Inhibition of the JAK/STAT signaling pathway prevents the high glucose-induced increase in TGF-β and fibronectin synthesis in mesangial cells

Diabetes

Volumn 51, Issue 12, 2002, Pages 3505-3509

  Wang, Xiaodan ^a   Shaw, Seán ^a   Amiri, Farhad ^a   Eaton, Douglas C ^b   Marrero, Mario B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FIBRONECTIN; GLUCOSE; JANUS KINASE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; HUMAN; HUMAN CELL; MESANGIUM CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036894194     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.12.3505     Document Type: Article

References (17)

1. Oh JH, Ha H, Yu MR, Lee HB: Sequential effects of high glucose on mesangial cell transforming growth factor-beta1 and fibronectin synthesis. Kidney Int 54:1872-1878, 1998
2. Kim SI, Han DC, Lee HB: Lovastatin inhibits transforming growth factor-β1 expression in diabetic rat glomeruli and cultured rat mesangial cells. J Am Soc Nephrol 11:80-87, 2000
3. Derubertis FR, Craven PA: Activation of protein kinase C in glomerular cells in diabetes: Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43:1-8, 1994
4. Kapor-Drezgic J, Zhou X, Babazono T, Dlugosz JA, Hohman T, Whiteside C: Effects of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. J Am Soc Nephrol 10:1193-1203, 1999
5. Ha H, Lee HB: Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int 58:S19-S25, 2000
6. Haneda M, Kikkawa R, Sugimoto T, Koya D, Araki S, Togawa S, Shigeta Y: Abnormalities in protein kinase C and MAP kinase cascade in mesangial cells cultured under high glucose conditions. J Diabetes Complications 9:246-248, 1995
7. Amiri F, Venema VJ, Wang X, Ju H, Venema RC, Marrero MB: Hyperglycemia enhances angiotensin II-induced janus-activated kinase/STAT signaling in vascular smooth muscle cells. J Biol Chem 274:32382-32386, 1999
8. Marrero MB, Schieffer B, Li B, Sun J, Harp JB, Ling BN: Role of janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J Biol Chem 272:24684-24690, 1997
9. Huang JS, Guh JY, Chen HC, Hung WC, Lai YH, Chuang LY: Role of receptor for advance glycation end-products (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells. J Cell Biochem 81:102-113, 2001
10. - channels in mesangial cells. Am J Physiol 270:C1834-C1842, 1996
11. Amiri F, Shaw S, Wang X, Tang J, Waller JL, Eaton DC, Marrero MB: Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose. Kidney Int 61:1605-1616, 2002
12. Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ: Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 102:1385-1392, 1998
13. Spector T: Refinement of the Coomassie blue method of protein quantification. Anal Biochem 86:142-146, 1978
14. Venema RC, Venema VJ, Eaton DC, Marrero MB: Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1. J Biol Chem 273:30795-30800, 1998
15. Darnell JE, Jr: STATs and gene regulation. Science 277:1630-1635, 1997
16. Simon AR, Rai U, Fanburg BL, Cochran BH: Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol 275:C1640-C1652, 1998
17. Schieffer B, Luchtefeld M, Braun S, Hilfiker A, Hilfiker-Kleiner D, Drexler H: Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ Res 87:1195-1201, 2001