10.2337/diabetes.54.6.1626
    • Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes 2005; 54: 1626-1634. (Pubitemid 40770751)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1626-1634
    • Wolf, G.1    Chen, S.2    Ziyadeh, F.N.3
  • 50
    • 55749103377 scopus 로고    scopus 로고
    • Gq-dependent signaling upregulates COX2 in glomerular podocytes
    • Wang L, Flannery PJ, Rosenberg PB et al. Gq-dependent signaling upregulates COX2 in glomerular podocytes. J Am Soc Nephrol 2008; 19: 2108-2118.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2108-2118
    • Wang, L.1    Flannery, P.J.2    Rosenberg, P.B.3
  • 51
    • 79960972131 scopus 로고    scopus 로고
    • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo
    • Wang L, Chang JH, Paik SY et al. Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. Mol Endocrinol 2011; 25: 1376-1386.
    • (2011) Mol Endocrinol , vol.25 , pp. 1376-1386
    • Wang, L.1    Chang, J.H.2    Paik, S.Y.3
  • 52
    • 0032561487 scopus 로고    scopus 로고
    • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor
    • DOI 10.1074/jbc.273.43.28496
    • Spurney RF. Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. J Biol Chem 1998; 273: 28496-28503. (Pubitemid 28496156)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.43 , pp. 28496-28503
    • Spurney, R.F.1
  • 53
    • 69449105718 scopus 로고    scopus 로고
    • Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2)
    • Wang L, Gesty-Palmer D, Fields TA et al. Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). Wang L, Gesty-Palmer D, Fields T Mol Endocrinol 2009; 23: 1455-1465.
    • (2009) T Mol Endocrinol , vol.23 , pp. 1455-1465
    • Wang, L.1    Gesty-Palmer, D.2    Fields, T.A.3
  • 54
    • 0018969926 scopus 로고
    • Some statistical methods useful in circulation research
    • Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res 1980; 47: 1-9. (Pubitemid 10046307)
    • (1980) Circulation Research , vol.47 , Issue.1 , pp. 1-9
    • Wallenstein, S.1    Zucker, C.L.2    Fleiss, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.