Functional characterization of global genomic DNA repair and its implications for cancer

Mutation Research - Reviews in Mutation Research

Volumn 544, Issue 2-3, 2003, Pages 107-114

  Hanawalt, Philip C ^a   Ford, James M ^b   Lloyd, Daniel R ^c  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KENT   (United Kingdom)

Author keywords

32P postlabeling; Apoptosis; Benzo(a)pyrene; Benzo(g)chrysene; Cancer; DNA repair; Genetic toxicology; Genomic instability; Global genomic repair; Li Fraumeni syndrome; p53; Rodent; Transcription coupled repair; Ultraviolet light

Indexed keywords

CARCINOGEN; CHRYSENE DERIVATIVE; CYCLOBUTANE; GENOMIC DNA; NUCLEOTIDE; PROTEIN; PYRIMIDINE DIMER; RNA POLYMERASE;

ANIMAL CELL; ANIMAL TISSUE; CELL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EXCISION REPAIR; FIBROBLAST; GENE EXPRESSION; GENE STRUCTURE; GENETIC TRAIT; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; RAT; SMOKING; STRESS; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; UPREGULATION;

RODENTIA;

EID: 0345686480     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrrev.2003.06.002     Document Type: Conference Paper

References (64)

1. Eisen J., Hanawalt P.C. A phylogenomic study of DNA repair genes, proteins, and processes. Mutat. Res. 435:1999;171-213.
2. Petit C., Sancar A. Nucleotide excision repair: from E. coli to man. Biochime. 81:1999;15-25.
3. Zou Y., van Houten B. Strand opening by the UvrA(2)B complex allows dynamic recognition of DNA damage. EMBO J. 18:1999;4889-4901.
4. Zolan M.E., Cortopassi G.A., Smith C.A., Hanawalt P.C. Deficient repair of chemical adducts in alpha DNA of monkey cells. Cell. 28:1982;613-619.
5. Cline S.D., Hanawalt P.C. Who's on first in the cellular response to DNA damage? Nat. Rev. Mol. Cell Biol. 4:2003;361-372.
6. Lindahl T., Wood R.D. Quality control by DNA repair. Science. 286:1999;1897-1905.
7. Bohr V.A., Smith C.A., Okumoto D.S., Hanawalt P.C. DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell. 40:1985;359-369.
8. Mellon I., Spivak G., Hanawalt P.C. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell. 51:1987;241-249.
9. Mellon I., Hanawalt P.C. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature. 342:1989;95-98.
10. Spivak G., Itoh T., Matsunaga T., Nikaido O., Hanawalt P., Yamaizumi M. Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers. DNA Repair. 1:2002;629-643.
11. Svejstrup J.Q. Mechanisms of transcription-coupled DNA repair. Nat. Rev. Mol. Cell Biol. 1:2002;21-29.
12. Tsutakawa S.E., Cooper P.K. Transcription-coupled repair of oxidative DNA damage in human cells: mechanisms and consequences. Cold Spring Harb. Symp. Quant. Biol. 65:2000;201-215.
13. Tang J., Chu G. Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein. DNA Repair. 1:2002;601-616.
14. Wakasugi M., Kawashima A., Morioka H., Linn S., Sancar A., Mori T., Nikaido O., Matsunaga T. DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair. J. Biol. Chem. 277:2002;1637-1640.
15. Scicchitano D., Hanawalt P.C. Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene. Proc. Natl. Acad. Sci. U.S.A. 86:1989;3050-3054.
16. Plosky B., Samson L., Engelward B.P., Gold B., Schlaen B., Millas T., Magnotti M., Schor J., Scicchitano D.A. Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes. DNA Repair. 1:2002;683-696.
17. Branum M.E., Reardon J.T., Sancar A. DNA repair excision nuclease attacks undamaged DNA. J. Biol. Chem. 276:2001;25421-25426.
18. Couch J.L., Hanawalt P.C. DNA repair replication in temperature- sensitive DNA synthesis deficient bacteria. Biochem. Biophys. Res. Commun. 26:1967;779-784.
19. Grivell A.R., Grivell M.B., Hanawalt P.C. Turnover in bacterial DNA containing thymine or 5-bromouracil. J. Mol. Biol. 98:1975;219-233.
20. Pauling C., Hanawalt P. Non-conservative DNA replication following thymine starvation in bacteria. Proc. Natl. Acad. Sci. U.S.A. 54:1965;1728-1735.
21. Hanawalt P.C., Pettijohn D.E., Pauling E.C., Brunk C.F., Smith D.W., Kanner L.C., Couch J.L. Repair replication of DNA in vivo. Cold Spring Harb. Symp. Quant. Biol. 33:1968;187-194.
22. Hanawalt P.C. Transcription-coupled repair and human disease. Science. 266:1994;1957-1958.
23. Hanawalt P.C., Crowley D.J., Ford J.M., Ganesan A.K., Lloyd D.R., Nouspikel T., Smith C.A., Spivak G., Tornaletti S. Regulation of nucleotide excision repair in bacteria and mammalian cells. Cold Spring Harbor Symp. Quant. Biol. 65:2001;183-191.
24. McKay B.C., Ljungman M. Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light. Neoplasia. 1:1999;276-284.
25. Dunkern T.R., Kaina B. Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. Mol. Biol. Cell. 13:2002;348-361.
26. Ford J.M., Hanawalt P.C. Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV-resistance. Proc. Natl. Acad. Sci. U.S.A. 92:1995;8876-8880.
27. Ford J.M., Hanawalt P.C. Expression of wild type p53 is required for efficient global nucleotide excision repair in UV-irradiated human fibroblasts. J. Biol. Chem. 272:1997;28073-28080.
28. Ford J.M., Baron E.L., Hanawalt P.C. Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to UV-irradiation. Cancer Res. 58:1998;599-603.
29. Crowley D.J., Hanawalt P.C. Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimer but not 6-4 photoproducts, in UV-irradiated Escherichia coli. J. Bacteriol. 180:1998;3345-3352.
30. Phillips D. Smoking-related DNA and protein adducts in human tissues. Carcinogenesis. 23:2002;1979-2004.
31. Lloyd D., Hanawalt P.C. p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells. Cancer Res. 60:2000;517-521.
32. Wani M.A., Zhu Q., El-Mahdy M., Venkatachalam S., Wani A.A. Enhanced sensitivity to anti-benzo(a)pyrene-diol-epoxide DNA damage correlates with decreased global genomic repair attributable to abrogated p53 function in human cells. Cancer Res. 60:2000;2273-2280.
33. Lloyd D., Hanawalt P.C. p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts. Cancer Res. 62:2002;5288-5294.
34. Hwang B.J., Ford J.M., Hanawalt P.C., Chu G. Expression of the p48 xeroderma pigmentosum gene is p53-dependent and involved in global genomic repair. Proc. Natl. Acad. Sci. U.S.A. 96:1999;424-428.
35. Tang J., Huang B.J., Ford J., Hanawalt P.C., Chu G. Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Mol. Cell. 5:2000;737-744.
36. Fitch M.E., Cross I.V., Turner S.J., Adimoolam S., Lin C.X., Williams K.G., Ford J.M. The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblast. DNA Repair. 2:2003;819-826.
37. Smith M.L., Ford J.M., Hollander M.C., Bortnick R.A., Amundson S.A., Seo Y.R., Deng C.-X., Hanawalt P.C., Fornace A.J. p53-mediated DNA repair responses to UV-radiation: studies of mouse cells lacking p53, p21 and/or gadd45 genes. Mol. Cell. Biol. 20:2000;3705-3714.
38. Adimoolam S., Ford J.M. p53 and DNA damage inducible expression of the xeroderma pigmentosum group C gene. Proc. Natl. Acad. Sci. U.S.A. 99:2002;12985-12990.
39. Fitch M.E., Cross I., Ford J.M. p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo. Carcinogenesis. 24:2003;843-850.
40. Wang Q.-E., Zhu Q., Wani M.A., Wani G., Chen J., Wani A.A. Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. DNA Repair. 2:2003;483-499.
41. Rubbi C.P., Milner J. p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J. 22:2003;975-986.
42. Therrien J.P., Drouin R., Baril C., Drobetsky E.A. Human cells compromised for the p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair. Proc. Natl. Acad. Sci. U.S.A. 96:1999;15030-15043.
43. Mathonnet G., Léger C., Desnoyers J., Drouin R., Therrien J.-P., Drobetsky E.A. Wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells. Proc. Natl. Acad. Sci. U.S.A. 100:2003;7219-7224.
44. Birrell G.W., Brown J.A., Wu H.I., Giaever G., Chu A.M., Davis R.W., Brown J.M. Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc. Natl. Acad. Sci. U.S.A. 99:2002;8778-8783.
45. Bowman K., Sicard D., Ford J., Hanawalt P.C. Reduced global genomic repair of UV light-induced cyclobutane pyrimidine dimers in Simian virus 40 transformed human cells. Mol. Carcinogen. 29:2000;17-24.
46. Prost S., Ford J.M., Taylor C., Doig J., Harrison D.J. Hepatitis B × protein inhibits p53-dependent DNA repair in primary mouse hepatocytes. J. Biol. Chem. 273:1998;33327-33332.
47. Pettijohn D., Hanawalt P.C. Evidence for repair-replication of ultraviolet damaged DNA in bacteria. J. Mol. Biol. 9:1964;395-410.
48. Painter R.B., Cleaver J.S. Repair replication, unscheduled DNA synthesis, and the repair of mammalian DNA. Radiat. Res. 37:1969;451-466.
49. Trosko J.E., Chu E.H.Y., Carrier W.L. The induction of thymine dimers in ultraviolet-irradiated mammalian cells. Radiat. Res. 24:1965;667-672.
50. Klimek K. Formation but no excision of thymine dimers in mammalian cells after UV-irradiation. Neoplasma. 12:1965;459-460.
51. Lohman P.H.M., Paterson M.C., Zelle B., Reynolds R.J. DNA repair in Chinese hamster cells after irradiation with ultraviolet light. Mutat. Res. 46:1976;138-139.
52. A.K. Ganesan, G. Spivak, P.C. Hanawalt, Expression of DNA repair genes in mammalian cells, in: P. Nagley, A.W. Linnane, W.J. Peacock, J.A. Pateman (Eds.), Manipulation and Expression of Genes in Eukaryotes, Academic Press, Australia, 1983, pp. 45-54.
53. van Zeeland A.A., Smith C.A., Hanawalt P.C. Sensitive determination of pyrimidine dimers in DNA of UV irradiated mammalian cells: introduction of T4 endonuclease V into frozen and thawed cells. Mutat. Res. 82:1981;173-189.
54. Vijg J., Mullaart E., van der Schans G.P., Lohman P.H.M., Knook D.L. Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts. Mutat. Res. 132:1984;129-138.
55. P.C. Hanawalt, V.A. Bohr, S.A. Leadon, J.N. Mansbridge, M.K.H. Reush, Comparative analysis of cutaneous DNA repair in vivo and in vitro, in: I. Bernstein, T. Hirone (Eds.), Processes in Cutaneous Epideramal Differentiation, Praeger Scientific, NY, 1987, pp. 217-231.
56. Mullaart E., Lohman P.H.M., Vijg J. Differences in pyrimidine dimer removal between rat skin cells in vitro and in vivo. J. Invest. Dermatol. 90:1988;346-349.
57. Randerath E., Agrawal H.P., Weaver J.A., Bordelon C.B., Randerath K. 32P-Postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin epidermis and dermis of mice treated topically with 7,2-dimethylbenz[a] anthracene. Carcinogenesis. 6:1985;1117-1126.
58. Giles A.S., Seidel A., Phillips D.H. Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene. Carcinogenesis. 17:1996;1331-1336.
59. Giles A.S., Seidel A., Phillips D.H. Covalent DNA adducts formed by benzo[c]chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol epoxides reacted with DNA and polynucleotides. Chem. Res. Toxicol. 10:1997;1275-1284.
60. De Flora S., Balansky R.M., D'Agostini F., Izzotti A., Camoirano A., Bennicelli C., Zhang Z., Wang Y., Lubet R.A., You M. Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke. Cancer Res. 63:2003;793-800.
61. R. Ben-Ishai, L. Peleg, Excision-repair in primary cultures of mouse embryo cells and its decline in progressive passages and established cell lines, in: P. Hanawalt, R. Setlow (Eds.), Molecular Mechanisms for Repair of DNA, Plenum Press, NY, 1975, pp. 607-610.
62. Peleg L., Raz E., Ben-Ishai R. Changing capacity for DNA excision repair in mouse embryonic cells in vitro. Exp. Cell Res. 104:1976;301-307.
63. Ljungman M., Zhang F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene. 13:1996;823-831.
64. Dumaz N., van Kranen H., de Vries A., Berg R., Wester P., van Kreijl C., Sarasin A., Daya-Grosjean L., de Gruijl F. The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice. Carcinogenesis. 18:1997;897-904.