메뉴 건너뛰기




Volumn 15, Issue 11, 2015, Pages 653-667

Functional and genetic deconstruction of the cellular origin in liver cancer

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED CANCER; BILE DUCT CARCINOMA; CANCER GENETICS; CANCER GROWTH; GENE MUTATION; GENE SEQUENCE; GENETIC HETEROGENEITY; GENOMICS; HUMAN; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; MALIGNANT TRANSFORMATION; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; RARE DISEASE; REVIEW; RNA EDITING; STEM CELL; TUMOR MICROENVIRONMENT; ANIMAL; CELL DIFFERENTIATION; GENETICS; PATHOLOGY;

EID: 84944906098     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc4017     Document Type: Review
Times cited : (261)

References (145)
  • 1
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of disease study 2010
    • Lozano, R. et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1
  • 2
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag, H. B. Hepatocellular carcinoma. N. Engl. J. Med. 365, 1118-1127 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 3
    • 84934823081 scopus 로고    scopus 로고
    • From non-A, non-B hepatitis to hepatitis C virus cure
    • Pawlotsky, J. M., Feld, J. J., Zeuzem, S. & Hoofnagle, J. H. From non-A, non-B hepatitis to hepatitis C virus cure. J. Hepatol. 62, S87-S99 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. S87-S99
    • Pawlotsky, J.M.1    Feld, J.J.2    Zeuzem, S.3    Hoofnagle, J.H.4
  • 4
    • 83555162579 scopus 로고    scopus 로고
    • Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies
    • Marquardt, J. U., Galle, P. R. & Teufel, A. Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): an emerging field for advanced technologies. J. Hepatol. 56, 267-275 (2012).
    • (2012) J. Hepatol. , vol.56 , pp. 267-275
    • Marquardt, J.U.1    Galle, P.R.2    Teufel, A.3
  • 5
    • 84870879515 scopus 로고    scopus 로고
    • Classification, diagnosis, and management of cholangiocarcinoma
    • Razumilava, N. & Gores, G. J. Classification, diagnosis, and management of cholangiocarcinoma. Clin. Gastroenterol. Hepatol. 11, 13-21 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , pp. 13-21
    • Razumilava, N.1    Gores, G.J.2
  • 6
    • 84900992727 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
    • Bridgewater, J. et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J. Hepatol. 60, 1268-1289 (2014).
    • (2014) J. Hepatol. , vol.60 , pp. 1268-1289
    • Bridgewater, J.1
  • 7
    • 61949171989 scopus 로고    scopus 로고
    • Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia
    • erratum 49,1058 (2009)
    • The International Consensus Group for Hepatocellular Neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology 49, 658-664 (2009); erratum 49,1058 (2009)
    • (2009) Hepatology , vol.49 , pp. 658-664
  • 8
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi, P. A. & DePinho, R. A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 6, 674-687 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 9
    • 84892548240 scopus 로고    scopus 로고
    • Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
    • Marquardt, J. U. et al. Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits. J. Hepatol. 60, 346-353 (2014).
    • (2014) J. Hepatol. , vol.60 , pp. 346-353
    • Marquardt, J.U.1
  • 10
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard, C. et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 44, 694-698 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 694-698
    • Guichard, C.1
  • 11
    • 84883718528 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
    • Kan, Z. et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 23, 1422-1433 (2013).
    • (2013) Genome Res. , vol.23 , pp. 1422-1433
    • Kan, Z.1
  • 12
    • 84881436148 scopus 로고    scopus 로고
    • High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    • Nault, J. C. et al. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat. Commun. 4, 2218 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2218
    • Nault, J.C.1
  • 13
    • 84918543521 scopus 로고    scopus 로고
    • Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: Molecular networks and biological concepts
    • Raggi, C., Invernizzi, P. & Andersen, J. B. Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: molecular networks and biological concepts. J. Hepatol. 62, 198-207 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 198-207
    • Raggi, C.1    Invernizzi, P.2    Andersen, J.B.3
  • 14
    • 80052271807 scopus 로고    scopus 로고
    • Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
    • Li, M. et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat. Genet. 43, 828-829 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 828-829
    • Li, M.1
  • 15
    • 85027927831 scopus 로고    scopus 로고
    • High-resolution characterization of a hepatocellular carcinoma genome
    • Totoki, Y. et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat. Genet. 43, 464-469 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 464-469
    • Totoki, Y.1
  • 16
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto, A. et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat. Genet. 44, 760-764 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 760-764
    • Fujimoto, A.1
  • 17
    • 84859441690 scopus 로고    scopus 로고
    • Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors
    • Andersen, J. B. et al. Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology 142, 1021-1031.e15 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1021-1031
    • Andersen, J.B.1
  • 18
    • 84868204026 scopus 로고    scopus 로고
    • Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
    • Oishi, N. et al. Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatology 56, 1792-1803 (2012).
    • (2012) Hepatology , vol.56 , pp. 1792-1803
    • Oishi, N.1
  • 19
    • 84875244110 scopus 로고    scopus 로고
    • Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes
    • Sia, D. et al. Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology 144, 829-840 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 829-840
    • Sia, D.1
  • 20
    • 84861560298 scopus 로고    scopus 로고
    • A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition
    • Seok, J. Y. et al. A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. Hepatology 55, 1776-1786 (2012).
    • (2012) Hepatology , vol.55 , pp. 1776-1786
    • Seok, J.Y.1
  • 21
    • 77951037177 scopus 로고    scopus 로고
    • Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
    • Woo, H. G. et al. Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma. Cancer Res. 70, 3034-3041 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3034-3041
    • Woo, H.G.1
  • 22
    • 4444367700 scopus 로고    scopus 로고
    • Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas
    • Cazals-Hatem, D. et al. Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas. J. Hepatol. 41, 292-298 (2004).
    • (2004) J. Hepatol. , vol.41 , pp. 292-298
    • Cazals-Hatem, D.1
  • 23
    • 0033798899 scopus 로고    scopus 로고
    • Genetic classification of combined hepatocellular-cholangiocarcinoma
    • Fujii, H. et al. Genetic classification of combined hepatocellular-cholangiocarcinoma. Hum. Pathol. 31, 1011-1017 (2000).
    • (2000) Hum. Pathol. , vol.31 , pp. 1011-1017
    • Fujii, H.1
  • 24
    • 84929129284 scopus 로고    scopus 로고
    • Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
    • Schulze, K. et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat. Genet. 47, 505-511 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 505-511
    • Schulze, K.1
  • 25
    • 84901430226 scopus 로고    scopus 로고
    • Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing
    • Jiang, J. H. et al. Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing. Hepatology 59, 2216-2227 (2014).
    • (2014) Hepatology , vol.59 , pp. 2216-2227
    • Jiang, J.H.1
  • 26
    • 66149152693 scopus 로고    scopus 로고
    • Central role of c-Myc during malignant conversion in human hepatocarcinogenesis
    • Kaposi-Novak, P. et al. Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. Cancer Res. 69, 2775-2782 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 2775-2782
    • Kaposi-Novak, P.1
  • 27
    • 84879494478 scopus 로고    scopus 로고
    • Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types
    • Holczbauer, A. et al. Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types. Gastroenterology 145, 221-231 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 221-231
    • Holczbauer, A.1
  • 28
    • 84911902519 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis
    • Nault, J. C. et al. Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis. Hepatology 60, 1983-1992 (2014).
    • (2014) Hepatology , vol.60 , pp. 1983-1992
    • Nault, J.C.1
  • 29
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • Tovar, V. et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J. Hepatol. 52, 550-559 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 550-559
    • Tovar, V.1
  • 30
    • 84919483713 scopus 로고    scopus 로고
    • Profiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma
    • Woo, H. G. et al. Profiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma. PLoS ONE 9, e115152 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e115152
    • Woo, H.G.1
  • 31
    • 84862999344 scopus 로고    scopus 로고
    • Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
    • Sung, W. K. et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat. Genet. 44, 765-769 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 765-769
    • Sung, W.K.1
  • 32
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 33
    • 84922551107 scopus 로고    scopus 로고
    • Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
    • Totoki, Y. et al. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nat. Genet. 46, 1267-1273 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1267-1273
    • Totoki, Y.1
  • 34
    • 84882628975 scopus 로고    scopus 로고
    • Exome capture sequencing reveals new insights into hepatitis B virus-induced hepatocellular carcinoma at the early stage of tumorigenesis
    • Chen, Y., Wang, L., Xu, H., Liu, X. & Zhao, Y. Exome capture sequencing reveals new insights into hepatitis B virus-induced hepatocellular carcinoma at the early stage of tumorigenesis. Oncol. Rep. 30, 1906-1912 (2013).
    • (2013) Oncol. Rep. , vol.30 , pp. 1906-1912
    • Chen, Y.1    Wang, L.2    Xu, H.3    Liu, X.4    Zhao, Y.5
  • 35
    • 84887022334 scopus 로고    scopus 로고
    • Identification of driver genes in hepatocellular carcinoma by exome sequencing
    • Cleary, S. P. et al. Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology 58, 1693-1702 (2013).
    • (2013) Hepatology , vol.58 , pp. 1693-1702
    • Cleary, S.P.1
  • 36
    • 84866868120 scopus 로고    scopus 로고
    • Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma
    • Huang, J. et al. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat. Genet. 44, 1117-1121 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 1117-1121
    • Huang, J.1
  • 37
    • 84864829326 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient
    • Liu, Y. X. et al. Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient. Oncol. Lett. 4, 847-851 (2012).
    • (2012) Oncol. Lett. , vol.4 , pp. 847-851
    • Liu, Y.X.1
  • 38
    • 84902967422 scopus 로고    scopus 로고
    • TERT promoter mutation in resectable hepatocellular carcinomas: A strong association with hepatitis C infection and absence of hepatitis B infection
    • Chen, Y. L. et al. TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection. Int. J. Surg. 12, 659-665 (2014).
    • (2014) Int. J. Surg. , vol.12 , pp. 659-665
    • Chen, Y.L.1
  • 39
    • 84872038565 scopus 로고    scopus 로고
    • Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach
    • Ding, D. et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet. 8, e1003065 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1003065
    • Ding, D.1
  • 40
    • 84964313795 scopus 로고    scopus 로고
    • Diverse modes of genomic alteration in hepatocellular carcinoma
    • Jhunjhunwala, S. et al. Diverse modes of genomic alteration in hepatocellular carcinoma. Genome Biol. 15, 436 (2014).
    • (2014) Genome Biol. , vol.15 , pp. 436
    • Jhunjhunwala, S.1
  • 41
    • 84919686143 scopus 로고    scopus 로고
    • Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers
    • Shiraishi, Y. et al. Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. PLoS ONE 9, e114263 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e114263
    • Shiraishi, Y.1
  • 42
    • 84899430918 scopus 로고    scopus 로고
    • Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: A new clue for the contribution of chromatin remodeling in carcinogenesis
    • Zhong, R. et al. Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis. Sci. Rep. 4, 4147 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 4147
    • Zhong, R.1
  • 43
    • 84897997022 scopus 로고    scopus 로고
    • A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
    • Chan, T. H. et al. A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. Gut 63, 832-843 (2014).
    • (2014) Gut , vol.63 , pp. 832-843
    • Chan, T.H.1
  • 44
    • 84873531277 scopus 로고    scopus 로고
    • Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma
    • Chen, L. et al. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat. Med. 19, 209-216 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 209-216
    • Chen, L.1
  • 45
    • 84922733768 scopus 로고    scopus 로고
    • Genome-wide identification of RNA editing in hepatocellular carcinoma
    • Kang, L. et al. Genome-wide identification of RNA editing in hepatocellular carcinoma. Genomics 105, 76-82 (2015).
    • (2015) Genomics , vol.105 , pp. 76-82
    • Kang, L.1
  • 46
    • 84921958175 scopus 로고    scopus 로고
    • Molecular pathogenesis of intrahepatic cholangiocarcinoma
    • Andersen, J. B. Molecular pathogenesis of intrahepatic cholangiocarcinoma. J. Hepatobiliary Pancreat. Sci. 22, 101-113 (2015).
    • (2015) J. Hepatobiliary Pancreat. Sci. , vol.22 , pp. 101-113
    • Andersen, J.B.1
  • 47
    • 84879418850 scopus 로고    scopus 로고
    • Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas
    • Wang, P. et al. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene 32, 3091-3100 (2013).
    • (2013) Oncogene , vol.32 , pp. 3091-3100
    • Wang, P.1
  • 48
    • 84888385562 scopus 로고    scopus 로고
    • Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers
    • Chan-On, W. et al. Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat. Genet. 45, 1474-1478 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1474-1478
    • Chan-On, W.1
  • 49
    • 84899032205 scopus 로고    scopus 로고
    • Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients
    • Gao, Q. et al. Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology 146, 1397-1407 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1397-1407
    • Gao, Q.1
  • 50
    • 84888353882 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
    • Jiao, Y. et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat. Genet. 45, 1470-1473 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1470-1473
    • Jiao, Y.1
  • 51
    • 84861581233 scopus 로고    scopus 로고
    • Exome sequencing of liver fluke-associated cholangiocarcinoma
    • Ong, C. K. et al. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat. Genet. 44, 690-693 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 690-693
    • Ong, C.K.1
  • 52
    • 84929292324 scopus 로고    scopus 로고
    • Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
    • Sia, D. et al. Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. Nat. Commun. 6, 6087 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6087
    • Sia, D.1
  • 53
    • 84923260975 scopus 로고    scopus 로고
    • Mutational landscape of intrahepatic cholangiocarcinoma
    • Zou, S. et al. Mutational landscape of intrahepatic cholangiocarcinoma. Nat. Commun. 5, 5696 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5696
    • Zou, S.1
  • 54
    • 84944871612 scopus 로고    scopus 로고
    • Liver cancer oncogenomics: Opportunities and dilemmas for clinical applications
    • Marquardt, J. U. & Andersen, J. B. Liver cancer oncogenomics: opportunities and dilemmas for clinical applications. Hepat. Oncol. 2, 79-93 (2015).
    • (2015) Hepat. Oncol. , vol.2 , pp. 79-93
    • Marquardt, J.U.1    Andersen, J.B.2
  • 55
    • 84928560439 scopus 로고    scopus 로고
    • Novel mutations in cholangiocarcinoma with low frequencies revealed by whole mitochondrial genome sequencing
    • Muisuk, K. et al. Novel mutations in cholangiocarcinoma with low frequencies revealed by whole mitochondrial genome sequencing. Asian Pac. J. Cancer Prev. 16, 1737-1742 (2015).
    • (2015) Asian Pac. J. Cancer Prev. , vol.16 , pp. 1737-1742
    • Muisuk, K.1
  • 56
    • 84878781242 scopus 로고    scopus 로고
    • Identification of targetable FGFR gene fusions in diverse cancers
    • Wu, Y. M. et al. Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov. 3, 636-647 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 636-647
    • Wu, Y.M.1
  • 57
    • 84896457874 scopus 로고    scopus 로고
    • New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing
    • Ross, J. S. et al. New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. Oncologist 19, 235-242 (2014).
    • (2014) Oncologist , vol.19 , pp. 235-242
    • Ross, J.S.1
  • 58
    • 84896492774 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
    • Arai, Y. et al. Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma. Hepatology 59, 1427-1434 (2014).
    • (2014) Hepatology , vol.59 , pp. 1427-1434
    • Arai, Y.1
  • 59
    • 84901742112 scopus 로고    scopus 로고
    • Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma
    • Borad, M. J. et al. Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma. PLoS Genet. 10, e1004135 (2014).
    • (2014) PLoS Genet. , vol.10 , pp. e1004135
    • Borad, M.J.1
  • 60
    • 84904618342 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma
    • Graham, R. P. et al. Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma. Hum. Pathol. 45, 1630-1638 (2014).
    • (2014) Hum. Pathol. , vol.45 , pp. 1630-1638
    • Graham, R.P.1
  • 61
    • 25844484569 scopus 로고    scopus 로고
    • Primary liver carcinoma arising in people younger than 30 years
    • Klein, W. M. et al. Primary liver carcinoma arising in people younger than 30 years. Am. J. Clin. Pathol. 124, 512-518 (2005).
    • (2005) Am. J. Clin. Pathol. , vol.124 , pp. 512-518
    • Klein, W.M.1
  • 62
    • 84898445933 scopus 로고    scopus 로고
    • Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation
    • Pilati, C. et al. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell 25, 428-441 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 428-441
    • Pilati, C.1
  • 63
    • 84876494014 scopus 로고    scopus 로고
    • Hepatocellular benign tumors - From molecular classification to personalized clinical care
    • Nault, J. C., Bioulac-Sage, P. & Zucman-Rossi, J. Hepatocellular benign tumors - from molecular classification to personalized clinical care. Gastroenterology 144, 888-902 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 888-902
    • Nault, J.C.1    Bioulac-Sage, P.2    Zucman-Rossi, J.3
  • 64
    • 84898424150 scopus 로고    scopus 로고
    • Next-generation genomic profiling of hepatocellular adenomas: A new era of individualized patient care
    • Marquardt, J. U. & Thorgeirsson, S. S. Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care. Cancer Cell 25, 409-411 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 409-411
    • Marquardt, J.U.1    Thorgeirsson, S.S.2
  • 65
    • 84922233037 scopus 로고    scopus 로고
    • The genomic landscape of hepatoblastoma and their progenies with HCC-like features
    • Eichenmuller, M. et al. The genomic landscape of hepatoblastoma and their progenies with HCC-like features. J. Hepatol. 61, 1312-1320 (2014).
    • (2014) J. Hepatol. , vol.61 , pp. 1312-1320
    • Eichenmuller, M.1
  • 66
    • 84922267671 scopus 로고    scopus 로고
    • Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex
    • Jia, D. et al. Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology 60, 1686-1696 (2014).
    • (2014) Hepatology , vol.60 , pp. 1686-1696
    • Jia, D.1
  • 67
    • 85006217670 scopus 로고    scopus 로고
    • Fibrolamellar hepatocellular carcinoma in the USA, 2000-2010: A detailed report on frequency, treatment and outcome based on the Surveillance, Epidemiology, and End Results database
    • Eggert, T. et al. Fibrolamellar hepatocellular carcinoma in the USA, 2000-2010: a detailed report on frequency, treatment and outcome based on the Surveillance, Epidemiology, and End Results database. United European Gastroenterol. J. 1, 351-357 (2013).
    • (2013) United European Gastroenterol. J. , vol.1 , pp. 351-357
    • Eggert, T.1
  • 68
    • 84896732099 scopus 로고    scopus 로고
    • Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma
    • Honeyman, J. N. et al. Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science 343, 1010-1014 (2014).
    • (2014) Science , vol.343 , pp. 1010-1014
    • Honeyman, J.N.1
  • 69
    • 84925358488 scopus 로고    scopus 로고
    • Unique genomic profile of fibrolamellar hepatocellular carcinoma
    • Cornella, H. et al. Unique genomic profile of fibrolamellar hepatocellular carcinoma. Gastroenterology 148, 806-818 (2014).
    • (2014) Gastroenterology , vol.148 , pp. 806-818
    • Cornella, H.1
  • 70
    • 84921741610 scopus 로고    scopus 로고
    • The genomic landscape of fibrolamellar hepatocellular carcinoma: Whole genome sequencing of ten patients
    • Darcy, D. G. et al. The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients. Oncotarget 6, 755-770 (2014).
    • (2014) Oncotarget , vol.6 , pp. 755-770
    • Darcy, D.G.1
  • 71
    • 84877156945 scopus 로고    scopus 로고
    • Cancer stem cells in the development of liver cancer
    • Yamashita, T. & Wang, X. W. Cancer stem cells in the development of liver cancer. J. Clin. Invest. 123, 1911-1918 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1911-1918
    • Yamashita, T.1    Wang, X.W.2
  • 72
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet, J. M. & Bruix, J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48, 1312-1327 (2008).
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 73
    • 77349086915 scopus 로고    scopus 로고
    • Stem cells in hepatocarcinogenesis: Evidence from genomic data
    • Marquardt, J. U. & Thorgeirsson, S. S. Stem cells in hepatocarcinogenesis: evidence from genomic data. Semin. Liver Dis. 30, 26-34 (2010).
    • (2010) Semin. Liver Dis. , vol.30 , pp. 26-34
    • Marquardt, J.U.1    Thorgeirsson, S.S.2
  • 75
    • 0030715611 scopus 로고    scopus 로고
    • Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
    • Overturf, K., al-Dhalimy, M., Ou, C. N., Finegold, M. & Grompe, M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am. J. Pathol. 151, 1273-1280 (1997).
    • (1997) Am. J. Pathol. , vol.151 , pp. 1273-1280
    • Overturf, K.1    Al-Dhalimy, M.2    Ou, C.N.3    Finegold, M.4    Grompe, M.5
  • 76
    • 84897846435 scopus 로고    scopus 로고
    • Hydrodynamic transfection for generation of novel mouse models for liver cancer research
    • Chen, X. & Calvisi, D. F. Hydrodynamic transfection for generation of novel mouse models for liver cancer research. Am. J. Pathol. 184, 912-923 (2014).
    • (2014) Am. J. Pathol. , vol.184 , pp. 912-923
    • Chen, X.1    Calvisi, D.F.2
  • 77
    • 77349084445 scopus 로고    scopus 로고
    • Mouse models of hepatocellular carcinoma
    • Fausto, N. & Campbell, J. S. Mouse models of hepatocellular carcinoma. Semin. Liver Dis. 30, 87-98 (2010).
    • (2010) Semin. Liver Dis. , vol.30 , pp. 87-98
    • Fausto, N.1    Campbell, J.S.2
  • 78
    • 77952528214 scopus 로고    scopus 로고
    • Cancer gene discovery in hepatocellular carcinoma
    • Zender, L. et al. Cancer gene discovery in hepatocellular carcinoma. J. Hepatol. 52, 921-929 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 921-929
    • Zender, L.1
  • 79
    • 84902081616 scopus 로고    scopus 로고
    • Hippo pathway activity influences liver cell fate
    • Yimlamai, D. et al. Hippo pathway activity influences liver cell fate. Cell 157, 1324-1338 (2014).
    • (2014) Cell , vol.157 , pp. 1324-1338
    • Yimlamai, D.1
  • 80
    • 84878273791 scopus 로고    scopus 로고
    • Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma
    • Tschaharganeh, D. F. et al. Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology 144, 1530-1542.e12 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1530-1542
    • Tschaharganeh, D.F.1
  • 81
    • 84925103805 scopus 로고    scopus 로고
    • YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression
    • Fitamant, J. et al. YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression. Cell Rep. 10, 1692-1707 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 1692-1707
    • Fitamant, J.1
  • 82
    • 77954945373 scopus 로고    scopus 로고
    • The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    • Zhang, N. et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev. Cell 19, 27-38 (2010).
    • (2010) Dev. Cell , vol.19 , pp. 27-38
    • Zhang, N.1
  • 83
    • 79958051227 scopus 로고    scopus 로고
    • Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    • Dorrell, C. et al. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 25, 1193-1203 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 1193-1203
    • Dorrell, C.1
  • 84
    • 84893646586 scopus 로고    scopus 로고
    • Hepatocytes as a source of cholangiocytes in injured liver
    • Lemaigre, F. P. Hepatocytes as a source of cholangiocytes in injured liver. Hepatology 59, 726-728 (2014).
    • (2014) Hepatology , vol.59 , pp. 726-728
    • Lemaigre, F.P.1
  • 85
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • Malato, Y. et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J. Clin. Invest. 121, 4850-4860 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 4850-4860
    • Malato, Y.1
  • 86
    • 84899505830 scopus 로고    scopus 로고
    • Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver
    • Sekiya, S. & Suzuki, A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am. J. Pathol. 184, 1468-1478 (2014).
    • (2014) Am. J. Pathol. , vol.184 , pp. 1468-1478
    • Sekiya, S.1    Suzuki, A.2
  • 87
    • 84876278823 scopus 로고    scopus 로고
    • Robust cellular reprogramming occurs spontaneously during liver regeneration
    • Yanger, K. et al. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 27, 719-724 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 719-724
    • Yanger, K.1
  • 88
    • 84868625552 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
    • Sekiya, S. & Suzuki, A. Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J. Clin. Invest. 122, 3914-3918 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3914-3918
    • Sekiya, S.1    Suzuki, A.2
  • 89
    • 84864773126 scopus 로고    scopus 로고
    • Cholangiocarcinomas can originate from hepatocytes in mice
    • Fan, B. et al. Cholangiocarcinomas can originate from hepatocytes in mice. J. Clin. Invest. 122, 2911-2915 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 2911-2915
    • Fan, B.1
  • 90
    • 84878985394 scopus 로고    scopus 로고
    • A critical role for notch signaling in the formation of cholangiocellular carcinomas
    • Zender, S. et al. A critical role for notch signaling in the formation of cholangiocellular carcinomas. Cancer Cell 23, 784-795 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 784-795
    • Zender, S.1
  • 91
    • 84922750939 scopus 로고    scopus 로고
    • Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
    • Tarlow, B. D. et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell 15, 605-618 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 605-618
    • Tarlow, B.D.1
  • 92
    • 84894229721 scopus 로고    scopus 로고
    • Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma
    • Guest, R. V. et al. Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer Res. 74, 1005-1010 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 1005-1010
    • Guest, R.V.1
  • 93
    • 84918355876 scopus 로고
    • Carcinoma of the liver in rats fed ethionine
    • Farber, E. Carcinoma of the liver in rats fed ethionine. AMA Arch. Pathol. 62, 445-453 (1956).
    • (1956) AMA Arch. Pathol. , vol.62 , pp. 445-453
    • Farber, E.1
  • 94
    • 84963089474 scopus 로고
    • The pathogenesis of tumors of the liver produced by butter yellow
    • Opie, E. L. The pathogenesis of tumors of the liver produced by butter yellow. J. Exp. Med. 80, 231-246 (1944).
    • (1944) J. Exp. Med. , vol.80 , pp. 231-246
    • Opie, E.L.1
  • 95
    • 0023442448 scopus 로고
    • A precursor-product relationship exists between oval cells and hepatocytes in rat liver
    • Evarts, R. P., Nagy, P., Marsden, E. & Thorgeirsson, S. S. A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 8, 1737-1740 (1987).
    • (1987) Carcinogenesis , vol.8 , pp. 1737-1740
    • Evarts, R.P.1    Nagy, P.2    Marsden, E.3    Thorgeirsson, S.S.4
  • 96
    • 84881052522 scopus 로고    scopus 로고
    • Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling
    • Kitade, M. et al. Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Genes Dev. 27, 1706-1717 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 1706-1717
    • Kitade, M.1
  • 97
    • 77955868800 scopus 로고    scopus 로고
    • Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
    • Benhamouche, S. et al. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev. 24, 1718-1730 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1718-1730
    • Benhamouche, S.1
  • 98
    • 84905377981 scopus 로고    scopus 로고
    • P53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
    • Tschaharganeh, D. F. et al. p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell 158, 579-592 (2014).
    • (2014) Cell , vol.158 , pp. 579-592
    • Tschaharganeh, D.F.1
  • 99
    • 84907033777 scopus 로고    scopus 로고
    • Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
    • Saha, S. K. et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature 513, 110-114 (2014).
    • (2014) Nature , vol.513 , pp. 110-114
    • Saha, S.K.1
  • 100
    • 0026447566 scopus 로고
    • Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis
    • Hsia, C. C., Evarts, R. P., Nakatsukasa, H., Marsden, E. R. & Thorgeirsson, S. S. Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 16, 1327-1333 (1992).
    • (1992) Hepatology , vol.16 , pp. 1327-1333
    • Hsia, C.C.1    Evarts, R.P.2    Nakatsukasa, H.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 101
    • 0031730816 scopus 로고    scopus 로고
    • Ductular reaction and its diagnostic significance
    • Roskams, T. & Desmet, V. Ductular reaction and its diagnostic significance. Semin. Diagn. Pathol. 15, 259-269 (1998).
    • (1998) Semin. Diagn. Pathol. , vol.15 , pp. 259-269
    • Roskams, T.1    Desmet, V.2
  • 102
    • 84908133376 scopus 로고    scopus 로고
    • MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism
    • Akita, H. et al. MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism. Cancer Res. 74, 5903-5913 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 5903-5913
    • Akita, H.1
  • 103
    • 45549103691 scopus 로고    scopus 로고
    • Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy
    • Kakarala, M. & Wicha, M. S. Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J. Clin. Oncol. 26, 2813-2820 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2813-2820
    • Kakarala, M.1    Wicha, M.S.2
  • 104
    • 84878887042 scopus 로고    scopus 로고
    • Oncofetal gene SALL4 in aggressive hepatocellular carcinoma
    • Yong, K. J. et al. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N. Engl. J. Med. 368, 2266-2276 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2266-2276
    • Yong, K.J.1
  • 105
    • 84874084734 scopus 로고    scopus 로고
    • Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma
    • Hernandez-Gea, V., Toffanin, S., Friedman, S. L. & Llovet, J. M. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology 144, 512-527 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 512-527
    • Hernandez-Gea, V.1    Toffanin, S.2    Friedman, S.L.3    Llovet, J.M.4
  • 106
    • 84885671431 scopus 로고    scopus 로고
    • Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling
    • He, G. et al. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155, 384-396 (2013).
    • (2013) Cell , vol.155 , pp. 384-396
    • He, G.1
  • 107
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1
  • 108
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park, E. J. et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140, 197-208 (2010).
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1
  • 109
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo, Y., Xu, F., Lu, T., Duan, Z. & Zhang, Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat. Rev. 38, 904-910 (2012).
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3    Duan, Z.4    Zhang, Z.5
  • 111
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan, S. et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 147, 1393-1404 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 1393-1404
    • Wan, S.1
  • 112
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida, Y. et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N. Engl. J. Med. 359, 1995-2004 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1995-2004
    • Hoshida, Y.1
  • 113
    • 73149100826 scopus 로고    scopus 로고
    • IkB kinaseb/nuclear factor-kB activation controls the development of liver metastasis by way of interleukin-6 expression
    • Maeda, S. et al. IkB kinaseb/nuclear factor-kB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology 50, 1851-1860 (2009).
    • (2009) Hepatology , vol.50 , pp. 1851-1860
    • Maeda, S.1
  • 114
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy, A. M. & Mann, D. A. Nuclear factor-kB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46, 590-597 (2007).
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 115
    • 79751492851 scopus 로고    scopus 로고
    • NF-kB in the liver - Linking injury, fibrosis and hepatocellular carcinoma
    • Luedde, T. & Schwabe, R. F. NF-kB in the liver - linking injury, fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 8, 108-118 (2011).
    • (2011) Nat. Rev. Gastroenterol. Hepatol. , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 116
    • 84939270207 scopus 로고    scopus 로고
    • Curcumin effectively inhibits oncogenic NF-kB signaling and restrains stemness features in liver cancer
    • Marquardt, J. U. et al. Curcumin effectively inhibits oncogenic NF-kB signaling and restrains stemness features in liver cancer. J. Hepatol. 63, 661-669 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 661-669
    • Marquardt, J.U.1
  • 117
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kB in cancer development and progression
    • Karin, M. Nuclear factor-kB in cancer development and progression. Nature 441, 431-436 (2006).
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 118
    • 24644478033 scopus 로고    scopus 로고
    • TWEAK induces liver progenitor cell proliferation
    • Jakubowski, A. et al. TWEAK induces liver progenitor cell proliferation. J. Clin. Invest. 115, 2330-2340 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2330-2340
    • Jakubowski, A.1
  • 119
    • 84876241811 scopus 로고    scopus 로고
    • Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling
    • Bird, T. G. et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc. Natl Acad. Sci. USA 110, 6542-6547 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6542-6547
    • Bird, T.G.1
  • 120
    • 84859614232 scopus 로고    scopus 로고
    • Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease
    • Boulter, L. et al. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat. Med. 18, 572-579 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 572-579
    • Boulter, L.1
  • 121
    • 84856994812 scopus 로고    scopus 로고
    • Conflicting roles of molecules in hepatocarcinogenesis: Paradigm or paradox
    • Feng, G. S. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. Cancer Cell 21, 150-154 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 150-154
    • Feng, G.S.1
  • 122
    • 84988648759 scopus 로고    scopus 로고
    • Cancer genomic research at the crossroads: Realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor
    • Li, S. C. et al. Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor. Cancer Cell. Int. 14, 115 (2014).
    • (2014) Cancer Cell. Int. , vol.14 , pp. 115
    • Li, S.C.1
  • 123
    • 84922018236 scopus 로고    scopus 로고
    • EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
    • Lanaya, H. et al. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nat. Cell Biol. 16, 972-981 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , pp. 972-981
    • Lanaya, H.1
  • 124
    • 84933183065 scopus 로고    scopus 로고
    • Cell-type specific functions of EGFR are involved in development of hepatocellular carcinoma
    • Timchenko, N. A. Cell-type specific functions of EGFR are involved in development of hepatocellular carcinoma. Hepatology 62, 314-316 (2015).
    • (2015) Hepatology , vol.62 , pp. 314-316
    • Timchenko, N.A.1
  • 125
    • 84916631333 scopus 로고    scopus 로고
    • Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation
    • Hefetz-Sela, S. et al. Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proc. Natl Acad. Sci. USA 111, 17582-17587 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 17582-17587
    • Hefetz-Sela, S.1
  • 126
    • 84938210994 scopus 로고    scopus 로고
    • Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma
    • Ji, J. et al. Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma. Hepatology 62, 481-495 (2015).
    • (2015) Hepatology , vol.62 , pp. 481-495
    • Ji, J.1
  • 128
    • 84901203792 scopus 로고    scopus 로고
    • Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma
    • Coulouarn, C. & Clement, B. Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma. J. Hepatol. 60, 1306-1309 (2014).
    • (2014) J. Hepatol. , vol.60 , pp. 1306-1309
    • Coulouarn, C.1    Clement, B.2
  • 129
    • 84861147161 scopus 로고    scopus 로고
    • Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma
    • Coulouarn, C. et al. Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Res. 72, 2533-2542 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2533-2542
    • Coulouarn, C.1
  • 130
    • 79960727727 scopus 로고    scopus 로고
    • Hepatic stellate cells: Partners in crime for liver metastases?
    • Kang, N., Gores, G. J. & Shah, V. H. Hepatic stellate cells: partners in crime for liver metastases? Hepatology 54, 707-713 (2011).
    • (2011) Hepatology , vol.54 , pp. 707-713
    • Kang, N.1    Gores, G.J.2    Shah, V.H.3
  • 131
    • 84866399814 scopus 로고    scopus 로고
    • Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma
    • Gentilini, A. et al. Role of the stromal-derived factor-1 (SDF-1)-CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma. J. Hepatol. 57, 813-820 (2012).
    • (2012) J. Hepatol. , vol.57 , pp. 813-820
    • Gentilini, A.1
  • 132
    • 84928797772 scopus 로고    scopus 로고
    • Current concepts of immune based treatments for patients with HCC: From basic science to novel treatment approaches
    • Greten, T. F., Wang, X. W. & Korangy, F. Current concepts of immune based treatments for patients with HCC: from basic science to novel treatment approaches. Gut 64, 842-848 (2015).
    • (2015) Gut , vol.64 , pp. 842-848
    • Greten, T.F.1    Wang, X.W.2    Korangy, F.3
  • 133
    • 84898767802 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Clinical frontiers and perspectives
    • Bruix, J., Gores, G. J. & Mazzaferro, V. Hepatocellular carcinoma: clinical frontiers and perspectives. Gut 63, 844-855 (2014).
    • (2014) Gut , vol.63 , pp. 844-855
    • Bruix, J.1    Gores, G.J.2    Mazzaferro, V.3
  • 135
    • 84926326528 scopus 로고    scopus 로고
    • Immune control in hepatocellular carcinoma development and progression: Role of stromal cells
    • Sprinzl, M. F. & Galle, P. R. Immune control in hepatocellular carcinoma development and progression: role of stromal cells. Semin. Liver Dis. 34, 376-388 (2014).
    • (2014) Semin. Liver Dis. , vol.34 , pp. 376-388
    • Sprinzl, M.F.1    Galle, P.R.2
  • 136
    • 84926408870 scopus 로고    scopus 로고
    • Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion
    • Sprinzl, M. F. et al. Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J. Hepatol. 62, 863-870 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 863-870
    • Sprinzl, M.F.1
  • 137
    • 84879141840 scopus 로고    scopus 로고
    • A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
    • Sangro, B. et al. A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. J. Hepatol. 59, 81-88 (2013).
    • (2013) J. Hepatol. , vol.59 , pp. 81-88
    • Sangro, B.1
  • 138
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1
  • 139
    • 84875225339 scopus 로고    scopus 로고
    • Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
    • Heo, J. et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat. Med. 19, 329-336 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 329-336
    • Heo, J.1
  • 140
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le, D. T. et al. Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J. Clin. Oncol. 33, 1325-1333 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1325-1333
    • Le, D.T.1
  • 143
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner, A., Llovet, J. M. & Bruix, J. Hepatocellular carcinoma. Lancet 379, 1245-1255 (2012).
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 144
    • 84888250929 scopus 로고    scopus 로고
    • Pathogenesis, diagnosis, and management of cholangiocarcinoma
    • Rizvi, S. & Gores, G. J. Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 145, 1215-1229 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 1215-1229
    • Rizvi, S.1    Gores, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.