Sidestream tobacco smoke is a male germ cell mutagen

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12811-12814

  Marchetti, Francesco ^a   Rowan Carroll, Andrea ^b   Williams, Andrew ^b   Polyzos, Aris ^a   Berndt Weis, M Lynn ^b   Yauk, Carole L ^b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b HEALTH CANADA   (Canada)

Author keywords

DNA mutation; Germline; Micronuclei; Spermatogenesis

Indexed keywords

MAINSTREAM TOBACCO SMOKE; MUTAGENIC AGENT; SIDESTREAM TOBACCO SMOKE; TOBACCO SMOKE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; ERYTHROCYTE; EXPANDED SIMPLE TANDEM REPEAT; EXPOSURE; GENE MUTATION; GENOTOXICITY; GERM CELL; IN VIVO STUDY; MALE; MICRONUCLEUS; MOUSE; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PASSIVE SMOKING; PRIORITY JOURNAL; RETICULOCYTE; SOMATIC CELL; SPERM; SPERMATOGENESIS; TANDEM REPEAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS, GERMLINE; MINISATELLITE REPEATS; MUTAGENS; MUTATION; RETICULOCYTES; SMOKE; SPERMATOZOA; TANDEM REPEAT SEQUENCES; TIME FACTORS; TOBACCO;

MUS; NICOTIANA TABACUM;

EID: 79961224402     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106896108     Document Type: Article

References (43)

1. Practice Committee of the American Society for Reproductive Medicine (2004) Smoking and infertility. Fertil Steril 81:1181-1186.
2. Soares SR, Melo MA (2008) Cigarette smoking and reproductive function. Curr Opin Obstet Gynecol 20:281-291. (Pubitemid 351643517)
3. DeMarini DM (2004) Genotoxicity of tobacco smoke and tobacco smoke condensate: A review. Mutat Res 567:447-474.
4. Yauk CL, et al. (2007) Mainstream tobacco smoke causes paternal germ-line DNA mutation. Cancer Res 67:5103-5106. (Pubitemid 46997245)
5. Secretan B, et al.; WHO International Agency for Research on Cancer Monograph Working Group (2009) A review of human carcinogens - Part E: Tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 10:1033-1034.
6. Oberg M, Jaakkola MS, Woodward A, Peruga A, Prüss-Ustün A (2011) Worldwide burden of disease from exposure to second-hand smoke: A retrospective analysis of data from 192 countries. Lancet 377:139-146.
7. Husgafvel-Pursiainen K (2004) Genotoxicity of environmental tobacco smoke: a review. Mutat Res 567:427-445.
8. US Department of Health and Human Services (2010) How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General (Centers for Disease Control and Prevention, Atlanta).
9. Fowles J, Dybing E (2003) Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control 12:424-430. (Pubitemid 39452045)
10. Higgins S (2002) Smoking in pregnancy. Curr Opin Obstet Gynecol 14:145-151.
11. Yauk CL (2004) Advances in the application of germline tandem repeat instability for in situ monitoring. Mutat Res 566:169-182.
12. Cimino MC (2006) Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes. Environ Mol Mutagen 47:362-390.
13. Ashby J, Tinwell H (2001) Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals. Mutat Res 478:211-213. (Pubitemid 32530868)
14. Polyzos A, Schmid TE, Piña-Guzmán B, Quintanilla-Vega B, Marchetti F (2009) Differential sensitivity of male germ cells to mainstream and sidestream tobacco smoke in the mouse. Toxicol Appl Pharmacol 237:298-305.
15. Adler ID (1996) Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res 352:169-172.
16. Yauk CL, Dubrova YE, Grant GR, Jeffreys AJ (2002) A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus. Mutat Res 500:147-156. (Pubitemid 34219435)
17. Barber RC, et al. (2004) Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat Res 554:287-295. (Pubitemid 39140836)
18. Dubrova YE, et al. (1998) Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation. Proc Natl Acad Sci USA 95:6251-6255. (Pubitemid 28248998)
19. Vilariño-Güell C, Smith AG, Dubrova YE (2003) Germline mutation induction at mouse repeat DNA loci by chemical mutagens. Mutat Res 526:63-73. (Pubitemid 36507213)
20. Glen CD, Smith AG, Dubrova YE (2008) Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. Cancer Res 68:3630-3636.
21. Dertinger SD, et al. (2007) Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: Dose-response and time-course profiles measured by flow cytometry. Mutat Res 634:119-125. (Pubitemid 47633997)
22. Dertinger SD, Torous DK, Hayashi M, MacGregor JT (2011) Flow cytometric scoring of micronucleated erythrocytes: An efficient platform for assessing in vivo cytogenetic damage. Mutagenesis 26:139-145.
23. Horký J, Vácha J, Znojil V (1978) Comparison of life span of erythrocytes in some inbred strains of mouse using 14C-labelled glycine. Physiol Bohemoslov 27:209-217. (Pubitemid 9038026)
24. Balansky RM, D'Agostini F, De Flora S (1999) Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice. Carcinogenesis 20:1491-1497. (Pubitemid 29385435)
25. Mohtashamipur E, Norpoth K, Straeter H (1987) Clastogenic effect of passive smoking on bone marrow polychromatic erythrocytes of NMRI mice. Toxicol Lett 35:153-156. (Pubitemid 17024020)
26. Witt KL, et al. (2003) Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxymethylacrylamide in the mouse dominant lethal assay. Environ Mol Mutagen 41:111-120. (Pubitemid 36314484)
27. Singer TM, Yauk CL (2010) Germ cell mutagens: Risk assessment challenges in the 21st century. Environ Mol Mutagen 51:919-928.
28. Wyrobek AJ, et al. (2006) Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci USA 103:9601-9606. (Pubitemid 43955871)
29. Robbins WA, et al. (1997) Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nat Genet 16:74-78. (Pubitemid 27198159)
30. Dubrova YE, et al. (1996) Human minisatellite mutation rate after the Chernobyl accident. Nature 380:683-686. (Pubitemid 26125464)
31. Dubrova YE, et al. (2002) Nuclear weapons tests and human germline mutation rate. Science 295:1037. (Pubitemid 34132226)
32. Dubrova YE, et al. (2008) Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice. Environ Mol Mutagen 49:308-311. (Pubitemid 351614739)
33. Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN (2002) Elevated minisatellite mutation rate in the post-Chernobyl families from Ukraine. Am J Hum Genet 71:801-809. (Pubitemid 135750513)
34. Furitsu K, et al. (2005) Microsatellite mutations show no increases in the children of the Chernobyl liquidators. Mutat Res 581:69-82. (Pubitemid 40255895)
35. Slebos RJ, et al. (2004) Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers. Mutat Res 559:143-151. (Pubitemid 38452926)
36. Kiuru A, et al. (2003) Hereditary minisatellite mutations among the offspring of Estonian Chernobyl cleanup workers. Radiat Res 159:651-655. (Pubitemid 36539244)
37. Livshits LA, et al. (2001) Children of Chernobyl cleanup workers do not show elevated rates of mutations in minisatellite alleles. Radiat Res 155:74-80. (Pubitemid 32125742)
38. Dubrova YE, Plumb M, Gutierrez B, Boulton E, Jeffreys AJ (2000) Transgenerational mutation by radiation. Nature 405:37.
39. Niwa O, Kominami R (2001) Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa. Proc Natl Acad Sci USA 98:1705-1710. (Pubitemid 32165562)
40. Somers CM, Yauk CL, White PA, Parfett CL, Quinn JS (2002) Air pollution induces heritable DNA mutations. Proc Natl Acad Sci USA 99:15904-15907. (Pubitemid 35462721)
41. Barber RC, et al. (2006) Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene 25:7336-7342. (Pubitemid 44853424)
42. De Grassi A, Ciccarelli FD (2009) Tandem repeats modify the structure of human genes hosted in segmental duplications. Genome Biol 10:R137.
43. Little JB (2000) Radiation carcinogenesis. Carcinogenesis 21:397-404.