Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes

Journal of Clinical Investigation

Volumn 107, Issue 7, 2001, Pages 889-898

  Komers, Radko ^a   Lindsley, Jessie N ^a   Oyama, Terry T ^a   Schutzer, William E ^b   Reed, John F ^b   Mader, Scott L ^b   Anderson, Sharon ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; STREPTOZOCIN; THROMBOXANE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; EXPERIMENTAL DIABETES MELLITUS; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; KIDNEY BLOOD FLOW; KIDNEY CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URINARY EXCRETION;

EID: 0035057565     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10228     Document Type: Article

References (71)

1. Increased ptostaglandin production by glomeruli isolated from tats with streptozotocin-induced diabetes mellitus
2. Renal hemodynamic abnormalities in patients with short term insulin-dependent diabetes mellitus
3. Effects of indomethacin on kidney function in type 1 (insulin-dependent) diabetic patients with nephropathy
4. Renal hemodynamics and urinary excretion of 6-keto-prostaglandin F1 alpha and thromboxane B2 in newly diagnosed type 1 diabetic patients
5. Glomerular hyperfiltration and urinary prostaglandins in type 1 diabetes mellitus
6. Glucose-induced increases in renal hemodynamic function. Possible modulation by renal prostaglandins
7. Effects of indomethacin on glomerular hemodynamics in experimental diabetes
8. Effect of aspirin on experimental diabetic nephropathy
9. Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: Relationship to the hyperfiltration of early diabetes
10. Atrial natriuretic peptide and prostacyclin synergistically mediate hyperfiltration and hyperperfusion of diabetic rats
11. Thromboxane in the pathogenesis of glomerular injury in diabetes
12. Acute and chronic effects of thromboxane A2 inhibition on the renal hemodynamics in streptozotocin-induced diabetic rats
13. Effects of thromboxane synthesis inhibitor triflusal on renal hemodynamics in microalbuminuric diabetic patients
14. Effect of thromboxane synthase inhibitor on renal function in diabetic nephropathy
15. Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex
16. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells
17. Structure of the mitogen-inducible TIS 10 gene and demonstration that the TIS 10-encoded protein is a functional prostaglandin G/H synthase
18. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction
19. Renal identification of cyclooxygenase-2 in a subset of thick ascending limb cells
20. Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: Implication for renal function
21. Selective increase of cyclooxygenase-2 expression in a model of renal ablation
22. Cyclooxygenase-2 participates in tubular flow-dependent afferent arteriolar tone: Interaction with neuronal NOS
23. Cyclooxygenase-2 modulates afferent arteriolar responses to increases in pressure
24. Cyclooxygenase-2 mediates increased renal renin content by low-sodium diet
25. Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension
26. Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2
27. Glomerular hemodynamics in experimental diabetes mellitus
28. Prevention of diabetic glomerulopathy by pharmacological ameliotation of glomerular capillary hypertension
29. Superoxide dismutase testores the influence of nitric oxide on renal arterioles in diabetes mellitus
30. Effect of modest hyperglycemia on tubuloglomerular feedback activity
31. Control of renal hemodynamics in hyperglycemia: Possible role of tubuloglomerular feedback
32. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats
33. Impaired myogenic responsiveness of the efferent arteriole in streptozotocin-induced diabetic rats: Role of eicosanoid derangements
34. Physiologic actions and molecular expression of the renin-angiotensin system in the diabetic rat
35. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid
36. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic
37. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes: Effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels
38. EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles
39. Vasoregulatory hormones and the hyperfiltration of diabetes
40. Thromboxane synthesis and action within the kidney
41. Eicosanoids in the pathogenesis of the functional and structural alterations of the kidney in diabetes
42. Role of prostaglandins on the renal effects of angiotensin and interstitial pressure during volume expansion
43. Paracrine regulation of the renal microcirculation
44. Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells
45. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
46. Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells
47. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression
48. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride
49. Glomerular p38 mitogen-activated protein kinase activity (MAPK) and MAPK kinase (MKK) 3/6 mRNA expression and activity are increased in early diabetic nephropathy
50. Activation of p38 MAPK in the diabetic kidney via MKK3 dependent pathway
51. Possible role of glycated albumin filtered during diabetic glomerulopathy, in the activation of tubular cells and progression of diabetic nephropathy
52. Angiotensin II control of the renal microcirculation in rats with reduced renal mass
53. Renin expression in renal ablation
54. Renal renin-angiotensin system in diabetes: Functional, immunohistochemical, and molecular biological correlations
55. Nifedipine versus fosinopril in uninephrectomized diabetic rats
56. Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat
57. Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system
58. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass
59. Fosinopril ameliorates exogenous cholesterol-induced incipient glomerular lesions in obese Zucker rats. Effects on eicosanoid secretion
60. Dietary protein intake modulates glomerular eicosanoid production in the rat
61. Mechanism of enhanced eicosanoid production by isolated glomeruli from rats with bilateral ureteral obstruction
62. Inhibition of the renin-angiotensin system upregulates cyclooxygenase-2 expression in the macula densa
63. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase
64. Angiotensinogen and AT(1) antisense inhibition of osteopontin translation in rat proximal tubular cells
65. Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus
66. Nitric oxide synthase in macula densa regulates glomerular capillary pressure
67. Role of neuronal NOS (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes
68. Effects of systemic inhibition of neuronal nitric oxide synthase in diabetic rats
69. Effects of nonsteroidal anti-inflammatory drugs on renal function: Focus on cyclooxygenase-2-selective inhibition
70. Effect of cyclooxygenase-2 inhibition on renal function after renal ablation
71. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats