Mutagenic Response of the Endogenous hprt Gene and lacl Transgene in Benzo[a]pyrene-Treated Big Blue™ B6C3F1 Mice

Environmental and Molecular Mutagenesis

Volumn 28, Issue 4, 1996, Pages 376-384

  Skopek, Thomas R ^a   Kort, Kristy L ^a   Marino, Deborah R ^a   Mittal, Lakshmi V ^a   Umbenhauer, Diane R ^a   Laws, George M ^a   Adams, Stephen P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Benzo a pyrene; Big Blue ; hprt; lacl

Indexed keywords

ANIMALIA;

BACTERIAL PROTEIN; BENZO[A]PYRENE; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; CARCINOGEN; CYTOCHROME P450; ESCHERICHIA COLI PROTEIN; ETHYLNITROSOUREA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LACI PROTEIN, BACTERIA; MUTAGENIC AGENT; REPRESSOR PROTEIN;

ANIMAL; ARTICLE; C57BL MOUSE; COMPARATIVE STUDY; DNA ADDUCT; DNA BASE COMPOSITION; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE VECTOR; GENETICS; LIVER; LUNG; MALE; METABOLISM; MOUSE; MUTAGEN TESTING; SPLEEN; TRANSGENE; TRANSGENIC MOUSE;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; BACTERIAL PROTEINS; BASE COMPOSITION; BENZO(A)PYRENE; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI PROTEINS; ETHYLNITROSOUREA; FEMALE; GENETIC VECTORS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIVER; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENICITY TESTS; MUTAGENS; REPRESSOR PROTEINS; SPLEEN; TRANSGENES;

EID: 0030344674     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2280(1996)28:4<376::aid-em11>3.0.co;2-c     Document Type: Article

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