Enhancement of nasal absorption of insulin using chitosan nanoparticles

Pharmaceutical Research

Volumn 16, Issue 10, 1999, Pages 1576-1581

  Fernández Urrusuno, Rocío ^a   Calvo, Pilar ^b   Remuñán López, Carmen ^a   Vila Jato, Jose Luis ^a   Alonso, María José ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIV PARIS SUD   (France)

Author keywords

Absorption enhancement; Chitosan; Insulin; Nanoparticles; Nasal delivery

Indexed keywords

CHITOSAN; GLUCOSE; INSULIN; NANOPARTICLE; PROTASAN; SEACURE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BINDING; DRUG RELEASE; GLUCOSE BLOOD LEVEL; INSULIN TREATMENT; INTRANASAL DRUG ADMINISTRATION; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ZETA POTENTIAL;

ABSORPTION; ADMINISTRATION, INTRANASAL; ANIMALS; BLOOD GLUCOSE; CHEMISTRY, PHYSICAL; CHITIN; CHITOSAN; EXCIPIENTS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSPHERES; NASAL MUCOSA; RABBITS; STIMULATION, CHEMICAL;

EID: 0141719284     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018908705446     Document Type: Article

References (22)

1. C. R. Behl, H. K. Pimplaskar, A. P. Sileno, W. J. Xia, J. C. Gries, and V. D. Romeo. Optimization of systemic nasal drug delivery with pharmaceutical excipients. Adv. Drug Del. Rev. 29:117-133 (1998).
2. C. McMartin, L. E. F. Hutchinson, R. Hyde, and G. E. Peters. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pham. Sci. 76:535-540 (1987).
3. A. E. Pontirolli. Intranasal administration of calcitonin and other peptides: studies with different promoters. J. Contr. Rel. 13:247-251 (1990).
4. S. Hirai, T. Ikenaga, and T. Matsuzawa. Nasal absorption of insulin in dogs. Diabetes 27:296-299 (1978).
5. V. H. L. Lee. Protease inhibitors and penetration enhancers as approaches to modify peptide absorption. J. Contr. Rel. 13:213-223 (1990).
6. N. F. Farraj, B. R. Johansen, S. S. Davis, and L. Illum. Nasal administration of insulin using bioadhesive microspheres as a delivery system. J. Contr. Rel. 13:253-261 (1990).
7. K. Morimoto, K. Morisaka, and A. Kamada. Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel. J. Pharm. Pharmacol. 37:134-136 (1985).
8. L. Illum. Drug delivery systems for nasal application. STP Pharma 3:594-598 (1987).
9. L. Ryden and P. Edman. Effect of polymers and microspheres on the nasal absorption of insulin in rats. Int. J. Pharm. 83:1-10 (1992).
10. L. Jian and L. W. Po. Effects of insulin and nasal absorption enhancers on ciliary activity. Int. J. Pharm. 95:101-104 (1993).
11. M. A. Wheatley, J. Dent, E. B. Wheeldon, and P. L. Smith. Nasal drug delivery: an in vitro characterization of transepithelial electrical properties and fluxes in the presence or absence of enhancers. J. Cont. Rel. 8:167-177 (1988).
12. N. G. M. Schipper, J. Verhoef, S. G. Romeijn, and F. W. H. M. Merkus. Absorption enhancers in nasal insulin delivery and their influence on nasal ciliary functioning. J. Contr. Rel. 21:173-186 (1992).
13. L. Illum, N. F. Farraj, and S. S. Davis. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 11:1186-1189 (1994).
14. P. Artursson, T. Lindmark, S. S Davis, and L. Illum. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 11:1358-1361 (1994).
15. P. Calvo, C. Remun̄an-Lopez, J. L. Vila-Jato, and M. J. Alonso. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J. Appl. Pol. Sci. 63:125-132 (1997).
16. P. Calvo, C. Remun̄an-Lopez, J. L. Vila-Jato, and M. J. Alonso. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm. Res. 14:1431-1436 (1997).
17. P. Calvo, A. S. Boughaba, M. Appel, E. Fattal, M. J. Alonso, and P. Couvreur. Oligonucleotide-chitosan nanoparticles as new gene therapy vector. Proceed. 2nd World Meeting APGI/APV, Paris, 1998, pp. 1111-1112.
18. P. Dondeti, H. Zia, and T. E. Needham. In vivo evaluation of spray formulations of human insulin for nasal delivery. Int. J. Pharm. 122:91-105 (1995).
19. S. H. Mayor and L. Illum. Investigation of the effect of anaesthesia on nasal absorption of insulin in rats. Int. J. Pharm. 149:123-129 (1997).
20. R. Fernandez-Urrusuno, P. Calvo, J. L. Vila-Jato, and M. J. Alonso. Chitosan nanoparticles as carriers for mucosal administration of peptides. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 25:520-521 (1998).
21. T. J. Aspden, L. Illum, and O. Skaugrud. Chitosan as a nasal delivery system: evaluation of insulin absorption and effect on nasal membrane integrity using rat models. Eur. J. Pharm. Sci. 4:23-31 (1996).
22. A. F. Kotzé, H. L. Lueßen, B. J. de Leeuw, B. G. de Boer, J. C. Verhoef, and H. E. Junginger. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J. Contr. Rel. 51:35-46 (1998).