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Volumn 78, Issue 9, 2010, Pages 883-894

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

Author keywords

HOMA IR; LPO; MCP 1; renal lipid metabolism

Indexed keywords

8 ISOPROSTANE; ALBUMIN; CHOLESTEROL; INSULIN; LIPID; LIPID HYDROPEROXIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; RS 04393; RS 504393; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 77958102050     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.263     Document Type: Article
Times cited : (101)

References (48)
  • 1
    • 32444451549 scopus 로고    scopus 로고
    • Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    • Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 2006; 116: 288-296.
    • (2006) J Clin Invest , vol.116 , pp. 288-296
    • Remuzzi, G.1    Benigni, A.2    Remuzzi, A.3
  • 2
    • 33645454310 scopus 로고    scopus 로고
    • Leukocyte recruitment and vascular injury in diabetic nephropathy
    • Galkina E, Ley K. Leukocyte recruitment and vascular injury in diabetic nephropathy. J Am Soc Nephrol 2006; 17: 368-377.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 368-377
    • Galkina, E.1    Ley, K.2
  • 3
    • 33845405589 scopus 로고    scopus 로고
    • Inflammation and diabetic nephropathy
    • Mora C, Navarro JF. Inflammation and diabetic nephropathy. Curr Diab Rep 2006; 6: 463-468.
    • (2006) Curr Diab Rep , vol.6 , pp. 463-468
    • Mora, C.1    Navarro, J.F.2
  • 4
    • 0025829825 scopus 로고
    • The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis
    • Bohle A, Wehrmann M, Bogenschutz O et al. The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis. Pathol Res Pract 1991; 187: 251-259.
    • (1991) Pathol Res Pract , vol.187 , pp. 251-259
    • Bohle, A.1    Wehrmann, M.2    Bogenschutz, O.3
  • 5
    • 0027231859 scopus 로고
    • The role of macrophages in diabetic glomerulosclerosis
    • Furuta T, Saito T, Ootaka T et al. The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis 1993; 21: 480-485.
    • (1993) Am J Kidney Dis , vol.21 , pp. 480-485
    • Furuta, T.1    Saito, T.2    Ootaka, T.3
  • 6
    • 33646366660 scopus 로고    scopus 로고
    • Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
    • Han SY, Kim CH, Kim HS et al. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. J Am Soc Nephrol 2006; 17: 1362-1372.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1362-1372
    • Han, S.Y.1    Kim, C.H.2    Kim, H.S.3
  • 7
    • 0034101762 scopus 로고    scopus 로고
    • Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats
    • Sassy-Prigent C, Heudes D, Mandet C et al. Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats. Diabetes 2000; 49: 466-475.
    • (2000) Diabetes , vol.49 , pp. 466-475
    • Sassy-Prigent, C.1    Heudes, D.2    Mandet, C.3
  • 8
    • 38449122654 scopus 로고    scopus 로고
    • The role of chemokines and chemokine receptors in diabetic nephropathy
    • Ruster C, Wolf G. The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci 2008; 13: 944-955.
    • (2008) Front Biosci , vol.13 , pp. 944-955
    • Ruster, C.1    Wolf, G.2
  • 9
    • 0033971775 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies
    • Segerer S, Nelson PJ, Schlondorff D. Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000; 11: 152-176.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 152-176
    • Segerer, S.1    Nelson, P.J.2    Schlondorff, D.3
  • 10
    • 34447534187 scopus 로고    scopus 로고
    • Inhibition of MCP-1/CCR2 pathway ameliorates the development ofdiabetic nephropathy
    • Kanamori H, Matsubara T, Mima A et al. Inhibition of MCP-1/CCR2 pathway ameliorates the development ofdiabetic nephropathy. Biochem Biophys Res Commun 2007; 360: 772-777.
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 772-777
    • Kanamori, H.1    Matsubara, T.2    Mima, A.3
  • 11
    • 36648999997 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 has prosclerotic effect both in a mouse model of experimental diabetes and in vitro in human mesangial cells
    • Giunti S, Tesch GH, Pinach S et al. Monocyte chemoattractant protein-1 has prosclerotic effect both in a mouse model of experimental diabetes and in vitro in human mesangial cells. Diabetologia 2008; 51: 198-207.
    • (2008) Diabetologia , vol.51 , pp. 198-207
    • Giunti, S.1    Tesch, G.H.2    Pinach, S.3
  • 12
    • 34447344360 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice
    • Chow FY, Nikolic-Paterson DJ, Ma FY et al. Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia 2007; 50: 471-480.
    • (2007) Diabetologia , vol.50 , pp. 471-480
    • Chow, F.Y.1    Nikolic-Paterson, D.J.2    Ma, F.Y.3
  • 13
    • 28544451946 scopus 로고    scopus 로고
    • Role of aldosterone in diabetic nephropathy
    • Cha DR, Kang YS, Han SY et al. Role of aldosterone in diabetic nephropathy. Nephrology 2005; 10(Suppl 2): S37-S39.
    • (2005) Nephrology , vol.10 , Issue.SUPPL. 2
    • Cha, D.R.1    Kang, Y.S.2    Han, S.Y.3
  • 14
    • 0033674097 scopus 로고    scopus 로고
    • Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis
    • Segerer S, Cui Y, Hudkins KL et al. Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis. J Am Soc Nephrol. 2000. 11. 2231-2242
    • (2000) J Am Soc Nephrol , vol.11 , pp. 2231-2242
    • Segerer, S.1    Cui, Y.2    Hudkins, K.L.3
  • 15
    • 0034998747 scopus 로고    scopus 로고
    • Obstructive nephropathy in the mouse: Progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2-and 5-positive leukocytes
    • Vielhauer V, Anders HJ, Mack M et al. Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2-and 5-positive leukocytes.J Am Soc Nephrol 2001; 12: 1173-1187.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1173-1187
    • Vielhauer, V.1    Anders, H.J.2    MacK, M.3
  • 16
    • 0026021161 scopus 로고
    • Insulin resistance A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 17
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
    • Ferrante Jr AW. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007; 262: 408-414.
    • (2007) J Intern Med , vol.262 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 18
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett 2006; 580: 2917-2921.
    • (2006) FEBS Lett , vol.580 , pp. 2917-2921
    • Matsuzawa, Y.1
  • 19
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007; 447: 1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3
  • 20
    • 20844458389 scopus 로고    scopus 로고
    • Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes
    • Dalla Vestra M, Mussap M, Gallina P et al. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. J Am Soc Nephrol 2005; 16(Suppl. 1): S78-S82.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.SUPPL. 1
    • Dalla Vestra, M.1    Mussap, M.2    Gallina, P.3
  • 21
    • 0033806619 scopus 로고    scopus 로고
    • Up-regulation of monocyte chemo-attractant protein-1 in tubulo-interstitial lesions of human diabetic nephropathy
    • Wada T, Furuichi K, Sakai N et al. Up-regulation of monocyte chemo-attractant protein-1 in tubulo-interstitial lesions of human diabetic nephropathy. Kidney Int 2000; 58: 1492-1499.
    • (2000) Kidney Int , vol.58 , pp. 1492-1499
    • Wada, T.1    Furuichi, K.2    Sakai, N.3
  • 22
    • 57549087753 scopus 로고    scopus 로고
    • Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice
    • Tamura Y, Sugimoto M, Murayama T et al. Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice. Arterioscler Thromb Vasc Biol 2008; 28: 2195-2201.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2195-2201
    • Tamura, Y.1    Sugimoto, M.2    Murayama, T.3
  • 23
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844-1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 24
    • 70149111743 scopus 로고    scopus 로고
    • Role of MCP-1 in cardiovascular disease: Molecular mechanisms and clinical implications
    • Niu J, Kolattukudy PE. Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. Clin Sci2009; 117: 95-109.
    • (2009) Clin Sci , vol.11 , pp. 95-109
    • Niu, J.1    Kolattukudy, P.E.2
  • 25
    • 48249108656 scopus 로고    scopus 로고
    • Lipid homeostasis in macrophages-implications for atherosclerosis
    • Schmitz G, Grandl M. Lipid homeostasis in macrophages-implications for atherosclerosis. Rev Physiol Biochem Pharmacol 2008; 160: 93-125.
    • (2008) Rev Physiol Biochem Pharmacol , vol.160 , pp. 93-125
    • Schmitz, G.1    Grandl, M.2
  • 26
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH. Lipotoxic diseases. Annu Rev Med 2002; 53: 319-336.
    • (2002) Annu Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 27
    • 0038691972 scopus 로고    scopus 로고
    • Low-grade systemic inflammation and the development oftype 2 diabetes: The Atherosclerosis Risk in Communities study
    • Atherosclerosis Risk in Communities Study
    • Duncan BB, Schmidt MI, Pankow JS et al. Atherosclerosis Risk in Communities Study. Low-grade systemic inflammation and the development oftype 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes 2003; 52: 1799-1805.
    • (2003) Diabetes , vol.52 , pp. 1799-1805
    • Duncan, B.B.1    Schmidt, M.I.2    Pankow, J.S.3
  • 28
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286: 327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3
  • 29
    • 0033562455 scopus 로고    scopus 로고
    • Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): A cohort study
    • Schmidt MI, Duncan BB, Sharrett AR et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 353: 1649-1652.
    • (1999) Lancet , vol.353 , pp. 1649-1652
    • Schmidt, M.I.1    Duncan, B.B.2    Sharrett, A.R.3
  • 30
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003; 52: 812-817.
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3
  • 31
    • 17844366621 scopus 로고    scopus 로고
    • Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance
    • Haffner S. Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance. Diabetes 2005; 54: 1566-1572.
    • (2005) Diabetes , vol.54 , pp. 1566-1572
    • Haffner, S.1
  • 32
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998; 83: 847-850.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 33
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan CM, Bailey ST, Bhat S et al. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307-312.
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 34
    • 15844381594 scopus 로고    scopus 로고
    • Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity
    • Shimomura I, Funahashi T, Takahashi M et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800-803.
    • (1996) Nat Med , vol.2 , pp. 800-803
    • Shimomura, I.1    Funahashi, T.2    Takahashi, M.3
  • 35
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 36
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 37
    • 33748750917 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    • Kamei N, Tobe K, Suzuki R et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006; 281: 26602-26614.
    • (2006) J Biol Chem , vol.281 , pp. 26602-26614
    • Kamei, N.1    Tobe, K.2    Suzuki, R.3
  • 38
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006; 116: 1494-1505.
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 39
    • 0036789973 scopus 로고    scopus 로고
    • Specific up-regulation of CRH or AVP secretion by acetylcholine or lipopolysaccharide in inflammatory susceptible Lewis rat fetal hypothalamic cells
    • Wei R, Phillips TM, Sternberg EM. Specific up-regulation of CRH or AVP secretion by acetylcholine or lipopolysaccharide in inflammatory susceptible Lewis rat fetal hypothalamic cells. J Neuroimmunol 2002; 131: 31-40.
    • (2002) J Neuroimmunol , vol.131 , pp. 31-40
    • Wei, R.1    Phillips, T.M.2    Sternberg, E.M.3
  • 40
    • 0031947781 scopus 로고    scopus 로고
    • Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells
    • Hauner H, Rohrig K, Spelleken M et al. Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells. Int J Obes Relat Metab Disord 1998; 22: 448-453.
    • (1998) Int J Obes Relat Metab Disord , vol.22 , pp. 448-453
    • Hauner, H.1    Rohrig, K.2    Spelleken, M.3
  • 41
    • 0026466915 scopus 로고
    • The morphology and metabolism of intraabdominal adipose tissue in men
    • Marin P, Andersson B, Ottosson M et al. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 1992; 41: 1242-1248.
    • (1992) Metabolism , vol.41 , pp. 1242-1248
    • Marin, P.1    Andersson, B.2    Ottosson, M.3
  • 42
    • 40449140901 scopus 로고    scopus 로고
    • Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice
    • Ninichuk V, Clauss S, Kulkarni O et al. Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. Am J Pathol 2008; 172: 628-637.
    • (2008) Am J Pathol , vol.172 , pp. 628-637
    • Ninichuk, V.1    Clauss, S.2    Kulkarni, O.3
  • 43
    • 31044456061 scopus 로고    scopus 로고
    • Diet induction of monocyte chemoattractant protein-1 and its impact on obesity
    • Chen A, Mumick S, Zhang C et al. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Obes Res 2005; 13: 1311-1320.
    • (2005) Obes Res , vol.13 , pp. 1311-1320
    • Chen, A.1    Mumick, S.2    Zhang, C.3
  • 44
    • 34047205064 scopus 로고    scopus 로고
    • Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice
    • Park CW, Kim HW, Ko SH et al. Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice. J Am Soc Nephrol 2007; 18: 1227-1238.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1227-1238
    • Park, C.W.1    Kim, H.W.2    Ko, S.H.3
  • 45
    • 33750580307 scopus 로고    scopus 로고
    • Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes
    • Proctor G, Jiang T, Iwahashi M et al. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 2006; 55: 2502-2509.
    • (2006) Diabetes , vol.55 , pp. 2502-2509
    • Proctor, G.1    Jiang, T.2    Iwahashi, M.3
  • 46
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 47
    • 51849092929 scopus 로고    scopus 로고
    • Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue
    • Lee MH, Song HK, Ko GJ et al. Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue. Kidney Int 2008; 74: 890-900.
    • (2008) Kidney Int , vol.74 , pp. 890-900
    • Lee, M.H.1    Song, H.K.2    Ko, G.J.3
  • 48
    • 0035968099 scopus 로고    scopus 로고
    • Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes
    • Fasshauer M, Klein J, Neumann S. Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Lett 2001; 500: 60-63.
    • (2001) FEBS Lett , vol.500 , pp. 60-63
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3


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