Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension

Journal of Clinical Investigation

Volumn 99, Issue 6, 1997, Pages 1380-1389

  Hocher, Berthold ^a,b   Thöne Reineke, Christa ^b   Rohmeiss, Peter ^c   Schmager, Fred ^d   Slowinski, Torsten ^a,b   Burst, Volker ^c   Siegmund, Fred ^d   Quertermous, Thomas ^e   Bauer, Christian ^b   Neumayer, Hans Hellmut ^a   Schleuning, Wolf Dieter ^d   Theuring, Franz ^d,f  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d BAYER PHARMA AG   (Germany)

^e VANDERBILT UNIVERSITY   (United States)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

blood pressure; glomerular filtration rate; glomerulosclerosis; human endothelin 1 transgenic mice; renal cysts

Indexed keywords

COMPLEMENTARY DNA; ENDOTHELIN 1; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; KIDNEY CYST; KIDNEY FIBROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TRANSGENE; TRANSGENIC MOUSE;

EID: 1842411863     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119297     Document Type: Article

References (35)

1. Kohan, D. 1993. Endothelins in the kidney: physiology and pathophysiology. American Journal of Kidney Diseases. 22:493-510.
2. Hocher, B., R. Zart, F. Diekmann, P. Rohmeiss, A. Distler, H.-H. Neumayer, C. Bauer, and P. Gross. 1996. Paracrine renal endothelin system in rats with liver cirrhosis. Br. J. Pharmacol. 118:220-227.
3. Lüscher, T.F., B.C. Seo, and F.R. Bühler. 1993. Potential role of endothelin in hypertension. Controversy on endothelin in hypertension. Hypertension. 26:752-757.
4. Hocher, B., P. Rohmeiss, R. Zart, F. Diekmann, V. Vogt, D. Metz, M. Fakhury, K. Koppenhagen, N. Gretz, C. Bauer, H.-H. Neumayer, and A. Distler. 1996. Function and expression of endothelin receptor subtypes in the kidneys of spontaneously hypertensive rats. Cardiovasc. Res. 31:499-510.
5. Mattana, J., and R.P. Singhal. 1995. L-arginine supplementation antagonizes the effects of angiotensin II and endothelin 1 on mesangial cell proliferation. Cell. Physiol. Biochem. 5:176-192.
6. Ruiz-Ortega, M., D. Gomez-Garre, R. Alcazar, I. Palacios, C. Bustos, S. Gonzalez, J.J. Plaza, E. Gonzalez, and J. Egido. 1994. Involvement of angiotensin II and endothelin in matrix protein production and renal sclerosis. J. Hypertens. 12:S51-58.
7. Murer, L., G. Zacchello, G. Basso, A. Scarpa, G. Montini, M.L. Chiozza, and F. Zacchello. 1994. Immunohistochemical distribution of endothelin in biopsies of pediatric nephrotic syndrome. Am. J. Nephrol. 14:157-161.
8. Orisio, S. 1993. Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. Kidney Int. 43:354-358.
9. Roccatello, D., R. Mosso, M. Ferro, R. Polloni, P.G. De Filippi, G. Quattrocchio, E. Bancale, G. Cesano, L.M. Sena, and G. Piccoli. 1994. Urinary endothelin in glomeruloncphritis patients with normal renal function. Clin. Nephrol. 41:323-330.
10. Bloch, K.D., S.P. Friedrich, M.E. Lee, R.L. Eddy, T.B. Shows, and T. Quertermous. 1989. Structural organization and chromosomal assignment of the gene encoding endothelin. J. Biol. Chem. 264:10851-10857.
11. Theuring, F., W. Götz, R. Balling, H.W. Korf, F. Schulze, R. Herken, and P. Gruss. 1989. Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen. Oncogene. 5:225-232.
12. 4-induced liver injury. Eur. J. Pharmacol. 293:361-368.
13. Raij, L., S. Azar, and W. Keane. 1984. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int. 26:137-143.
14. Yamamoto, T., N.A. Noble, D.E. Miller, and W. Border. 1994. Sustained expression of TGF-betal underlies development of progressive kidney fibrosis. Kidney Int. 45:916-927.
15. Schiffrin, E.L., R. Lariviere, and J.S. Li. 1995. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and serves vascular hypertrophy in spontaneously hypertensive rats. Hypertension (Dallas). 25: 769-773.
16. Télémaque, S., D. de Wit, and M. Yanagisawa. 1996. Elevated systemic blood pressure via adenovirus-mediated overexpression of endothelin-1 is mediated by the ETA receptors in anesthetized rats. Eur. J. Clin. Invest. 26(Suppl. 1):A47. (Abstr.)
17. Gellai, M.R., R. DeWolf, M. Pullen, and P. Nambi. 1994. Distribution and functional role of renal ET receptors subtypes in normotensive and hypertensive rats. Kidney Int. 46:1287-1294.
18. Bazil, M.K., R.W. Lappe, and R.L. Webb. 1992. Pharmacologic characterization of an endothelin A (ETA) receptor antagonist in conscious rats. J. Cardiovas. Pharmacol. 20:940-948.
19. Li, J.S., and E.L. Schiffrin. 1995. Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension (Dallas). 25:495-500.
20. Hirata, Y., T. Emori, S. Eguchi, K. Kanno, T. Imai, K. Ohta, and F. Marumo. 1993. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest. 91:1367-1373.
21. Kohan, D.E., and E. Padilla. 1994. Endothelin-1 production by rat inner medullary collecting duct: effect of nitric oxide, cGMP. and immune cytokines. Am. J. Physiol. 266:F291-F297.
22. Moritoki, H., H. Miyano, S. Takeuchi, M. Yamaguchi, T. Hisayama, and W. Kondoh. 1993. Endothelin-3-induced relaxation of rat thoracic aorta: a role for nitric oxide formation. Br. J. Pharmacol. 108:1125-1130.
23. Kurihara, Y., H. Kurihara, H. Suzuki, T. Kodama, K. Maemura, R. Nagal, H. Oda, T. Kuwaki, W.H. Cao, N. Kamada, et al. 1994. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature (Lond.). 368:703-710.
24. Sibilia, M., and E.F. Wagner. 1995. Strain-dependent epithelial defects in mice lacking the EGF-receptor. Science (Wash. DC). 269:234-238.
25. Schäfer, K., M. Bader, N. Gretz, I. Oberbäumer, and S. Bachmann. 1994. Focal overexpression of collagen 4 characterizes the initiation of epithelial changes in polycystic kidney disease. Exp. Nephrol. 2:190-195.
26. Carone, F.A., R.J. Butkowski, S. Nakamura, M. Polenakovic, and Y.S. Kanwar. 1994. Tubular basement membrane changes during induction and regression of drug-induced polycystic kidney disease. Kidney Int. 46:1368-1374.
27. Carone, F.A., R. Bacallao, and Y.S. Kanwar. 1995. The pathogenesis of polycystic kidney disease. Histol. Histopathol. 10:213-221.
28. Benigni, A., C. Zoja, D. Corna, S. Orisio, L. Longaretti, T. Berlani, and G. Remuzzi. 1993. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int. 44:440-444.
29. Nakamura, T., Y. Ebihara, Y. Tomino, and H. Koide. 1995. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Kidney Int. 47:481-489.
30. Hocher, B., L. Liefeldt, C. Thöne-Reineke, H.-D. Orzekowski, A. Distler, C. Bauer, and M. Paul. 1996. Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene. Hypertension (Dallas). 28:196-201.
31. Nath, K.A. 1992. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am. J. Kidney Dis. 20:1-17.
32. Riston, R.A., J.C. Sloper, and H.E. de Wardener. 1968. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet. ii:363-366.
33. Wehrmann, M., A. Bohle, O. Bogenschütz, R. Eissrle, A. Freislederer, C. Öhlschlegel, G. Schumm, C. Batz, and H.V. Gärtner. 1989. Long-term progression of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes. Clin. Nephrol. 31: 67-76.
34. Nassar, G.M., and K.F. Badr. 1994. Endothelin in kidney disease. Cur. Opin. Nephrol. Hypertens. 31:86-91.
35. Ong, A.C.M., T.P. Jowett, J.D. Firth, S. Burton, F.E. Karet, and L.G. Fine. 1995. An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney Int. 48:390-401.