Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

Nature Medicine

Volumn 19, Issue 2, 2013, Pages 209-216

  Chen, Leilei ^a,b,c   Li, Yan ^a,c,e   Lin, Chi Ho ^d   Chan, Tim Hon Man ^a,b,c   Chow, Raymond Kwok Kei ^a   Song, Yangyang ^a,c   Liu, Ming ^a,c   Yuan, Yun Fei ^e   Fu, Li ^a   Kong, Kar Lok ^a   Qi, Lihua ^b   Zhang, Na ^d   Tong, Amy Hin Yan ^f   Kwong, Dora Lai Wan ^a   Man, Kwan ^a   Lo, Chung Mau ^a   Lok, Si ^d   Tenen, Daniel G ^b   Guan, Xin Yuan ^a,c,e  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^f CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; ANTIZYME; AZIN1 PROTEIN; CYCLIN D1; DOUBLE STRANDED RNA; ORNITHINE DECARBOXYLASE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PYROSEQUENCING; RNA EDITING;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE DEAMINASE; ANIMALS; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; HUMANS; LIVER NEOPLASMS; MALE; MICE; ORNITHINE DECARBOXYLASE; RNA EDITING;

EID: 84873531277     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3043     Document Type: Article

References (37)

1. Parkin, D.M., Bray, F., Ferlay, J. & Pisani, P. Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108 (2005
2. Farazi, P.A. & DePinho, R.A. Hepatocellular carcinoma pathogenesis: From genes to environment. Nat. Rev. Cancer 6, 674-687 (2006 (Pubitemid 44286000)
3. Thorgeirsson, S.S. & Grisham, J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat. Genet. 31, 339-346 (2002 (Pubitemid 35154440)
4. Meyerson, M., Gabriel, S. & Getz, G. Advances in understanding cancer genomes through second-generation sequencing. Nat. Rev. Genet. 11, 685-696 (2010
5. Morozova, O. & Marra, M.A. Applications of next-generation sequencing technologies in functional genomics. Genomics 92, 255-264 (2008
6. Wang, Z., Gerstein, M. & Snyder, M. RNA-Seq: A revolutionary tool for transcriptomics. Nat. Rev. Genet. 10, 57-63 (2009
7. Bass, B.L. RNA editing by adenosine deaminases that act on RNA. Annu. Rev. Biochem. 71, 817-846 (2002 (Pubitemid 34800236)
8. Nishikura, K. Functions and regulation of RNA editing by ADAR deaminases. Annu. Rev. Biochem. 79, 321-349 (2010
9. Herb, A., Higuchi, M., Sprengel, R. & Seeburg, P.H. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc. Natl. Acad. Sci. USA 93, 1875-1880 (1996 (Pubitemid 26079847)
10. Higuchi, M. et al. RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370 (1993 (Pubitemid 24021910)
11. Samuel, C.E. Antiviral actions of interferons. Clin. Microbiol. Rev. 14, 778-809 (2001 (Pubitemid 32979631)
12. Farajollahi, S. & Maas, S. Molecular diversity through RNA editing: A balancing act. Trends Genet. 26, 221-230 (2010
13. Mangold, U., Hayakawa, H., Coughlin, M., Munger, K. & Zetter, B.R. Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification. Oncogene 27, 604-613 (2008 (Pubitemid 351158895)
14. Young, M., Kirshenbaum, K., Dill, K.A. & Highsmith, S. Predicting conformational switches in proteins. Protein Sci. 8, 1752-1764 (1999 (Pubitemid 29430475)
15. Fujita, K., Murakami, Y. & Hayashi, S. A macromolecular inhibitor of the antizyme to ornithine decarboxylase. Biochem. J. 204, 647-652 (1982
16. Mangold, U. Antizyme inhibitor: Mysterious modulator of cell proliferation. Cell. Mol. Life Sci. 63, 2095-2101 (2006 (Pubitemid 44465684)
17. Bercovich, Z. & Kahana, C. Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme. J. Biol. Chem. 279, 54097-54102 (2004 (Pubitemid 40053144)
18. Kahana, C. Antizyme and antizyme inhibitor, a regulatory tango. Cell. Mol. Life Sci. 66, 2479-2488 (2009
19. Newman, R.M. et al. Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J. Biol. Chem. 279, 41504-41511 (2004 (Pubitemid 39313591)
20. Vivanco, I. & Sawyers, C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (2002 (Pubitemid 37328931)
21. Morgan, D.O. Principles of CDK regulation. Nature 374, 131-134 (1995
22. Pyronnet, S., Pradayrol, L. & Sonenberg, N. A cell cycle-dependent internal ribosome entry site. Mol. Cell 5, 607-616 (2000
23. Lukas, J., Petersen, B.O., Holm, K., Bartek, J. & Helin, K. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol. Cell. Biol. 16, 1047-1057 (1996
24. Gommans, W.M., Mullen, S.P & Maas, S. RNA editing: A driving force for adaptive evolutioñ Bioessays 31, 1137-1145 (2009
25. Mattick, J.S. & Mehler, M.F. RNA editing, DNA recoding and the evolution of human cognition. Trends Neurosci. 31, 227-233 (2008
26. Reenan, R.A. Molecular determinants and guided evolution of species-specific RNA editing. Nature 434, 409-413 (2005 (Pubitemid 40469187)
27. Li, J.B. et al. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science 324, 1210-1213 (2009
28. Shah, S.P. et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461, 809-813 (2009
29. Cenci, C. et al. Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. J. Biol. Chem. 283, 7251-7260 (2008
30. Maas, S., Patt, S., Schrey, M. & Rich, A. Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc. Natl. Acad. Sci. USA 98, 14687-14692 (2001 (Pubitemid 33121452)
31. Paz, N. et al. Altered adenosine-to-inosine RNA editing in human cancer. Genome Res. 17, 1586-1595 (2007 (Pubitemid 350074854)
32. Gallo, A. & Galardi, S. A-to-I RNA editing and cancer: From pathology to basic science. RNA Biol. 5, 135-139 (2008
33. Albeck, S. et al. Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function. Protein Sci. 17, 793-802 (2008 (Pubitemid 351629574)
34. Matsufuji, S. et al. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell 80, 51-60 (1995
35. Rom, E. & Kahana, C. Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting. Proc. Natl. Acad. Sci. USA 91, 3959-3963 (1994 (Pubitemid 24139552)
36. Olsen, R.R. & Zetter, B.R. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Mol. Cancer Res. 9, 1285-1293 (2011
37. Hu, L. et al. Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 23, 298-302 (2004 (Pubitemid 38142264)