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Volumn 56, Issue 1, 2012, Pages 267-275

Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies

Author keywords

Gene expression profile; Liver cancer; Molecular pathogenesis; Target therapy

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN P53; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 83555162579     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.07.007     Document Type: Review
Times cited : (153)

References (140)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
    • DOI 10.1053/j.gastro.2007.04.061, PII S0016508507007998
    • H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576 (Pubitemid 46890874)
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 77349084899 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology, surveillance, and diagnosis
    • M. Sherman Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis Semin Liver Dis 30 2010 3 16
    • (2010) Semin Liver Dis , vol.30 , pp. 3-16
    • Sherman, M.1
  • 3
    • 63349085247 scopus 로고    scopus 로고
    • Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis
    • V. Paradis, S. Zalinski, E. Chelbi, N. Guedj, F. Degos, and V. Vilgrain Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis Hepatology 49 2009 851 859
    • (2009) Hepatology , vol.49 , pp. 851-859
    • Paradis, V.1    Zalinski, S.2    Chelbi, E.3    Guedj, N.4    Degos, F.5    Vilgrain, V.6
  • 4
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • J. Bruix, and M. Sherman Management of hepatocellular carcinoma: an update Hepatology 53 2010 1020 1022
    • (2010) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 5
    • 79960319151 scopus 로고    scopus 로고
    • Hepatocarcinogenesis: Imaging-pathologic correlation
    • Y.N. Park, and M.J. Kim Hepatocarcinogenesis: imaging-pathologic correlation Abdom Imaging 36 3 2011 232 243
    • (2011) Abdom Imaging , vol.36 , Issue.3 , pp. 232-243
    • Park, Y.N.1    Kim, M.J.2
  • 6
    • 77953776656 scopus 로고    scopus 로고
    • Future perspectives in hepatocellular carcinoma
    • M.A. Worns, and P.R. Galle Future perspectives in hepatocellular carcinoma Dig Liver Dis 42 2010 S302 309
    • (2010) Dig Liver Dis , vol.42 , pp. 302-309
    • Worns, M.A.1    Galle, P.R.2
  • 8
    • 79955433548 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • A. Villanueva, and J.M. Llovet Targeted therapies for hepatocellular carcinoma Gastroenterology 140 2011 1410 1426
    • (2011) Gastroenterology , vol.140 , pp. 1410-1426
    • Villanueva, A.1    Llovet, J.M.2
  • 9
    • 77951490498 scopus 로고    scopus 로고
    • Novel inhibitors in development for hepatocellular carcinoma
    • M.A. Worns, and P.R. Galle Novel inhibitors in development for hepatocellular carcinoma Expert Opin Investig Drugs 19 2010 615 629
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 615-629
    • Worns, M.A.1    Galle, P.R.2
  • 11
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • Z. Kan, B.S. Jaiswal, J. Stinson, V. Janakiraman, D. Bhatt, and H.M. Stern Diverse somatic mutation patterns and pathway alterations in human cancers Nature 466 2010 869 873
    • (2010) Nature , vol.466 , pp. 869-873
    • Kan, Z.1    Jaiswal, B.S.2    Stinson, J.3    Janakiraman, V.4    Bhatt, D.5    Stern, H.M.6
  • 13
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • T.R. Golub, D.K. Slonim, P. Tamayo, C. Huard, M. Gaasenbeek, and J.P. Mesirov Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Science 286 1999 531 537
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3    Huard, C.4    Gaasenbeek, M.5    Mesirov, J.P.6
  • 18
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • R.N. Aravalli, C.J. Steer, and E.N. Cressman Molecular mechanisms of hepatocellular carcinoma Hepatology 48 2008 2047 2063
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.3
  • 19
    • 20344399151 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma and dysplastic nodules
    • DOI 10.1055/s-2005-871193
    • M. Kojiro, and T. Roskams Early hepatocellular carcinoma and dysplastic nodules Semin Liver Dis 25 2005 133 142 (Pubitemid 40781066)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 133-142
    • Kojiro, M.1    Roskams, T.2
  • 20
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • DOI 10.1038/nrc1934, PII NRC1934
    • P.A. Farazi, and R.A. DePinho Hepatocellular carcinoma pathogenesis: from genes to environment Nat Rev Cancer 6 2006 674 687 (Pubitemid 44286000)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 22
    • 85027954267 scopus 로고    scopus 로고
    • Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma
    • V. Kumar, N. Kato, Y. Urabe, A. Takahashi, R. Muroyama, and N. Hosono Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma Nat Genet 43 2011 455 458
    • (2011) Nat Genet , vol.43 , pp. 455-458
    • Kumar, V.1    Kato, N.2    Urabe, Y.3    Takahashi, A.4    Muroyama, R.5    Hosono, N.6
  • 23
    • 78651227093 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    • E. Melum, A. Franke, C. Schramm, T.J. Weismuller, D.N. Gotthardt, and F.A. Offner Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci Nat Genet 43 2011 17 19
    • (2011) Nat Genet , vol.43 , pp. 17-19
    • Melum, E.1    Franke, A.2    Schramm, C.3    Weismuller, T.J.4    Gotthardt, D.N.5    Offner, F.A.6
  • 24
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • V. Suppiah, M. Moldovan, G. Ahlenstiel, T. Berg, M. Weltman, and M.L. Abate IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy Nat Genet 41 2009 1100 1104
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3    Berg, T.4    Weltman, M.5    Abate, M.L.6
  • 25
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Y. Tanaka, N. Nishida, M. Sugiyama, M. Kurosaki, K. Matsuura, and N. Sakamoto Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Nat Genet 41 2009 1105 1109
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3    Kurosaki, M.4    Matsuura, K.5    Sakamoto, N.6
  • 27
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • M. Meyerson, S. Gabriel, and G. Getz Advances in understanding cancer genomes through second-generation sequencing Nat Rev Genet 11 2010 685 696
    • (2010) Nat Rev Genet , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 28
    • 20344374424 scopus 로고    scopus 로고
    • Genetic profiling of human hepatocellular carcinoma
    • DOI 10.1055/s-2005-871192
    • J.S. Lee, and S.S. Thorgeirsson Genetic profiling of human hepatocellular carcinoma Semin Liver Dis 25 2005 125 132 (Pubitemid 40781065)
    • (2005) Seminars in Liver Disease , vol.25 , Issue.2 , pp. 125-132
    • Lee, J.-S.1    Thorgeirsson, S.S.2
  • 30
    • 33749359258 scopus 로고    scopus 로고
    • A Tumor Progression Model for Hepatocellular Carcinoma: Bioinformatic Analysis of Genomic Data
    • DOI 10.1053/j.gastro.2006.08.014, PII S0016508506017537
    • T.C. Poon, N. Wong, P.B. Lai, M. Rattray, P.J. Johnson, and J.J. Sung A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data Gastroenterology 131 2006 1262 1270 (Pubitemid 44515104)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1262-1270
    • Poon, T.C.W.1    Wong, N.2    Lai, P.B.S.3    Rattray, M.4    Johnson, P.J.5    Sung, J.J.Y.6
  • 31
    • 0032905155 scopus 로고    scopus 로고
    • Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines
    • DOI 10.1016/S0165-4608(98)00210-6, PII S0165460898002106
    • C.L. Keck, D.B. Zimonjic, B.Z. Yuan, S.S. Thorgeirsson, and N.C. Popescu Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines Cancer Genet Cytogenet 111 1999 37 44 (Pubitemid 29214333)
    • (1999) Cancer Genetics and Cytogenetics , vol.111 , Issue.1 , pp. 37-44
    • Keck, C.L.1    Zimonjic, D.B.2    Yuan, B.-Z.3    Thorgeirsson, S.S.4    Popescu, N.C.5
  • 32
    • 0032898742 scopus 로고    scopus 로고
    • Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization
    • D.B. Zimonjic, C.L. Keck, S.S. Thorgeirsson, and N.C. Popescu Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization Hepatology 29 1999 1208 1214 (Pubitemid 29168756)
    • (1999) Hepatology , vol.29 , Issue.4 , pp. 1208-1214
    • Zimonjic, D.B.1    Keck, C.L.2    Thorgeirsson, S.S.3    Popescu, N.C.4
  • 33
    • 78049487254 scopus 로고    scopus 로고
    • Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma
    • C.F. Chen, E.C. Hsu, K.T. Lin, P.H. Tu, H.W. Chang, and C.H. Lin Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma Hepatology 52 2010 1690 1701
    • (2010) Hepatology , vol.52 , pp. 1690-1701
    • Chen, C.F.1    Hsu, E.C.2    Lin, K.T.3    Tu, P.H.4    Chang, H.W.5    Lin, C.H.6
  • 34
    • 84984578427 scopus 로고    scopus 로고
    • Onco DB. HCC: An integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci
    • W.H. Su, C.C. Chao, S.H. Yeh, D.S. Chen, P.J. Chen, and Y.S. Jou Onco DB. HCC: an integrated oncogenomic database of hepatocellular carcinoma revealed aberrant cancer target genes and loci Nucleic Acids Res 35 2007 D727 731
    • (2007) Nucleic Acids Res , vol.35 , pp. 727-731
    • Su, W.H.1    Chao, C.C.2    Yeh, S.H.3    Chen, D.S.4    Chen, P.J.5    Jou, Y.S.6
  • 35
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • DOI 10.1038/ng1481
    • J.S. Lee, I.S. Chu, A. Mikaelyan, D.F. Calvisi, J. Heo, and J.K. Reddy Application of comparative functional genomics to identify best-fit mouse models to study human cancer Nat Genet 36 2004 1306 1311 (Pubitemid 39577940)
    • (2004) Nature Genetics , vol.36 , Issue.12 , pp. 1306-1311
    • Lee, J.-S.1    Chu, I.-S.2    Mikaelyan, A.3    Calvisi, D.F.4    Heo, J.5    Reddy, J.K.6    Thorgeirsson, S.S.7
  • 37
    • 64649092340 scopus 로고    scopus 로고
    • Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: Implications for human disease
    • D.B. Zimonjic, V. Ullmannova-Benson, V.M. Factor, S.S. Thorgeirsson, and N.C. Popescu Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease Cancer Genet Cytogenet 191 2009 17 26
    • (2009) Cancer Genet Cytogenet , vol.191 , pp. 17-26
    • Zimonjic, D.B.1    Ullmannova-Benson, V.2    Factor, V.M.3    Thorgeirsson, S.S.4    Popescu, N.C.5
  • 38
    • 65949098918 scopus 로고    scopus 로고
    • Identification of potential driver genes in human liver carcinoma by genomewide screening
    • H.G. Woo, E.S. Park, J.S. Lee, Y.H. Lee, T. Ishikawa, and Y.J. Kim Identification of potential driver genes in human liver carcinoma by genomewide screening Cancer Res 69 2009 4059 4066
    • (2009) Cancer Res , vol.69 , pp. 4059-4066
    • Woo, H.G.1    Park, E.S.2    Lee, J.S.3    Lee, Y.H.4    Ishikawa, T.5    Kim, Y.J.6
  • 39
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: A new tool for biomedical research
    • DOI 10.1038/nrc2044, PII NRC2044
    • J. Lamb The connectivity map: a new tool for biomedical research Nat Rev Cancer 7 2007 54 60 (Pubitemid 46020847)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.1 , pp. 54-60
    • Lamb, J.1
  • 41
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • J.S. Lee, J. Heo, L. Libbrecht, I.S. Chu, P. Kaposi-Novak, and D.F. Calvisi A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells Nat Med 12 2006 410 416
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3    Chu, I.S.4    Kaposi-Novak, P.5    Calvisi, D.F.6
  • 44
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • J.S. Lee Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling Hepatology 40 2004 667 676
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1
  • 46
  • 47
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 48
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Y. Hoshida, S.M. Nijman, M. Kobayashi, J.A. Chan, J.P. Brunet, and D.Y. Chiang Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma Cancer Res 69 2009 7385 7392
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3    Chan, J.A.4    Brunet, J.P.5    Chiang, D.Y.6
  • 49
    • 77958610661 scopus 로고    scopus 로고
    • An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer
    • J.B. Andersen, V.M. Factor, J.U. Marquardt, C. Raggi, Y.H. Lee, and D. Seo An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer Sci Transl Med 2 2010 54ra77
    • (2010) Sci Transl Med , vol.2
    • Andersen, J.B.1    Factor, V.M.2    Marquardt, J.U.3    Raggi, C.4    Lee, Y.H.5    Seo, D.6
  • 50
    • 77951037177 scopus 로고    scopus 로고
    • Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
    • H.G. Woo, J.H. Lee, J.H. Yoon, C.Y. Kim, H.S. Lee, and J.J. Jang Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma Cancer Res 70 2011 3034 3041
    • (2011) Cancer Res , vol.70 , pp. 3034-3041
    • Woo, H.G.1    Lee, J.H.2    Yoon, J.H.3    Kim, C.Y.4    Lee, H.S.5    Jang, J.J.6
  • 51
    • 78449283414 scopus 로고    scopus 로고
    • Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma
    • Y.H. Lee, J.B. Andersen, H.T. Song, A.D. Judge, D. Seo, and T. Ishikawa Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma Cancer Res 70 21 2010 8264 8269
    • (2010) Cancer Res , vol.70 , Issue.21 , pp. 8264-8269
    • Lee, Y.H.1    Andersen, J.B.2    Song, H.T.3    Judge, A.D.4    Seo, D.5    Ishikawa, T.6
  • 52
    • 80053583011 scopus 로고    scopus 로고
    • Molecular targeting of CSN5 in human hepatocellular carcinoma: A mechanism of therapeutic response
    • Lee YH, Judge AD, Seo D, Kitade M, Gomez-Quiroz LE, Ishikawa T, et al. Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response. Oncogene 2011.
    • (2011) Oncogene
    • Lee, Y.H.1    Judge, A.D.2    Seo, D.3    Kitade, M.4    Gomez-Quiroz, L.E.5    Ishikawa, T.6
  • 54
    • 79955401037 scopus 로고    scopus 로고
    • Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma
    • e1502
    • A. Villanueva, Y. Hoshida, C. Battiston, V. Tovar, D. Sia, and C. Alsinet Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma Gastroenterology 140 2011 1501 1512 e1502
    • (2011) Gastroenterology , vol.140 , pp. 1501-1512
    • Villanueva, A.1    Hoshida, Y.2    Battiston, C.3    Tovar, V.4    Sia, D.5    Alsinet, C.6
  • 58
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • DOI 10.1016/j.ccr.2006.06.016, PII S1535610806002145
    • A. Budhu, M. Forgues, Q.H. Ye, H.L. Jia, P. He, and K.A. Zanetti Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment Cancer Cell 10 2006 99 111 (Pubitemid 44202603)
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.-H.3    Jia, H.-L.4    He, P.5    Zanetti, K.A.6    Kammula, U.S.7    Chen, Y.8    Qin, L.-X.9    Tang, Z.-Y.10    Wang, X.W.11
  • 61
    • 77951925183 scopus 로고    scopus 로고
    • Library of molecular associations: Curating the complex molecular basis of liver diseases
    • S. Buchkremer, J. Hendel, M. Krupp, A. Weinmann, K. Schlamp, and T. Maass Library of molecular associations: curating the complex molecular basis of liver diseases BMC Genomics 11 2010 189
    • (2010) BMC Genomics , vol.11 , pp. 189
    • Buchkremer, S.1    Hendel, J.2    Krupp, M.3    Weinmann, A.4    Schlamp, K.5    Maass, T.6
  • 63
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • DOI 10.1038/nature05919, PII NATURE05919
    • A.P. Feinberg Phenotypic plasticity and the epigenetics of human disease Nature 447 2007 433 440 (Pubitemid 46816750)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 433-440
    • Feinberg, A.P.1
  • 64
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • A.P. Feinberg, and B. Tycko The history of cancer epigenetics Nat Rev Cancer 4 2004 143 153 (Pubitemid 38198742)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 65
    • 53349171172 scopus 로고    scopus 로고
    • Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
    • W. Gao, Y. Kondo, L. Shen, Y. Shimizu, T. Sano, and K. Yamao Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas Carcinogenesis 29 2008 1901 1910
    • (2008) Carcinogenesis , vol.29 , pp. 1901-1910
    • Gao, W.1    Kondo, Y.2    Shen, L.3    Shimizu, Y.4    Sano, T.5    Yamao, K.6
  • 67
    • 79954692738 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis
    • T.H. Um, H. Kim, B.K. Oh, M.S. Kim, K.S. Kim, and G. Jung Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis J Hepatol 54 2011 939 947
    • (2011) J Hepatol , vol.54 , pp. 939-947
    • Um, T.H.1    Kim, H.2    Oh, B.K.3    Kim, M.S.4    Kim, K.S.5    Jung, G.6
  • 69
    • 79952705527 scopus 로고    scopus 로고
    • Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake
    • M.P. Lambert, A. Paliwal, T. Vaissiere, I. Chemin, F. Zoulim, and M. Tommasino Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake J Hepatol 54 2010 705 715
    • (2010) J Hepatol , vol.54 , pp. 705-715
    • Lambert, M.P.1    Paliwal, A.2    Vaissiere, T.3    Chemin, I.4    Zoulim, F.5    Tommasino, M.6
  • 71
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • J.S. Lee A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells Nat Med 12 2006 410 416
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1
  • 72
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • M. Esteller Epigenetics in cancer N Engl J Med 358 2008 1148 1159
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 73
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: Short RNAs go a long way
    • A. Ventura, and T. Jacks MicroRNAs and cancer: short RNAs go a long way Cell 136 2009 586 591
    • (2009) Cell , vol.136 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 74
    • 70349976819 scopus 로고    scopus 로고
    • Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    • C. Coulouarn, V.M. Factor, J.B. Andersen, M.E. Durkin, and S.S. Thorgeirsson Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties Oncogene 28 2009 3526 3536
    • (2009) Oncogene , vol.28 , pp. 3526-3536
    • Coulouarn, C.1    Factor, V.M.2    Andersen, J.B.3    Durkin, M.E.4    Thorgeirsson, S.S.5
  • 75
    • 68949190853 scopus 로고    scopus 로고
    • MicroRNAs involved in tumor suppressor and oncogene pathways: Implications for hepatobiliary neoplasia
    • J.L. Mott MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia Hepatology 50 2009 630 637
    • (2009) Hepatology , vol.50 , pp. 630-637
    • Mott, J.L.1
  • 76
    • 68049097296 scopus 로고    scopus 로고
    • MicroRNAs and parallel stem cell lives
    • P.B. Dirks MicroRNAs and parallel stem cell lives Cell 138 2009 423 424
    • (2009) Cell , vol.138 , pp. 423-424
    • Dirks, P.B.1
  • 77
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • J. Ji, T. Yamashita, A. Budhu, M. Forgues, H.L. Jia, and C. Li Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells Hepatology 50 2009 472 480
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Li, C.6
  • 78
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • S. Ma, K.H. Tang, Y.P. Chan, T.K. Lee, P.S. Kwan, and A. Castilho miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1 Cell Stem Cell 7 6 2010 694 707
    • (2010) Cell Stem Cell , vol.7 , Issue.6 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3    Lee, T.K.4    Kwan, P.S.5    Castilho, A.6
  • 79
    • 77955852219 scopus 로고    scopus 로고
    • Epigenetic regulation of cancer stem cells in liver cancer: Current concepts and clinical implications
    • J.U. Marquardt, V.M. Factor, and S.S. Thorgeirsson Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications J Hepatol 53 2010 568 577
    • (2010) J Hepatol , vol.53 , pp. 568-577
    • Marquardt, J.U.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 81
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • J. Ji, J. Shi, A. Budhu, Z. Yu, M. Forgues, and S. Roessler MicroRNA expression, survival, and response to interferon in liver cancer N Engl J Med 361 2009 1437 1447
    • (2009) N Engl J Med , vol.361 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3    Yu, Z.4    Forgues, M.5    Roessler, S.6
  • 82
    • 46249083024 scopus 로고    scopus 로고
    • MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    • DOI 10.1002/hep.22256
    • Y. Ladeiro, G. Couchy, C. Balabaud, P. Bioulac-Sage, L. Pelletier, and S. Rebouissou MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations Hepatology 47 2008 1955 1963 (Pubitemid 351952843)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1955-1963
    • Ladeiro, Y.1    Couchy, G.2    Balabaud, C.3    Bioulac-Sage, P.4    Pelletier, L.5    Rebouissou, S.6    Zucman-Rossi, J.7
  • 84
    • 78650046221 scopus 로고    scopus 로고
    • Complete characterization of the microRNAome in a patient with acute myeloid leukemia
    • G. Ramsingh, D.C. Koboldt, M. Trissal, K.B. Chiappinelli, T. Wylie, and S. Koul Complete characterization of the microRNAome in a patient with acute myeloid leukemia Blood 116 2010 5316 5326
    • (2010) Blood , vol.116 , pp. 5316-5326
    • Ramsingh, G.1    Koboldt, D.C.2    Trissal, M.3    Chiappinelli, K.B.4    Wylie, T.5    Koul, S.6
  • 85
    • 77955439834 scopus 로고    scopus 로고
    • Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
    • J.H. Schulte, T. Marschall, M. Martin, P. Rosenstiel, P. Mestdagh, and S. Schlierf Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma Nucleic Acids Res 38 2010 5919 5928
    • (2010) Nucleic Acids Res , vol.38 , pp. 5919-5928
    • Schulte, J.H.1    Marschall, T.2    Martin, M.3    Rosenstiel, P.4    Mestdagh, P.5    Schlierf, S.6
  • 86
    • 0035869520 scopus 로고    scopus 로고
    • From the molecule to the clinic inhibiting HER2 to treat breast cancer
    • DOI 10.1056/NEJM200103153441110
    • E.A. Eisenhauer From the molecule to the clinic - inhibiting HER2 to treat breast cancer N Engl J Med 344 2001 841 842 (Pubitemid 32222164)
    • (2001) New England Journal of Medicine , vol.344 , Issue.11 , pp. 841-842
    • Eisenhauer, E.A.1
  • 88
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • J.M. Llovet, and J. Bruix Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 89
    • 33749319341 scopus 로고    scopus 로고
    • Genomic Decoding of Hepatocellular Carcinoma
    • DOI 10.1053/j.gastro.2006.08.060, PII S001650850601938X
    • S.S. Thorgeirsson Genomic decoding of hepatocellular carcinoma Gastroenterology 131 2006 1344 1346 (Pubitemid 44498720)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1344-1346
    • Thorgeirsson, S.S.1
  • 90
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • DOI 10.1038/ng0802-339
    • S.S. Thorgeirsson, and J.W. Grisham Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 2002 339 346 (Pubitemid 35154440)
    • (2002) Nature Genetics , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 92
    • 77349086915 scopus 로고    scopus 로고
    • Stem cells in hepatocarcinogenesis: Evidence from genomic data
    • J.U. Marquardt, and S.S. Thorgeirsson Stem cells in hepatocarcinogenesis: evidence from genomic data Semin Liver Dis 30 2010 26 34
    • (2010) Semin Liver Dis , vol.30 , pp. 26-34
    • Marquardt, J.U.1    Thorgeirsson, S.S.2
  • 93
    • 45549103691 scopus 로고    scopus 로고
    • Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy
    • M. Kakarala, and M.S. Wicha Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy J Clin Oncol 26 2008 2813 2820
    • (2008) J Clin Oncol , vol.26 , pp. 2813-2820
    • Kakarala, M.1    Wicha, M.S.2
  • 94
    • 83555167076 scopus 로고    scopus 로고
    • Cancer stem cells and liver cancer
    • X.W. Wang, S.S. Thorgeirsson, Springer New York, Dordrecht, Heidelberg, London
    • J.U. Marquardt, and S.S. Thorgeirsson Cancer stem cells and liver cancer X.W. Wang, S.S. Thorgeirsson, Molecular genetics of liver neoplasia 2011 Springer New York, Dordrecht, Heidelberg, London 279 301
    • (2011) Molecular Genetics of Liver Neoplasia , pp. 279-301
    • Marquardt, J.U.1    Thorgeirsson, S.S.2
  • 96
    • 73949107880 scopus 로고    scopus 로고
    • Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment
    • P.A. Philip, M. Mooney, D. Jaffe, G. Eckhardt, M. Moore, and N. Meropol Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment J Clin Oncol 27 2009 5660 5669
    • (2009) J Clin Oncol , vol.27 , pp. 5660-5669
    • Philip, P.A.1    Mooney, M.2    Jaffe, D.3    Eckhardt, G.4    Moore, M.5    Meropol, N.6
  • 97
    • 77953155085 scopus 로고    scopus 로고
    • Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation
    • T. Yamashita, M. Honda, K. Nio, Y. Nakamoto, H. Takamura, and T. Tani Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation Cancer Res 70 2010 4687 4697
    • (2010) Cancer Res , vol.70 , pp. 4687-4697
    • Yamashita, T.1    Honda, M.2    Nio, K.3    Nakamoto, Y.4    Takamura, H.5    Tani, T.6
  • 98
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • T. Yamashita, J. Ji, A. Budhu, M. Forgues, W. Yang, and H.Y. Wang EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features Gastroenterology 136 2009 1012 1024
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6
  • 99
    • 79953742352 scopus 로고    scopus 로고
    • CD13: Waving the flag for a novel cancer stem cell target
    • B. Christ, P. Stock, and M.M. Dollinger CD13: waving the flag for a novel cancer stem cell target Hepatology 53 2011 1388 1390
    • (2011) Hepatology , vol.53 , pp. 1388-1390
    • Christ, B.1    Stock, P.2    Dollinger, M.M.3
  • 103
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • S. Yachida, S. Jones, I. Bozic, T. Antal, R. Leary, and B. Fu Distant metastasis occurs late during the genetic evolution of pancreatic cancer Nature 467 2010 1114 1117
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3    Antal, T.4    Leary, R.5    Fu, B.6
  • 106
    • 49849093873 scopus 로고    scopus 로고
    • Capturing cancer stem cells
    • Capturing cancer stem cells. Nat Med 2008;14:814.
    • (2008) Nat Med , vol.14 , pp. 814
  • 107
    • 33646426898 scopus 로고    scopus 로고
    • Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression
    • P.A. Farazi, J. Glickman, J. Horner, and R.A. Depinho Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression Cancer Res 66 2006 4766 4773
    • (2006) Cancer Res , vol.66 , pp. 4766-4773
    • Farazi, P.A.1    Glickman, J.2    Horner, J.3    Depinho, R.A.4
  • 108
    • 0036022848 scopus 로고    scopus 로고
    • Mutation of p53 gene in regenerative nodules in cirrhotic liver
    • DOI 10.1016/S0168-8278(02)00144-7, PII S0168827802001447
    • K. Minouchi, S. Kaneko, and K. Kobayashi Mutation of p53 gene in regenerative nodules in cirrhotic liver J Hepatol 37 2002 231 239 (Pubitemid 34833085)
    • (2002) Journal of Hepatology , vol.37 , Issue.2 , pp. 231-239
    • Minouchi, K.1    Kaneko, S.2    Kobayashi, K.3
  • 110
    • 79952286128 scopus 로고    scopus 로고
    • Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma
    • H.G. Woo, X.W. Wang, A. Budhu, Y.H. Kim, S.M. Kwon, and Z.Y. Tang Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma Gastroenterology 140 2011 1063 1070
    • (2011) Gastroenterology , vol.140 , pp. 1063-1070
    • Woo, H.G.1    Wang, X.W.2    Budhu, A.3    Kim, Y.H.4    Kwon, S.M.5    Tang, Z.Y.6
  • 111
    • 0035882530 scopus 로고    scopus 로고
    • Tumor heterogeneity in small hepatocellular carcinoma: Analysis of tumor cell proliferation, expression and mutation of p53 and [beta]-catenin
    • F.Q. An Tumor heterogeneity in small hepatocellular carcinoma: analysis of tumor cell proliferation, expression and mutation of p53 and [beta]-catenin Int J Cancer 93 2001 468 474
    • (2001) Int J Cancer , vol.93 , pp. 468-474
    • An, F.Q.1
  • 112
    • 2142812377 scopus 로고    scopus 로고
    • Disruption of β-Catenin Pathway or Genomic Instability Define Two Distinct Categories of Liver Cancer in Transgenic Mice
    • DOI 10.1053/j.gastro.2004.02.014
    • D.F. Calvisi, V.M. Factor, S. Ladu, E.A. Conner, and S.S. Thorgeirsson Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice Gastroenterology 126 2004 1374 1386 (Pubitemid 38552801)
    • (2004) Gastroenterology , vol.126 , Issue.5 , pp. 1374-1386
    • Calvisi, D.F.1    Factor, V.M.2    Ladu, S.3    Conner, E.A.4    Thorgeirsson, S.S.5
  • 113
    • 6944250147 scopus 로고    scopus 로고
    • Immunohistochemical analysis and mutational analyses of [beta]-catenin, Axin family and APC genes in hepatocellular carcinomas
    • Y. Ishizaki Immunohistochemical analysis and mutational analyses of [beta]-catenin, Axin family and APC genes in hepatocellular carcinomas Int J Oncol 24 2004 1077 1083
    • (2004) Int J Oncol , vol.24 , pp. 1077-1083
    • Ishizaki, Y.1
  • 114
    • 9644255742 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
    • DOI 10.1016/j.jhep.2004.08.024, PII S016882780400460X
    • M. Hopfner Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma J Hepatol 41 2004 1008 1016 (Pubitemid 39575669)
    • (2004) Journal of Hepatology , vol.41 , Issue.6 , pp. 1008-1016
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3    Schuppan, D.4    Zeitz, M.5    Scherubl, H.6
  • 117
    • 0029776419 scopus 로고    scopus 로고
    • Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: Implications of IGF-I receptor gene activation by hepatitis B virus X gene product
    • S.O. Kim, J.G. Park, and Y.I. Lee Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product Cancer Res 56 1996 3831 3836 (Pubitemid 26272036)
    • (1996) Cancer Research , vol.56 , Issue.16 , pp. 3831-3836
    • Kim, S.-O.1    Park, J.-G.2    Lee, Y.I.3
  • 118
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • M. Pollak Insulin and insulin-like growth factor signalling in neoplasia Nat Rev Cancer 8 2008 915 928
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 119
    • 39049192533 scopus 로고    scopus 로고
    • Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population
    • S.H. Tang, D.H. Yang, W. Huang, H.K. Zhou, X.H. Lu, and G. Ye Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population Clin Cancer Res 12 2006 4171 4177
    • (2006) Clin Cancer Res , vol.12 , pp. 4171-4177
    • Tang, S.H.1    Yang, D.H.2    Huang, W.3    Zhou, H.K.4    Lu, X.H.5    Ye, G.6
  • 120
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • V. Tovar, C. Alsinet, A. Villanueva, Y. Hoshida, D.Y. Chiang, and M. Sole IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage J Hepatol 52 2011 550 559
    • (2011) J Hepatol , vol.52 , pp. 550-559
    • Tovar, V.1    Alsinet, C.2    Villanueva, A.3    Hoshida, Y.4    Chiang, D.Y.5    Sole, M.6
  • 121
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • P. Kaposi-Novak, J.S. Lee, L. Gomez-Quiroz, C. Coulouarn, V.M. Factor, and S.S. Thorgeirsson Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype J Clin Invest 116 2006 1582 1595
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 123
    • 46249085489 scopus 로고    scopus 로고
    • Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
    • DOI 10.1002/hep.22283
    • C. Coulouarn, V.M. Factor, and S.S. Thorgeirsson Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer Hepatology 47 2008 2059 2067 (Pubitemid 351945572)
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 2059-2067
    • Coulouarn, C.1    Factor, V.M.2    Thorgeirsson, S.S.3
  • 124
    • 26444585020 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling in stem cells and cancer
    • DOI 10.1126/science.1118389
    • L. Mishra, R. Derynck, and B. Mishra Transforming growth factor-beta signaling in stem cells and cancer Science 310 2005 68 71 (Pubitemid 41434534)
    • (2005) Science , vol.310 , Issue.5745 , pp. 68-71
    • Mishra, L.1    Derynck, R.2    Mishra, B.3
  • 125
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • DOI 10.1038/nature04870, PII NATURE04870
    • M. Karin Nuclear factor-kappaB in cancer development and progression Nature 441 2006 431 436 (Pubitemid 44050137)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 431-436
    • Karin, M.1
  • 126
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis
    • DOI 10.1002/hep.21802
    • A.M. Elsharkawy, and D.A. Mann Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis Hepatology 46 2007 590 597 (Pubitemid 47344795)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 127
    • 54249125424 scopus 로고    scopus 로고
    • NF-kappaB signaling, liver disease and hepatoprotective agents
    • B. Sun, and M. Karin NF-kappaB signaling, liver disease and hepatoprotective agents Oncogene 27 2008 6228 6244
    • (2008) Oncogene , vol.27 , pp. 6228-6244
    • Sun, B.1    Karin, M.2
  • 128
    • 0031955570 scopus 로고    scopus 로고
    • Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma
    • X.M. Li, Z.Y. Tang, G. Zhou, Y.K. Lui, and S.L. Ye Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma J Exp Clin Cancer Res 17 1998 13 17 (Pubitemid 28215959)
    • (1998) Journal of Experimental and Clinical Cancer Research , vol.17 , Issue.1 , pp. 13-17
    • Li, X.M.1    Tang, Z.Y.2    Zhou, G.3    Lui, Y.K.4    Ye, S.L.5
  • 129
    • 4944234987 scopus 로고    scopus 로고
    • Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
    • DOI 10.1002/bjs.4594
    • R.T. Poon, J.W. Ho, C.S. Tong, C. Lau, I.O. Ng, and S.T. Fan Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma Br J Surg 91 2004 1354 1360 (Pubitemid 39331462)
    • (2004) British Journal of Surgery , vol.91 , Issue.10 , pp. 1354-1360
    • Poon, R.T.P.1    Ho, J.W.Y.2    Tong, C.S.W.3    Lau, C.4    Ng, I.O.L.5    Fan, S.-T.6
  • 130
    • 77955010960 scopus 로고    scopus 로고
    • Hypoxia: A link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease
    • O. Rosmorduc, and C. Housset Hypoxia: a link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease Semin Liver Dis 30 2010 258 270
    • (2010) Semin Liver Dis , vol.30 , pp. 258-270
    • Rosmorduc, O.1    Housset, C.2
  • 131
    • 78650885839 scopus 로고    scopus 로고
    • Mst1/2 signalling to Yap: Gatekeeper for liver size and tumour development
    • J. Avruch, D. Zhou, J. Fitamant, and N. Bardeesy Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development Br J Cancer 104 2011 24 32
    • (2011) Br J Cancer , vol.104 , pp. 24-32
    • Avruch, J.1    Zhou, D.2    Fitamant, J.3    Bardeesy, N.4
  • 132
    • 77955481151 scopus 로고    scopus 로고
    • Hippo tumor suppressor pathway: Novel implications for the treatment of hepatocellular carcinoma
    • A. Lachenmayer, Y. Hoshida, and J.M. Llovet Hippo tumor suppressor pathway: novel implications for the treatment of hepatocellular carcinoma Gastroenterology 139 2010 692 694
    • (2010) Gastroenterology , vol.139 , pp. 692-694
    • Lachenmayer, A.1    Hoshida, Y.2    Llovet, J.M.3
  • 133
    • 77952336576 scopus 로고    scopus 로고
    • The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
    • K.P. Lee, J.H. Lee, T.S. Kim, T.H. Kim, H.D. Park, and J.S. Byun The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis Proc Natl Acad Sci USA 107 2010 8248 8253
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8248-8253
    • Lee, K.P.1    Lee, J.H.2    Kim, T.S.3    Kim, T.H.4    Park, H.D.5    Byun, J.S.6
  • 134
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • D. Zhou, C. Conrad, F. Xia, J.S. Park, B. Payer, and Y. Yin Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene Cancer Cell 16 2009 425 438
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3    Park, J.S.4    Payer, B.5    Yin, Y.6
  • 135
    • 35948981211 scopus 로고    scopus 로고
    • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma
    • DOI 10.1158/1078-0432.CCR-06-2236
    • S.M. Wang, L.L. Ooi, and K.M. Hui Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma Clin Cancer Res 13 2007 6275 6283 (Pubitemid 350075015)
    • (2007) Clinical Cancer Research , vol.13 , Issue.21 , pp. 6275-6283
    • Suk, M.W.1    Ooi, L.L.P.J.2    Hui, K.M.3
  • 138
    • 61349127144 scopus 로고    scopus 로고
    • Molecular prediction of early recurrence after resection of hepatocellular carcinoma
    • S. Yoshioka, I. Takemasa, H. Nagano, N. Kittaka, T. Noda, and H. Wada Molecular prediction of early recurrence after resection of hepatocellular carcinoma Eur J Cancer 45 2009 881 889
    • (2009) Eur J Cancer , vol.45 , pp. 881-889
    • Yoshioka, S.1    Takemasa, I.2    Nagano, H.3    Kittaka, N.4    Noda, T.5    Wada, H.6
  • 139
    • 70349739285 scopus 로고    scopus 로고
    • Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma
    • Y. Hoshida, S.M. Nijman, M. Kobayashi, J.A. Chan, J.P. Brunet, and D.Y. Chiang Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma Cancer Res 69 2009 7385 7392
    • (2009) Cancer Res , vol.69 , pp. 7385-7392
    • Hoshida, Y.1    Nijman, S.M.2    Kobayashi, M.3    Chan, J.A.4    Brunet, J.P.5    Chiang, D.Y.6
  • 140
    • 78650361904 scopus 로고    scopus 로고
    • A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients
    • S. Roessler, H.L. Jia, A. Budhu, M. Forgues, Q.H. Ye, and J.S. Lee A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients Cancer Res 70 2010 10202 10212
    • (2010) Cancer Res , vol.70 , pp. 10202-10212
    • Roessler, S.1    Jia, H.L.2    Budhu, A.3    Forgues, M.4    Ye, Q.H.5    Lee, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.