Brain-targeted delivery of protein using chitosan- and RVG peptide-conjugated, pluronic-based nano-carrier

Biomaterials

Volumn 34, Issue 4, 2013, Pages 1170-1178

  Kim, Ja Young ^a   Choi, Won Il ^a   Kim, Young Ha ^b   Tae, Giyoong ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

galactosidase; BBB; Chitosan; Pluronic; Rabies virus glycoprotein (RVG)

Indexed keywords

BBB; BIODISTRIBUTIONS; BLOOD-BRAIN BARRIER; BRAIN DISEASE; BRAIN TISSUE; GALACTOSIDASES; IMAGING AGENT; IN-VIVO; MODEL PROTEINS; NANOCARRIERS; PHYSIC-CHEMICAL PROPERTIES; PLURONICS; PROTEIN DELIVERY; RABIES VIRUS GLYCOPROTEIN (RVG); THERAPEUTIC PROTEIN;

BRAIN; DIAGNOSIS; DISEASE CONTROL; GLYCOPROTEINS; LOADING; PEPTIDES; VIRUSES;

CHITOSAN;

BETA GALACTOSIDASE; CHITOSAN; NANOCARRIER; PEPTIDE; RABIES VIRUS GLYCOPROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN TISSUE; CONJUGATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; CHITOSAN; DIFFUSION; GLYCOPROTEINS; MALE; MICE; MICE, INBRED C3H; MICE, NUDE; NANOCAPSULES; PEPTIDES; POLOXAMER; RABIES VIRUS; TISSUE DISTRIBUTION;

MUS; RABIES VIRUS;

EID: 84870386548     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.09.047     Document Type: Article

References (42)

1. Wadia J.S., Dowdy S.F. Modulation of cellular function by TAT mediated transduction of full length proteins. Curr Protein Pept Sci 2003, 4:97-104.
2. Asoh S., Ohsawa I., Mori T., Katsura K., Hiraide T., Katayama Y., et al. Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci U S A 2002, 29:17107-17112.
3. Alam M.I., Beg S., Samad A., Baboota S., Kohli K., Ali J., et al. Strategy for effective brain drug deliver. Eur J Pharm Sci 2010, 40:385-403.
4. Egleton R.D., Davis T.P. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides 1997, 18:1431-1439.
5. Leader B., Baca Q.J., Golan D.E. Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov 2008, 7:21-39.
6. Zhou Y., Huang W., Liu J., Zhu X., Yan D. Self-assembly of hyperbranched polymers and its biomedical applications. Adv Mater 2010, 22:4567-4590.
7. Zhang S., Kucharski C., Doschak M.R., Sebald W., Uludag H. Polyethylenimine-PEG coated albumin nanoparticles for BMP-2 delivery. Biomaterials 2010, 31:952-963.
8. Nam J.-P., Choi C., Jang M.-K., Jeong Y.-I., Nah J.-W., Kim S.-H., et al. Insulin-incorporated chitosan nanoparticles based on polyelectrolyte complex formation. Macromol Res 2010, 18:630-635.
9. Ye Q., Asherman J., Stevenson M., Brownson E., Katre N.V. DepoFoam™ technology: a vehicle for controlled delivery of protein and peptide drugs. J Control Release 2000, 64:155-166.
10. Chertok B., David A.E., Yang V.C. Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers. Biomaterials 2011, 32:6245-6253.
11. Wang F.H., Kim D.K., Yoshitake T., Johansson S.M., Bjelke B., Muhammed M., et al. Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques. Nanotechnology 2011, 22:1-9.
12. Duffy K.R., Pardridge W.M., Rosenfeld R.G. Human blood-brain barrier insulin like growth factor receptor. Metabolism 1988, 37:136-140.
13. Santra S., Yang H., Dutta D., Stanley J.T., Holloway P.H., Tan W., et al. TAT conjugated, FITC doped silica nanoparticles for bioimaging applications. Chem Commun 2004, 24:2810-2811.
14. Kim D., Jeon C., Kim J.-H., Kim M.-S., Yoon C.-H., Choi I.-S., et al. Cytoplasmic transduction peptide (CTP): New approach for the delivery of biomolecules into cytoplasm in vitro and in vivo. Exp Cell Res 2006, 312:1277-1288.
15. Vergoni A.V., Tosi G., Tacchi R., Vandelli M.A., Bertolini A., Costantino L. Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution. Nanomedicine: Nanotech Biol Med 2009, 5:369-377.
16. Xu G., Yong K.T., Roy I., Mahajan S.D., Ding H., Schwartz S.A., et al. Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier. Bioconjug Chem 2008, 19:1179-1185.
17. Pham W., Zhao B.-Q., Lo E.H., Medarova Z. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage 2005, 28:287-292.
18. Yan H., Wang L., Wang J., Weng X., Lei H., Wang X., et al. Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier. ACS Nano 2012, 6:410-420.
19. Bickel U., Yoshikawa T., Pardridge W.M. Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev 2001, 46:247-279.
20. Sauer I., Dunay I.R., Weisgraber K., Bienert M., Dathe M. An apolipoprotein E derived peptide mediates uptake of statically stabilized liposomes into brain capillary endothelial cells. Biochemistry 2005, 44:2021-2029.
21. Xin H., Jiang X., Gu J., Sha X., Chen L., Law K., et al. Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. Biomaterials 2011, 32:4293-4305.
22. Kwon E.J., Lasiene J., Jacobson B.E., Park I.-K., Horner P.J., Pun S.H. Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials 2010, 31:2417-2424.
23. Li J., Feng L., Fan L., Zha Y., Guo L., Zhang Q., et al. Targeting the brain with PEG-PLGA nanoparticles modified with phage-displatyed peptides. Biomaterials 2011, 32:4943-4950.
24. Hu K., Li J., Shen Y., Lu W., Gao Z., Zhang Q., et al. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release 2009, 134:55-61.
25. Choi W.I., Tae G., Kim Y.H. One pot, single phase synthesis of thermo-sensitive nano-carriers by photo-crosslinking of a diacrylated pluronic. J Mater Chem 2008, 18:2769-2774.
26. Kim J.-Y., Choi W.I., Kim Y.H., Tae G., Lee S.-Y., Kim K., et al. In-vivo tumor targeting of pluronic-based nano-carriers. J Control Release 2010, 147:109-117.
27. Choi W.I., Kim J.-Y., Kang C., Byeon C.C., Kim Y.H., Tae G. Tumor regression in vivo by photothermal therapy based on gold-nanordod-loaded functional nanocarriers. ACS Nano 2011, 5:1995-2003.
28. Choi W.I., Kim Y.H., Tae G. Controlled release of proteins from Pluronic-based nano-carrier. Macromol Res 2011, 19:639-642.
29. Choi W.I., Lee J.H., Kim J.-Y., Kim J.-C., Kim Y.H., Tae G. Efficient skin permeation of soluble proteins via flexible and functional nano-carrier. J Control Release 2012, 157:272-278.
30. Kumar P., Wu H., McBride J.L., Jung K.-E., Kim M.H., Davidson B.L., et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007, 448:39-45.
31. Son S., Hwang D.W., Singha K., Jeong J.H., Park T.G., Lee D.S., et al. RVG peptide tethered bioreducible polyethylenimine for gene delivery to brain. J Control Release 2011, 155:18-25.
32. Wang Z.H., Wang Z.Y., Sun C.S., Wang C.Y., Jiang T.Y., Wang S.L. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials 2010, 31:908-915.
33. Liu Y., Huang G., Han L., Ke W., Shao K., Ye L., et al. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials 2009, 30:4195-4202.
34. Teixido M., Giralt E. The role of peptides in blood-brain barrier nanotechnology. J Pept Sci 2008, 14:163-173.
35. Orive G., Ali O.A., Anitua E., Pedraz J.L., Emerich D.F. Biomaterial-based technologies for brain anti-cancer therapeutics and imaging. Biochem Biophys Acta 2010, 1806:96-107.
36. Felt O., Buri P., Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm 1998, 24:979-993.
37. Patel M.P., Patel R.R., Patel J.K. Chitosan mediated targeted drug delivery system: a review. J Pharm Pharm Sci 2010, 13:536-557.
38. Mitra S., Gaur U., Ghosh P.C., Maitra A.N. Tumor targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Control Release 2001, 74:317-323.
39. Hwang H.Y., Kim I.S., Kwon I.C., Kim Y.H. Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release 2008, 128:23-31.
40. Huang S.-F., Liu D.-B., Zeng J.-M., Yuan Y., Xiao Q., Sun C.-M., et al. Cloning, expression, purification, distribution and kinetics characterization of the bacterial β-galactosidase fused to the cytoplasmic transduction peptide in vitro and iv vivo. Protein Expr Purif 2009, 68:167-176.
41. Drin G., Rousselle C., Schermann J.-M., Rees A.R., Temsamani J. Peptide delivery to the brain via adsorptive-mediated endocytosis: Advances with SynB vectors. AAPS PharmSci 2002, 4:1-7.
42. Pasqualini R., Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature 1996, 380:364-366.