Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Chemico-Biological Interactions

Volumn 184, Issue 1-2, 2010, Pages 279-285

  Bette Meek, M E ^a   Klaunig, James E ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Benzene; Critical data gaps; Leukemia; Metabolism; Mode of action; Risk assessment

Indexed keywords

BENZENE; CYTOCHROME P450; CYTOCHROME P450 2E1; REACTIVE OXYGEN METABOLITE;

ARTICLE; CANCER RISK; CARCINOGENIC ACTIVITY; CELL MUTANT; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); CONCEPTUAL FRAMEWORK; HUMAN; INDUCED MUTATION; LEUKEMIA; LIVER METABOLISM; METABOLIC ACTIVATION; METABOLITE; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; TARGET CELL;

ANIMALS; BENZENE; BONE MARROW CELLS; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LEUKEMIA; MUTATION; RISK ASSESSMENT;

ANIMALIA;

EID: 77950630300     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.006     Document Type: Article

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