Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriers

International Journal of Pharmaceutics

Volumn 416, Issue 2, 2011, Pages 515-524

  Di Tommaso, Claudia ^a   Torriglia, Alicia ^b,c,d,e   Furrer, Pascal ^a   Behar Cohen, Francine ^b,d,e,f   Gurny, Robert ^a   Möller, Michael ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f HÔTEL DIEU   (France)

Author keywords

Biocompatibility; Cyclosporin A; Drug delivery; Ocular tolerance; Polymeric micelles

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; APOPTOSIS INDUCING FACTOR; CASPASE 3; COPOLYMER; CYCLOSPORIN A; EXCIPIENT; METHOXY POLY(ETHYLENE GLYCOL)HEXYLSUBSTITUTED POLY(LACTIDE); MICROTUBULE ASSOCIATED PROTEIN 1; NANOCARRIER; POLYLACTIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; CLONOGENIC ASSAY; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TOLERANCE; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MICELLE; NONHUMAN; PRIORITY JOURNAL; SCANNING LASER OPHTHALMOSCOPY; SURFACE PROPERTY;

ADMINISTRATION, OPHTHALMIC; ANIMALS; APOPTOSIS; CYCLOSPORINE; DRUG CARRIERS; EPITHELIUM, CORNEAL; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICELLES; OPHTHALMOSCOPY; POLYESTERS; POLYETHYLENE GLYCOLS; RABBITS; SOLUBILITY; TOXICITY TESTS;

EID: 80051912837     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.01.004     Document Type: Article

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