메뉴 건너뛰기




Volumn 123, Issue 5, 2013, Pages 1911-1918

Cancer stem cells in the development of liver cancer

Author keywords

[No Author keywords available]

Indexed keywords

CANCER STEM CELL; CARCINOGENESIS; DISEASE MARKER; HEPATITIS; HUMAN; LIVER CELL; LIVER DEVELOPMENT; NONHUMAN; ORGANOGENESIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; STRATIFICATION; TREATMENT FAILURE; TUMOR MICROENVIRONMENT;

EID: 84877156945     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66024     Document Type: Review
Times cited : (462)

References (150)
  • 1
    • 0017105982 scopus 로고
    • Clonal origin of human tumors
    • Fialkow PJ. Clonal origin of human tumors. Biochim Biophys Acta. 1976;458(3):283-321.
    • (1976) Biochim Biophys Acta , vol.458 , Issue.3 , pp. 283-321
    • Fialkow, P.J.1
  • 2
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science. 1977;197(4306):893-895.
    • (1977) Science , vol.197 , Issue.4306 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 3
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science. 1976;194(4260):23-28.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 4
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - Biological and translational implications
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer. 2011;11(10):726-734.
    • (2011) Nat Rev Cancer , vol.11 , Issue.10 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 5
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer. 2004;4(11):839-849.
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 7
    • 34447607512 scopus 로고
    • Congenitales, quergestreiftes Muskelsarkom der Nieren
    • Cohnheim J. Congenitales, quergestreiftes Muskelsarkom der Nieren. Path Anat Physiol Klin Med. 1875; 65:64-69.
    • (1875) Path Anat Physiol Klin Med. , vol.65 , pp. 64-69
    • Cohnheim, J.1
  • 8
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea - A paradigm shift
    • Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res. 2006; 66(4):1883-1890.
    • (2006) Cancer Res. , vol.66 , Issue.4 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 9
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997; 3(7):730-737.
    • (1997) Nat Med. , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 10
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645-648.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1
  • 11
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283-296.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 13
    • 80051734611 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma: An international multi-institutional analysis of prognostic factors and lymph node assessment
    • de Jong MC, et al. Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. J Clin Oncol. 2011;29(23):3140-3145.
    • (2011) J Clin Oncol. , vol.29 , Issue.23 , pp. 3140-3145
    • De Jong, M.C.1
  • 14
    • 37549021879 scopus 로고    scopus 로고
    • Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: Immunohistochemical and double-fluorescence immunostaining evidence
    • Zhang F, et al. Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence. Histopathology. 2008;52(2):224-232.
    • (2008) Histopathology , vol.52 , Issue.2 , pp. 224-232
    • Zhang, F.1
  • 15
    • 84861552732 scopus 로고    scopus 로고
    • Mucin-producing cholangiocarcinoma might derive from biliary tree stem/progenitor cells located in peribiliary glands
    • Cardinale V, Wang Y, Carpino G, Reid LM, Gaudio E, Alvaro D. Mucin-producing cholangiocarcinoma might derive from biliary tree stem/progenitor cells located in peribiliary glands. Hepatology. 2012;55(6):2041-2042.
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 2041-2042
    • Cardinale, V.1    Wang, Y.2    Carpino, G.3    Reid, L.M.4    Gaudio, E.5    Alvaro, D.6
  • 16
    • 43949123310 scopus 로고    scopus 로고
    • Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin
    • Komuta M, et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008;47(5):1544-1556.
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1544-1556
    • Komuta, M.1
  • 17
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • Ma S, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology. 2007;132(7):2542-2556.
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2542-2556
    • Ma, S.1
  • 18
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/ progenitor cell features
    • Yamashita T, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/ progenitor cell features. Gastroenterology. 2009; 136(3):1012-1024.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 1012-1024
    • Yamashita, T.1
  • 19
    • 77956388547 scopus 로고    scopus 로고
    • CD13 is a therapeutic target in human liver cancer stem cells
    • Haraguchi N, et al. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest. 2010; 120(9):3326-3339.
    • (2010) J Clin Invest. , vol.120 , Issue.9 , pp. 3326-3339
    • Haraguchi, N.1
  • 20
    • 38549139140 scopus 로고    scopus 로고
    • Significance of CD90+ cancer stem cells in human liver cancer
    • Yang ZF, et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell. 2008; 13(2):153-166.
    • (2008) Cancer Cell , vol.13 , Issue.2 , pp. 153-166
    • Yang, Z.F.1
  • 21
    • 79960006754 scopus 로고    scopus 로고
    • CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation
    • Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell. 2011; 9(1):50-63.
    • (2011) Cell Stem Cell , vol.9 , Issue.1 , pp. 50-63
    • Lee, T.K.1    Castilho, A.2    Cheung, V.C.3    Tang, K.H.4    Ma, S.5    Ng, I.O.6
  • 22
    • 51649119918 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    • Ma S, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res. 2008;6(7):1146-1153.
    • (2008) Mol Cancer Res. , vol.6 , Issue.7 , pp. 1146-1153
    • Ma, S.1
  • 23
    • 84865138796 scopus 로고    scopus 로고
    • OV6(+) tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma
    • Yang W, et al. OV6(+) tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 2012; 57(3):613-620.
    • (2012) J Hepatol. , vol.57 , Issue.3 , pp. 613-620
    • Yang, W.1
  • 24
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • Chiba T, et al. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology. 2006;44(1):240-251.
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 240-251
    • Chiba, T.1
  • 25
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002;31(4):339-346.
    • (2002) Nat Genet. , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 26
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene. 2006;25(27):3818-3822.
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3818-3822
    • Roskams, T.1
  • 27
    • 39149115049 scopus 로고    scopus 로고
    • Stem cells, cell transplantation and liver repopulation
    • Oertel M, Shafritz DA. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta. 2008;1782(2):61-74.
    • (2008) Biochim Biophys Acta , vol.1782 , Issue.2 , pp. 61-74
    • Oertel, M.1    Shafritz, D.A.2
  • 28
    • 0042668538 scopus 로고    scopus 로고
    • Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle
    • Nguyen H, Mudryj M, Guadalupe M, Dandekar S. Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle. Virology. 2003;312(1):245-253.
    • (2003) Virology , vol.312 , Issue.1 , pp. 245-253
    • Nguyen, H.1    Mudryj, M.2    Guadalupe, M.3    Dandekar, S.4
  • 29
    • 11144339385 scopus 로고    scopus 로고
    • Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection
    • Marshall A, et al. Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology. 2005;128(1):33-42.
    • (2005) Gastroenterology , vol.128 , Issue.1 , pp. 33-42
    • Marshall, A.1
  • 30
    • 16244416190 scopus 로고    scopus 로고
    • Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis
    • Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology. 2005;41(4):809-818.
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 809-818
    • Clouston, A.D.1    Powell, E.E.2    Walsh, M.J.3    Richardson, M.M.4    Demetris, A.J.5    Jonsson, J.R.6
  • 31
    • 1942487273 scopus 로고    scopus 로고
    • Canals of Hering: Recent insights and current knowledge
    • Saxena R, Theise N. Canals of Hering: recent insights and current knowledge. Semin Liver Dis. 2004; 24(1):43-48.
    • (2004) Semin Liver Dis. , vol.24 , Issue.1 , pp. 43-48
    • Saxena, R.1    Theise, N.2
  • 32
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden DT. The stem-cell niche as an entity of action. Nature. 2006;441(7097):1075-1079.
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1075-1079
    • Scadden, D.T.1
  • 33
    • 77954045897 scopus 로고    scopus 로고
    • Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis
    • Ziol M, et al. Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis. Gastroenterology. 2010;139(1):335-343.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 335-343
    • Ziol, M.1
  • 34
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson MA, Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 2007;252(2):157-170.
    • (2007) Cancer Lett. , vol.252 , Issue.2 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 35
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A. 1994;91(6):2230-2234.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.6 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 36
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology. 2002;122(2):366-375.
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 366-375
    • Okuda, M.1
  • 37
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 2006;6(9):674-687.
    • (2006) Nat Rev Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 38
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
    • Hussain SP, Schwank J, Staib F, Wang XW, Harris CC. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene. 2007;26(15):2166-2176.
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 39
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A, et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. 2006;10(2):99-111.
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1
  • 41
    • 0029026661 scopus 로고
    • Cytokines and cellular crosstalk involved in the activation of fat-storing cells
    • Gressner AM. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol. 1995;22(2 suppl):28-36.
    • (1995) J Hepatol. , vol.22 , Issue.2 SUPPL. , pp. 28-36
    • Gressner, A.M.1
  • 42
    • 34248674146 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in liver health and disease
    • Thompson MD, Monga SP. WNT/beta-catenin signaling in liver health and disease. Hepatology. 2007;45(5):1298-1305.
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 43
    • 0035024760 scopus 로고    scopus 로고
    • Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver
    • Sato T, El-Assal ON, Ono T, Yamanoi A, Dhar DK, Nagasue N. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol. 2001;34(5):690-698.
    • (2001) J Hepatol. , vol.34 , Issue.5 , pp. 690-698
    • Sato, T.1    El-Assal, O.N.2    Ono, T.3    Yamanoi, A.4    Dhar, D.K.5    Nagasue, N.6
  • 44
    • 0035013447 scopus 로고    scopus 로고
    • Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats
    • Shimizu H, et al. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol. 2001;34(5):683-689.
    • (2001) J Hepatol. , vol.34 , Issue.5 , pp. 683-689
    • Shimizu, H.1
  • 45
    • 0033580985 scopus 로고    scopus 로고
    • Initiation of mammalian liver development from endoderm by fibroblast growth factors
    • Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science. 1999; 284(5422):1998-2003.
    • (1999) Science , vol.284 , Issue.5422 , pp. 1998-2003
    • Jung, J.1    Zheng, M.2    Goldfarb, M.3    Zaret, K.S.4
  • 46
    • 0035423751 scopus 로고    scopus 로고
    • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
    • Rossi JM, Dunn NR, Hogan BL, Zaret KS. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 2001;15(15):1998- 2009.
    • (2001) Genes Dev. , vol.15 , Issue.15 , pp. 1998-2009
    • Rossi, J.M.1    Dunn, N.R.2    Hogan, B.L.3    Zaret, K.S.4
  • 47
    • 33747033130 scopus 로고    scopus 로고
    • Mesodermal Wnt2b signalling positively regulates liver specification
    • Ober EA, Verkade H, Field HA, Stainier DY. Mesodermal Wnt2b signalling positively regulates liver specification. Nature. 2006;442(7103):688-691.
    • (2006) Nature , vol.442 , Issue.7103 , pp. 688-691
    • Ober, E.A.1    Verkade, H.2    Field, H.A.3    Stainier, D.Y.4
  • 48
    • 38649093310 scopus 로고    scopus 로고
    • Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate
    • Decaens T, et al. Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate. Hepatology. 2008;47(1):247-258.
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 247-258
    • Decaens, T.1
  • 49
    • 0037064554 scopus 로고    scopus 로고
    • Cytokine regulation of liver development
    • Kinoshita T, Miyajima A. Cytokine regulation of liver development. Biochim Biophys Acta. 2002; 1592(3):303-312.
    • (2002) Biochim Biophys Acta , vol.1592 , Issue.3 , pp. 303-312
    • Kinoshita, T.1    Miyajima, A.2
  • 50
    • 5444247776 scopus 로고    scopus 로고
    • Liver development update: New embryo models, cell lineage control, and morphogenesis
    • Lemaigre F, Zaret KS. Liver development update: new embryo models, cell lineage control, and morphogenesis. Curr Opin Genet Dev. 2004;14(5):582-590.
    • (2004) Curr Opin Genet Dev. , vol.14 , Issue.5 , pp. 582-590
    • Lemaigre, F.1    Zaret, K.S.2
  • 51
    • 0037220834 scopus 로고    scopus 로고
    • Beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification
    • Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GK. Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology. 2003;124(1):202-216.
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 202-216
    • Monga, S.P.1    Monga, H.K.2    Tan, X.3    Mule, K.4    Pediaditakis, P.5    Michalopoulos, G.K.6
  • 52
    • 84864465226 scopus 로고    scopus 로고
    • Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    • Ji J, Wang XW. Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin Oncol. 2012;39(4):461-472.
    • (2012) Semin Oncol. , vol.39 , Issue.4 , pp. 461-472
    • Ji, J.1    Wang, X.W.2
  • 53
    • 79952212865 scopus 로고    scopus 로고
    • Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis
    • Gauglhofer C, et al. Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis. Hepatology. 2011;53(3):854-864.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 854-864
    • Gauglhofer, C.1
  • 54
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene. 2010; 29(36):4989-5005.
    • (2010) Oncogene , vol.29 , Issue.36 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 55
    • 5144226941 scopus 로고    scopus 로고
    • Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma
    • Merle P, et al. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology. 2004;127(4):1110-1122.
    • (2004) Gastroenterology , vol.127 , Issue.4 , pp. 1110-1122
    • Merle, P.1
  • 56
    • 36348991571 scopus 로고    scopus 로고
    • Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma
    • Yamashita T, Budhu A, Forgues M, Wang XW. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res. 2007;67(22):10831-10839.
    • (2007) Cancer Res. , vol.67 , Issue.22 , pp. 10831-10839
    • Yamashita, T.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 57
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 2008; 68(5):1451-1461.
    • (2008) Cancer Res. , vol.68 , Issue.5 , pp. 1451-1461
    • Yamashita, T.1
  • 58
    • 49249122615 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    • Yang W, et al. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008;68(11):4287- 4295.
    • (2008) Cancer Res. , vol.68 , Issue.11 , pp. 4287-4295
    • Yang, W.1
  • 59
    • 38649103789 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling mediates oval cell response in rodents
    • Apte U, Thompson MD, Cui S, Liu B, Cieply B, Monga SP. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology. 2008; 47(1):288-295.
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 288-295
    • Apte, U.1    Thompson, M.D.2    Cui, S.3    Liu, B.4    Cieply, B.5    Monga, S.P.6
  • 60
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology. 2009;50(2):472-480.
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 472-480
    • Ji, J.1
  • 61
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard C, et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet. 2012;44(6):694-698.
    • (2012) Nat Genet. , vol.44 , Issue.6 , pp. 694-698
    • Guichard, C.1
  • 62
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto A, et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet. 2012;44(7):760-764.
    • (2012) Nat Genet. , vol.44 , Issue.7 , pp. 760-764
    • Fujimoto, A.1
  • 63
    • 80052271807 scopus 로고    scopus 로고
    • Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
    • Li M, et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet. 2011;43(9):828-829.
    • (2011) Nat Genet. , vol.43 , Issue.9 , pp. 828-829
    • Li, M.1
  • 64
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Hoshida Y, et al. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009; 69(18):7385-7392.
    • (2009) Cancer Res. , vol.69 , Issue.18 , pp. 7385-7392
    • Hoshida, Y.1
  • 65
    • 84865562740 scopus 로고    scopus 로고
    • Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFbeta signaling pathways
    • Coulouarn C, et al. Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFbeta signaling pathways. Carcinogenesis. 2012;33(9):1791-1796.
    • (2012) Carcinogenesis , vol.33 , Issue.9 , pp. 1791-1796
    • Coulouarn, C.1
  • 66
    • 84865133667 scopus 로고    scopus 로고
    • BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma
    • Zhang L, et al. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma. Cancer Res. 2012;72(16):4276-4285.
    • (2012) Cancer Res. , vol.72 , Issue.16 , pp. 4276-4285
    • Zhang, L.1
  • 67
    • 77953155085 scopus 로고    scopus 로고
    • Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation
    • Yamashita T, et al. Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. Cancer Res. 2010; 70(11):4687-4697.
    • (2010) Cancer Res. , vol.70 , Issue.11 , pp. 4687-4697
    • Yamashita, T.1
  • 68
    • 23944458649 scopus 로고    scopus 로고
    • Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    • Clotman F, et al. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev. 2005; 19(16):1849-1854.
    • (2005) Genes Dev. , vol.19 , Issue.16 , pp. 1849-1854
    • Clotman, F.1
  • 69
    • 77950602936 scopus 로고    scopus 로고
    • Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver
    • Thenappan A, et al. Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver. Hepatology. 2010;51(4):1373-1382.
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1373-1382
    • Thenappan, A.1
  • 70
    • 58949088366 scopus 로고    scopus 로고
    • Liver stem cells and hepatocellular carcinoma
    • Mishra L, et al. Liver stem cells and hepatocellular carcinoma. Hepatology. 2009;49(1):318-329.
    • (2009) Hepatology , vol.49 , Issue.1 , pp. 318-329
    • Mishra, L.1
  • 71
    • 84155180680 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss
    • Morris SM, Baek JY, Koszarek A, Kanngurn S, Knoblaugh SE, Grady WM. Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss. Hepatology. 2012;55(1):121-131.
    • (2012) Hepatology , vol.55 , Issue.1 , pp. 121-131
    • Morris, S.M.1    Baek, J.Y.2    Koszarek, A.3    Kanngurn, S.4    Knoblaugh, S.E.5    Grady, W.M.6
  • 72
    • 84870518210 scopus 로고    scopus 로고
    • Hepatic TGF-bet a gives rise to tumor-initiating cells and promotes liver cancer development
    • Wu K, et al. Hepatic TGF-bet a gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology. 2012;56(6):2255-2267.
    • (2012) Hepatology , vol.56 , Issue.6 , pp. 2255-2267
    • Wu, K.1
  • 73
    • 77951460399 scopus 로고    scopus 로고
    • Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta
    • You H, Ding W, Rountree CB. Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology. 2010; 51(5):1635-1644.
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1635-1644
    • You, H.1    Ding, W.2    Rountree, C.B.3
  • 74
    • 84866052345 scopus 로고    scopus 로고
    • Transforming the microenvironment: A trick of the metastatic cancer cell
    • Budhu A, Wang XW. Transforming the microenvironment: a trick of the metastatic cancer cell. Cancer Cell. 2012;22(3):279-280.
    • (2012) Cancer Cell , vol.22 , Issue.3 , pp. 279-280
    • Budhu, A.1    Wang, X.W.2
  • 75
    • 84866018690 scopus 로고    scopus 로고
    • TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • Yang P, et al. TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012;22(3):291-303.
    • (2012) Cancer Cell , vol.22 , Issue.3 , pp. 291-303
    • Yang, P.1
  • 76
    • 34848864570 scopus 로고    scopus 로고
    • Liver regeneration
    • Michalopoulos GK. Liver regeneration. J Cell Physiol. 2007;213(2):286-300.
    • (2007) J Cell Physiol. , vol.213 , Issue.2 , pp. 286-300
    • Michalopoulos, G.K.1
  • 77
    • 40649116943 scopus 로고    scopus 로고
    • Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling
    • Tang Y, et al. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A. 2008;105(7):2445-2450.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.7 , pp. 2445-2450
    • Tang, Y.1
  • 78
    • 80555154065 scopus 로고    scopus 로고
    • Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
    • Viatour P, et al. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011;208(10):1963-1976.
    • (2011) J Exp Med. , vol.208 , Issue.10 , pp. 1963-1976
    • Viatour, P.1
  • 79
    • 84869774410 scopus 로고    scopus 로고
    • Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice
    • Villanueva A, et al. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology. 2012; 143(6):1660-1669.
    • (2012) Gastroenterology , vol.143 , Issue.6 , pp. 1660-1669
    • Villanueva, A.1
  • 80
    • 84859153211 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice
    • Ishikawa T, et al. Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice. Hepatology. 2012;55(4):1215-1226.
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1215-1226
    • Ishikawa, T.1
  • 81
    • 43949098305 scopus 로고    scopus 로고
    • Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium
    • Limaye PB, Bowen WC, Orr AV, Luo J, Tseng GC, Michalopoulos GK. Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology. 2008;47(5):1702-1713.
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1702-1713
    • Limaye, P.B.1    Bowen, W.C.2    Orr, A.V.3    Luo, J.4    Tseng, G.C.5    Michalopoulos, G.K.6
  • 82
    • 77956635530 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion
    • Ding W, et al. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010;52(3):945-953.
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 945-953
    • Ding, W.1
  • 83
    • 34547803161 scopus 로고    scopus 로고
    • Human hepatic stem cells from fetal and postnatal donors
    • Schmelzer E, et al. Human hepatic stem cells from fetal and postnatal donors. J Exp Med. 2007; 204(8):1973-1987.
    • (2007) J Exp Med. , vol.204 , Issue.8 , pp. 1973-1987
    • Schmelzer, E.1
  • 84
    • 0032986367 scopus 로고    scopus 로고
    • Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells
    • Niki T, et al. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology. 1999;29(2):520-527.
    • (1999) Hepatology , vol.29 , Issue.2 , pp. 520-527
    • Niki, T.1
  • 86
    • 0035127758 scopus 로고    scopus 로고
    • Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium
    • Crosby HA, Kelly DA, Strain AJ. Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium. Gastroenterology. 2001;120(2):534-544.
    • (2001) Gastroenterology , vol.120 , Issue.2 , pp. 534-544
    • Crosby, H.A.1    Kelly, D.A.2    Strain, A.J.3
  • 87
    • 58149386485 scopus 로고    scopus 로고
    • Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver
    • Suzuki A, et al. Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver. Hepatology. 2008;48(6):1964-1978.
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1964-1978
    • Suzuki, A.1
  • 88
    • 35348840809 scopus 로고    scopus 로고
    • A CD133-expressing murine liver oval cell population with bilineage potential
    • Rountree CB, Barsky L, Ge S, Zhu J, Senadheera S, Crooks GM. A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells. 2007;25(10):2419-2429.
    • (2007) Stem Cells , vol.25 , Issue.10 , pp. 2419-2429
    • Rountree, C.B.1    Barsky, L.2    Ge, S.3    Zhu, J.4    Senadheera, S.5    Crooks, G.M.6
  • 89
    • 48249142320 scopus 로고    scopus 로고
    • Hepatic progenitor cells from adult human livers for cell transplantation
    • Weiss TS, et al. Hepatic progenitor cells from adult human livers for cell transplantation. Gut. 2008;57(8):1129-1138.
    • (2008) Gut. , vol.57 , Issue.8 , pp. 1129-1138
    • Weiss, T.S.1
  • 90
    • 0036403853 scopus 로고    scopus 로고
    • Purification of fetal mouse hepatoblasts by magnetic beads coated with monoclonal anti-e-cadherin antibodies and their in vitro culture
    • Nitou M, Sugiyama Y, Ishikawa K, Shiojiri N. Purification of fetal mouse hepatoblasts by magnetic beads coated with monoclonal anti-e-cadherin antibodies and their in vitro culture. Exp Cell Res. 2002; 279(2):330-343.
    • (2002) Exp Cell Res. , vol.279 , Issue.2 , pp. 330-343
    • Nitou, M.1    Sugiyama, Y.2    Ishikawa, K.3    Shiojiri, N.4
  • 91
    • 39749131737 scopus 로고    scopus 로고
    • Purification of fetal liver stem/ progenitor cells containing all the repopulation potential for normal adult rat liver
    • Oertel M, Menthena A, Chen YQ, Teisner B, Jensen CH, Shafritz DA. Purification of fetal liver stem/ progenitor cells containing all the repopulation potential for normal adult rat liver. Gastroenterology. 2008;134(3):823-832.
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 823-832
    • Oertel, M.1    Menthena, A.2    Chen, Y.Q.3    Teisner, B.4    Jensen, C.H.5    Shafritz, D.A.6
  • 92
    • 0038325629 scopus 로고    scopus 로고
    • Isolation of hepatoblasts based on the expression of Dlk/Pref-1
    • Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci. 2003; 116(pt 9):1775-1786.
    • (2003) J Cell Sci. , vol.116 , Issue.PART 9 , pp. 1775-1786
    • Tanimizu, N.1    Nishikawa, M.2    Saito, H.3    Tsujimura, T.4    Miyajima, A.5
  • 93
    • 0032171536 scopus 로고    scopus 로고
    • Hepatic OV-6 expression in human liver disease and rat experiments: Evidence for hepatic progenitor cells in man
    • Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, Desmet V. Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol. 1998; 29(3):455-463.
    • (1998) J Hepatol. , vol.29 , Issue.3 , pp. 455-463
    • Roskams, T.1    De Vos, R.2    Van Eyken, P.3    Myazaki, H.4    Van Damme, B.5    Desmet, V.6
  • 94
    • 0034987293 scopus 로고    scopus 로고
    • Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers
    • Van Den Heuvel MC, et al. Expression of anti-OV6 antibody and anti-N-CAM antibody along the biliary line of normal and diseased human livers. Hepatology. 2001;33(6):1387-1393.
    • (2001) Hepatology , vol.33 , Issue.6 , pp. 1387-1393
    • Van Den Heuvel, M.C.1
  • 95
    • 39549111466 scopus 로고    scopus 로고
    • Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
    • Yovchev MI, Grozdanov PN, Zhou H, Racherla H, Guha C, Dabeva MD. Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology. 2008;47(2):636-647.
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 636-647
    • Yovchev, M.I.1    Grozdanov, P.N.2    Zhou, H.3    Racherla, H.4    Guha, C.5    Dabeva, M.D.6
  • 96
    • 82455188301 scopus 로고    scopus 로고
    • CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells
    • Qiu Q, Hernandez JC, Dean AM, Rao PH, Darlington GJ. CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells. Stem Cells Dev. 2011;20(12):2177-2188.
    • (2011) Stem Cells Dev. , vol.20 , Issue.12 , pp. 2177-2188
    • Qiu, Q.1    Hernandez, J.C.2    Dean, A.M.3    Rao, P.H.4    Darlington, G.J.5
  • 97
    • 84860155827 scopus 로고    scopus 로고
    • Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development
    • Okada K, et al. Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells Dev. 2012;21(7):1124-1133.
    • (2012) Stem Cells Dev. , vol.21 , Issue.7 , pp. 1124-1133
    • Okada, K.1
  • 98
    • 84859401074 scopus 로고    scopus 로고
    • DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma
    • Xu X, et al. DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma. Mol Cancer Ther. 2012;11(3):629-638.
    • (2012) Mol Cancer Ther. , vol.11 , Issue.3 , pp. 629-638
    • Xu, X.1
  • 99
    • 59749103834 scopus 로고    scopus 로고
    • Nuclear signalling by tumour-associated antigen EpCAM
    • Maetzel D, et al. Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol. 2009; 11(2):162-171.
    • (2009) Nat Cell Biol. , vol.11 , Issue.2 , pp. 162-171
    • Maetzel, D.1
  • 100
    • 80053038156 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (EpCAM) complex proteins promote transcription factor-mediated pluripotency reprogramming
    • Huang HP, et al. Epithelial cell adhesion molecule (EpCAM) complex proteins promote transcription factor-mediated pluripotency reprogramming. J Biol Chem. 2011;286(38):33520-33532.
    • (2011) J Biol Chem. , vol.286 , Issue.38 , pp. 33520-33532
    • Huang, H.P.1
  • 101
    • 84862777489 scopus 로고    scopus 로고
    • CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/ CXCL1 signaling
    • Tang KH, et al. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/ CXCL1 signaling. Hepatology. 2012;55(3):807-820.
    • (2012) Hepatology , vol.55 , Issue.3 , pp. 807-820
    • Tang, K.H.1
  • 102
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • Ishimoto T, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell. 2011;19(3):387-400.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1
  • 103
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861-872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1
  • 104
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 105
    • 84867212473 scopus 로고    scopus 로고
    • Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells
    • Chow EK, Fan LL, Chen X, Bishop JM. Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells. Hepatology. 2012; 56(4):1331-1341.
    • (2012) Hepatology , vol.56 , Issue.4 , pp. 1331-1341
    • Chow, E.K.1    Fan, L.L.2    Chen, X.3    Bishop, J.M.4
  • 106
    • 60849102149 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog
    • Machida K, et al. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009;106(5):1548-1553.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.5 , pp. 1548-1553
    • Machida, K.1
  • 107
    • 79955860688 scopus 로고    scopus 로고
    • Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy
    • Huang P, et al. Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. Clin Biochem. 2011;44(8-9):582-589.
    • (2011) Clin Biochem. , vol.44 , Issue.8-9 , pp. 582-589
    • Huang, P.1
  • 108
    • 84867400951 scopus 로고    scopus 로고
    • Coexpression of stemness factors oct4 and nanog predict liver resection
    • Yin X, et al. Coexpression of stemness factors oct4 and nanog predict liver resection. Ann Surg Oncol. 2012;19(9):2877-2887.
    • (2012) Ann Surg Oncol. , vol.19 , Issue.9 , pp. 2877-2887
    • Yin, X.1
  • 109
    • 79952286128 scopus 로고    scopus 로고
    • Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma
    • Woo HG, et al. Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma. Gastroenterology. 2011;140(3):1063-1070.
    • (2011) Gastroenterology , vol.140 , Issue.3 , pp. 1063-1070
    • Woo, H.G.1
  • 110
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature. 2009;460(7259):1132-1135.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1132-1135
    • Hong, H.1
  • 111
    • 69349094006 scopus 로고    scopus 로고
    • A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Marion RM, et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature. 2009;460(7259):1149-1153.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1149-1153
    • Marion, R.M.1
  • 112
    • 69349098273 scopus 로고    scopus 로고
    • Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
    • Utikal J, et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature. 2009;460(7259):1145-1148.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1145-1148
    • Utikal, J.1
  • 113
    • 34250361494 scopus 로고    scopus 로고
    • Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration
    • Jelnes P, et al. Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration. Hepatology. 2007; 45(6):1462-1470.
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1462-1470
    • Jelnes, P.1
  • 114
    • 36248981887 scopus 로고    scopus 로고
    • Comparison of hepatic properties and transplantation of Thy-1(+) and Thy-1(-) cells isolated from embryonic day 14 rat fetal liver
    • Oertel M, Menthena A, Chen YQ, Shafritz DA. Comparison of hepatic properties and transplantation of Thy-1(+) and Thy-1(-) cells isolated from embryonic day 14 rat fetal liver. Hepatology. 2007; 46(4):1236-1245.
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1236-1245
    • Oertel, M.1    Menthena, A.2    Chen, Y.Q.3    Shafritz, D.A.4
  • 115
    • 33745601104 scopus 로고    scopus 로고
    • Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages
    • Dan YY, et al. Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages. Proc Natl Acad Sci U S A. 2006;103(26):9912-9917.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.26 , pp. 9912-9917
    • Dan, Y.Y.1
  • 116
    • 84876098953 scopus 로고    scopus 로고
    • Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma
    • Yamashita T, et al. Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma. Hepatology. 2013;57(4):1484-1497.
    • (2013) Hepatology , vol.57 , Issue.4 , pp. 1484-1497
    • Yamashita, T.1
  • 117
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008;359(19):1995-2004.
    • (2008) N Engl J Med. , vol.359 , Issue.19 , pp. 1995-2004
    • Hoshida, Y.1
  • 118
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • Ji J, et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med. 2009;361(15):1437-1447.
    • (2009) N Engl J Med. , vol.361 , Issue.15 , pp. 1437-1447
    • Ji, J.1
  • 119
    • 78650529134 scopus 로고    scopus 로고
    • Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer
    • Cairo S, et al. Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. Proc Natl Acad Sci U S A. 2010;107(47):20471-20476.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.47 , pp. 20471-20476
    • Cairo, S.1
  • 120
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006;12(4):410-416.
    • (2006) Nat Med. , vol.12 , Issue.4 , pp. 410-416
    • Lee, J.S.1
  • 121
    • 80055060696 scopus 로고    scopus 로고
    • Human hepatocellular carcinomas with "stemness"-related marker expression: Keratin 19 expression and a poor prognosis
    • Kim H, et al. Human hepatocellular carcinomas with "Stemness"- related marker expression: keratin 19 expression and a poor prognosis. Hepatology. 2011;54(5):1707-1717.
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1707-1717
    • Kim, H.1
  • 122
    • 84863603551 scopus 로고    scopus 로고
    • CD44s regulates the TGF-beta-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma
    • Mima K, et al. CD44s regulates the TGF-beta-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res. 2012;72(13):3414-3423.
    • (2012) Cancer Res. , vol.72 , Issue.13 , pp. 3414-3423
    • Mima, K.1
  • 123
    • 77954019973 scopus 로고    scopus 로고
    • High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma
    • Yang XR, et al. High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma. Gut. 2010;59(7):953-962.
    • (2010) Gut. , vol.59 , Issue.7 , pp. 953-962
    • Yang, X.R.1
  • 124
    • 84868204026 scopus 로고    scopus 로고
    • Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
    • Oishi N, et al. Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma. Hepatology. 2012; 56(5):1792-1803.
    • (2012) Hepatology , vol.56 , Issue.5 , pp. 1792-1803
    • Oishi, N.1
  • 125
    • 40949160140 scopus 로고    scopus 로고
    • Identification of local and circulating cancer stem cells in human liver cancer
    • Yang ZF, et al. Identification of local and circulating cancer stem cells in human liver cancer. Hepatology. 2008;47(3):919-928.
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 919-928
    • Yang, Z.F.1
  • 126
    • 72249093615 scopus 로고    scopus 로고
    • Tumor self-seeding by circulating cancer cells
    • Kim MY, et al. Tumor self-seeding by circulating cancer cells. Cell. 2009;139(7):1315-1326.
    • (2009) Cell , vol.139 , Issue.7 , pp. 1315-1326
    • Kim, M.Y.1
  • 127
    • 84876111096 scopus 로고    scopus 로고
    • Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
    • Sun YF, et al. Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection. Hepatology. 2013;57(4):1458-1468.
    • (2013) Hepatology , vol.57 , Issue.4 , pp. 1458-1468
    • Sun, Y.F.1
  • 128
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S, et al. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell. 2010;7(6):694-707.
    • (2010) Cell Stem Cell , vol.7 , Issue.6 , pp. 694-707
    • Ma, S.1
  • 130
    • 40749150740 scopus 로고    scopus 로고
    • CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene. 2008;27(12):1749-1758.
    • (2008) Oncogene , vol.27 , Issue.12 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 131
    • 78751552761 scopus 로고    scopus 로고
    • Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation
    • Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology. 2011;53(1):160-170.
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 160-170
    • Lee, T.K.1    Castilho, A.2    Cheung, V.C.3    Tang, K.H.4    Ma, S.5    Ng, I.O.6
  • 132
    • 33947507817 scopus 로고    scopus 로고
    • Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes
    • Lazaro CA, et al. Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol. 2007;170(2):478-489.
    • (2007) Am J Pathol. , vol.170 , Issue.2 , pp. 478-489
    • Lazaro, C.A.1
  • 133
    • 79956079665 scopus 로고    scopus 로고
    • Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?
    • Arzumanyan A, Friedman T, Ng IO, Clayton MM, Lian Z, Feitelson MA. Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res. 2011;71(10):3701-3708.
    • (2011) Cancer Res. , vol.71 , Issue.10 , pp. 3701-3708
    • Arzumanyan, A.1    Friedman, T.2    Ng, I.O.3    Clayton, M.M.4    Lian, Z.5    Feitelson, M.A.6
  • 134
    • 81255200425 scopus 로고    scopus 로고
    • Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts
    • Ali N, et al. Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. J Virol. 2011;85(23):12292-12303.
    • (2011) J Virol. , vol.85 , Issue.23 , pp. 12292-12303
    • Ali, N.1
  • 135
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader JE. Cells of origin in cancer. Nature. 2011; 469(7330):314-322.
    • (2011) Nature , vol.469 , Issue.7330 , pp. 314-322
    • Visvader, J.E.1
  • 136
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer CL, et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A. 2011;108(19):7950-7955.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.19 , pp. 7950-7955
    • Chaffer, C.L.1
  • 137
    • 84863073374 scopus 로고    scopus 로고
    • Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture
    • Chen Y, Wong PP, Sjeklocha L, Steer CJ, Sahin MB. Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture. Hepatology. 2012;55(2):563-574.
    • (2012) Hepatology , vol.55 , Issue.2 , pp. 563-574
    • Chen, Y.1    Wong, P.P.2    Sjeklocha, L.3    Steer, C.J.4    Sahin, M.B.5
  • 138
    • 34548471937 scopus 로고    scopus 로고
    • Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation
    • Chiba T, et al. Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology. 2007;133(3):937-950.
    • (2007) Gastroenterology , vol.133 , Issue.3 , pp. 937-950
    • Chiba, T.1
  • 139
    • 0036920208 scopus 로고    scopus 로고
    • Cellular origin of hepatocellular carcinomas
    • Sell S. Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol. 2002;13(6):419-424.
    • (2002) Semin Cell Dev Biol. , vol.13 , Issue.6 , pp. 419-424
    • Sell, S.1
  • 140
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender L, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006;125(7):1253-1267.
    • (2006) Cell , vol.125 , Issue.7 , pp. 1253-1267
    • Zender, L.1
  • 141
    • 45549084904 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • Sell S, Leffert HL. Liver cancer stem cells. J Clin Oncol. 2008;26(17):2800-2805.
    • (2008) J Clin Oncol. , vol.26 , Issue.17 , pp. 2800-2805
    • Sell, S.1    Leffert, H.L.2
  • 142
    • 84864773126 scopus 로고    scopus 로고
    • Cholangiocarcinomas can originate from hepatocytes in mice
    • Fan B, et al. Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012; 122(8):2911-2915.
    • (2012) J Clin Invest. , vol.122 , Issue.8 , pp. 2911-2915
    • Fan, B.1
  • 143
    • 84859550605 scopus 로고    scopus 로고
    • The stem cell niche in regenerative medicine
    • Wagers AJ. The stem cell niche in regenerative medicine. Cell Stem Cell. 2012;10(4):362-369.
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 362-369
    • Wagers, A.J.1
  • 144
    • 84866082606 scopus 로고    scopus 로고
    • MTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
    • Kalaitzidis D, et al. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012;11(3):429-439.
    • (2012) Cell Stem Cell , vol.11 , Issue.3 , pp. 429-439
    • Kalaitzidis, D.1
  • 145
    • 84866064701 scopus 로고    scopus 로고
    • Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression
    • Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012;11(3):415-428.
    • (2012) Cell Stem Cell , vol.11 , Issue.3 , pp. 415-428
    • Magee, J.A.1    Ikenoue, T.2    Nakada, D.3    Lee, J.Y.4    Guan, K.L.5    Morrison, S.J.6
  • 146
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell. 2011;146(4):633-644.
    • (2011) Cell , vol.146 , Issue.4 , pp. 633-644
    • Gupta, P.B.1
  • 147
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133(4):704-715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1
  • 148
    • 14244252656 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
    • Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology. 2005;41(3):535-544.
    • (2005) Hepatology , vol.41 , Issue.3 , pp. 535-544
    • Michalopoulos, G.K.1    Barua, L.2    Bowen, W.C.3
  • 149
    • 0030715611 scopus 로고    scopus 로고
    • Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
    • Overturf K, al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol. 1997;151(5):1273-1280.
    • (1997) Am J Pathol. , vol.151 , Issue.5 , pp. 1273-1280
    • Overturf, K.1    Al-Dhalimy, M.2    Ou, C.N.3    Finegold, M.4    Grompe, M.5
  • 150
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • Notta F, et al. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature. 2011;469(7330):362-367.
    • (2011) Nature , vol.469 , Issue.7330 , pp. 362-367
    • Notta, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.