Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages 17582-17587

  Hefetz Sela, Simona ^a,b   Stein, Ilan ^a,b   Klieger, Yair ^a   Porat, Rinnat ^a,b   Sade Feldman, Moshe ^a   Zreik, Farid ^a,b   Nagler, Arnon ^c   Pappo, Orit ^b   Quagliata, Luca ^d   Dazert, Eva ^e   Eferl, Robert ^f   Terracciano, Luigi ^d   Wagner, Erwin F ^g   Ben Neriah, Yinon ^a   Baniyash, Michal ^a   Pikarsky, Eli ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

^g Structural Biology and Biocomputing Programme   (Spain)

Author keywords

c Jun phosphorylation; HCC; M1 macrophages; M2 macrophages; Tregs

Indexed keywords

MACROPHAGE DERIVED CHEMOKINE; PROTEIN C JUN; SERINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; CHEMOKINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL DENSITY; CHRONIC HEPATITIS; CYTOKINE PRODUCTION; DISEASE COURSE; GERM LINE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; TUMOR MICROENVIRONMENT; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CYTOLOGY; GENE EXPRESSION REGULATION; HEPATITIS; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; KNOCKOUT MOUSE; LIVER; LIVER TUMOR; METABOLISM; PHOSPHORYLATION; PROGNOSIS; PROTEIN TERTIARY STRUCTURE;

MUS;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHEMOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LIVER; LIVER NEOPLASMS; MACROPHAGES; MICE; MICE, KNOCKOUT; PHENOTYPE; PHOSPHORYLATION; PROGNOSIS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-JUN; TUMOR MICROENVIRONMENT;

EID: 84916631333     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409700111     Document Type: Article

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