Preparation and characterization of biocompatible chitosan nanoparticles for targeted brain delivery of peptides

Methods in Molecular Biology

Volumn 846, Issue , 2012, Pages 321-332

  Caban, Secil ^a   Capan, Yilmaz ^a   Couvreur, Patrick ^b   Dalkara, Turgay ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b UNIV PARIS SUD   (France)

Author keywords

Blood brain barrier; Brain drug delivery; Caspase inhibitors; Nanoparticles; Neuroprotection; Neurotrophic factors

Indexed keywords

BENZOYLCARBONYL ASPARTYL GLUTAMYL VALYL ASPARTYL FLUOROMETHYL KETONE; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; BIOMATERIAL; CHITOSAN; FIBROBLAST GROWTH FACTOR; MONOCLONAL ANTIBODY; NANOPARTICLE; OLIGOPEPTIDE; PEPTIDE; STREPTAVIDIN;

ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; KINETICS; METABOLISM; METHODOLOGY; SCANNING ELECTRON MICROSCOPY;

ANTIBODIES, MONOCLONAL; BIOCOMPATIBLE MATERIALS; BLOOD-BRAIN BARRIER; CHITOSAN; DRUG DELIVERY SYSTEMS; FIBROBLAST GROWTH FACTORS; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; NANOPARTICLES; OLIGOPEPTIDES; PEPTIDES; STREPTAVIDIN;

EID: 84859836479     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-536-7_27     Document Type: Article

References (28)

1. Abbott, N. J., Ronnback, L., and Hansson, E. (2006) Astrocyte-endothelial interactions at the blood-brain barrier, Nature Reviews Neuroscience 7, 41-53. (Pubitemid 41828930)
2. Pardridge, W. M. (1998) CNS drug design based on principles of blood-brain barrier transport, J Neurochem 70, 1781-92. (Pubitemid 28207799)
3. Bickel, U., Yoshikawa, T., and Pardridge, W. M. (2001) Delivery of peptides and proteins through the blood-brain barrier, Adv Drug Deliv Rev 46, 247-79.
4. Pardridge, W. M. (2002) Drug and gene delivery to the brain: the vascular route, Neuron 36, 555-8. (Pubitemid 35346750)
5. Huwyler, J., and Pardridge, W. M. (1998) Examination of blood-brain barrier transferrin receptor by confocal fl uorescent microscopy of unfixed isolated rat brain capillaries, J Neurochem 70, 883-6. (Pubitemid 28079381)
6. Pardridge, W. M., Wu, D., and Sakane, T. (1998) Combined use of carboxyl-directed protein pegylation and vector-mediated bloodbrain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration, Pharm Res 15, 576-82. (Pubitemid 28214951)
7. Karatas, H., Aktas, Y., Gursoy-Ozdemir, Y., Bodur, E., Yemisci, M., Caban, S., Vural, A., Pinarbasli, O., Capan, Y., Fernandez-Megia, E., Novoa-Carballal, R., Riguera, R., Andrieux, K., Couvreur, P., and Dalkara, T. (2009) A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection, J Neurosci 29, 13761-9.
8. Chang, J., Jallouli, Y., Kroubi, M., Yuan, X. B., Feng, W., Kang, C. S., Pu, P. Y., and Betbeder, D. (2009) Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood-brain barrier, Int J Pharm 379, 285-92.
9. Skarlatos, S., Yoshikawa, T., and Pardridge, W. M. (1995) Transport of [125I]transferrin through the rat blood-brain barrier, Brain Res 683, 164-71.
10. Lee, H. J., Engelhardt, B., Lesley, J., Bickel, U., and Pardridge, W. M. (2000) Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse, J Pharmacol Exp Ther 292, 1048-52. (Pubitemid 30136600)
11. Jefferies, W. A., Brandon, M. R., Hunt, S. V., Williams, A. F., Gatter, K. C., and Mason, D. Y. (1984) Transferrin receptor on endothelium of brain capillaries, Nature 312, 162-3. (Pubitemid 14000081)
12. Pardridge, W. M., Buciak, J. L., and Friden, P. M. (1991) Selective transport of an anti-transferrin receptor antibody through the bloodbrain barrier in vivo, J Pharmacol Exp Ther 259, 66-70.
13. Rawat, M., Singh, D., and Saraf, S. (2006) Nanocarriers: promising vehicle for bioactive drugs, Biol Pharm Bull 29, 1790-8. (Pubitemid 44338396)
14. Peracchia, M. T., Fattal, E., Desmaele, D., Besnard, M., Noel, J. P., Gomis, J. M., Appel, M., d'Angelo, J., and Couvreur, P. (1999). Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting. J Control Release 60, 121-8. (Pubitemid 29255834)
15. Prabaharan, M. (2008) Review paper: chitosan derivatives as promising materials for controlled drug delivery, J Biomater Appl 23, 5-36.
16. Fernandez-Urrusuno, R., Calvo, P., Remunan-Lopez, C., Vila-Jato, J. L., and Alonso, M. J. (1999) Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm Res 16, 1576-81. (Pubitemid 29510555)
17. Pan, Y., Li, Y. J., Zhao, H. Y., Zheng, J. M., Xu, H., Wei, G., Hao, J. S., and Cui, F. D. (2002) Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo, Int J Pharm 249, 139-47. (Pubitemid 35333440)
18. Vila, A., Sanchez, A., Tobio, M., Calvo, P., and Alonso, M. J. (2002) Design of biodegradable particles for protein delivery, J Control Release 78, 15-24. (Pubitemid 34081849)
19. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Cellular survival: a play in three Akts, Genes Dev 13, 2905-27.
20. Hara, H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z. H., ShimizuSasamata, M., Yuan, J. Y., and Moskowitz, M. A. (1997) Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage, Proceedings of the National Academy of Sciences of the United States of America 94, 2007-12. (Pubitemid 27113952)
21. Schulz, J. B., Weller, M., and Moskowitz, M. A. (1999) Caspases as treatment targets in stroke and neurodegenerative diseases, Annals of Neurology 45, 421-29. (Pubitemid 29165807)
22. Chen, J., Nagayama, T., Jin, K. L., Stetler, R. A., Zhu, R. L., Graham, S. H., and Simon, R. P. (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia, Journal of Neuroscience 18, 4914-28. (Pubitemid 28285400)
23. Thornberry, N. A., and Lazebnik, Y. (1998) Caspases: Enemies within, Science 281, 1312-16. (Pubitemid 28406817)
24. Aktas, Y., Yemisci, M., Andrieux, K., Gursoy, R. N., Alonso, M. J., Fernandez-Megia, E., Novoa-Carballal, R., Quinoa, E., Riguera, R., Sargon, M. F., Celik, H. H., Demir, A. S., Hincal, A. A., Dalkara, T., Capan, Y., and Couvreur, P. (2005) Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26, Bioconjugate Chemistry 16, 1503-11. (Pubitemid 41681517)
25. Illum, L. (1998) Chitosan and its use as a pharmaceutical excipient, Pharm Res 15, 1326-31. (Pubitemid 28427917)
26. Caban, S., Yemisci, M., Gursoy-Ozdemir, Y., Fernandez-Megia, E., Novoa-Carballal, R., Riguera, R., Andrieux, K., Couvreur, P., Capan, Y., and Dalkara, T. (2010) in "AAPS Annual Meeting and Exposition", New Orleans, Louisiana, USA.
27. Ma, J., Qiu, J., Hirt, L., Dalkara, T., and Moskowitz, M. A. (2001) Synergistic protective effect of caspase inhibitors and bFGF against brain injury induced by transient focal ischaemia, Br J Pharmacol 133, 345-50. (Pubitemid 33027770)
28. Cho, Y., Shi, R., and Ben Borgens, R. (2010) Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury, J Biol Eng 4, 2.