Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization

International Journal of Pharmaceutics

Volumn 428, Issue 1-2, 2012, Pages 164-170

  Shahnaz, Gul ^a   Vetter, Anja ^a   Barthelmes, Jan ^a   Rahmat, Deni ^a   Laffleur, Flavia ^a   Iqbal, Javed ^a   Perera, Glen ^a   Schlocker, Wolfgang ^a   Dünnhaput, Sarah ^a   Augustijns, Patrick ^b   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

Bioavailability; Leuprolide; Nanoparticles (NPs); Nasal delivery; Thiolated polymer

Indexed keywords

CHITOSAN; DISULFIDE; LEUPRORELIN; THIOGLYCOLIC ACID; THIOL;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CILIARY MOTILITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG TRANSPORT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL AVAILABILITY; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HALF-LIFE; HUMANS; LEUPROLIDE; MALE; NANOPARTICLES; NASAL MUCOSA; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; SWINE; THIOGLYCOLATES;

EID: 84859429245     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.02.044     Document Type: Article

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