Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Environmental and Molecular Mutagenesis

Volumn 56, Issue 9, 2015, Pages 724-750

  Yauk, Carole L ^a   Lambert, Iain B ^b   Meek, M E Bette ^c   Douglas, George R ^a   Marchetti, Francesco ^a  

^a HEALTH CANADA   (Canada)

^b CARLETON UNIVERSITY   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Adverse outcome pathway; Alkylation; Germ cell; Heritable mutation; Weight of evidence

Indexed keywords

ALKYLATING AGENT; DNA;

ARTICLE; DNA ALKYLATION; DNA DAMAGE; DNA REPAIR; GERM CELL; HERITABILITY; HUMAN; MEIOSIS; MUTATION; NONHUMAN; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PROGENY; SPERM; SPERMATOGENESIS; ALKYLATION; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; MALE; MUTAGEN TESTING; PRACTICE GUIDELINE; PROCEDURES; RISK ASSESSMENT; RODENT; SPERMATOZOON; TOXICOGENETICS; TRANSGENIC ANIMAL;

ALKYLATION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; GUIDELINES AS TOPIC; HUMANS; MALE; MEIOSIS; MUTAGENICITY TESTS; MUTATION; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; RISK ASSESSMENT; RODENTIA; SPERMATOGENESIS; SPERMATOZOA; TOXICOGENETICS;

EID: 84946499957     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21954     Document Type: Article

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