Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A

Pharmaceutical Research

Volumn 13, Issue 2, 1996, Pages 311-315

  Calvo, Pilar ^a   Sánchez, Alejandro ^a   Martínez, Jésus ^b   López, Maria Isabel ^b   Calonge, Margarita ^b   Pastor, José Carlos ^b   Alonso, María José ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Corneal penetration; Cyclosporin A; Nanocapsules; Ophthalmic administration; Polyepsiloncaprolactone

Indexed keywords

CYCLOSPORIN A; DRUG VEHICLE; MIGLYOL; NANOPARTICLE; POLOXAMER; POLYCAPROLACTONE; POLYESTER; SYNPERONIC; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CORNEA EPITHELIUM; DRUG ABSORPTION; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CORNEA; CYCLOSPORINE; DRUG DELIVERY SYSTEMS; IMMUNOSUPPRESSIVE AGENTS; MALE; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; POLYESTERS; RABBITS;

EID: 0029917195     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016015803611     Document Type: Article

References (14)

1. 14C) acrylate nanoparticles in the albino rabbit. Int. J. Pharm. 23:175-183 (1985).
2. C. Losa, P. Calvo, E. Castro, J. L. Vila-Jato and M. J. Alonso. Improvement of ocular penetration of amikacin sulphate by association to poly(butylcyanoacrylate) nanoparticles. J. Pharm. Pharmacol. 43:548-552 (1991)
3. C. Losa, L. Marchal-Heussler, F. Orallo, J. L. Vila Jato and M. J. Alonso. Design of new formulations for topical ocular administration: polymeric nanocapsules containing metipranolol. Pharm. Res. 10:80-87 (1993)
4. A. Zimmer, J. Kreuter and J. R. Robinson. Studies on the transport pathway of PBCA nanoparticles in ocular tissues. J. Microencapsulation 8:497-504 (1991).
5. L. Marchal-Haussler, H. Fessi, J. P. Devissaguet, M. Hoffman and P. Maincent. Colloidal drug delivery systems for the eye. A comparison of the efficacy of three different polymers: polyisobutylcyanoacrylate, polylactic-coglycolic acid, poly-epsilon-caprolactone. S.T.P. Pharm. Sci. 2:98-104 (1992).
6. P. Calvo, C. Thomas, M. J. Alonso, J. L. Vila Jato and J. R. Robinson. Study of the mechanism of interaction of poly(ε-caprolactone) nanocapsules with the cornea by confocal laser scanning microscopy. Int. J. Pharm. 103:283-291 (1994).
7. Y. Rojanasakul, Mechanisms of ocular peptide absorption and its enhancement. In D. S. Hsieh (ed.), Drug permeation enhancement, Marcel Dekker, Inc., New York, 1994, pp. 397-410.
8. J. C. Zhao and X. Y. Jin. Local therapy of corneal allograft rejection with cyclosporine. Am. J. Opthalmol. 119:189-194 (1995).
9. E. J. Holland, T. W. Olsen, J. M. Ketcham, C. Florine, J. H. Krachmer, J. J. Purcell, S. Lam, H. H. Tessler and J. Sugar. Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea 12:413-419 (1993).
10. A. G. Palestine, R. B. Nussenblatt and C. C. Chan. Side effects of systemic cyclosporine in patients not undergoing transplantation. Am. J. Med. 77:652-656 (1984).
11. M. W. Belin, C. S. Bouchard and T. M. Phillips. Update on topical cyclosporin A. Cornea 9:184-195 (1990).
12. H. Fessi, F. Puisieux, J. P. Devissaguet, N. Ammoury and S. Benita. Nanocapsules formation by interfacial deposition following solvent displacement. Int. J. Pharm. 55:R1-R4 (1989)
13. S. Bonduelle, C. Foucher, J. C. Leroux, F. Chouinard, C. Cadieux and V. Lenaerts. Association of cyclosporin to isohexylcyanoacrylate nanospheres and subsequent release in human plasma in vitro. J. Microencapsulation 9:173-182 (1992).
14. U. Pleyer, B. Elkins, D. Rücker, L. Sabine, J. Grammer, J. Chou, K. H. Schmidt and B. J. Mondino. Ocular absorption of cyclosporin A from liposomes incorporated into collagen shields. Curr. Eye Res. 13:177-181 (1994).