Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis

Toxicological Sciences

Volumn 129, Issue 1, 2012, Pages 213-224

  Labib, Sarah ^a   Yauk, Carole ^a   Williams, Andrew ^a   Arlt, Volker M ^b   Phillips, David H ^b   White, Paul A ^a   Halappanavar, Sabina ^a  

^a HEALTH CANADA   (Canada)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

DNA adducts; Gene expression; Genotoxicity; Lung cancer; Mutant frequency; P53 response

Indexed keywords

BENZO[A]PYRENE; BETA GALACTOSIDASE; CARCINOGEN; DNA; MESSENGER RNA; MUTANT PROTEIN; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGEN DNA INTERACTION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; GENE INDUCTION; GENOTOXICITY; LUNG CARCINOGENESIS; MALE; MOUSE; MUTATION RATE; NONHUMAN; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

ADMINISTRATION, ORAL; ANIMALS; BENZO(A)PYRENE; CELL TRANSFORMATION, NEOPLASTIC; LUNG; MALE; MICE; MICE, TRANSGENIC; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

ANIMALIA; MUS;

EID: 84865723912     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs177     Document Type: Article

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