Formation and persistence of the miscoding DNA alkylation product O6-ethylguanine in male germ cells of the hamster

Mutation Research - DNA Repair

Volumn 385, Issue 3, 1997, Pages 205-211

  Seiler, Frank ^a   Kamino, Kenji ^b   Emura, Makito ^b   Mohr, Ulrich ^b   Thomale, Jürgen ^c  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Alkyltransferase; Diethylnitrosamine; DNA repair; Ethylnitrosourea; Germ line carcinogenesis; Immunofluorescence; Metabolic activation; Sperm cell

Indexed keywords

CELL NUCLEUS DNA; GUANINE DERIVATIVE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; DNA ADDUCT; DNA ALKYLATION; DNA REPAIR; GERM CELL; HAMSTER; MALE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; CARCINOGENS; CRICETINAE; DIETHYLNITROSAMINE; DNA; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; ETHYLNITROSOUREA; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GUANINE; MALE; MESOCRICETUS; SPERMATOGONIA;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0031422786     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(97)00043-8     Document Type: Article

References (22)

1. Tomatis L. Transgeneration carcinogenesis: A review of the experimental and epidemiological evidence. Jpn. J. Cancer Res. 85:1994;443-454.
2. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis. 7:1986;745-749.
3. Buschfort C., Müller M.R., Seeber S., Rajewsky M.F., Thomale J. DNA excision repair profiles of normal and leukemic human lymphocytes: Functional analysis at the single cell level. Cancer Res. 57:1997;651-658.
4. Mohr U., Emura M., Kamino K., Steinmann J., Kohler M., Morawietz G., Dasenbrock C., Tomatis L. Increased risk of cancer in the descendants of Syrian hamsters exposed prenatally to diethylnitrosamine (DEN). Int. J. Cancer. 63:1995;86-91.
5. Shelby M.D., Tindall K.R. Mammalian germ cell mutagenicity of ENU, IPMS and MMS, chemicals selected for a transgenic mouse collaborative study. Mutation Res. 388:1997;99-109.
6. Vogel E.W., Natarajan A.T. DNA damage and repair in somatic and germ cells in vivo. Mutation Res. 330:1995;183-208.
7. Pelkonen P., Kirby G.M., Wild C.P., Bartsch H., Lang M. Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes. Chem. Biol. Interact. 93(1):1994;41-50.
8. Verna L., Whysner J., Williams G.M. N-Nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther. 71:1996;57-81.
9. Beranek D.T. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutation Res. 231:1990;11-30.
10. 6-methylguanine in cells with different DNA repair backgrounds. Chem. Res. Toxicol. 9:1996;980-987.
11. Seiler F., Kirstein U., Eberle G., Hochleitner K., Rajewsky M F. Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis. 9:1993;1907-1913.
12. G. Eberle, Ph.D. Dissertation, University of Essen, Essen, Germany, 1989.
13. Adler I.-D. Comparison of the duration of spermatogenesis between male rodents and humans. Mutation Res. 352:1996;169-172.
14. Sega G.A., Rohrer C.R., Harvey H.R., Jetton A.E. Chemical dosimetry of ethylnitrosourea in the mouse testis. Mutation Res. 159:1986;65-74.
15. Vogel E.W., Natarajan A.T. DNA damage and repair in somatic and germ cells in vivo. Mutation Res. 330:1995;183-208.
16. Generoso W.M., Witt K.L., Cain K.T., Hughes L., Cacheiro N.L.A., Lockhart A.-M.C., Shelby M.D. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutation Res. 345:1995;167-180.
17. 6-alkylguanine. Jpn. J. Cancer Res. (Gann.). 78:1987;1094-1099.
18. 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells. Cancer Res. 54:1994;3857-3863.
19. 6-methylguanine-DNA methyltransferase in rat and hamster liver after treatment with dimethylnitrosamine. Cancer Res. 50:1990;5426-5430.
20. 6-ethylguanine in spermatogonial DNA of adult Syrian golden hamster by intraperitoneal injection of diethylnitrosamine. Exp. Toxic. Pathol. 47:1995;443-445.
21. 6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine, diethylnitrosamine and ethylnitrosourea. Cancer Lett. 46:1989;21-29.
22. Seiler F., Rehn B., Kamino K., Emura M., Bruch J. Significance of cell type specific formation and elimination of DNA adducts in respiratory tissues of hamster and rat induced by alkylating chemical carcinogens. Exp. Toxic. Pathol. 48:1996;544-547.