Assessing the evolutionary impact of amino acid mutations in the human genome

PLoS Genetics

Volumn 4, Issue 5, 2008, Pages

  Boyko, Adam R ^a,b   Williamson, Scott H ^a   Indap, Amit R ^a   Degenhardt, Jeremiah D ^a   Hernandez, Ryan D ^a   Lohmueller, Kirk E ^a,b   Adams, Mark D ^c   Schmidt, Steffen ^d   Sninsky, John J ^e   Sunyaev, Shamil R ^d   White, Thomas J ^e   Nielsen, Rasmus ^f   Clark, Andrew G ^b   Bustamante, Carlos D ^a  

^a Plant Breeding and Genetics Section in the School of Integrative Plant Science   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e CELERA   (United States)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

AFRICAN AMERICAN; AMINO ACID SUBSTITUTION; ARTICLE; BOTTLENECK POPULATION; CHIMPANZEE; EUROPEAN AMERICAN; EVOLUTION; FITNESS; GENE MAPPING; GENETIC SELECTION; GENETIC VARIABILITY; HUMAN; HUMAN GENOME; MUTATION; PHENOTYPE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ANIMAL; CAUCASIAN; COMPARATIVE STUDY; FEMALE; GENETICS; GENOME; MALE; MISSENSE MUTATION; MOLECULAR EVOLUTION; NEGRO; PAN TROGLODYTES; POPULATION GENETICS;

PAN;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION, MOLECULAR; FEMALE; GENETICS, POPULATION; GENOME, HUMAN; HUMANS; MALE; MUTATION, MISSENSE; PAN TROGLODYTES; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION (GENETICS);

EID: 44949129000     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000083     Document Type: Article

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