Naturally occurring and therapy-induced antibodies to human granulocyte colony-stimulating factor (G-CSF) in human serum

Journal of Cellular Physiology

Volumn 173, Issue 2, 1997, Pages 219-226

  Laricchia Robbio, Leopoldo ^a   Moscato, Stefania ^a   Genua, Angelo ^b   Liberati, Anna Marina ^b   Revoltella, Roberto P ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; ETOPOSIDE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LOMUSTINE; MEPREDNISONE; MITOXANTRONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADOLESCENT; ADULT; AGED; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; NEUTROPENIA; NONHODGKIN LYMPHOMA; NORMAL HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIBODIES; ANTINEOPLASTIC AGENTS; FEMALE; FETAL BLOOD; GRANULOCYTE COLONY-STIMULATING FACTOR; HODGKIN DISEASE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; MULTIPLE MYELOMA; RECOMBINANT PROTEINS; REFERENCE VALUES;

EID: 0030727797     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199711)173:2<219::AID-JCP25>3.0.CO;2-9     Document Type: Conference Paper

References (21)

1. Nagata, S., Tsuchiya, M., Asano, S., Yamamoto, O., Hirata, Y., Kubata, N., Oheda, M., Nomura, H., and Yamazaki, T. (1986) The chromosomal gene structure and two mRNAs for human granulocyte colony stimulating factor. EMBO J., 5:575-581.
2. Asano, S. (1991) Human granulocyte-colony stimulating factor: Its basic aspects and clinical applications. Am. J. Pediatr. Hematol. Oncol., 13:400-413.
3. Nicola, N. (1990) Granulocyte-colony stimulating factor. In: Colonv Stimulating Factors: Molecular and Cellular Biology. T.M. Dexter, J.M. Garland, and N.G. Testa, eds. Marcel Dekker, New York, pp. 77-109.
4. Nemunaitis, J. (1996) Cytokine-mobilized peripheral blood progenitor cells. Semin. Oncol., 23:9-14.
5. Avalos, B.R., Glasson, G.C., Hedvat, C., Quan, S.G., Baldwin, G.C., Weisbart, R.H., Williams, R.E., Golde, D.W., and DiPersio, J.F. (1990) Human granulocyte colony-stimulating factor biological activities and receptor characterization on hematopoietic cells and small cell lung cancer cells. Blood, 75:851-857.
6. s encoding human granulocyte colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA, 87:8702-8706.
7. American Society of Clinical Oncology. (1994) Recommendation for the use of hematopoietic colony-stimulating factors: Evidence-based, clinical practice guidelines. Am. Soc. Clin. Oncol., 12:2471-2508.
8. Bendtzen, K., Svenson, M., Jonsson, V., and Hippe, E. (1990) Autoantibodies to cytokines - Friends or foes? Immunol. Today, 11:167-169.
9. Ragnhammer, P., Friesen, H.J., Frodin, J.E., Lefvert, A.K., Hassan, M., Ostenborg, A., and Mellstedt, H. (1994) Induction of anti-recombinant granulocyte-macrophage colony stimulating factor (Escherichia coli derived) antibodies and clinical effects in nonimmunocompromised patients. Blood, 584:4078-4087.
10. Beffy, P., Rovero, P., Di Bartolo, V., Laricchia-Robbio, L., Danè, A., Pegoraro, S., Bertolero, F, and Revoltella, P.R. (1994) An immunodominant epitope in a functional domain near the N-terminus of hGM-CSF identified by cross-reaction of synthetic peptides with neutralising antiprotein and antipeptide antibodies. Hybridoma, 13:457-468.
11. Revoltella, R.P., Laricchia-Robbio, L., and Liberati, A.M. (1995) Natural and therapy induced anti-GM-CSF antibodies in human serum. In: Challenges of Modern Medicine. S. Waxman, ed. Ares-Serono Symposia Vol. 10. Ares-Serono, Christengraf Publ., New York, Rome, pp. 165-172.
12. Laemmli, U.K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature, 227:680-685.
13. Towbin, H., Staehelin, T., and Gordon, T. (1979) Electrophoretic transfer of proteins from polyacrilamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA, 76:4350-4354.
14. Svenson, M., Poulsen, L.K., Fomsgaard, A., and Bendtzen, K. (1989) IgG auto-antibodies against interleukin-1α in sera of normal individuals. Scand. J. Immunol., 29:489-492.
15. Bendtzen, K., Hansen, M.B., Diamant, M., Ross, C., and Svenson, M. (1994) Naturally occurring autoantibodies to interleukin-1α, interleukin-6, interleukin-10 and interferon-α. J. Interferon Res., 14:157-158.
16. Bost, K.L., Hahn, D.K., Saag, M.S., Shaw, G.M., Weigent, D.A., and Blalock, J.E. (1988) Individual infected with HIV possess antibodies against IL-2. Immunology, 65:611-615.
17. Kearnly, J.F. (1994) Formation of autoantibodies, including anti-cytokine antibodies, is a hallmark of the immune response of early B cells. J. Interpheron Res., 14:151-152.
18. Bendtzen, K., Hansen, M.B., Ross, C., Poulsen, L.K., and Svenson, M. (1995) Cytokines and autoantibodies to cytokines. Stem Cells, 13:202-222.
19. Finkelman, F.D., Madden, K.B., Morris, S.C., Holmes, J.M., Boiani, N., Katoma, I.M., and Maliszewski, G.R. (1993) Anti-cytokine antibodies as carries proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol., 151:1235-1244.
20. Chen, T.C., and Levy, R. (1995) Induction of autoantibody responses to GM-CSF by hyperimmunization with an Ig-GM-CSF fusion protein. J. Immunol., 153:3105-3117.
21. Chen, T.C., Tao, M., and Levy, R. (1994) Idiotype-cytokine fusion protein as cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J. Immunol., 153:4775.