메뉴 건너뛰기




Volumn 4, Issue 4, 2012, Pages 847-851

Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient

Author keywords

Exome sequencing; Hepatocellular carcinoma; Somatic mutation

Indexed keywords

CDH12 PROTEIN; DNA; HUWE1 PROTEIN; OR1L3 PROTEIN; PCK2 PROTEIN; PHF16 PROTEIN; PPCS PROTEIN; PROTEIN; SPATA21 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

EID: 84864829326     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.825     Document Type: Article
Times cited : (13)

References (25)
  • 3
    • 14744291909 scopus 로고    scopus 로고
    • Epidemiology and natural history of hepatocellular carcinoma
    • McGlynn KA and London WT: Epidemiology and natural history of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol 19: 3-23, 2005.
    • (2005) Best Pract Res Clin Gastroenterol , vol.19 , pp. 3-23
    • McGlynn, K.A.1    London, W.T.2
  • 4
    • 33747517955 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease in adults
    • Clark JM: The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 40 (Suppl 1): S5-S10, 2006.
    • (2006) J Clin Gastroenterol , vol.40 , Issue.1 SUPPL.
    • Clark, J.M.1
  • 5
    • 0035732841 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: An Asian perspective
    • Teo EK and Fock KM: Hepatocellular carcinoma: an Asian perspective. Dig Dis 19: 263-268, 2001.
    • (2001) Dig Dis , vol.19 , pp. 263-268
    • Teo, E.K.1    Fock, K.M.2
  • 6
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate long-read alignment with Burrows-Wheeler transform
    • Li H and Durbin R: Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26: 589-595, 2010.
    • (2010) Bioinformatics , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 7
    • 68549104404 scopus 로고    scopus 로고
    • 1000 Genome Project Data Processing Subgroup: The Sequence Alignment/Map format and SAMtools
    • Li H, Handsaker B, Wysoker A, et al; 1000 Genome Project Data Processing Subgroup: The Sequence Alignment/Map format and SAMtools. Bioinformatics 25: 2078-2079, 2009.
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1    Handsaker, B.2    Wysoker, A.3
  • 8
    • 84863229597 scopus 로고    scopus 로고
    • VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
    • Koboldt DC, Zhang Q, Larson DE, et al: VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res 22: 568-576, 2012.
    • (2012) Genome Res , vol.22 , pp. 568-576
    • Koboldt, D.C.1    Zhang, Q.2    Larson, D.E.3
  • 10
    • 74949092081 scopus 로고    scopus 로고
    • Detection of nonneutral substitution rates on mammalian phylogenies
    • Pollard KS, Hubisz MJ, Rosenbloom KR and Siepel A: Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res 20: 110-121, 2010.
    • (2010) Genome Res , vol.20 , pp. 110-121
    • Pollard, K.S.1    Hubisz, M.J.2    Rosenbloom, K.R.3    Siepel, A.4
  • 11
    • 77955151784 scopus 로고    scopus 로고
    • MutationTaster evaluates disease-causing potential of sequence alterations
    • Schwarz JM, Rödelsperger C, Schuelke M and Seelow D: MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods 7: 575-576, 2010.
    • (2010) Nat Methods , vol.7 , pp. 575-576
    • Schwarz, J.M.1    Rödelsperger, C.2    Schuelke, M.3    Seelow, D.4
  • 12
    • 48449106792 scopus 로고    scopus 로고
    • The Jpred 3 secondary structure prediction server
    • Cole C, Barber JD and Barton GJ: The Jpred 3 secondary structure prediction server. Nucleic Acids Res 36: W197-W201, 2008.
    • (2008) Nucleic Acids Res , vol.36
    • Cole, C.1    Barber, J.D.2    Barton, G.J.3
  • 13
    • 44449085884 scopus 로고    scopus 로고
    • Panel of Experts in HCC-Design Clinical Trials: Design and endpoints of clinical trials in hepatocellular carcinoma
    • Llovet JM, Di Bisceglie AM, Bruix J, et al; Panel of Experts in HCC-Design Clinical Trials: Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 100: 698-711, 2008.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 698-711
    • Llovet, J.M.1    Di Bisceglie, A.M.2    Bruix, J.3
  • 14
    • 0038505659 scopus 로고    scopus 로고
    • Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis
    • Edamoto Y, Hara A, Biernat W, et al: Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. Int J Cancer 106: 334-341, 2003.
    • (2003) Int J Cancer , vol.106 , pp. 334-341
    • Edamoto, Y.1    Hara, A.2    Biernat, W.3
  • 15
    • 0033992478 scopus 로고    scopus 로고
    • p53 and human cancer: The first ten thousand mutations
    • Hainaut P and Hollstein M: p53 and human cancer: the first ten thousand mutations. Adv Cancer Res 77: 81-137, 2000.
    • (2000) Adv Cancer Res , vol.77 , pp. 81-137
    • Hainaut, P.1    Hollstein, M.2
  • 16
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M: Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8: 915-928, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 17
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • Sachdev D and Yee D: Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 6: 1-12, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 18
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • Laurent-Puig P and Zucman-Rossi J: Genetics of hepatocellular tumors. Oncogene 25: 3778-3786, 2006.
    • (2006) Oncogene , vol.25 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 19
    • 39049192533 scopus 로고    scopus 로고
    • Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population
    • Tang SH, Yang DH, Huang W, Zhou HK, Lu XH and Ye G: Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population. Clin Cancer Res 12: 4171-4177, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 4171-4177
    • Tang, S.H.1    Yang, D.H.2    Huang, W.3    Zhou, H.K.4    Lu, X.H.5    Ye, G.6
  • 20
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • De Souza AT, Hankins GR, Washington MK, Orton TC and Jirtle RL: M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 11: 447-449, 1995.
    • (1995) Nat Genet , vol.11 , pp. 447-449
    • de Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 21
    • 18244401685 scopus 로고    scopus 로고
    • Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma
    • Hanafusa T, Yumoto Y, Nouso K, et al: Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma. Cancer Lett 176: 149-158, 2002.
    • (2002) Cancer Lett , vol.176 , pp. 149-158
    • Hanafusa, T.1    Yumoto, Y.2    Nouso, K.3
  • 22
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • Tovar V, Alsinet C, Villanueva A, et al: IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol 52: 550-559, 2010.
    • (2010) J Hepatol , vol.52 , pp. 550-559
    • Tovar, V.1    Alsinet, C.2    Villanueva, A.3
  • 23
    • 0029776419 scopus 로고    scopus 로고
    • Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: Implications of IGF-I receptor gene activation by hepatitis B virus X gene product
    • Kim SO, Park JG and Lee YI: Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product. Cancer Res 56: 3831-3836, 1996.
    • (1996) Cancer Res , vol.56 , pp. 3831-3836
    • Kim, S.O.1    Park, J.G.2    Lee, Y.I.3
  • 24
    • 0026768040 scopus 로고
    • Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice
    • Hill MR and McCallum RE: Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice. Infect Immun 60: 4040-4050, 1992.
    • (1992) Infect Immun , vol.60 , pp. 4040-4050
    • Hill, M.R.1    McCallum, R.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.