메뉴 건너뛰기




Volumn 21, Issue 29, 2015, Pages 4155-4173

Role of nanotechnology in delivery of protein and peptide drugs

Author keywords

Bioavailability; Immunogenicity; Nanocarrier; Peptides; Proteins; Stability

Indexed keywords

DRUG; PEPTIDE; PEPTIDE DRUG; PROTEIN; PROTEIN DRUG; UNCLASSIFIED DRUG; DRUG CARRIER;

EID: 84945893726     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150901095722     Document Type: Review
Times cited : (26)

References (255)
  • 1
    • 37749004225 scopus 로고    scopus 로고
    • Protein therapeutics: A summary and pharmacological classification
    • Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov 2008; 7(1): 21-39
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.1 , pp. 21-39
    • Leader, B.1    Baca, Q.J.2    Golan, D.E.3
  • 3
    • 84908299353 scopus 로고    scopus 로고
    • Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
    • Mitragotri S, Burke PA, Langer R. Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov 2014; 13(9): 655-72
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.9 , pp. 655-672
    • Mitragotri, S.1    Burke, P.A.2    Langer, R.3
  • 4
    • 33645523763 scopus 로고    scopus 로고
    • Optimizing the affinity and specificity of proteins with molecular display
    • Levin AM, Weiss GA. Optimizing the affinity and specificity of proteins with molecular display. Mol Biosyst 2006; 2(1): 49-57
    • (2006) Mol Biosyst , vol.2 , Issue.1 , pp. 49-57
    • Levin, A.M.1    Weiss, G.A.2
  • 5
    • 0020684912 scopus 로고
    • Human insulin from recombinant DNA technology
    • Johnson IS. Human insulin from recombinant DNA technology. Science 1983; 219(4585): 632-7
    • (1983) Science , vol.219 , Issue.4585 , pp. 632-637
    • Johnson, I.S.1
  • 6
    • 84861326639 scopus 로고    scopus 로고
    • Administration of growth factors for bone regeneration
    • Yun YR, Jang JH, Jeon E, et al. Administration of growth factors for bone regeneration. Regen Med 2012; 7(3): 369-85
    • (2012) Regen Med , vol.7 , Issue.3 , pp. 369-385
    • Yun, Y.R.1    Jang, J.H.2    Jeon, E.3
  • 7
    • 0023682069 scopus 로고
    • Transdermal delivery of a melanotropic peptide hormone analogue
    • Dawson BV, Hadley ME, Kreutzfeld K, et al. Transdermal delivery of a melanotropic peptide hormone analogue. Life Sci 1988; 43(14): 1111-7
    • (1988) Life Sci , vol.43 , Issue.14 , pp. 1111-1117
    • Dawson, B.V.1    Hadley, M.E.2    Kreutzfeld, K.3
  • 8
    • 36949008754 scopus 로고    scopus 로고
    • Intranasal delivery of a thyrotropin- releasing hormone analog attenuates seizures in the amygdala-kindled rat
    • Veronesi MC, Kubek DJ, Kubek MJ. Intranasal delivery of a thyrotropin- releasing hormone analog attenuates seizures in the amygdala-kindled rat. Epilepsia 2007; 48(12): 2280-86
    • (2007) Epilepsia , vol.48 , Issue.12 , pp. 2280-2286
    • Veronesi, M.C.1    Kubek, D.J.2    Kubek, M.J.3
  • 9
    • 78650902011 scopus 로고    scopus 로고
    • Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men
    • Stanley TL, Chen CY, Branch KL, Makimura H, Grinspoon SK. Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men. J Clin Endocrinol Metab 2011; 96(1): 150-8
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.1 , pp. 150-158
    • Stanley, T.L.1    Chen, C.Y.2    Branch, K.L.3    Makimura, H.4    Grinspoon, S.K.5
  • 10
    • 84883252388 scopus 로고    scopus 로고
    • Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules
    • Tang R, Kim CS, Solfiell DJ, et al. Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. ACS Nano 2013; 7(8): 6667-73
    • (2013) ACS Nano , vol.7 , Issue.8 , pp. 6667-6673
    • Tang, R.1    Kim, C.S.2    Solfiell, D.J.3
  • 11
    • 71249155233 scopus 로고    scopus 로고
    • Low dose oral administration of cytokines for treatment of allergic asthma
    • Gariboldi S, Palazzo M, Zanobbio L, et al. Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther 2009; 22(6): 497-510
    • (2009) Pulm Pharmacol Ther , vol.22 , Issue.6 , pp. 497-510
    • Gariboldi, S.1    Palazzo, M.2    Zanobbio, L.3
  • 12
    • 84901593674 scopus 로고    scopus 로고
    • A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential
    • Yu Z, Li J, Zhu J, et al. A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential. J Mater Chem B 2014; 2(24): 3809-18
    • (2014) J Mater Chem B , vol.2 , Issue.24 , pp. 3809-3818
    • Yu, Z.1    Li, J.2    Zhu, J.3
  • 13
    • 61849184972 scopus 로고    scopus 로고
    • Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease
    • Hemsley KM, Luck AJ, Crawley AC, et al. Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease. Eur J Neurosci 2009; 29(6): 1197-214
    • (2009) Eur J Neurosci , vol.29 , Issue.6 , pp. 1197-1214
    • Hemsley, K.M.1    Luck, A.J.2    Crawley, A.C.3
  • 14
    • 18244365849 scopus 로고    scopus 로고
    • Protein drug stability: A formulation challenge
    • Frokjaer S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov 2005; 4(4): 298-306
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.4 , pp. 298-306
    • Frokjaer, S.1    Otzen, D.E.2
  • 15
    • 12344281758 scopus 로고    scopus 로고
    • Commercial challenges of protein drug delivery
    • Brown LR. Commercial challenges of protein drug delivery. Expert Opin Drug Deliv 2005; 2(1): 29-42
    • (2005) Expert Opin Drug Deliv , vol.2 , Issue.1 , pp. 29-42
    • Brown, L.R.1
  • 16
    • 84879092151 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as effective reservoir systems for long-term preservation of multidose formulations
    • Cerreto F, Paolicelli P, Cesa S, et al. Solid lipid nanoparticles as effective reservoir systems for long-term preservation of multidose formulations. AAPS PharmSciTech 2013; 14(2): 847-53
    • (2013) AAPS Pharmscitech , vol.14 , Issue.2 , pp. 847-853
    • Cerreto, F.1    Paolicelli, P.2    Cesa, S.3
  • 17
    • 75149175575 scopus 로고    scopus 로고
    • Colloidal nanocarriers: A review on formulation technology, types and applications toward targeted drug delivery
    • Mishra B, Patel BB, Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine 2010; 6(1): 9-24
    • (2010) Nanomedicine , vol.6 , Issue.1 , pp. 9-24
    • Mishra, B.1    Patel, B.B.2    Tiwari, S.3
  • 18
    • 84903534030 scopus 로고    scopus 로고
    • Liposomal bortezomib nanoparticles via boronic ester prodrug formulation for improved therapeutic efficacy in vivo
    • Ashley JD, Stefanick JF, Schroeder VA, Suckow MA, Kiziltepe T, Bilgicer B. Liposomal bortezomib nanoparticles via boronic ester prodrug formulation for improved therapeutic efficacy in vivo. J Med Chem 2014; 57(12): 5282-92
    • (2014) J Med Chem , vol.57 , Issue.12 , pp. 5282-5292
    • Ashley, J.D.1    Stefanick, J.F.2    Schroeder, V.A.3    Suckow, M.A.4    Kiziltepe, T.5    Bilgicer, B.6
  • 19
    • 70450221930 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles based drug delivery systems
    • Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010; 75(1): 1-18
    • (2010) Colloids Surf B Biointerfaces , vol.75 , Issue.1 , pp. 1-18
    • Kumari, A.1    Yadav, S.K.2    Yadav, S.C.3
  • 20
    • 84904859704 scopus 로고    scopus 로고
    • Carbohydrate based nanoparticles for drug delivery across biological barriers
    • Peptu CA, Ochiuz L, Alupei L, Peptu C, Popa M. Carbohydrate based nanoparticles for drug delivery across biological barriers. J Biomed Nanotechnol 2014; 10(9): 2107-48
    • (2014) J Biomed Nanotechnol , vol.10 , Issue.9 , pp. 2107-2148
    • Peptu, C.A.1    Ochiuz, L.2    Alupei, L.3    Peptu, C.4    Popa, M.5
  • 21
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and Biodistribution of Nanoparticles
    • Li S-D, Huang L. Pharmacokinetics and Biodistribution of Nanoparticles. Mol Pharm 2008; 5(4): 496-504
    • (2008) Mol Pharm , vol.5 , Issue.4 , pp. 496-504
    • Li, S.-D.1    Huang, L.2
  • 22
    • 81855198887 scopus 로고    scopus 로고
    • Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective
    • Moghimi SM, Hunter AC, Andresen TL. Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective. Annu Rev Pharmacol Toxicol 2012; 52: 481-503
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 481-503
    • Moghimi, S.M.1    Hunter, A.C.2    Resen, T.L.3
  • 23
    • 0037275061 scopus 로고    scopus 로고
    • Colloidal drug carriers: Achievements and perspectives
    • Barratt G. Colloidal drug carriers: achievements and perspectives. Cell Mol Life Sci 2003; 60(1): 21-37
    • (2003) Cell Mol Life Sci , vol.60 , Issue.1 , pp. 21-37
    • Barratt, G.1
  • 24
    • 84857512892 scopus 로고    scopus 로고
    • The ligand nanoparticle conjugation approach for targeted cancer therapy
    • Karra N, Benita S. The ligand nanoparticle conjugation approach for targeted cancer therapy. Curr Drug Metab 2012; 13(1): 22-41
    • (2012) Curr Drug Metab , vol.13 , Issue.1 , pp. 22-41
    • Karra, N.1    Benita, S.2
  • 25
    • 33947524896 scopus 로고    scopus 로고
    • How do you treat bleeding disorders with desmopressin?
    • Ozgonenel B, Rajpurkar M, Lusher JM. How do you treat bleeding disorders with desmopressin? Postgrad Med J 2007; 83(977): 159-63
    • (2007) Postgrad Med J , vol.83 , Issue.977 , pp. 159-163
    • Ozgonenel, B.1    Rajpurkar, M.2    Lusher, J.M.3
  • 28
    • 84929806002 scopus 로고    scopus 로고
    • Protein stability in pulmonary drug delivery via nebulization
    • [Epub ahead of print]
    • Hertel SP, Winter G, Friess W. Protein stability in pulmonary drug delivery via nebulization. Adv Drug Deliv Rev 2014 [Epub ahead of print]
    • (2014) Adv Drug Deliv Rev
    • Hertel, S.P.1    Winter, G.2    Friess, W.3
  • 31
    • 84907886592 scopus 로고    scopus 로고
    • High-Throughput Thermal Stability Analysis of a Monoclonal Antibody by Attenuated Total Reflection FT-IR Spectroscopic Imaging
    • Boulet-Audet M, Byrne B, Kazarian SG. High-Throughput Thermal Stability Analysis of a Monoclonal Antibody by Attenuated Total Reflection FT-IR Spectroscopic Imaging. Anal Chem 2014; 86(19): 9786-93
    • (2014) Anal Chem , vol.86 , Issue.19 , pp. 9786-9793
    • Boulet-Audet, M.1    Byrne, B.2    Kazarian, S.G.3
  • 32
    • 33748041958 scopus 로고    scopus 로고
    • Effects of protein aggregates: An immunologic perspective
    • Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J 2006; 8(3): E501-7
    • (2006) AAPS J , vol.8 , Issue.3
    • Rosenberg, A.S.1
  • 33
    • 79959208737 scopus 로고    scopus 로고
    • The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations?
    • Pinholt C, Hartvig RA, Medlicott NJ, Jorgensen L. The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations? Expert Opin Drug Deliv 2011; 8(7): 949-64
    • (2011) Expert Opin Drug Deliv , vol.8 , Issue.7 , pp. 949-964
    • Pinholt, C.1    Hartvig, R.A.2    Medlicott, N.J.3    Jorgensen, L.4
  • 34
    • 79952222483 scopus 로고    scopus 로고
    • Direct visualization of protein adsorption to primary containers by gold nanoparticles
    • Eu B, Cairns A, Ding G, Cao X, Wen ZQ. Direct visualization of protein adsorption to primary containers by gold nanoparticles. J Pharm Sci 2011; 100(5): 1663-70
    • (2011) J Pharm Sci , vol.100 , Issue.5 , pp. 1663-1670
    • Eu, B.1    Cairns, A.2    Ding, G.3    Cao, X.4    Wen, Z.Q.5
  • 35
    • 0024544308 scopus 로고
    • Adsorption of proteins onto glass surfaces and its effect on the intensity of circular dichroism spectra
    • Wu CS, Chen GC. Adsorption of proteins onto glass surfaces and its effect on the intensity of circular dichroism spectra. Anal Biochem 1989; 177(1): 178-82
    • (1989) Anal Biochem , vol.177 , Issue.1 , pp. 178-182
    • Wu, C.S.1    Chen, G.C.2
  • 36
    • 0025513327 scopus 로고
    • The behavior of some model proteins at solidliquid interfaces 1. Adsorption from single protein solutions
    • Arai T, Norde W. The behavior of some model proteins at solidliquid interfaces 1. Adsorption from single protein solutions. Colloids Surf 1990; 51(0): 1-15
    • (1990) Colloids Surf , vol.51 , pp. 1-15
    • Arai, T.1    Norde, W.2
  • 37
    • 77949821607 scopus 로고    scopus 로고
    • Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions
    • Ludwig DB, Carpenter JF, Hamel JB, Randolph TW. Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions. J Pharm Sci 2010; 99(4): 1721-33
    • (2010) J Pharm Sci , vol.99 , Issue.4 , pp. 1721-1733
    • Ludwig, D.B.1    Carpenter, J.F.2    Hamel, J.B.3    Randolph, T.W.4
  • 38
    • 78650050688 scopus 로고    scopus 로고
    • Adsorption of monoclonal antibodies to glass microparticles
    • Hoehne M, Samuel F, Dong A, et al. Adsorption of monoclonal antibodies to glass microparticles. J Pharm Sci 2011; 100(1): 123-32
    • (2011) J Pharm Sci , vol.100 , Issue.1 , pp. 123-132
    • Hoehne, M.1    Samuel, F.2    Dong, A.3
  • 39
    • 71849101103 scopus 로고    scopus 로고
    • Alternative routes of administration for systemic delivery of protein pharmaceuticals
    • Moeller EH, Jorgensen L. Alternative routes of administration for systemic delivery of protein pharmaceuticals. Drug Discov Today: Technol 2008; 5(2–3): e89-e94
    • (2008) Drug Discov Today: Technol , vol.5 , Issue.2-3
    • Moeller, E.H.1    Jorgensen, L.2
  • 40
    • 84893276441 scopus 로고    scopus 로고
    • Basics and recent advances in peptide and protein drug delivery
    • Bruno BJ, Miller GD, Lim CS. Basics and recent advances in peptide and protein drug delivery. Ther Deliv 2013; 4(11): 1443-67
    • (2013) Ther Deliv , vol.4 , Issue.11 , pp. 1443-1467
    • Bruno, B.J.1    Miller, G.D.2    Lim, C.S.3
  • 41
    • 0342437513 scopus 로고    scopus 로고
    • Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
    • R TB, Jeffrey A, Siahaan TJ, Gangwar S, Pauletti GM. Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies. Adv Drug Deliv Rev 1997; 27(2-3): 235-56
    • (1997) Adv Drug Deliv Rev , vol.27 , Issue.2-3 , pp. 235-256
    • Tb, R.1    Jeffrey, A.2    Siahaan, T.J.3    Gangwar, S.4    Pauletti, G.M.5
  • 42
    • 55949126429 scopus 로고    scopus 로고
    • Clearance properties of nano-sized particles and molecules as imaging agents: Considerations and caveats
    • Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine (Lond) 2008; 3(5): 703-17
    • (2008) Nanomedicine (Lond) , vol.3 , Issue.5 , pp. 703-717
    • Longmire, M.1    Choyke, P.L.2    Kobayashi, H.3
  • 43
    • 0035937527 scopus 로고    scopus 로고
    • Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: Studies in the rat
    • Kisel MA, Kulik LN, Tsybovsky IS, et al. Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat. Int J Pharm 2001; 216(1-2): 105-14
    • (2001) Int J Pharm , vol.216 , Issue.1-2 , pp. 105-114
    • Kisel, M.A.1    Kulik, L.N.2    Tsybovsky, I.S.3
  • 44
    • 84899835829 scopus 로고    scopus 로고
    • Conformational stability as a design target to control protein aggregation
    • Costanzo JA, O'Brien CJ, Tiller K, et al. Conformational stability as a design target to control protein aggregation. Protein Eng Des Sel 2014; 27(5): 157-67
    • (2014) Protein Eng Des Sel , vol.27 , Issue.5 , pp. 157-167
    • Costanzo, J.A.1    O'brien, C.J.2    Tiller, K.3
  • 45
    • 84874994703 scopus 로고    scopus 로고
    • Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid
    • Sánchez-Martín MJ, Ramon E, Torrent-Burgués J, Garriga P. Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. ChemBioChem 2013; 14(5): 639-44
    • (2013) Chembiochem , vol.14 , Issue.5 , pp. 639-644
    • Sánchez-Martín, M.J.1    Ramon, E.2    Torrent-Burgués, J.3    Garriga, P.4
  • 46
    • 67449119292 scopus 로고    scopus 로고
    • Effects of Glycosylation on the Stability of Protein Pharmaceuticals
    • SolÁ RJ, Griebenow KAI. Effects of Glycosylation on the Stability of Protein Pharmaceuticals. J Pharm Sci 2009; 98(4): 1223-45
    • (2009) J Pharm Sci , vol.98 , Issue.4 , pp. 1223-1245
    • Rj, S.1    Griebenow, K.A.I.2
  • 47
    • 40549116348 scopus 로고    scopus 로고
    • Engineering proteins with tunable thermodynamic and kinetic stabilities
    • Pey AL, Rodriguez-Larrea D, Bomke S, et al. Engineering proteins with tunable thermodynamic and kinetic stabilities. Proteins 2008; 71(1): 165-74
    • (2008) Proteins , vol.71 , Issue.1 , pp. 165-174
    • Pey, A.L.1    Rodriguez-Larrea, D.2    Bomke, S.3
  • 48
    • 84915826732 scopus 로고    scopus 로고
    • Structural and functional stabilization of protein entities: State-of-the-art
    • Balcao VM, Vila MM. Structural and functional stabilization of protein entities: state-of-the-art. Adv Drug Deliv Rev 2014
    • (2014) Adv Drug Deliv Rev
    • Balcao, V.M.1    Vila, M.M.2
  • 49
    • 0031968351 scopus 로고    scopus 로고
    • Stability of a commercial lipase from mucor jav anicus: Kinetic modelling Of Ph and temperature dependencies
    • Balcão VM, Oliveira TA, Malcata FX. Stability of a commercial lipase from mucor jav anicus: kinetic modelling Of Ph and temperature dependencies. Biocatal Biotransfor 1998; 16(1): 45-66
    • (1998) Biocatal Biotransfor , vol.16 , Issue.1 , pp. 45-66
    • Balcão, V.M.1    Oliveira, T.A.2    Malcata, F.X.3
  • 50
    • 0028858297 scopus 로고
    • Nanoparticulate systems in drug delivery and targeting
    • Kreuter J. Nanoparticulate systems in drug delivery and targeting. J Drug Target 1995; 3(3): 171-73
    • (1995) J Drug Target , vol.3 , Issue.3 , pp. 171-173
    • Kreuter, J.1
  • 51
    • 60449093310 scopus 로고    scopus 로고
    • Covalent conjugation of tetrameric bovine liver catalase to liposome membranes for stabilization of the enzyme tertiary and quaternary structures
    • Yoshimoto M, Sakamoto H, Shirakami H. Covalent conjugation of tetrameric bovine liver catalase to liposome membranes for stabilization of the enzyme tertiary and quaternary structures. Colloids Surf B Biointerfaces 2009; 69(2): 281-7
    • (2009) Colloids Surf B Biointerfaces , vol.69 , Issue.2 , pp. 281-287
    • Yoshimoto, M.1    Sakamoto, H.2    Shirakami, H.3
  • 52
    • 45149113100 scopus 로고    scopus 로고
    • Liposomal encapsulation of yeast alcohol dehydrogenase with cofactor for stabilization of the enzyme structure and activity
    • Yoshimoto M, Sato M, Yoshimoto N, Nakao K. Liposomal encapsulation of yeast alcohol dehydrogenase with cofactor for stabilization of the enzyme structure and activity. Biotechnol Prog 2008; 24(3): 576-82
    • (2008) Biotechnol Prog , vol.24 , Issue.3 , pp. 576-582
    • Yoshimoto, M.1    Sato, M.2    Yoshimoto, N.3    Nakao, K.4
  • 53
    • 84870485258 scopus 로고    scopus 로고
    • Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres
    • Morales-Cruz M, Flores-Fernandez GM, Morales-Cruz M, et al. Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres. Results Pharma Sci 2012; 2: 79-85
    • (2012) Results Pharma Sci , vol.2 , pp. 79-85
    • Morales-Cruz, M.1    Flores-Fernandez, G.M.2    Morales-Cruz, M.3
  • 54
    • 14844317382 scopus 로고    scopus 로고
    • Strategic approaches for overcoming peptide and protein instability within biodegradable nanoand microparticles
    • Bilati U, Allémann E, Doelker E. Strategic approaches for overcoming peptide and protein instability within biodegradable nanoand microparticles. Eur J Pharm Biopharm 2005; 59(3): 375-88
    • (2005) Eur J Pharm Biopharm , vol.59 , Issue.3 , pp. 375-388
    • Bilati, U.1    Allémann, E.2    Doelker, E.3
  • 55
    • 0033987939 scopus 로고    scopus 로고
    • Protein stability in controlledrelease systems
    • Fu K, Klibanov AM, Langer R. Protein stability in controlledrelease systems. Nat Biotechnol 2000; 18(1): 24-5
    • (2000) Nat Biotechnol , vol.18 , Issue.1 , pp. 24-25
    • Fu, K.1    Klibanov, A.M.2    Langer, R.3
  • 56
    • 84906234295 scopus 로고    scopus 로고
    • Reverse micelles based on [small beta]-Cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery
    • Du X, Song N, Yang Y-W, Wu G, Ma J, Gao H. Reverse micelles based on [small beta]-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery. Polym Chem 2014; 5(18): 5300-09
    • (2014) Polym Chem , vol.5 , Issue.18 , pp. 5300-5309
    • Du, X.1    Song, N.2    Yang, Y.-W.3    Wu, G.4    Ma, J.5    Gao, H.6
  • 58
    • 0035131382 scopus 로고    scopus 로고
    • Protein-fatty acid complex for enhanced loading and stability within biodegradable nanoparticles
    • Yoo HS, Choi HK, Park TG. Protein-fatty acid complex for enhanced loading and stability within biodegradable nanoparticles. J Pharm Sci 2001; 90(2): 194-201
    • (2001) J Pharm Sci , vol.90 , Issue.2 , pp. 194-201
    • Yoo, H.S.1    Choi, H.K.2    Park, T.G.3
  • 59
    • 84892478123 scopus 로고    scopus 로고
    • Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles
    • Gaudana R, Khurana V, Parenky A, Mitra AK. Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles. J Drug Deliv 2011; 2011
    • (2011) J Drug Deliv , pp. 2011
    • Gaudana, R.1    Khurana, V.2    Parenky, A.3    Mitra, A.K.4
  • 60
    • 84867139131 scopus 로고    scopus 로고
    • The use of pH-sensitive positively charged polymeric micelles for protein delivery
    • Gao GH, Park MJ, Li Y, et al. The use of pH-sensitive positively charged polymeric micelles for protein delivery. Biomaterials 2012; 33(35): 9157-64
    • (2012) Biomaterials , vol.33 , Issue.35 , pp. 9157-9164
    • Gao, G.H.1    Park, M.J.2    Li, Y.3
  • 61
    • 84862833264 scopus 로고    scopus 로고
    • Liposomes containing glycocholate as potential oral insulin delivery systems: Preparation, in vitro characterization, and improved protection against enzymatic degradation
    • Niu M, Lu Y, Hovgaard L, Wu W. Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation. Int J Nanomed 2011; 6: 1155-66
    • (2011) Int J Nanomed , vol.6 , pp. 1155-1166
    • Niu, M.1    Lu, Y.2    Hovgaard, L.3    Wu, W.4
  • 62
    • 84888599853 scopus 로고    scopus 로고
    • Enhanced oral absorption of insulinloaded liposomes containing bile salts: A mechanistic study
    • Niu M, Tan Y, Guan P, et al. Enhanced oral absorption of insulinloaded liposomes containing bile salts: a mechanistic study. Int J Pharm 2014; 460(1-2): 119-30
    • (2014) Int J Pharm , vol.460 , Issue.1-2 , pp. 119-130
    • Niu, M.1    Tan, Y.2    Guan, P.3
  • 63
    • 84884815498 scopus 로고    scopus 로고
    • Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles
    • Li X, Guo S, Zhu C, et al. Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles. Biomaterials 2013; 34(37): 9678-87
    • (2013) Biomaterials , vol.34 , Issue.37 , pp. 9678-9687
    • Li, X.1    Guo, S.2    Zhu, C.3
  • 64
    • 0033047397 scopus 로고    scopus 로고
    • Application of surface-coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin
    • Iwanaga K, Ono S, Narioka K, et al. Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. J Pharm Sci 1999; 88(2): 248-52
    • (1999) J Pharm Sci , vol.88 , Issue.2 , pp. 248-252
    • Iwanaga, K.1    Ono, S.2    Narioka, K.3
  • 65
    • 33750501785 scopus 로고    scopus 로고
    • Lectinmodified solid lipid nanoparticles as carriers for oral administration of insulin
    • Zhang N, Ping Q, Huang G, Xu W, Cheng Y, Han X. Lectinmodified solid lipid nanoparticles as carriers for oral administration of insulin. Int J Pharm 2006; 327(1–2): 153-59
    • (2006) Int J Pharm , vol.327 , Issue.1-2 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6
  • 66
    • 16244422972 scopus 로고    scopus 로고
    • Investigation of lectinmodified insulin liposomes as carriers for oral administration
    • Zhang N, Ping QN, Huang GH, Xu WF. Investigation of lectinmodified insulin liposomes as carriers for oral administration. Int J Pharm 2005; 294(1–2): 247-59
    • (2005) Int J Pharm , vol.294 , Issue.1-2 , pp. 247-259
    • Zhang, N.1    Ping, Q.N.2    Huang, G.H.3    Xu, W.F.4
  • 67
    • 84891002990 scopus 로고    scopus 로고
    • Biotinylated liposomes as potential carriers for the oral delivery of insulin
    • Zhang X, Qi J, Lu Y, He W, Li X, Wu W. Biotinylated liposomes as potential carriers for the oral delivery of insulin. Nanomedicine 2014; 10(1): 167-76
    • (2014) Nanomedicine , vol.10 , Issue.1 , pp. 167-176
    • Zhang, X.1    Qi, J.2    Lu, Y.3    He, W.4    Li, X.5    Wu, W.6
  • 68
    • 38349112036 scopus 로고    scopus 로고
    • Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes
    • Thirawong N, Thongborisute J, Takeuchi H, Sriamornsak P. Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. J Control Release 2008; 125(3): 236-45
    • (2008) J Control Release , vol.125 , Issue.3 , pp. 236-245
    • Thirawong, N.1    Thongborisute, J.2    Takeuchi, H.3    Sriamornsak, P.4
  • 69
    • 84892585292 scopus 로고    scopus 로고
    • Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration
    • Agrawal AK, Harde H, Thanki K, Jain S. Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration. Biomacromolecules 2013; 15(1): 350-60
    • (2013) Biomacromolecules , vol.15 , Issue.1 , pp. 350-360
    • Agrawal, A.K.1    Harde, H.2    Thanki, K.3    Jain, S.4
  • 71
    • 84859429245 scopus 로고    scopus 로고
    • Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization
    • Shahnaz G, Vetter A, Barthelmes J, et al. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. Int J Pharm 2012; 428(1-2): 164-70
    • (2012) Int J Pharm , vol.428 , Issue.1-2 , pp. 164-170
    • Shahnaz, G.1    Vetter, A.2    Barthelmes, J.3
  • 72
    • 77955983828 scopus 로고    scopus 로고
    • Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin
    • Makhlof A, Werle M, Tozuka Y, Takeuchi H. Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. Int J Pharm 2010; 397(1-2): 92-5
    • (2010) Int J Pharm , vol.397 , Issue.1-2 , pp. 92-95
    • Makhlof, A.1    Werle, M.2    Tozuka, Y.3    Takeuchi, H.4
  • 73
    • 84881003810 scopus 로고    scopus 로고
    • Evaluation of neuropeptide loaded trimethyl chitosan nanoparticles for nose to brain delivery
    • Kumar M, Pandey RS, Patra KC, et al. Evaluation of neuropeptide loaded trimethyl chitosan nanoparticles for nose to brain delivery. Int J Biol Macromol 2013; 61: 189-95
    • (2013) Int J Biol Macromol , vol.61 , pp. 189-195
    • Kumar, M.1    Pandey, R.S.2    Patra, K.C.3
  • 74
    • 74149094269 scopus 로고    scopus 로고
    • Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting
    • Wang S, Jiang T, Ma M, Hu Y, Zhang J. Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting. Int J Pharm 2010; 386(1-2): 249-55
    • (2010) Int J Pharm , vol.386 , Issue.1-2 , pp. 249-255
    • Wang, S.1    Jiang, T.2    Ma, M.3    Hu, Y.4    Zhang, J.5
  • 75
    • 51849102750 scopus 로고    scopus 로고
    • Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery
    • Sayin B, Somavarapu S, Li XW, et al. Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery. Int J Pharm 2008; 363(1-2): 139-48
    • (2008) Int J Pharm , vol.363 , Issue.1-2 , pp. 139-148
    • Sayin, B.1    Somavarapu, S.2    Li, X.W.3
  • 76
    • 33644789168 scopus 로고    scopus 로고
    • Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform
    • Baudner BC, Verhoef JC, Giuliani MM, et al. Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. J Drug Target 2005; 13(8-9): 489-98
    • (2005) J Drug Target , vol.13 , Issue.8-9 , pp. 489-498
    • Baudner, B.C.1    Verhoef, J.C.2    Giuliani, M.M.3
  • 77
    • 0242317689 scopus 로고    scopus 로고
    • The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines
    • Baudner BC, Giuliani MM, Verhoef JC, Rappuoli R, Junginger HE, Giudice GD. The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines. Vaccine 2003; 21(25-26): 3837-44
    • (2003) Vaccine , vol.21 , Issue.25-26 , pp. 3837-3844
    • Baudner, B.C.1    Giuliani, M.M.2    Verhoef, J.C.3    Rappuoli, R.4    Junginger, H.E.5    Giudice, G.D.6
  • 78
    • 11844282711 scopus 로고    scopus 로고
    • Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
    • Yamamoto H, Kuno Y, Sugimoto S, Takeuchi H, Kawashima Y. Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. J Control Release 2005; 102(2): 373-81
    • (2005) J Control Release , vol.102 , Issue.2 , pp. 373-381
    • Yamamoto, H.1    Kuno, Y.2    Sugimoto, S.3    Takeuchi, H.4    Kawashima, Y.5
  • 79
    • 84897526295 scopus 로고    scopus 로고
    • Preparation and in vivo absorption evaluation of spray dried powders containing salmon calcitonin loaded chitosan nanoparticles for pulmonary delivery
    • Sinsuebpol C, Chatchawalsaisin J, Kulvanich P. Preparation and in vivo absorption evaluation of spray dried powders containing salmon calcitonin loaded chitosan nanoparticles for pulmonary delivery. Drug Des Develop Ther 2013; 7: 861-73
    • (2013) Drug Des Develop Ther , vol.7 , pp. 861-873
    • Sinsuebpol, C.1    Chatchawalsaisin, J.2    Kulvanich, P.3
  • 80
    • 67349152120 scopus 로고    scopus 로고
    • Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery
    • Chono S, Fukuchi R, Seki T, Morimoto K. Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery. J Control Release 2009; 137(2): 104-09
    • (2009) J Control Release , vol.137 , Issue.2 , pp. 104-109
    • Chono, S.1    Fukuchi, R.2    Seki, T.3    Morimoto, K.4
  • 81
    • 33744536662 scopus 로고    scopus 로고
    • Pulmonary delivery of insulin by liposomal carriers
    • Huang Y-Y, Wang C-H. Pulmonary delivery of insulin by liposomal carriers. J Control Release 2006; 113(1): 9-14
    • (2006) J Control Release , vol.113 , Issue.1 , pp. 9-14
    • Huang, Y.-Y.1    Wang, C.-H.2
  • 82
    • 55849123635 scopus 로고    scopus 로고
    • Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery
    • Bi R, Shao W, Wang Q, Zhang N. Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery. J Drug Target 2008; 16(9): 639-48
    • (2008) J Drug Target , vol.16 , Issue.9 , pp. 639-648
    • Bi, R.1    Shao, W.2    Wang, Q.3    Zhang, N.4
  • 83
    • 54949087525 scopus 로고    scopus 로고
    • Increased biological half-life of aerosolized liposomal recombinant human Cu/Zn superoxide dismutase in pigs
    • Kaipel M, Wagner A, Wassermann E, et al. Increased biological half-life of aerosolized liposomal recombinant human Cu/Zn superoxide dismutase in pigs. J Aerosol Med Pulm Drug Deliv 2008; 21(3): 281-90
    • (2008) J Aerosol Med Pulm Drug Deliv , vol.21 , Issue.3 , pp. 281-290
    • Kaipel, M.1    Wagner, A.2    Wassermann, E.3
  • 84
    • 27744601939 scopus 로고    scopus 로고
    • A preliminary pharmacokinetic study of liposomal leuprolide dry powder inhaler: A technical note
    • Shahiwala A, Misra A. A preliminary pharmacokinetic study of liposomal leuprolide dry powder inhaler: A technical note. AAPS PharmSciTech 2005; 6(3): E482-E86
    • (2005) AAPS Pharmscitech , vol.6 , Issue.3
    • Shahiwala, A.1    Misra, A.2
  • 85
    • 42649135116 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for pulmonary delivery of insulin
    • Liu J, Gong T, Fu H, et al. Solid lipid nanoparticles for pulmonary delivery of insulin. Int J Pharm 2008; 356(1-2): 333-44
    • (2008) Int J Pharm , vol.356 , Issue.1-2 , pp. 333-344
    • Liu, J.1    Gong, T.2    Fu, H.3
  • 86
    • 0035821406 scopus 로고    scopus 로고
    • Prolonged hypoglycemic effect of insulin- loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats
    • Zhang Q, Shen Z, Nagai T. Prolonged hypoglycemic effect of insulin- loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats. Int J Pharm 2001; 218(1-2): 75-80
    • (2001) Int J Pharm , vol.218 , Issue.1-2 , pp. 75-80
    • Zhang, Q.1    Shen, Z.2    Nagai, T.3
  • 87
    • 34547554369 scopus 로고    scopus 로고
    • Engineering of poly (DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system
    • Yamamoto H, Hoshina W, Kurashima H, et al. Engineering of poly (DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system. Adv Powder Technol 2007; 18(2): 215-28
    • (2007) Adv Powder Technol , vol.18 , Issue.2 , pp. 215-228
    • Yamamoto, H.1    Hoshina, W.2    Kurashima, H.3
  • 91
    • 0032545780 scopus 로고    scopus 로고
    • Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin
    • Cevc G, Gebauer D, Stieber J, Schätzlein A, Blume G. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta - Biomembr 1998; 1368(2): 201-15
    • (1998) Biochim Biophys Acta - Biomembr , vol.1368 , Issue.2 , pp. 201-215
    • Cevc, G.1    Gebauer, D.2    Stieber, J.3    Schätzlein, A.4    Blume, G.5
  • 92
    • 0031986076 scopus 로고    scopus 로고
    • Transdermal immunisation with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transfersomes
    • Paul A, Cevc G, Bachhawat BK. Transdermal immunisation with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transfersomes. Vaccine 1998; 16(2-3): 188-95
    • (1998) Vaccine , vol.16 , Issue.2-3 , pp. 188-195
    • Paul, A.1    Cevc, G.2    Bachhawat, B.K.3
  • 93
    • 0029558813 scopus 로고
    • Transdermal immunization with large proteins by means of ultradeformable drug carriers
    • Paul A, Cevc G, Bachhawat BK. Transdermal immunization with large proteins by means of ultradeformable drug carriers. Eur J Immunol 1995; 25(12): 3521-4
    • (1995) Eur J Immunol , vol.25 , Issue.12 , pp. 3521-3524
    • Paul, A.1    Cevc, G.2    Bachhawat, B.K.3
  • 94
    • 14644395468 scopus 로고    scopus 로고
    • Tetanus toxoid-loaded transfersomes for topical immunization
    • Gupta PN, Mishra V, Singh P, et al. Tetanus toxoid-loaded transfersomes for topical immunization. J Pharm Pharmacol 2005; 57(3): 295-301
    • (2005) J Pharm Pharmacol , vol.57 , Issue.3 , pp. 295-301
    • Gupta, P.N.1    Mishra, V.2    Singh, P.3
  • 95
    • 15044349794 scopus 로고    scopus 로고
    • Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: A comparative study
    • Gupta PN, Mishra V, Rawat A, et al. Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study. Int J Pharm 2005; 293(1-2): 73-82
    • (2005) Int J Pharm , vol.293 , Issue.1-2 , pp. 73-82
    • Gupta, P.N.1    Mishra, V.2    Rawat, A.3
  • 96
    • 0035941996 scopus 로고    scopus 로고
    • Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: A randomised study. Xeroderma Pigmentosum Study Group
    • Yarosh D, Klein J, O'Connor A, Hawk J, Rafal E, Wolf P. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet 2001; 357(9260): 926-9
    • (2001) Lancet , vol.357 , Issue.9260 , pp. 926-929
    • Yarosh, D.1    Klein, J.2    O'connor, A.3    Hawk, J.4    Rafal, E.5    Wolf, P.6
  • 97
    • 46749097976 scopus 로고    scopus 로고
    • Brownell I. Repairing DNA damage in xeroderma pigmentosum: T4N5 lotion and gene therapy
    • Zahid S, Brownell I. Repairing DNA damage in xeroderma pigmentosum: T4N5 lotion and gene therapy. J Drugs Dermatol 2008; 7(4): 405-8
    • (2008) J Drugs Dermatol , vol.7 , Issue.4 , pp. 405-408
    • Zahid, S.1
  • 98
    • 0025099698 scopus 로고
    • Topical delivery of liposomally encapsulated interferon evaluated by in vitro diffusion studies
    • Egbaria K, Ramachandran C, Kittayanond D, Weiner N. Topical delivery of liposomally encapsulated interferon evaluated by in vitro diffusion studies. Antimicrob Agents Chemother 1990; 34(1): 107-10
    • (1990) Antimicrob Agents Chemother , vol.34 , Issue.1 , pp. 107-110
    • Egbaria, K.1    Ramachandran, C.2    Kittayanond, D.3    Weiner, N.4
  • 99
    • 0024309652 scopus 로고
    • Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model
    • Weiner N, Williams N, Birch G, Ramachandran C, Shipman C, Jr., Flynn G. Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model. Antimicrob Agents Chemother 1989; 33(8): 1217-21
    • (1989) Antimicrob Agents Chemother , vol.33 , Issue.8 , pp. 1217-1221
    • Weiner, N.1    Williams, N.2    Birch, G.3    Ramachandran, C.4    Shipman, C.5    Flynn, G.6
  • 100
    • 84866767389 scopus 로고    scopus 로고
    • Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery
    • Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharm J 2012; 20(4): 355-63
    • (2012) Saudi Pharm J , vol.20 , Issue.4 , pp. 355-363
    • Malakar, J.1    Sen, S.O.2    Nayak, A.K.3    Sen, K.K.4
  • 102
    • 33646590986 scopus 로고    scopus 로고
    • Biphasic lipid vesicles as a subcutaneous delivery system for protein antigens and CpG oligonucleotides
    • Alcon VL, Baca-Estrada ME, Potter A, Babiuk LA, Kumar P, Foldvari M. Biphasic lipid vesicles as a subcutaneous delivery system for protein antigens and CpG oligonucleotides. Curr Drug Deliv 2006; 3(2): 129-35
    • (2006) Curr Drug Deliv , vol.3 , Issue.2 , pp. 129-135
    • Alcon, V.L.1    Baca-Estrada, M.E.2    Potter, A.3    Babiuk, L.A.4    Kumar, P.5    Foldvari, M.6
  • 103
    • 84879108665 scopus 로고    scopus 로고
    • In vivo sustained dermal delivery and pharmacokinetics of interferon alpha in biphasic vesicles after topical application
    • King M, Kumar P, Michel D, Batta R, Foldvari M. In vivo sustained dermal delivery and pharmacokinetics of interferon alpha in biphasic vesicles after topical application. Eur J Pharm Biopharm 2013; 84(3): 532-9
    • (2013) Eur J Pharm Biopharm , vol.84 , Issue.3 , pp. 532-539
    • King, M.1    Kumar, P.2    Michel, D.3    Batta, R.4    Foldvari, M.5
  • 104
    • 84877256284 scopus 로고    scopus 로고
    • Enhanced brain delivery of the opioid peptide DAMGO in glutathione pegylated liposomes: A microdialysis study
    • Lindqvist A, Rip J, Gaillard PJ, Bjorkman S, Hammarlund-Udenaes M. Enhanced brain delivery of the opioid peptide DAMGO in glutathione pegylated liposomes: a microdialysis study. Mol Pharm 2013; 10(5): 1533-41
    • (2013) Mol Pharm , vol.10 , Issue.5 , pp. 1533-1541
    • Lindqvist, A.1    Rip, J.2    Gaillard, P.J.3    Bjorkman, S.4    Hammarlund-Udenaes, M.5
  • 105
    • 84859836479 scopus 로고    scopus 로고
    • Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides
    • In: Skaper SD, Ed., USA: Humana Press
    • Caban S, Capan Y, Couvreur P, Dalkara T. Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides. In: Skaper SD, Ed. Neurotrophic Factors. Methods in Molecular Biology. USA: Humana Press; 2012; pp. 321-32
    • (2012) Neurotrophic Factors. Methods in Molecular Biology , pp. 321-332
    • Caban, S.1    Capan, Y.2    Couvreur, P.3    Dalkara, T.4
  • 106
    • 84870386548 scopus 로고    scopus 로고
    • Brain-targeted delivery of protein using chitosan- and RVG peptide-conjugated, pluronicbased nano-carrier
    • Kim J-Y, Choi WI, Kim YH, Tae G. Brain-targeted delivery of protein using chitosan- and RVG peptide-conjugated, pluronicbased nano-carrier. Biomaterials 2013; 34(4): 1170-78
    • (2013) Biomaterials , vol.34 , Issue.4 , pp. 1170-1178
    • Kim, J.-Y.1    Choi, W.I.2    Kim, Y.H.3    Tae, G.4
  • 107
    • 78650217902 scopus 로고    scopus 로고
    • Proteins conjugated to poly(Butyl cyanoacrylate) nanoparticles as potential neuroprotective agents
    • Reukov V, Maximov V, Vertegel A. Proteins conjugated to poly(butyl cyanoacrylate) nanoparticles as potential neuroprotective agents. Biotechnol Bioeng 2011; 108(2): 243-52
    • (2011) Biotechnol Bioeng , vol.108 , Issue.2 , pp. 243-252
    • Reukov, V.1    Maximov, V.2    Vertegel, A.3
  • 108
    • 84876406479 scopus 로고    scopus 로고
    • Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury
    • Yun X, Maximov VD, Yu J, Zhu H, Vertegel AA, Kindy MS. Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury. J Cereb Blood Flow Metab 2013; 33(4): 583-92
    • (2013) J Cereb Blood Flow Metab , vol.33 , Issue.4 , pp. 583-592
    • Yun, X.1    Maximov, V.D.2    Yu, J.3    Zhu, H.4    Vertegel, A.A.5    Kindy, M.S.6
  • 109
    • 84874406744 scopus 로고    scopus 로고
    • Nanofiber-Based Delivery of Therapeutic Peptides to the Brain
    • Mazza M, Notman R, Anwar J, et al. Nanofiber-Based Delivery of Therapeutic Peptides to the Brain. ACS Nano 2013; 7(2): 1016-26
    • (2013) ACS Nano , vol.7 , Issue.2 , pp. 1016-1026
    • Mazza, M.1    Notman, R.2    Anwar, J.3
  • 110
    • 33745002935 scopus 로고    scopus 로고
    • Cationic liposomes as potential carriers for ocular administration of peptides with antiherpetic activity
    • Cortesi R, Argnani R, Esposito E, et al. Cationic liposomes as potential carriers for ocular administration of peptides with antiherpetic activity. Int J Pharm 2006; 317(1): 90-100
    • (2006) Int J Pharm , vol.317 , Issue.1 , pp. 90-100
    • Cortesi, R.1    Argnani, R.2    Esposito, E.3
  • 111
    • 34548057327 scopus 로고    scopus 로고
    • Downregulation of endotoxin- induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes
    • Lajavardi L, Bochot A, Camelo S, et al. Downregulation of endotoxin- induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes. Invest Ophthalmol Vis Sci 2007; 48(7): 3230-8
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.7 , pp. 3230-3238
    • Lajavardi, L.1    Bochot, A.2    Camelo, S.3
  • 112
    • 84889255994 scopus 로고    scopus 로고
    • Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab
    • Yandrapu SK, Upadhyay AK, Petrash JM, Kompella UB. Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab. Mol Pharm 2013; 10(12): 4676-86
    • (2013) Mol Pharm , vol.10 , Issue.12 , pp. 4676-4686
    • Yandrapu, S.K.1    Upadhyay, A.K.2    Petrash, J.M.3    Kompella, U.B.4
  • 113
    • 0029917195 scopus 로고    scopus 로고
    • Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A
    • Calvo P, Sanchez A, Martinez J, et al. Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A. Pharmaceut Res 1996; 13(2): 311-5
    • (1996) Pharmaceut Res , vol.13 , Issue.2 , pp. 311-315
    • Calvo, P.1    Sanchez, A.2    Martinez, J.3
  • 114
    • 80051912837 scopus 로고    scopus 로고
    • Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(Ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers
    • Di Tommaso C, Torriglia A, Furrer P, Behar-Cohen F, Gurny R, Möller M. Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers. Int J Pharm 2011; 416(2): 515-24
    • (2011) Int J Pharm , vol.416 , Issue.2 , pp. 515-524
    • Di Tommaso, C.1    Torriglia, A.2    Furrer, P.3    Behar-Cohen, F.4    Gurny, R.5    Möller, M.6
  • 115
    • 33747874701 scopus 로고    scopus 로고
    • A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres
    • Li H, Tran VV, Hu Y, Mark Saltzman W, Barnstable CJ, Tombran- Tink J. A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp Eye Res 2006; 83(4): 824-33
    • (2006) Exp Eye Res , vol.83 , Issue.4 , pp. 824-833
    • Li, H.1    Tran, V.V.2    Hu, Y.3    Mark Saltzman, W.4    Barnstable, C.J.5    Tombran- Tink, J.6
  • 116
    • 0037118290 scopus 로고    scopus 로고
    • Pure red-cell aplasia and recombinant erythropoietin
    • Casadevall N, Mayeux, M. Pure red-cell aplasia and recombinant erythropoietin. N Engl J Med 2002; 346(20): 1584-86
    • (2002) N Engl J Med , vol.346 , Issue.20 , pp. 1584-1586
    • Casadevall, N.1    Mayeux, M.2
  • 117
    • 0037075272 scopus 로고    scopus 로고
    • Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin
    • Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med 2002; 346(7): 469-75
    • (2002) N Engl J Med , vol.346 , Issue.7 , pp. 469-475
    • Casadevall, N.1    Nataf, J.2    Viron, B.3
  • 119
    • 0027519426 scopus 로고
    • Immunogenicity and allergenic potential of animal and human insulins
    • Schernthaner G. Immunogenicity and allergenic potential of animal and human insulins. Diabetes Care 1993; 16 (Suppl 3): 155-65
    • (1993) Diabetes Care , vol.16 , pp. 155-165
    • Schernthaner, G.1
  • 120
    • 0021024367 scopus 로고
    • Development of antihuman chorionic gonadotropin antibodies in patients with hypogonadotropic hypogonadism. A study of four patients
    • Claustrat B, David L, Faure A, Francois R. Development of antihuman chorionic gonadotropin antibodies in patients with hypogonadotropic hypogonadism. A study of four patients. J Clin Endocrinol Metab 1983; 57(5): 1041-7
    • (1983) J Clin Endocrinol Metab , vol.57 , Issue.5 , pp. 1041-1047
    • Claustrat, B.1    David, L.2    Faure, A.3    Francois, R.4
  • 121
    • 0023765154 scopus 로고
    • Gonadotropin-releasing hormone (GnRH) antibodies formation in hypogonadotropic azoospermic men treated with pulsatile GnRH--diagnosis and possible alternative treatment
    • Blumenfeld Z, Frisch L, Conn PM. Gonadotropin-releasing hormone (GnRH) antibodies formation in hypogonadotropic azoospermic men treated with pulsatile GnRH--diagnosis and possible alternative treatment. Fertil Steril 1988; 50(4): 622-9
    • (1988) Fertil Steril , vol.50 , Issue.4 , pp. 622-629
    • Blumenfeld, Z.1    Frisch, L.2    Conn, P.M.3
  • 122
    • 0028853791 scopus 로고
    • Clinical significance of antibodies against calcitonin
    • Grauer A, Ziegler R, Raue F. Clinical significance of antibodies against calcitonin. Exp Clin Endocrinol Diabetes 1995; 103(6): 345-51
    • (1995) Exp Clin Endocrinol Diabetes , vol.103 , Issue.6 , pp. 345-351
    • Grauer, A.1    Ziegler, R.2    Raue, F.3
  • 123
    • 0035158301 scopus 로고    scopus 로고
    • Human immune response to recombinant human proteins
    • Porter S. Human immune response to recombinant human proteins. J Pharm Sci 2001; 90(1): 1-11
    • (2001) J Pharm Sci , vol.90 , Issue.1 , pp. 1-11
    • Porter, S.1
  • 124
    • 0030727797 scopus 로고    scopus 로고
    • Naturally occurring and therapy-induced antibodies to human granulocyte colony-stimulating factor (G-CSF) in human serum
    • Laricchia-Robbio L, Moscato S, Genua A, Liberati AM, Revoltella RP. Naturally occurring and therapy-induced antibodies to human granulocyte colony-stimulating factor (G-CSF) in human serum. J Cell Physiol 1997; 173(2): 219-26
    • (1997) J Cell Physiol , vol.173 , Issue.2 , pp. 219-226
    • Laricchia-Robbio, L.1    Moscato, S.2    Genua, A.3    Liberati, A.M.4    Revoltella, R.P.5
  • 125
    • 0028088531 scopus 로고
    • Induction of antirecombinant human granulocyte-macrophage colony-stimulating factor (Escherichia coli-derived) antibodies and clinical effects in nonimmunocompromised patients
    • Ragnhammar P, Friesen HJ, Frodin JE, et al. Induction of antirecombinant human granulocyte-macrophage colony-stimulating factor (Escherichia coli-derived) antibodies and clinical effects in nonimmunocompromised patients. Blood 1994; 84(12): 4078-87
    • (1994) Blood , vol.84 , Issue.12 , pp. 4078-4087
    • Ragnhammar, P.1    Friesen, H.J.2    Frodin, J.E.3
  • 126
    • 0033562815 scopus 로고    scopus 로고
    • Abrogation of the hematological and biological activities of the interleukin-3/granulocytemacrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin
    • Miller LL, Korn EL, Stevens DS, et al. Abrogation of the hematological and biological activities of the interleukin-3/granulocytemacrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin. Blood 1999; 93(10): 3250-8
    • (1999) Blood , vol.93 , Issue.10 , pp. 3250-3258
    • Miller, L.L.1    Korn, E.L.2    Stevens, D.S.3
  • 127
    • 0030722116 scopus 로고    scopus 로고
    • Safety of repeated intermittent courses of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis
    • Eisenberg JD, Aitken ML, Dorkin HL, et al. Safety of repeated intermittent courses of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis. J Pediatr 1997; 131(1 Pt 1): 118-24
    • (1997) J Pediatr , vol.131 , pp. 118-124
    • Eisenberg, J.D.1    Aitken, M.L.2    Dorkin, H.L.3
  • 128
    • 0035029304 scopus 로고    scopus 로고
    • The incidence of inhibitors in hemophilia A and the induction of immune tolerance
    • Briet E, Peters M. The incidence of inhibitors in hemophilia A and the induction of immune tolerance. Adv Exp Med Biol 2001; 489: 89-97
    • (2001) Adv Exp Med Biol , vol.489 , pp. 89-97
    • Briet, E.1    Peters, M.2
  • 130
    • 0025943513 scopus 로고
    • Streptokinase immunogenicity in thrombolytic therapy for acute myocardial infarction
    • Rosenschein U, Lenz R, Radnay J, Ben Tovim T, Rozenszajn LA. Streptokinase immunogenicity in thrombolytic therapy for acute myocardial infarction. Isr J Med Sci 1991; 27(10): 541-5
    • (1991) Isr J Med Sci , vol.27 , Issue.10 , pp. 541-545
    • Rosenschein, U.1    Lenz, R.2    Radnay, J.3    Ben Tovim, T.4    Rozenszajn, L.A.5
  • 131
    • 0026637034 scopus 로고
    • Monitoring of streptokinase resistance titre in acute myocardial infarction patients up to 30 months after giving streptokinase or anistreplase and related studies to measure specific antistreptokinase IgG
    • Fears R, Ferres H, Glasgow E, et al. Monitoring of streptokinase resistance titre in acute myocardial infarction patients up to 30 months after giving streptokinase or anistreplase and related studies to measure specific antistreptokinase IgG. Br Heart J 1992; 68(2): 167-70
    • (1992) Br Heart J , vol.68 , Issue.2 , pp. 167-170
    • Fears, R.1    Ferres, H.2    Glasgow, E.3
  • 132
    • 0030841117 scopus 로고    scopus 로고
    • Treatment-induced antibodies to interleukin-2
    • Prümmer O. Treatment-induced antibodies to interleukin-2. Biotherapy 1997; 10(1): 15-24
    • (1997) Biotherapy , vol.10 , Issue.1 , pp. 15-24
    • Prümmer, O.1
  • 133
    • 0033841877 scopus 로고    scopus 로고
    • Immunoregulation and blocking antibodies induced by interferon beta treatment in MS
    • Zang YC, Yang D, Hong J, Tejada-Simon MV, Rivera VM, Zhang JZ. Immunoregulation and blocking antibodies induced by interferon beta treatment in MS. Neurology 2000; 55(3): 397-404
    • (2000) Neurology , vol.55 , Issue.3 , pp. 397-404
    • Zang, Y.C.1    Yang, D.2    Hong, J.3    Tejada-Simon, M.V.4    Rivera, V.M.5    Zhang, J.Z.6
  • 134
    • 9044247457 scopus 로고    scopus 로고
    • Phase I trial of subcutaneous interleukin 3 in patients with refractory malignancy: Hematological, immunological, and pharmacodynamic findings
    • Bukowski RM, Olencki T, Gunn H, et al. Phase I trial of subcutaneous interleukin 3 in patients with refractory malignancy: hematological, immunological, and pharmacodynamic findings. Clin Cancer Res 1996; 2(2): 347-57
    • (1996) Clin Cancer Res , vol.2 , Issue.2 , pp. 347-357
    • Bukowski, R.M.1    Olencki, T.2    Gunn, H.3
  • 135
    • 0024523620 scopus 로고
    • Treatment of malignant carcinoid tumors with recombinant interferon alfa-2b: Development of neutralizing interferon antibodies and possible loss of antitumor activity
    • Oberg K, Alm G, Magnusson A, et al. Treatment of malignant carcinoid tumors with recombinant interferon alfa-2b: development of neutralizing interferon antibodies and possible loss of antitumor activity. J Natl Cancer Inst 1989; 81(7): 531-5
    • (1989) J Natl Cancer Inst , vol.81 , Issue.7 , pp. 531-535
    • Oberg, K.1    Alm, G.2    Magnusson, A.3
  • 136
    • 0028219410 scopus 로고
    • Interferon antibodies in patients with chronic hepatitic C virus infection treated with recombinant interferon alpha-2 alpha
    • Bonetti P, Diodati G, Drago C, et al. Interferon antibodies in patients with chronic hepatitic C virus infection treated with recombinant interferon alpha-2 alpha. J Hepatol 1994; 20(3): 416-20
    • (1994) J Hepatol , vol.20 , Issue.3 , pp. 416-420
    • Bonetti, P.1    Diodati, G.2    Drago, C.3
  • 137
    • 0026598364 scopus 로고
    • Recombinant interferon alpha-2A combined with prednisone in metastatic renal-cell carcinoma: Treatment results, serum interferon levels and the development of antibodies
    • Fossa SD, Lehne G, Gunderson R, Hjelmaas U, Holdener EE. Recombinant interferon alpha-2A combined with prednisone in metastatic renal-cell carcinoma: treatment results, serum interferon levels and the development of antibodies. Int J Cancer 1992; 50(6): 868-70
    • (1992) Int J Cancer , vol.50 , Issue.6 , pp. 868-870
    • Fossa, S.D.1    Lehne, G.2    Gunderson, R.3    Hjelmaas, U.4    Holdener, E.E.5
  • 138
    • 0025607230 scopus 로고
    • Interferon antibodies may negate the antiviral effects of recombinant alpha-interferon treatment in patients with chronic hepatitis B virus infection
    • Lok AS, Lai CL, Leung EK. Interferon antibodies may negate the antiviral effects of recombinant alpha-interferon treatment in patients with chronic hepatitis B virus infection. Hepatology 1990; 12(6): 1266-70
    • (1990) Hepatology , vol.12 , Issue.6 , pp. 1266-1270
    • Lok, A.S.1    Lai, C.L.2    Leung, E.K.3
  • 139
    • 0027377837 scopus 로고
    • Recombinant interferon alfa 2a in the treatment of patients with early stage B chronic lymphocytic leukaemia
    • McSweeney EN, Giles FJ, Worman CP, et al. Recombinant interferon alfa 2a in the treatment of patients with early stage B chronic lymphocytic leukaemia. Br J Haematol 1993; 85(1): 77-83
    • (1993) Br J Haematol , vol.85 , Issue.1 , pp. 77-83
    • McSweeney, E.N.1    Giles, F.J.2    Worman, C.P.3
  • 140
    • 0027981534 scopus 로고
    • Biological and clinical significance of neutralizing and binding antibodies to interferonalpha (IFN-alpha) during therapy for chronic hepatitis C
    • Giannelli G, Antonelli G, Fera G, et al. Biological and clinical significance of neutralizing and binding antibodies to interferonalpha (IFN-alpha) during therapy for chronic hepatitis C. Clin Exp Immunol 1994; 97(1): 4-9
    • (1994) Clin Exp Immunol , vol.97 , Issue.1 , pp. 4-9
    • Giannelli, G.1    Antonelli, G.2    Fera, G.3
  • 141
    • 9044230923 scopus 로고    scopus 로고
    • Antibodies to interferon (IFN) in hepatitis C patients relapsing while continuing recombinant IFN-alpha2 therapy
    • Antonelli G, Giannelli G, Currenti M, et al. Antibodies to interferon (IFN) in hepatitis C patients relapsing while continuing recombinant IFN-alpha2 therapy. Clin Exp Immunol 1996; 104(3): 384-7
    • (1996) Clin Exp Immunol , vol.104 , Issue.3 , pp. 384-387
    • Antonelli, G.1    Giannelli, G.2    Currenti, M.3
  • 142
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group, TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 1999; 53(3): 457-65
    • (1999) Neurology , vol.53 , Issue.3 , pp. 457-465
  • 143
    • 75749087940 scopus 로고    scopus 로고
    • Can we prevent immunogenicity of human protein drugs?
    • Scott DW, De Groot AS. Can we prevent immunogenicity of human protein drugs? Ann Rheum Dis 2010; 69 (Suppl 1): i72-76
    • (2010) Ann Rheum Dis , vol.69
    • Scott, D.W.1    De Groot, A.S.2
  • 144
    • 0030856842 scopus 로고    scopus 로고
    • Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice
    • Braun A, Kwee L, Labow MA, Alsenz J. Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice. Pharmaceut Res 1997; 14(10): 1472-8
    • (1997) Pharmaceut Res , vol.14 , Issue.10 , pp. 1472-1478
    • Braun, A.1    Kwee, L.2    Labow, M.A.3    Alsenz, J.4
  • 145
    • 0033763507 scopus 로고    scopus 로고
    • Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group
    • Ross C, Clemmesen KM, Svenson M, et al. Immunogenicity of interferon-beta in multiple sclerosis patients: influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group. Ann Neurol 2000; 48(5): 706-12
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 706-712
    • Ross, C.1    Clemmesen, K.M.2    Svenson, M.3
  • 146
    • 71649095495 scopus 로고    scopus 로고
    • Effect of route of administration of human recombinant factor VIII on its immunogenicity in Hemophilia A mice
    • Peng A, Gaitonde P, Kosloski MP, Miclea RD, Varma P, Balu-Iyer SV. Effect of route of administration of human recombinant factor VIII on its immunogenicity in Hemophilia A mice. J Pharm Sci 2009; 98(12): 4480-4
    • (2009) J Pharm Sci , vol.98 , Issue.12 , pp. 4480-4484
    • Peng, A.1    Gaitonde, P.2    Kosloski, M.P.3    Miclea, R.D.4    Varma, P.5    Balu-Iyer, S.V.6
  • 147
    • 63749128279 scopus 로고    scopus 로고
    • Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics
    • De Groot AS, Martin W. Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics. Clin Immunol 2009; 131(2): 189-201
    • (2009) Clin Immunol , vol.131 , Issue.2 , pp. 189-201
    • De Groot, A.S.1    Martin, W.2
  • 148
    • 0036861899 scopus 로고    scopus 로고
    • Immunogenicity of therapeutic proteins: Clinical implications and future prospects
    • discussion 19
    • Schellekens H. Immunogenicity of therapeutic proteins: clinical implications and future prospects. Clin Ther 2002; 24(11): 1720-40 ; discussion 19
    • (2002) Clin Ther , vol.24 , Issue.11 , pp. 1720-1740
    • Schellekens, H.1
  • 150
    • 85039827825 scopus 로고    scopus 로고
    • Nanoparticle encapsulated Lasparaginase
    • Ortac I, Ruff L, Yeh Y, Esener S. Nanoparticle encapsulated Lasparaginase. Blood 2013; 122(21): 2669-69
    • (2013) Blood , vol.122 , Issue.21 , pp. 2669-2679
    • Ortac, I.1    Ruff, L.2    Yeh, Y.3    Esener, S.4
  • 151
    • 0022991475 scopus 로고
    • Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase
    • Nucci ML, Olejarczyk J, Abuchowski A. Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase. J Free Radic Biol Med 1986; 2(5-6): 321-5
    • (1986) J Free Radic Biol Med , vol.2 , Issue.5-6 , pp. 321-325
    • Nucci, M.L.1    Olejarczyk, J.2    Abuchowski, A.3
  • 152
    • 0031118521 scopus 로고    scopus 로고
    • Strategies for the preparation and characterization of polyethylene glycol (PEG) conjugated pharmaceutical proteins
    • Fung W-J, Porter, JE, Bailon, P. Strategies for the preparation and characterization of polyethylene glycol (PEG) conjugated pharmaceutical proteins. Polym Preprint 1997; 38: 565-66
    • (1997) Polym Preprint , vol.38 , pp. 565-566
    • Fung, W.-J.1    Porter, J.E.2    Bailon, P.3
  • 153
    • 84857627016 scopus 로고    scopus 로고
    • PEGylation of a factor VIII–phosphatidylinositol complex: Pharmacokinetics and immunogenicity in hemophilia a mice
    • Peng A, Kosloski MP, Nakamura G, Ding H, Balu-Iyer SV. PEGylation of a factor VIII–phosphatidylinositol complex: pharmacokinetics and immunogenicity in hemophilia a mice. AAPS J 2012; 14(1): 35-42
    • (2012) AAPS J , vol.14 , Issue.1 , pp. 35-42
    • Peng, A.1    Kosloski, M.P.2    Nakamura, G.3    Ding, H.4    Balu-Iyer, S.V.5
  • 154
    • 77955962214 scopus 로고    scopus 로고
    • Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a mice
    • Peng A, Straubinger RM, Balu-Iyer SV. Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a mice. AAPS J 2010; 12(3): 473-81
    • (2010) AAPS J , vol.12 , Issue.3 , pp. 473-481
    • Peng, A.1    Straubinger, R.M.2    Balu-Iyer, S.V.3
  • 155
    • 33744936587 scopus 로고    scopus 로고
    • Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity
    • Purohit VS, Balasubramanian SV. Interaction of dicaproyl phosphatidylserine with recombinant factor VIII and its impact on immunogenicity. AAPS J 2006; 8(2): E362-70
    • (2006) AAPS J , vol.8 , Issue.2
    • Purohit, V.S.1    Balasubramanian, S.V.2
  • 156
    • 24044517504 scopus 로고    scopus 로고
    • Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-Lserine complex
    • Purohit VS, Ramani K, Sarkar R, Kazazian HH, Jr., Balasubramanian SV. Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-Lserine complex. J Biol Chem 2005; 280(18): 17593-600
    • (2005) J Biol Chem , vol.280 , Issue.18 , pp. 17593-17600
    • Purohit, V.S.1    Ramani, K.2    Sarkar, R.3    Kazazian, H.H.4    Balasubramanian, S.V.5
  • 157
    • 0026769985 scopus 로고
    • Interaction of factor VIII with phospholipids: Role of composition and negative charge
    • Kemball-Cook G, Barrowcliffe TW. Interaction of factor VIII with phospholipids: role of composition and negative charge. Thromb Res 1992; 67(1): 57-71
    • (1992) Thromb Res , vol.67 , Issue.1 , pp. 57-71
    • Kemball-Cook, G.1    Barrowcliffe, T.W.2
  • 158
    • 84859838781 scopus 로고    scopus 로고
    • Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype
    • Demento SL, Cui W, Criscione JM, et al. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials 2012; 33(19): 4957-64
    • (2012) Biomaterials , vol.33 , Issue.19 , pp. 4957-4964
    • Demento, S.L.1    Cui, W.2    Criscione, J.M.3
  • 159
    • 84906934542 scopus 로고    scopus 로고
    • Induction of potent antigen-specific cytotoxic T cell response by PLGAnanoparticles containing antigen and TLR agonist
    • Lee Y-R, Lee Y-H, Kim K-H, Im S-A, Lee C-K. Induction of potent antigen-specific cytotoxic T cell response by PLGAnanoparticles containing antigen and TLR agonist. Immune Network 2013; 13(1): 30-33
    • (2013) Immune Network , vol.13 , Issue.1 , pp. 30-33
    • Lee, Y.-R.1    Lee, Y.-H.2    Kim, K.-H.3    Im, S.-A.4    Lee, C.-K.5
  • 160
    • 84879464437 scopus 로고    scopus 로고
    • Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice
    • Camacho AI, Irache JM, de Souza J, Sanchez-Gomez S, Gamazo C. Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice. Vaccine 2013; 31(32): 3288-94
    • (2013) Vaccine , vol.31 , Issue.32 , pp. 3288-3294
    • Camacho, A.I.1    Irache, J.M.2    De Souza, J.3    Sanchez-Gomez, S.4    Gamazo, C.5
  • 161
    • 77955653919 scopus 로고    scopus 로고
    • Nasal vaccination with Ntrimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen
    • Slutter B, Bal S, Keijzer C, et al. Nasal vaccination with Ntrimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen. Vaccine 2010; 28(38): 6282-91
    • (2010) Vaccine , vol.28 , Issue.38 , pp. 6282-6291
    • Slutter, B.1    Bal, S.2    Keijzer, C.3
  • 162
    • 77955967773 scopus 로고    scopus 로고
    • Immunization of guinea pigs with novel hepatitis B antigen as nanoparticle aggregate powders administered by the pulmonary route
    • Muttil P, Prego C, Garcia-Contreras L, et al. Immunization of guinea pigs with novel hepatitis B antigen as nanoparticle aggregate powders administered by the pulmonary route. AAPS J 2010; 12(3): 330-7
    • (2010) AAPS J , vol.12 , Issue.3 , pp. 330-337
    • Muttil, P.1    Prego, C.2    Garcia-Contreras, L.3
  • 163
    • 78649671311 scopus 로고    scopus 로고
    • Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses
    • Muttil P, Pulliam B, Garcia-Contreras L, et al. Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses. AAPS J 2010; 12(4): 699-707
    • (2010) AAPS J , vol.12 , Issue.4 , pp. 699-707
    • Muttil, P.1    Pulliam, B.2    Garcia-Contreras, L.3
  • 164
    • 0037435875 scopus 로고    scopus 로고
    • Liposomal delivery of antigen to human dendritic cells
    • Copland MJ, Baird MA, Rades T, et al. Liposomal delivery of antigen to human dendritic cells. Vaccine 2003; 21(9-10): 883-90
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 883-890
    • Copland, M.J.1    Baird, M.A.2    Rades, T.3
  • 165
    • 2942562255 scopus 로고    scopus 로고
    • Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells
    • Elamanchili P, Diwan M, Cao M, Samuel J. Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine 2004; 22(19): 2406-12
    • (2004) Vaccine , vol.22 , Issue.19 , pp. 2406-2412
    • Elamanchili, P.1    Diwan, M.2    Cao, M.3    Samuel, J.4
  • 166
    • 0036805438 scopus 로고    scopus 로고
    • Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro
    • Lutsiak ME, Robinson DR, Coester C, Kwon GS, Samuel J. Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro. Pharmaceut Res 2002; 19(10): 1480-7
    • (2002) Pharmaceut Res , vol.19 , Issue.10 , pp. 1480-1487
    • Lutsiak, M.E.1    Robinson, D.R.2    Coester, C.3    Kwon, G.S.4    Samuel, J.5
  • 167
    • 34948832042 scopus 로고    scopus 로고
    • Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response
    • Kanchan V, Panda AK. Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response. Biomaterials 2007; 28(35): 5344-57
    • (2007) Biomaterials , vol.28 , Issue.35 , pp. 5344-5357
    • Kanchan, V.1    Panda, A.K.2
  • 168
    • 21344448185 scopus 로고    scopus 로고
    • Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
    • Foged C, Brodin B, Frokjaer S, Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 2005; 298(2): 315-22
    • (2005) Int J Pharm , vol.298 , Issue.2 , pp. 315-322
    • Foged, C.1    Brodin, B.2    Frokjaer, S.3    Sundblad, A.4
  • 169
    • 33645533255 scopus 로고    scopus 로고
    • Role of target geometry in phagocytosis
    • Champion JA, Mitragotri S. Role of target geometry in phagocytosis. Proc Natl Acad Sci USA 2006; 103(13): 4930-4
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.13 , pp. 4930-4934
    • Champion, J.A.1    Mitragotri, S.2
  • 170
    • 57749178400 scopus 로고    scopus 로고
    • Shape induced inhibition of phagocytosis of polymer particles
    • Champion JA, Mitragotri S. Shape induced inhibition of phagocytosis of polymer particles. Pharmaceut Res 2009; 26(1): 244-9
    • (2009) Pharmaceut Res , vol.26 , Issue.1 , pp. 244-249
    • Champion, J.A.1    Mitragotri, S.2
  • 171
    • 78649621864 scopus 로고    scopus 로고
    • Surface modification of poly(D,Llactic- co-glycolic acid) nanoparticles with protamine enhanced cross-presentation of encapsulated ovalbumin by bone marrowderived dendritic cells
    • Han R, Zhu J, Yang X, Xu H. Surface modification of poly(D,Llactic- co-glycolic acid) nanoparticles with protamine enhanced cross-presentation of encapsulated ovalbumin by bone marrowderived dendritic cells. J Biomed Mater Res A 2011; 96(1): 142-9
    • (2011) J Biomed Mater Res A , vol.96 , Issue.1 , pp. 142-149
    • Han, R.1    Zhu, J.2    Yang, X.3    Xu, H.4
  • 172
    • 21744448012 scopus 로고    scopus 로고
    • Enhanced antigen presentation and immunostimulation of dendritic cells using aciddegradable cationic nanoparticles
    • Kwon YJ, Standley SM, Goh SL, Frechet JM. Enhanced antigen presentation and immunostimulation of dendritic cells using aciddegradable cationic nanoparticles. J Control Release 2005; 105(3): 199-212
    • (2005) J Control Release , vol.105 , Issue.3 , pp. 199-212
    • Kwon, Y.J.1    Standley, S.M.2    Goh, S.L.3    Frechet, J.M.4
  • 173
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 2003; 348(7): 601-8
    • (2003) N Engl J Med , vol.348 , Issue.7 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 174
    • 0033014677 scopus 로고    scopus 로고
    • Autoimmunity resulting from cytokine treatment predicts long-term survival in patients with metastatic renal cell cancer
    • Franzke A, Peest D, Probst-Kepper M, et al. Autoimmunity resulting from cytokine treatment predicts long-term survival in patients with metastatic renal cell cancer. J Clin Oncol 1999; 17(2): 529-33
    • (1999) J Clin Oncol , vol.17 , Issue.2 , pp. 529-533
    • Franzke, A.1    Peest, D.2    Probst-Kepper, M.3
  • 175
    • 0033062297 scopus 로고    scopus 로고
    • Pharmacodynamics of insulin in polyethylene glycol-coated liposomes
    • Kim A, Yun MO, Oh YK, Ahn WS, Kim CK. Pharmacodynamics of insulin in polyethylene glycol-coated liposomes. Int J Pharm 1999; 180(1): 75-81
    • (1999) Int J Pharm , vol.180 , Issue.1 , pp. 75-81
    • Kim, A.1    Yun, M.O.2    Oh, Y.K.3    Ahn, W.S.4    Kim, C.K.5
  • 176
    • 0029683047 scopus 로고    scopus 로고
    • Biological characterization of L-asparaginase liposomal formulations
    • Gaspar MM, Perez-Soler R, Cruz ME. Biological characterization of L-asparaginase liposomal formulations. Cancer Chemother Pharmacol 1996; 38(4): 373-7
    • (1996) Cancer Chemother Pharmacol , vol.38 , Issue.4 , pp. 373-377
    • Gaspar, M.M.1    Perez-Soler, R.2    Cruz, M.E.3
  • 177
    • 84889854139 scopus 로고    scopus 로고
    • Polymeric nanoparticle formulation of octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn
    • Nandedkar TD, Sagvekar P, Thakur B, et al. Polymeric nanoparticle formulation of octapeptide (NP-OP): in vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn. Indian J Exp Biol 2013; 51(12): 1055-62
    • (2013) Indian J Exp Biol , vol.51 , Issue.12 , pp. 1055-1062
    • Nandedkar, T.D.1    Sagvekar, P.2    Thakur, B.3
  • 178
    • 0023855203 scopus 로고
    • One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (Leuprolide acetate) for treating experimental endometriosis in rats
    • Okada H, Heya T, Ogawa Y, Shimamoto T. One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J Pharmacol Exp Ther 1988; 244(2): 744-50
    • (1988) J Pharmacol Exp Ther , vol.244 , Issue.2 , pp. 744-750
    • Okada, H.1    Heya, T.2    Ogawa, Y.3    Shimamoto, T.4
  • 179
    • 78349294409 scopus 로고    scopus 로고
    • Targeted delivery of protein drugs by nanocarriers
    • Solaro R, Chiellini F, Battisti A. Targeted delivery of protein drugs by nanocarriers. Materials 2010; 3(3): 1928-80
    • (2010) Materials , vol.3 , Issue.3 , pp. 1928-1980
    • Solaro, R.1    Chiellini, F.2    Battisti, A.3
  • 180
    • 2642677624 scopus 로고    scopus 로고
    • Improving protein therapeutics with sustained- release formulations
    • Putney SD, Burke PA. Improving protein therapeutics with sustained- release formulations. Nat Biotechnol 1998; 16(2): 153-57
    • (1998) Nat Biotechnol , vol.16 , Issue.2 , pp. 153-157
    • Putney, S.D.1    Burke, P.A.2
  • 181
    • 0030944482 scopus 로고    scopus 로고
    • Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters
    • Almeida AJ, Runge S, Müller RH. Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters. Int J Pharm 1997; 149(2): 255-65
    • (1997) Int J Pharm , vol.149 , Issue.2 , pp. 255-265
    • Almeida, A.J.1    Runge, S.2    Müller, R.H.3
  • 182
    • 0035850227 scopus 로고    scopus 로고
    • Lipid microparticles as a parenteral controlled release device for peptides
    • Reithmeier H, Herrmann J, Göpferich A. Lipid microparticles as a parenteral controlled release device for peptides. J Control Release 2001; 73(2): 339-50
    • (2001) J Control Release , vol.73 , Issue.2 , pp. 339-350
    • Reithmeier, H.1    Herrmann, J.2    Göpferich, A.3
  • 184
    • 0345148806 scopus 로고    scopus 로고
    • Enzymatic degradation of SLN—effect of surfactant and surfactant mixtures
    • Olbrich C, Müller R. Enzymatic degradation of SLN—effect of surfactant and surfactant mixtures. Int J Pharm 1999; 180(1): 31-39
    • (1999) Int J Pharm , vol.180 , Issue.1 , pp. 31-39
    • Olbrich, C.1    Müller, R.2
  • 185
    • 33750503424 scopus 로고    scopus 로고
    • Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    • Cheng J, Teply BA, Sherifi I, et al. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 2007; 28(5): 869-76
    • (2007) Biomaterials , vol.28 , Issue.5 , pp. 869-876
    • Cheng, J.1    Teply, B.A.2    Sherifi, I.3
  • 186
    • 0031679652 scopus 로고    scopus 로고
    • Surface-induced changes in the structure and activity of enzymes physically immobilized at solid/liquid interfaces
    • Norde W, Zoungrana T. Surface-induced changes in the structure and activity of enzymes physically immobilized at solid/liquid interfaces. Biotechnol Appl Biochem 1998; 28(2): 133-43
    • (1998) Biotechnol Appl Biochem , vol.28 , Issue.2 , pp. 133-143
    • Norde, W.1    Zoungrana, T.2
  • 188
    • 10044251257 scopus 로고    scopus 로고
    • Adsorption of a therapeutic enzyme to self-assembled monolayers: Effect of surface chemistry and solution pH on the amount and activity of adsorbed enzyme
    • Barrias CC, Martins MCL, Miranda MCS, Barbosa MA. Adsorption of a therapeutic enzyme to self-assembled monolayers: effect of surface chemistry and solution pH on the amount and activity of adsorbed enzyme. Biomaterials 2005; 26(15): 2695-704
    • (2005) Biomaterials , vol.26 , Issue.15 , pp. 2695-2704
    • Barrias, C.C.1    Martins, M.2    Miranda, M.3    Barbosa, M.A.4
  • 189
    • 84873721895 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of paclitaxel- loaded mesoporous silica nanoparticles with three pore sizes
    • Jia L, Shen J, Li Z, et al. In vitro and in vivo evaluation of paclitaxel- loaded mesoporous silica nanoparticles with three pore sizes. Int J Pharm 2013; 445(1-2): 12-9
    • (2013) Int J Pharm , vol.445 , Issue.1-2 , pp. 12-19
    • Jia, L.1    Shen, J.2    Li, Z.3
  • 190
    • 84893175988 scopus 로고    scopus 로고
    • Engineered nanoparticles interacting with cells: Size matters
    • Shang L, Nienhaus K, Nienhaus GU. Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnol 2014; 12(5).
    • (2014) J Nanobiotechnol , vol.12 , Issue.5
    • Shang, L.1    Nienhaus, K.2    Nienhaus, G.U.3
  • 191
    • 84875048654 scopus 로고    scopus 로고
    • Fabrication of protein-loaded PLGA nanoparticles: Effect of selected formulation variables on particle size and release profile
    • Azizi M, Farahmandghavi F, Joghataei M, et al. Fabrication of protein-loaded PLGA nanoparticles: effect of selected formulation variables on particle size and release profile. J Polym Res 2013; 20(4): 1-14
    • (2013) J Polym Res , vol.20 , Issue.4 , pp. 1-14
    • Azizi, M.1    Farahmandghavi, F.2    Joghataei, M.3
  • 192
  • 193
    • 47849098030 scopus 로고    scopus 로고
    • The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function
    • Lipski AM, Pino CJ, Haselton FR, Chen I-W, Shastri VP. The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and function. Biomaterials 2008; 29(28): 3836-46
    • (2008) Biomaterials , vol.29 , Issue.28 , pp. 3836-3846
    • Lipski, A.M.1    Pino, C.J.2    Haselton, F.R.3    Chen, I.-W.4    Shastri, V.P.5
  • 194
    • 84888006928 scopus 로고    scopus 로고
    • Nanoparticles mimicking viral surface topography for enhanced cellular delivery
    • Niu Y, Yu M, Hartono SB, et al. Nanoparticles mimicking viral surface topography for enhanced cellular delivery. Adv Mater 2013; 25(43): 6233-7
    • (2013) Adv Mater , vol.25 , Issue.43 , pp. 6233-6237
    • Niu, Y.1    Yu, M.2    Hartono, S.B.3
  • 195
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • He C, Hu Y, Yin L, Tang C, Yin C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 2010; 31(13): 3657-66
    • (2010) Biomaterials , vol.31 , Issue.13 , pp. 3657-3666
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 196
    • 0020662785 scopus 로고
    • Zero-order controlled-release polymer matrices for micro- and macromolecules
    • Hsieh DS, Rhine WD, Langer R. Zero-order controlled-release polymer matrices for micro- and macromolecules. J Pharm Sci 1983; 72(1): 17-22
    • (1983) J Pharm Sci , vol.72 , Issue.1 , pp. 17-22
    • Hsieh, D.S.1    Rhine, W.D.2    Langer, R.3
  • 197
    • 84897847745 scopus 로고    scopus 로고
    • Collagen scaffolds with controlled insulin release and controlled pore structure for cartilage tissue engineering
    • Nanda HS, Chen S, Zhang Q, Kawazoe N, Chen G. Collagen scaffolds with controlled insulin release and controlled pore structure for cartilage tissue engineering. BioMed Res Int 2014; 2014: 10
    • (2014) Biomed Res Int , vol.2014 , pp. 10
    • Nanda, H.S.1    Chen, S.2    Zhang, Q.3    Kawazoe, N.4    Chen, G.5
  • 198
    • 34447259574 scopus 로고    scopus 로고
    • Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholinebased mixed micelles: Preparation and characterization
    • Liu J, Gong T, Wang C, Zhong Z, Zhang Z. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholinebased mixed micelles: preparation and characterization. Int J Pharm 2007; 340(1-2): 153-62
    • (2007) Int J Pharm , vol.340 , Issue.1-2 , pp. 153-162
    • Liu, J.1    Gong, T.2    Wang, C.3    Zhong, Z.4    Zhang, Z.5
  • 199
    • 34447259574 scopus 로고    scopus 로고
    • Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholinebased mixed micelles: Preparation and characterization
    • Liu J, Gong T, Wang C, Zhong Z, Zhang Z. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholinebased mixed micelles: preparation and characterization. Int J Pharm 2007; 340(1): 153-62
    • (2007) Int J Pharm , vol.340 , Issue.1 , pp. 153-162
    • Liu, J.1    Gong, T.2    Wang, C.3    Zhong, Z.4    Zhang, Z.5
  • 200
    • 34548312508 scopus 로고    scopus 로고
    • Solid lipid nanoparticles formed by solvent-in-water emulsiondiffusion technique: Development and influence on insulin stability
    • Battaglia L, Trotta M, Gallarate M, Carlotti ME, Zara GP, Bargoni A. Solid lipid nanoparticles formed by solvent-in-water emulsiondiffusion technique: development and influence on insulin stability. J Microencapsul 2007; 24(7): 672-84
    • (2007) J Microencapsul , vol.24 , Issue.7 , pp. 672-684
    • Battaglia, L.1    Trotta, M.2    Gallarate, M.3    Carlotti, M.E.4    Zara, G.P.5    Bargoni, A.6
  • 201
    • 18844459351 scopus 로고    scopus 로고
    • New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin
    • Garcia-Fuentes M, Torres D, Alonso MJ. New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. Int J Pharm 2005; 296(1): 122-32
    • (2005) Int J Pharm , vol.296 , Issue.1 , pp. 122-132
    • Garcia-Fuentes, M.1    Torres, D.2    Alonso, M.J.3
  • 202
    • 33748363105 scopus 로고    scopus 로고
    • Core/shell nanoparticles with lecithin lipid cores for protein delivery
    • Oh KS, Han SK, Lee HS, et al. Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules 2006; 7(8): 2362-67
    • (2006) Biomacromolecules , vol.7 , Issue.8 , pp. 2362-2367
    • Oh, K.S.1    Han, S.K.2    Lee, H.S.3
  • 203
    • 11044223222 scopus 로고    scopus 로고
    • Liposome-based depot injection technologies
    • Katre NV. Liposome-based depot injection technologies. Am J Drug Deliv 2004; 2(4): 213-27
    • (2004) Am J Drug Deliv , vol.2 , Issue.4 , pp. 213-227
    • Katre, N.V.1
  • 204
    • 36248956678 scopus 로고    scopus 로고
    • Designing Lipid Nanostructures for Local Delivery of Biologically Active Macromolecules
    • Trif M, Roseanu A, Brock JH, Brewer JM. Designing Lipid Nanostructures for Local Delivery of Biologically Active Macromolecules. J Liposome Res 2007; 17(3-4): 237-48
    • (2007) J Liposome Res , vol.17 , Issue.3-4 , pp. 237-248
    • Trif, M.1    Roseanu, A.2    Brock, J.H.3    Brewer, J.M.4
  • 205
    • 31044453148 scopus 로고    scopus 로고
    • Controlled delivery of PDGF-BB for myocardial protection using in jectable self-assembling peptide nanofibers
    • Hsieh PCH, Davis ME, Gannon J, MacGillivray C, Lee RT. Controlled delivery of PDGF-BB for myocardial protection using in jectable self-assembling peptide nanofibers. J Clin Invest 2006; 116(1): 237-48
    • (2006) J Clin Invest , vol.116 , Issue.1 , pp. 237-248
    • Hsieh, P.1    Davis, M.E.2    Gannon, J.3    Macgillivray, C.4    Lee, R.T.5
  • 206
    • 63849135735 scopus 로고    scopus 로고
    • Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold
    • Koutsopoulos S, Unsworth LD, Nagai Y, Zhang S. Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold. Proc Natl Acad Sci USA 2009; 106(12): 4623-28
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.12 , pp. 4623-4628
    • Koutsopoulos, S.1    Unsworth, L.D.2    Nagai, Y.3    Zhang, S.4
  • 207
    • 84906839761 scopus 로고    scopus 로고
    • Activation of caspase-dependent apoptosis by intracellular delivery of Cytochrome c-based nanoparticles
    • Morales-Cruz M, Figueroa CM, Gonzalez-Robles T, et al. Activation of caspase-dependent apoptosis by intracellular delivery of Cytochrome c-based nanoparticles. J Nanobiotechnol 2014; 12: 33
    • (2014) J Nanobiotechnol , vol.12 , pp. 33
    • Morales-Cruz, M.1    Figueroa, C.M.2    Gonzalez-Robles, T.3
  • 208
    • 77953477857 scopus 로고    scopus 로고
    • Factory neovessels: Engineered human blood vessels secreting therapeutic proteins as a new drug delivery system
    • Compte M, Alonso-Camino V, Santos-Valle P, et al. Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system. Gene therapy 2010; 17(6): 745-51
    • (2010) Gene Therapy , vol.17 , Issue.6 , pp. 745-751
    • Compte, M.1    Alonso-Camino, V.2    Santos-Valle, P.3
  • 209
    • 0038681076 scopus 로고    scopus 로고
    • Bone marrow stromal cells as a genetic platformfor systemic delivery of therapeutic proteins in vivo: Human Factor IX model
    • Krebsbach PH, Zhang K, Malik AK, Kurachi K. Bone marrow stromal cells as a genetic platformfor systemic delivery of therapeutic proteins in vivo: human Factor IX model. J Gen Med 2003; 5(1): 11-17
    • (2003) J Gen Med , vol.5 , Issue.1 , pp. 11-17
    • Krebsbach, P.H.1    Zhang, K.2    Malik, A.K.3    Kurachi, K.4
  • 210
    • 0016246083 scopus 로고
    • Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats
    • Gregoriadis G, Putman D, Louis L, Neerunjun D. Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats. Biochem J 1974; 140(2): 323-30
    • (1974) Biochem J , vol.140 , Issue.2 , pp. 323-330
    • Gregoriadis, G.1    Putman, D.2    Louis, L.3    Neerunjun, D.4
  • 211
    • 0018114381 scopus 로고
    • Enzyme replacement using liposome carriers in feline GM1 gangliosidosis fibroblasts
    • Reynolds GD, Baker HJ, Reynolds RH. Enzyme replacement using liposome carriers in feline GM1 gangliosidosis fibroblasts. Nature 1978; 275(5682): 754-55
    • (1978) Nature , vol.275 , Issue.5682 , pp. 754-755
    • Reynolds, G.D.1    Baker, H.J.2    Reynolds, R.H.3
  • 212
    • 0017578647 scopus 로고
    • Enzyme therapy. VI: Comparative in vivo fates and effects on lysosomal integrity of enzyme entrapped in negatively and positively charged liposomes
    • Steger LD, Desnick RJ. Enzyme therapy. VI: Comparative in vivo fates and effects on lysosomal integrity of enzyme entrapped in negatively and positively charged liposomes. Biochim Biophys Acta 1977; 464(3): 530-46
    • (1977) Biochim Biophys Act , vol.464 , Issue.3 , pp. 530-546
    • Steger, L.D.1    Desnick, R.J.2
  • 213
    • 84885322825 scopus 로고    scopus 로고
    • Topical enzymereplacement therapy restores transglutaminase 1 activity and corrects architecture of transglutaminase-1-deficient skin grafts
    • Aufenvenne K, Larcher F, Hausser I, et al. Topical enzymereplacement therapy restores transglutaminase 1 activity and corrects architecture of transglutaminase-1-deficient skin grafts. Am J Hum Genet 2013; 93(4): 620-30
    • (2013) Am J Hum Genet , vol.93 , Issue.4 , pp. 620-630
    • Aufenvenne, K.1    Larcher, F.2    Hausser, I.3
  • 214
    • 0017289464 scopus 로고
    • Introduction of purified hexosaminidase A into Tay-Sachs leukocytes by means of immunoglobulin-coated liposomes
    • Cohen CM, Weissmann G, Hoffstein S, Awasthi YC, Srivastava SK. Introduction of purified hexosaminidase A into Tay-Sachs leukocytes by means of immunoglobulin-coated liposomes. Biochemistry 1976; 15(2): 452-60
    • (1976) Biochemistry , vol.15 , Issue.2 , pp. 452-460
    • Cohen, C.M.1    Weissmann, G.2    Hoffstein, S.3    Awasthi, Y.C.4    Srivastava, S.K.5
  • 215
    • 0017185570 scopus 로고
    • Preparation of glucocerebroside betaglucosidase for entrapment in liposomes and treatment of patients with adult Gaucher's disease
    • Braidman I, Gregoriadis G. Preparation of glucocerebroside betaglucosidase for entrapment in liposomes and treatment of patients with adult Gaucher's disease. Biochem Soc Trans 1976; 4(2): 259-61
    • (1976) Biochem Soc Trans , vol.4 , Issue.2 , pp. 259-261
    • Braidman, I.1    Gregoriadis, G.2
  • 216
    • 0019467837 scopus 로고
    • Experiences after long-term treatment of a type I Gaucher disease patient with liposome-entrapped glucocerebroside: Beta-glucosidase
    • Gregoriadis G, Neerunjun D, Meade TW, Goolamali SK, Weereratne H, Bull G. Experiences after long-term treatment of a type I Gaucher disease patient with liposome-entrapped glucocerebroside: beta-glucosidase. Birth Defects Orig Artic Ser 1980; 16(1): 383-92
    • (1980) Birth Defects Orig Artic Ser , vol.16 , Issue.1 , pp. 383-392
    • Gregoriadis, G.1    Neerunjun, D.2    Meade, T.W.3    Goolamali, S.K.4    Weereratne, H.5    Bull, G.6
  • 217
    • 84879624770 scopus 로고    scopus 로고
    • Lysosome-targeted octadecyl-rhodamine B-liposomes enhance lysosomal accumulation of glucocerebrosidase in Gaucher’s cells in vitro
    • Thekkedath R, Koshkaryev A, Torchilin VP. Lysosome-targeted octadecyl-rhodamine B-liposomes enhance lysosomal accumulation of glucocerebrosidase in Gaucher’s cells in vitro. Nanomedicine 2012; 8(7): 1055-65
    • (2012) Nanomedicine , vol.8 , Issue.7 , pp. 1055-1065
    • Thekkedath, R.1    Koshkaryev, A.2    Torchilin, V.P.3
  • 218
    • 0015379583 scopus 로고
    • Lysosomal localization of - fructofuranosidase-containing liposomes injected into rats
    • Gregoriadis G, Ryman BE. Lysosomal localization of - fructofuranosidase-containing liposomes injected into rats. Biochem J 1972; 129(1): 123-33
    • (1972) Biochem J , vol.129 , Issue.1 , pp. 123-133
    • Gregoriadis, G.1    Ryman, B.E.2
  • 219
    • 0342557321 scopus 로고
    • A general method for the introduction of enzymes, by means of immunoglobulincoated liposomes, into lysosomes of deficient cells
    • Weissmann G, Bloomgarden D, Kaplan R, et al. A general method for the introduction of enzymes, by means of immunoglobulincoated liposomes, into lysosomes of deficient cells. Proc Natl Acad Sci USA 1975; 72(1): 88-92
    • (1975) Proc Natl Acad Sci USA , vol.72 , Issue.1 , pp. 88-92
    • Weissmann, G.1    Bloomgarden, D.2    Kaplan, R.3
  • 220
    • 84891822166 scopus 로고    scopus 로고
    • Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells
    • Méndez J, Morales Cruz M, Delgado Y, et al. Delivery of chemically glycosylated cytochrome c immobilized in mesoporous silica nanoparticles induces apoptosis in HeLa cancer cells. Mol Pharm 2013; 11(1): 102-11
    • (2013) Mol Pharm , vol.11 , Issue.1 , pp. 102-111
    • Méndez, J.1    Morales Cruz, M.2    Delgado, Y.3
  • 221
    • 84870485258 scopus 로고    scopus 로고
    • Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres
    • Morales-Cruz M, Flores-Fernández GM, Morales-Cruz M, et al. Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres. Results Pharma Sci 2012; 2(0): 79-85
    • (2012) Results Pharma Sci , vol.2 , pp. 79-85
    • Morales-Cruz, M.1    Flores-Fernández, G.M.2    Morales-Cruz, M.3
  • 222
    • 84902188616 scopus 로고    scopus 로고
    • Novel polymeric nanoparticles for intracellular delivery of peptide Cargos: Antitumor efficacy of the BCL-2 conversion peptide NuBCP-9
    • Kumar M, Gupta D, Singh G, et al. Novel polymeric nanoparticles for intracellular delivery of peptide Cargos: antitumor efficacy of the BCL-2 conversion peptide NuBCP-9. Cancer Res 2014; 74(12): 3271-81
    • (2014) Cancer Res , vol.74 , Issue.12 , pp. 3271-3281
    • Kumar, M.1    Gupta, D.2    Singh, G.3
  • 223
    • 84904430752 scopus 로고    scopus 로고
    • Light-Responsive Polyion Complex Micelles with Switchable Surface Charge for Efficient Protein Delivery
    • Jin Q, Cai T, Wang Y, Wang H, Ji J. Light-Responsive Polyion Complex Micelles with Switchable Surface Charge for Efficient Protein Delivery. ACS Macro Lett 2014; 3(7): 679-83
    • (2014) ACS Macro Lett , vol.3 , Issue.7 , pp. 679-683
    • Jin, Q.1    Cai, T.2    Wang, Y.3    Wang, H.4    Ji, J.5
  • 224
    • 42949178917 scopus 로고    scopus 로고
    • Self-assembled cationic nanogels for intracellular protein delivery
    • Ayame H, Morimoto N, Akiyoshi K. Self-assembled cationic nanogels for intracellular protein delivery. Bioconjug Chem 2008; 19(4): 882-90
    • (2008) Bioconjug Chem , vol.19 , Issue.4 , pp. 882-890
    • Ayame, H.1    Morimoto, N.2    Akiyoshi, K.3
  • 225
    • 84901433769 scopus 로고    scopus 로고
    • Protein cytoplasmic delivery using polyampholyte nanoparticles and freeze concentration
    • Ahmed S, Hayashi F, Nagashima T, Matsumura K. Protein cytoplasmic delivery using polyampholyte nanoparticles and freeze concentration. Biomaterials 2014; 35(24): 6508-18
    • (2014) Biomaterials , vol.35 , Issue.24 , pp. 6508-6518
    • Ahmed, S.1    Hayashi, F.2    Nagashima, T.3    Matsumura, K.4
  • 226
    • 84866985545 scopus 로고    scopus 로고
    • Bacitracinconjugated superparamagnetic iron oxide nanoparticles: Synthesis, characterization and antibacterial activity
    • Zhang W, Shi X, Huang J, Zhang Y, Wu Z, Xian Y. Bacitracinconjugated superparamagnetic iron oxide nanoparticles: synthesis, characterization and antibacterial activity. ChemPhysChem 2012; 13(14): 3388-96
    • (2012) Chemphyschem , vol.13 , Issue.14 , pp. 3388-3396
    • Zhang, W.1    Shi, X.2    Huang, J.3    Zhang, Y.4    Wu, Z.5    Xian, Y.6
  • 227
    • 84885375706 scopus 로고    scopus 로고
    • Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria
    • Mei L, Lu Z, Zhang W, et al. Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria. Biomaterials 2013; 34(38): 10328-37
    • (2013) Biomaterials , vol.34 , Issue.38 , pp. 10328-10337
    • Mei, L.1    Lu, Z.2    Zhang, W.3
  • 228
    • 84873985749 scopus 로고    scopus 로고
    • Distribution of cyclosporine A in ocular tissues after topical administration of cyclosporine A cationic emulsions to pigmented rabbits
    • Daull P, Lallemand F, Philips B, Lambert G, Buggage R, Garrigue JS. Distribution of cyclosporine A in ocular tissues after topical administration of cyclosporine A cationic emulsions to pigmented rabbits. Cornea 2013; 32(3): 345-54
    • (2013) Cornea , vol.32 , Issue.3 , pp. 345-354
    • Daull, P.1    Lallemand, F.2    Philips, B.3    Lambert, G.4    Buggage, R.5    Garrigue, J.S.6
  • 229
    • 80051912837 scopus 로고    scopus 로고
    • Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(Ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers
    • Di Tommaso C, Torriglia A, Furrer P, Behar-Cohen F, Gurny R, Moller M. Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers. Int J Pharm 2011; 416(2): 515-24
    • (2011) Int J Pharm , vol.416 , Issue.2 , pp. 515-524
    • Di Tommaso, C.1    Torriglia, A.2    Furrer, P.3    Behar-Cohen, F.4    Gurny, R.5    Moller, M.6
  • 230
    • 78650715703 scopus 로고    scopus 로고
    • Novel cyclosporin A formulations using MPEG-hexyl-substituted polylactide micelles: A suitability study
    • Mondon K, Zeisser-Labouebe M, Gurny R, Moller M. Novel cyclosporin A formulations using MPEG-hexyl-substituted polylactide micelles: a suitability study. Eur J Pharm Biopharm 2011; 77(1): 56-65
    • (2011) Eur J Pharm Biopharm , vol.77 , Issue.1 , pp. 56-65
    • Mondon, K.1    Zeisser-Labouebe, M.2    Gurny, R.3    Moller, M.4
  • 231
    • 0036830221 scopus 로고    scopus 로고
    • Enhanced activity of liposomal polymyxin B against Pseudomonas aeruginosa in a rat model of lung infection
    • Omri A, Suntres ZE, Shek PN. Enhanced activity of liposomal polymyxin B against Pseudomonas aeruginosa in a rat model of lung infection. Biochem Pharmacol 2002; 64(9): 1407-13
    • (2002) Biochem Pharmacol , vol.64 , Issue.9 , pp. 1407-1413
    • Omri, A.1    Suntres, Z.E.2    Shek, P.N.3
  • 232
    • 84875492526 scopus 로고    scopus 로고
    • Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy
    • Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z. Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy. Int J Nanomed 2013; 8: 1285-92
    • (2013) Int J Nanomed , vol.8 , pp. 1285-1292
    • Li, C.1    Zhang, X.2    Huang, X.3    Wang, X.4    Liao, G.5    Chen, Z.6
  • 233
    • 84865819679 scopus 로고    scopus 로고
    • Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb
    • Lallemand F, Daull P, Benita S, Buggage R, Garrigue JS. Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb. J Drug Deliv 2012; 2012: 604204
    • (2012) J Drug Deliv , pp. 2012
    • Lallemand, F.1    Daull, P.2    Benita, S.3    Buggage, R.4    Garrigue, J.S.5
  • 234
    • 0024464455 scopus 로고
    • Transfer of phospholipid and protein into the envelope of Gram-negative bacteria by liposome fusion
    • Tomlinson S, Taylor PW, Luzio JP. Transfer of phospholipid and protein into the envelope of Gram-negative bacteria by liposome fusion. Biochemistry 1989; 28(21): 8303-11
    • (1989) Biochemistry , vol.28 , Issue.21 , pp. 8303-8311
    • Tomlinson, S.1    Taylor, P.W.2    Luzio, J.P.3
  • 235
    • 0022361645 scopus 로고
    • Liposomes as carriers of 14C-labelled penicillin and 125Ilabelled albumin through the cell wall of Pseudomonas aeruginosa
    • Sekeri-Pataryas KH, Vakirtzi-Lemonias C, Pataryas HA, Legakis JN. Liposomes as carriers of 14C-labelled penicillin and 125Ilabelled albumin through the cell wall of Pseudomonas aeruginosa. Int J Biol Macromol 1985; 7(6): 379-81
    • (1985) Int J Biol Macromol , vol.7 , Issue.6 , pp. 379-381
    • Sekeri-Pataryas, K.H.1    Vakirtzi-Lemonias, C.2    Pataryas, H.A.3    Legakis, J.N.4
  • 236
    • 84945945783 scopus 로고    scopus 로고
    • Novo Nordisc
    • Insulin in a tablet - why is it so difficult?, Novo Nordisc, http://www.novonordisk.com/about_us/stories/story/insulin-in-atablet.asp, acccessed on 23 Jan 2015., accessed on
    • (2015) Insulin in a Tablet - Why is It So Difficult?
  • 237
    • 0034878181 scopus 로고    scopus 로고
    • The effects of HDV-insulin on carbohydrate metabolism in Type 1 diabetic patients
    • Davis SN, Geho B, Tate D, et al. The effects of HDV-insulin on carbohydrate metabolism in Type 1 diabetic patients. J Diabetes Complications 2001; 15(5): 227-33
    • (2001) J Diabetes Complications , vol.15 , Issue.5 , pp. 227-233
    • Davis, S.N.1    Geho, B.2    Tate, D.3
  • 238
    • 34447577190 scopus 로고    scopus 로고
    • Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
    • Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Control Release 2007; 122(2): 141-50
    • (2007) J Control Release , vol.122 , Issue.2 , pp. 141-150
    • Chalasani, K.B.1    Russell-Jones, G.J.2    Jain, A.K.3    Diwan, P.V.4    Jain, S.K.5
  • 240
    • 79955862560 scopus 로고    scopus 로고
    • Safety of BLP25 Liposome Vaccine (L-BLP25) in Japanese Patients with Unresectable Stage III NSCLC after Primary Chemoradiotherapy: Preliminary Results from a Phase I/II Study
    • Ohyanagi F, Horai T, Sekine I, et al. Safety of BLP25 Liposome Vaccine (L-BLP25) in Japanese Patients with Unresectable Stage III NSCLC after Primary Chemoradiotherapy: Preliminary Results from a Phase I/II Study. Jap J Clin Oncol 2011; 41(5): 718-22
    • (2011) Jap J Clin Oncol , vol.41 , Issue.5 , pp. 718-722
    • Ohyanagi, F.1    Horai, T.2    Sekine, I.3
  • 241
    • 47649084543 scopus 로고    scopus 로고
    • BLP-25 liposomal vaccine: A promising potential therapy in non-small-cell lung cancer
    • Powell E, Chow LQ. BLP-25 liposomal vaccine: a promising potential therapy in non-small-cell lung cancer. Expert Rev Respir Med 2008; 2(1): 37-45
    • (2008) Expert Rev Respir Med , vol.2 , Issue.1 , pp. 37-45
    • Powell, E.1    Chow, L.Q.2
  • 242
    • 33645104916 scopus 로고    scopus 로고
    • Immunogenicity and safety of a virosomal hepatitis A vaccine (Epaxal) in the elderly
    • D'Acremont V, Herzog C, Genton B. Immunogenicity and safety of a virosomal hepatitis A vaccine (Epaxal) in the elderly. J Travel Med 2006; 13(2): 78-83
    • (2006) J Travel Med , vol.13 , Issue.2 , pp. 78-83
    • D'acremont, V.1    Herzog, C.2    Genton, B.3
  • 243
    • 4043142797 scopus 로고    scopus 로고
    • Immunogenicity of booster vaccination with a virosomal hepatitis A vaccine after primary immunization with an aluminum-adsorbed hepatitis A vaccine
    • Beck BR, Hatz CF, Loutan L, Steffen R. Immunogenicity of booster vaccination with a virosomal hepatitis A vaccine after primary immunization with an aluminum-adsorbed hepatitis A vaccine. J Travel Med 2004; 11(4): 201-6
    • (2004) J Travel Med , vol.11 , Issue.4 , pp. 201-206
    • Beck, B.R.1    Hatz, C.F.2    Loutan, L.3    Steffen, R.4
  • 244
    • 0033795671 scopus 로고    scopus 로고
    • Inhalational interleukin-2 liposomes for pulmonary metastases: A phase I clinical trial
    • Skubitz KM, Anderson PM. Inhalational interleukin-2 liposomes for pulmonary metastases: a phase I clinical trial. Anticancer Drugs 2000; 11(7): 555-63
    • (2000) Anticancer Drugs , vol.11 , Issue.7 , pp. 555-563
    • Skubitz, K.M.1    Erson, P.M.2
  • 246
    • 0034965123 scopus 로고    scopus 로고
    • Structural and functional stabilization of L-asparaginase via multisubunit immobilization onto highly activated supports
    • Balcão VM, Mateo C, Fernández-Lafuente R, Malcata FX, Guisán JM. Structural and functional stabilization of L-asparaginase via multisubunit immobilization onto highly activated supports. Biotechnol Prog 2001; 17(3): 537-42
    • (2001) Biotechnol Prog , vol.17 , Issue.3 , pp. 537-542
    • Balcão, V.M.1    Mateo, C.2    Fernández-Lafuente, R.3    Malcata, F.X.4    Guisán, J.M.5
  • 247
    • 84881639252 scopus 로고    scopus 로고
    • Therapeutic proteins and nanotechnology: Immune response and stealth bioengineered constructs
    • Lopez-Marin LM, Tamariz E, Acosta-Torres LS, Castano VM. Therapeutic proteins and nanotechnology: immune response and stealth bioengineered constructs. Curr Drug Metab 2013; 14(5): 531-9
    • (2013) Curr Drug Metab , vol.14 , Issue.5 , pp. 531-539
    • Lopez-Marin, L.M.1    Tamariz, E.2    Acosta-Torres, L.S.3    Castano, V.M.4
  • 248
    • 84899543578 scopus 로고    scopus 로고
    • Site-specific thermodynamic stability and unfolding of a de novo designed protein structural motif mapped by 13C isotopically edited IR spectroscopy
    • Kubelka GS, Kubelka J. Site-specific thermodynamic stability and unfolding of a de novo designed protein structural motif mapped by 13C isotopically edited IR spectroscopy. J Am Chem Soc 2014; 136(16): 6037-48
    • (2014) J am Chem Soc , vol.136 , Issue.16 , pp. 6037-6048
    • Kubelka, G.S.1    Kubelka, J.2
  • 249
    • 77951977004 scopus 로고    scopus 로고
    • Protein kinetic stability
    • Sanchez-Ruiz JM. Protein kinetic stability. Biophys Chem 2010; 148(1-3): 1-15
    • (2010) Biophys Chem , vol.148 , Issue.1-3 , pp. 1-15
    • Sanchez-Ruiz, J.M.1
  • 250
    • 1542353920 scopus 로고    scopus 로고
    • Current clinical applications of the (111)Incapromab pendetide scan (ProstaScint® Scan, Cyt-356)
    • Han M, Partin AW. Current clinical applications of the (111)Incapromab pendetide scan (ProstaScint® Scan, Cyt-356). Rev Urology 2001; 3(4): 165-71
    • (2001) Rev Urology , vol.3 , Issue.4 , pp. 165-171
    • Han, M.1    Partin, A.W.2
  • 251
    • 0034234654 scopus 로고    scopus 로고
    • Carcinoembryonic antigen immunoscintigraphy complements mammography in the diagnosis of breast carcinoma
    • Goldenberg DM, Abdel-Nabi H, Sullivan CL, et al. Carcinoembryonic antigen immunoscintigraphy complements mammography in the diagnosis of breast carcinoma. Cancer 2000; 89(1): 104-15
    • (2000) Cancer , vol.89 , Issue.1 , pp. 104-115
    • Goldenberg, D.M.1    Abdel-Nabi, H.2    Sullivan, C.L.3
  • 252
    • 0030036419 scopus 로고    scopus 로고
    • Neuroendocrine gastrointestinal tumours
    • Öberg K. Neuroendocrine gastrointestinal tumours. Ann Oncol 1996; 7(5): 453-63
    • (1996) Ann Oncol , vol.7 , Issue.5 , pp. 453-463
    • Öberg, K.1
  • 253
    • 34250655364 scopus 로고    scopus 로고
    • The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange
    • Hill HD, Mirkin CA. The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange. Nat Protoc 2006; 1(1): 324-36
    • (2006) Nat Protoc , vol.1 , Issue.1 , pp. 324-336
    • Hill, H.D.1    Mirkin, C.A.2
  • 254
    • 70849093115 scopus 로고    scopus 로고
    • Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy
    • Thaxton CS, Elghanian R, Thomas AD, et al. Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy. Proc Natl Acad Sci USA 2009; 106(44): 18437-42
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.44 , pp. 18437-18442
    • Thaxton, C.S.1    Elghanian, R.2    Thomas, A.D.3
  • 255
    • 14044279957 scopus 로고    scopus 로고
    • Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
    • Georganopoulou DG, Chang L, Nam J-M, et al. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci USA 2005; 102(7): 2273-76.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.7 , pp. 2273-2276
    • Georganopoulou, D.G.1    Chang, L.2    Nam, J.-M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.