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Volumn 14, Issue 1, 2014, Pages

Cancer genomic research at the crossroads: Realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; CANCER GROWTH; CANCER PREVENTION; CANCER RESEARCH; CARCINOGENESIS; CONSENSUS SEQUENCE; COST BENEFIT ANALYSIS; DECISION MAKING; GENE MUTATION; GENE SEQUENCE; GENETIC BACKGROUND; HUMAN; METASTASIS; NONHUMAN; PRIMARY TUMOR; REVIEW; SINGLE CELL ANALYSIS; STANDARDIZATION; TUMOR MICROENVIRONMENT;

EID: 84988648759     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-014-0115-7     Document Type: Review
Times cited : (33)

References (114)
  • 1
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM: Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21(3):309-322.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 3
    • 34547641984 scopus 로고    scopus 로고
    • Cancer genome sequencing: the challenges ahead
    • Heng HH: Cancer genome sequencing: the challenges ahead. Bioessays 2007, 29(8):783-794.
    • (2007) Bioessays , vol.29 , Issue.8 , pp. 783-794
    • Heng, H.H.1
  • 4
    • 78049435816 scopus 로고    scopus 로고
    • Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis
    • LaFramboise T, Dewal N, Wilkins K, Pe'er I, Freedman ML: Allelic selection of amplicons in glioblastoma revealed by combining somatic and germline analysis. PLoS Genet 2010, 6(9):e1001086.
    • (2010) PLoS Genet , vol.6 , Issue.9
    • LaFramboise, T.1    Dewal, N.2    Wilkins, K.3    Pe'er, I.4    Freedman, M.L.5
  • 10
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward PS, Thompson CB: Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21(3):297-308.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 17
    • 84877099987 scopus 로고    scopus 로고
    • Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas
    • Zhao Q, Caballero OL, Davis ID, Jonasch E, Tamboli P, Yung WK, Weinstein JN, Kenna Shaw for Trn, Strausberg RL, Yao J: Tumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomas. Clin Cancer Res 2013, 19(9):2460-2472.
    • (2013) Clin Cancer Res , vol.19 , Issue.9 , pp. 2460-2472
    • Zhao, Q.1    Caballero, O.L.2    Davis, I.D.3    Jonasch, E.4    Tamboli, P.5    Yung, W.K.6    Weinstein, J.N.7    Strausberg, R.L.8    Yao, J.9
  • 19
    • 84885767421 scopus 로고    scopus 로고
    • Genomics: comparisons across cancers
    • Ashworth A, Hudson TJ: Genomics: comparisons across cancers. Nature 2013, 502(7471):306-307.
    • (2013) Nature , vol.502 , Issue.7471 , pp. 306-307
    • Ashworth, A.1    Hudson, T.J.2
  • 20
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • (211 September 2014) doi:2010.1038/nature13480
    • TCGA-ResNetwork: Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014, 513:202-209. (211 September 2014) doi:2010.1038/nature13480.
    • (2014) Nature , vol.513 , pp. 202-209
  • 22
    • 84863146161 scopus 로고    scopus 로고
    • Control dominating subclones for managing cancer progression and posttreatment recurrence by subclonal switchboard signal: implication for new therapies
    • Li SC, Lee KL, Luo J: Control dominating subclones for managing cancer progression and posttreatment recurrence by subclonal switchboard signal: implication for new therapies. Stem Cells Dev 2012, 21(4):503-506.
    • (2012) Stem Cells Dev , vol.21 , Issue.4 , pp. 503-506
    • Li, S.C.1    Lee, K.L.2    Luo, J.3
  • 23
    • 79958849271 scopus 로고    scopus 로고
    • Heterogeneity maintenance in glioblastoma: a social network
    • Bonavia R, Inda MM, Cavenee WK, Furnari FB: Heterogeneity maintenance in glioblastoma: a social network. Cancer Res 2011, 71(12):4055-4060.
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4055-4060
    • Bonavia, R.1    Inda, M.M.2    Cavenee, W.K.3    Furnari, F.B.4
  • 25
    • 84857820489 scopus 로고    scopus 로고
    • Tumor heterogeneity and personalized medicine
    • Longo DL: Tumor heterogeneity and personalized medicine. N Engl J Med 2012, 366(10):956-957.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 956-957
    • Longo, D.L.1
  • 27
    • 80755187961 scopus 로고    scopus 로고
    • Current treatment options in triple negative breast cancer
    • Rodler E, Korde L, Gralow J: Current treatment options in triple negative breast cancer. Breast Dis 2010, 32(1-2):99-122.
    • (2010) Breast Dis , vol.32 , Issue.1-2 , pp. 99-122
    • Rodler, E.1    Korde, L.2    Gralow, J.3
  • 29
    • 33749595041 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray
    • Shin SJ, Hyjek E, Early E, Knowles DM: Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray. Int J Surg Pathol 2006, 14(4):279-284.
    • (2006) Int J Surg Pathol , vol.14 , Issue.4 , pp. 279-284
    • Shin, S.J.1    Hyjek, E.2    Early, E.3    Knowles, D.M.4
  • 30
    • 33749499419 scopus 로고    scopus 로고
    • Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections
    • Wemmert S, Romeike BF, Ketter R, Steudel WI, Zang KD, Urbschat S: Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections. Int J Oncol 2006, 28(2):353-360.
    • (2006) Int J Oncol , vol.28 , Issue.2 , pp. 353-360
    • Wemmert, S.1    Romeike, B.F.2    Ketter, R.3    Steudel, W.I.4    Zang, K.D.5    Urbschat, S.6
  • 32
    • 0032101568 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of von Hippel-Lindau gene deletions in renal cell carcinoma detected by fluorescence in situ hybridization
    • Moch H, Schraml P, Bubendorf L, Richter J, Gasser TC, Mihatsch MJ, Sauter G: Intratumoral heterogeneity of von Hippel-Lindau gene deletions in renal cell carcinoma detected by fluorescence in situ hybridization. Cancer Res 1998, 58(11):2304-2309.
    • (1998) Cancer Res , vol.58 , Issue.11 , pp. 2304-2309
    • Moch, H.1    Schraml, P.2    Bubendorf, L.3    Richter, J.4    Gasser, T.C.5    Mihatsch, M.J.6    Sauter, G.7
  • 33
    • 0028261067 scopus 로고
    • Intratumoral heterogeneity for amplified genes in human breast carcinoma
    • Lonn U, Lonn S, Nilsson B, Stenkvist B: Intratumoral heterogeneity for amplified genes in human breast carcinoma. Int J Cancer 1994, 58(1):40-45.
    • (1994) Int J Cancer , vol.58 , Issue.1 , pp. 40-45
    • Lonn, U.1    Lonn, S.2    Nilsson, B.3    Stenkvist, B.4
  • 34
    • 77953900746 scopus 로고    scopus 로고
    • A biological global positioning system: considerations for tracking stem cell behaviors in the whole body
    • Li SC, Tachiki LM, Luo J, Dethlefs BA, Chen Z, Loudon WG: A biological global positioning system: considerations for tracking stem cell behaviors in the whole body. Stem Cell Rev 2010, 6(2):317-333.
    • (2010) Stem Cell Rev , vol.6 , Issue.2 , pp. 317-333
    • Li, S.C.1    Tachiki, L.M.2    Luo, J.3    Dethlefs, B.A.4    Chen, Z.5    Loudon, W.G.6
  • 36
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: causes and consequences
    • Marusyk A, Polyak K: Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2010, 1805(1):105-117.
    • (2010) Biochim Biophys Acta , vol.1805 , Issue.1 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 38
    • 84901594818 scopus 로고    scopus 로고
    • Biology: three known unknowns
    • Bourzac K: Biology: three known unknowns. Nature 2014, 509(7502):S69-S71.
    • (2014) Nature , vol.509 , Issue.7502 , pp. S69-S71
    • Bourzac, K.1
  • 39
    • 84873289947 scopus 로고    scopus 로고
    • Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development
    • Li X, Lees JR: Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development. Immunology 2013, 138(3):208-215.
    • (2013) Immunology , vol.138 , Issue.3 , pp. 208-215
    • Li, X.1    Lees, J.R.2
  • 40
    • 79961087495 scopus 로고    scopus 로고
    • Controversies in clinical cancer dormancy
    • Uhr JW, Pantel K: Controversies in clinical cancer dormancy. Proc Natl Acad Sci U S A 2011, 108(30):12396-12400.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.30 , pp. 12396-12400
    • Uhr, J.W.1    Pantel, K.2
  • 41
    • 84883205105 scopus 로고    scopus 로고
    • The aging of the 2000 and 2011 Hallmarks of Cancer reviews: a critique
    • Sonnenschein C, Soto AM: The aging of the 2000 and 2011 Hallmarks of Cancer reviews: a critique. J Biosci 2013, 38(3):651-663.
    • (2013) J Biosci , vol.38 , Issue.3 , pp. 651-663
    • Sonnenschein, C.1    Soto, A.M.2
  • 42
    • 84988588689 scopus 로고    scopus 로고
    • Edited by Scientific American. USA: Scientific American;
    • Milbury K: Changing the Cancer Landscape. Edited by Scientific American. USA: Scientific American; 2013:1-8.
    • (2013) Changing the Cancer Landscape , pp. 1-8
    • Milbury, K.1
  • 43
    • 84988644680 scopus 로고    scopus 로고
    • Changing the cancer landscape
    • discussion 2133
    • Nash I: Changing the cancer landscape. N Engl J Med 2012, 366:2132-2133. discussion 2133.
    • (2012) N Engl J Med , vol.366 , pp. 2132-2133
    • Nash, I.1
  • 46
    • 77955897975 scopus 로고    scopus 로고
    • BATTLE to personalize lung cancer treatment. Novel clinical trial design and tissue gathering procedures drive biomarker discovery
    • Printz C: BATTLE to personalize lung cancer treatment. Novel clinical trial design and tissue gathering procedures drive biomarker discovery. Cancer 2010, 116(14):3307-3308.
    • (2010) Cancer , vol.116 , Issue.14 , pp. 3307-3308
    • Printz, C.1
  • 47
    • 80051533002 scopus 로고    scopus 로고
    • The BATTLE trial: a bold step toward improving the efficiency of biomarker-based drug development
    • Rubin EH, Anderson KM, Gause CK: The BATTLE trial: a bold step toward improving the efficiency of biomarker-based drug development. Cancer Discovery 2011, 1(1):17-20.
    • (2011) Cancer Discovery , vol.1 , Issue.1 , pp. 17-20
    • Rubin, E.H.1    Anderson, K.M.2    Gause, C.K.3
  • 49
    • 33645124560 scopus 로고    scopus 로고
    • Negative clonal selection in tumor evolution
    • Beckman RA, Loeb LA: Negative clonal selection in tumor evolution. Genetics 2005, 171(4):2123-2131.
    • (2005) Genetics , vol.171 , Issue.4 , pp. 2123-2131
    • Beckman, R.A.1    Loeb, L.A.2
  • 51
    • 84865973305 scopus 로고    scopus 로고
    • Impact of genetic dynamics and singlecell heterogeneity on development of nonstandard personalized medicine strategies for cancer
    • Beckman RA, Schemmann GS, Yeang CH: Impact of genetic dynamics and singlecell heterogeneity on development of nonstandard personalized medicine strategies for cancer. Proc Natl Acad Sci U S A 2012, 109(36):14586-14591.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.36 , pp. 14586-14591
    • Beckman, R.A.1    Schemmann, G.S.2    Yeang, C.H.3
  • 55
    • 61549138442 scopus 로고    scopus 로고
    • Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients
    • Wu C, Hao H, Li L, Zhou X, Guo Z, Zhang L, Zhang X, Zhong W, Guo H, Bremner RM, Lin P: Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients. J Thorac Oncol 2009, 4(1):30-36.
    • (2009) J Thorac Oncol , vol.4 , Issue.1 , pp. 30-36
    • Wu, C.1    Hao, H.2    Li, L.3    Zhou, X.4    Guo, Z.5    Zhang, L.6    Zhang, X.7    Zhong, W.8    Guo, H.9    Bremner, R.M.10    Lin, P.11
  • 57
    • 84856317859 scopus 로고    scopus 로고
    • Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect versus Veridex CellSearch system
    • Andreopoulou E, Yang LY, Rangel KM, Reuben JM, Hsu L, Krishnamurthy S, Valero V, Fritsche HA, Cristofanilli M: Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect versus Veridex CellSearch system. Int J Cancer 2012, 130:1590-1597.
    • (2012) Int J Cancer , vol.130 , pp. 1590-1597
    • Andreopoulou, E.1    Yang, L.Y.2    Rangel, K.M.3    Reuben, J.M.4    Hsu, L.5    Krishnamurthy, S.6    Valero, V.7    Fritsche, H.A.8    Cristofanilli, M.9
  • 59
    • 84860681783 scopus 로고    scopus 로고
    • Catch me if you can: isolating circulating tumor cells from flowing blood
    • Neeves KB: Catch me if you can: isolating circulating tumor cells from flowing blood. Clin Chem 2012, 58(5):803-804.
    • (2012) Clin Chem , vol.58 , Issue.5 , pp. 803-804
    • Neeves, K.B.1
  • 60
    • 79957815376 scopus 로고    scopus 로고
    • Future medical applications of single-cell sequencing in cancer
    • Navin N, Hicks J: Future medical applications of single-cell sequencing in cancer. Genome Med 2011, 3:31.
    • (2011) Genome Med , vol.3 , pp. 31
    • Navin, N.1    Hicks, J.2
  • 61
    • 84882455458 scopus 로고    scopus 로고
    • Single-cell sequencing-based technologies will revolutionize whole-organism science
    • Shapiro E, Biezuner T, Linnarsson S: Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat Rev Genet 2013, 14:618-630.
    • (2013) Nat Rev Genet , vol.14 , pp. 618-630
    • Shapiro, E.1    Biezuner, T.2    Linnarsson, S.3
  • 62
    • 33646448782 scopus 로고    scopus 로고
    • Tailor-made chemotherapy for non-small cell lung cancer patients
    • Huang CL, Yokomise H, Fukushima M, Kinoshita M: Tailor-made chemotherapy for non-small cell lung cancer patients. Future Oncol 2006, 2:289-299.
    • (2006) Future Oncol , vol.2 , pp. 289-299
    • Huang, C.L.1    Yokomise, H.2    Fukushima, M.3    Kinoshita, M.4
  • 64
    • 79959357339 scopus 로고    scopus 로고
    • Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
    • Kelley RK, Venook AP: Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling? Clin Colorectal Cancer 2011, 10:73-80.
    • (2011) Clin Colorectal Cancer , vol.10 , pp. 73-80
    • Kelley, R.K.1    Venook, A.P.2
  • 65
    • 79251513942 scopus 로고    scopus 로고
    • Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer
    • Kelley RK, Van Bebber SL, Phillips KA, Venook AP: Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer. J Natl Compr Cancer Netw 2011, 9:13-25.
    • (2011) J Natl Compr Cancer Netw , vol.9 , pp. 13-25
    • Kelley, R.K.1    Van Bebber, S.L.2    Phillips, K.A.3    Venook, A.P.4
  • 67
    • 84896277174 scopus 로고    scopus 로고
    • Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics
    • Warren AD, Kwong GA, Wood DK, Lin KY, Bhatia SN: Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Proc Natl Acad Sci U S A 2014, 111:3671-3676.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 3671-3676
    • Warren, A.D.1    Kwong, G.A.2    Wood, D.K.3    Lin, K.Y.4    Bhatia, S.N.5
  • 68
    • 84856532705 scopus 로고    scopus 로고
    • De novo discovery of mutated driver pathways in cancer
    • Vandin F, Upfal E, Raphael BJ: De novo discovery of mutated driver pathways in cancer. Genome Res 2013, 22(2):375-385.
    • (2013) Genome Res , vol.22 , Issue.2 , pp. 375-385
    • Vandin, F.1    Upfal, E.2    Raphael, B.J.3
  • 70
    • 50649093738 scopus 로고    scopus 로고
    • Natural selection: the evolution of cancer
    • Goymer P: Natural selection: the evolution of cancer. Nature 2008, 454(7208):1046-1048.
    • (2008) Nature , vol.454 , Issue.7208 , pp. 1046-1048
    • Goymer, P.1
  • 71
    • 84871479196 scopus 로고    scopus 로고
    • From TCGA to treatment
    • TCGA-2: From TCGA to treatment. Cancer Discovery 2013, 2(12):1068.
    • (2013) Cancer Discovery , vol.2 , Issue.12 , pp. 1068
  • 73
    • 84872544617 scopus 로고    scopus 로고
    • Targeting of TGF beta signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma
    • Fox JL, Dews M, Minn AJ, Thomas-Tikhonenko A: Targeting of TGF beta signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA 2013, 19:177-190.
    • (2013) RNA , vol.19 , pp. 177-190
    • Fox, J.L.1    Dews, M.2    Minn, A.J.3    Thomas-Tikhonenko, A.4
  • 75
    • 79551513940 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    • Radpour R, Barekati Z, Kohler C, Lv Q, Burki N, Diesch C, Bitzer J, Zheng H, Schmid S, Zhong XY: Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer. PLoS One 2011, 6:e16080.
    • (2011) PLoS One , vol.6
    • Radpour, R.1    Barekati, Z.2    Kohler, C.3    Lv, Q.4    Burki, N.5    Diesch, C.6    Bitzer, J.7    Zheng, H.8    Schmid, S.9    Zhong, X.Y.10
  • 77
    • 84880829314 scopus 로고    scopus 로고
    • Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients
    • Majchrzak-Celinska A, Paluszczak J, Kleszcz R, Magiera M, Barciszewska AM, Nowak S, Baer-Dubowska W: Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. J Appl Genet 2013, 54:335-344.
    • (2013) J Appl Genet , vol.54 , pp. 335-344
    • Majchrzak-Celinska, A.1    Paluszczak, J.2    Kleszcz, R.3    Magiera, M.4    Barciszewska, A.M.5    Nowak, S.6    Baer-Dubowska, W.7
  • 78
    • 2942709840 scopus 로고    scopus 로고
    • Metabolic profiles to define the genome: can we hear the phenotypes?
    • Griffin JL: Metabolic profiles to define the genome: can we hear the phenotypes? Philos T Roy Soc B 2004, 359(1446):857-871.
    • (2004) Philos T Roy Soc B , vol.359 , Issue.1446 , pp. 857-871
    • Griffin, J.L.1
  • 79
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O: On respiratory impairment in cancer cells. Science 1956, 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 80
    • 0023158728 scopus 로고
    • Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
    • Flier JS, Mueckler MM, Usher P, Lodish HF: Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 1987, 235:1492-1495.
    • (1987) Science , vol.235 , pp. 1492-1495
    • Flier, J.S.1    Mueckler, M.M.2    Usher, P.3    Lodish, H.F.4
  • 81
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: what do metabolic outliers teach us?
    • DeBerardinis RJ, Thompson CB: Cellular metabolism and disease: what do metabolic outliers teach us? Cell 2012, 148(6):1132-1144.
    • (2012) Cell , vol.148 , Issue.6 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 82
    • 84862776612 scopus 로고    scopus 로고
    • Alterations of metabolic genes and metabolites in cancer
    • Oermann EK, Wu J, Guan KL, Xiong Y: Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol 2012, 23(4):370-380.
    • (2012) Semin Cell Dev Biol , vol.23 , Issue.4 , pp. 370-380
    • Oermann, E.K.1    Wu, J.2    Guan, K.L.3    Xiong, Y.4
  • 84
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV: Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011, 11(5):325-337.
    • (2011) Nat Rev Cancer , vol.11 , Issue.5 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 85
    • 84884325809 scopus 로고    scopus 로고
    • Cancer metabolism: new validated targets for drug discovery
    • Sotgia F, Martinez-Outschoorn UE, Lisanti MP: Cancer metabolism: new validated targets for drug discovery. Oncotarget 2013, 4(8):1309-1315.
    • (2013) Oncotarget , vol.4 , Issue.8 , pp. 1309-1315
    • Sotgia, F.1    Martinez-Outschoorn, U.E.2    Lisanti, M.P.3
  • 87
    • 41749115677 scopus 로고    scopus 로고
    • Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patients. Clinico-pathological remarks on our series of seven cases and critical review of the literature
    • Piccirilli M, Brunetto GM, Rocchi G, Giangaspero F, Salvati M: Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patients. Clinico-pathological remarks on our series of seven cases and critical review of the literature. Tumori 2008, 94(1):40-51.
    • (2008) Tumori , vol.94 , Issue.1 , pp. 40-51
    • Piccirilli, M.1    Brunetto, G.M.2    Rocchi, G.3    Giangaspero, F.4    Salvati, M.5
  • 88
    • 84904507149 scopus 로고    scopus 로고
    • Ipilimumab in pretreated patients with unresectable or metastatic cutaneous, uveal and mucosal melanoma
    • Alexander M, Mellor JD, McArthur G, Kee D: Ipilimumab in pretreated patients with unresectable or metastatic cutaneous, uveal and mucosal melanoma. MedJ Austr 2014, 201(1):49-53.
    • (2014) MedJ Austr , vol.201 , Issue.1 , pp. 49-53
    • Alexander, M.1    Mellor, J.D.2    McArthur, G.3    Kee, D.4
  • 90
    • 84927591933 scopus 로고    scopus 로고
    • Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene
    • Savas P, Caramia F, Teo ZL, Loi S: Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. Curr Opin Oncol 2014, 26:562-567.
    • (2014) Curr Opin Oncol , vol.26 , pp. 562-567
    • Savas, P.1    Caramia, F.2    Teo, Z.L.3    Loi, S.4
  • 91
    • 79961227372 scopus 로고    scopus 로고
    • From the cover: increase developmental plasticity of human keratinocytes with gene suppression
    • Li SC, Jin Y, Loudon WG, Song Y, Ma Z, Weiner LP, Zhong JF: From the cover: increase developmental plasticity of human keratinocytes with gene suppression. Proc Natl Acad Sci U S A 2011, 108(31):12793-12798.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.31 , pp. 12793-12798
    • Li, S.C.1    Jin, Y.2    Loudon, W.G.3    Song, Y.4    Ma, Z.5    Weiner, L.P.6    Zhong, J.F.7
  • 92
    • 77958149635 scopus 로고    scopus 로고
    • Therapeutic window, a critical developmental stage for stem cell therapies
    • Li SC, Han YP, Dethlefs BA, Loudon WG: Therapeutic window, a critical developmental stage for stem cell therapies. Curr Stem Cell Res Ther 2010, 5:293-297.
    • (2010) Curr Stem Cell Res Ther , vol.5 , pp. 293-297
    • Li, S.C.1    Han, Y.P.2    Dethlefs, B.A.3    Loudon, W.G.4
  • 93
    • 79952576691 scopus 로고    scopus 로고
    • Reprint edition (August 9, 2011) edn. New York, NY: Scribner; a division of Simon & Schuster Inc;
    • Mukherjee S: THE EMPEROR OF ALL MALADIES: A Biography of Cancer, Reprint edition (August 9, 2011) edn. New York, NY: Scribner; a division of Simon & Schuster Inc; 2010:1-608.
    • (2010) THE EMPEROR OF ALL MALADIES: A Biography of Cancer , pp. 1-608
    • Mukherjee, S.1
  • 94
    • 24944546620 scopus 로고    scopus 로고
    • Genetic instability in cancer: theory and experiment
    • Beckman RA, Loeb LA: Genetic instability in cancer: theory and experiment. Semin Cancer Biol 2005, 15(6):423-435.
    • (2005) Semin Cancer Biol , vol.15 , Issue.6 , pp. 423-435
    • Beckman, R.A.1    Loeb, L.A.2
  • 95
    • 45549102966 scopus 로고    scopus 로고
    • Cancers exhibit a mutator phenotype: clinical implications
    • discussion 3557
    • Loeb LA, Bielas JH, Beckman RA: Cancers exhibit a mutator phenotype: clinical implications. Cancer Res 2008, 68(10):3551-3557. discussion 3557.
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3551-3557
    • Loeb, L.A.1    Bielas, J.H.2    Beckman, R.A.3
  • 96
    • 33749012528 scopus 로고    scopus 로고
    • Efficiency of carcinogenesis with and without a mutator mutation
    • Beckman RA, Loeb LA: Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A 2006, 103(38):14140-14145.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.38 , pp. 14140-14145
    • Beckman, R.A.1    Loeb, L.A.2
  • 97
    • 80053484515 scopus 로고    scopus 로고
    • Integrating predictive biomarkers and classifiers into oncology clinical development programmes
    • Beckman RA, Clark J, Chen C: Integrating predictive biomarkers and classifiers into oncology clinical development programmes. Nat Rev Drug Discov 2014, 10:735-748.
    • (2014) Nat Rev Drug Discov , vol.10 , pp. 735-748
    • Beckman, R.A.1    Clark, J.2    Chen, C.3
  • 98
    • 78649491871 scopus 로고    scopus 로고
    • Efficiency of carcinogenesis: is the mutator phenotype inevitable?
    • Beckman RA: Efficiency of carcinogenesis: is the mutator phenotype inevitable? Semin Cancer Biol 2014, 20:340-352.
    • (2014) Semin Cancer Biol , vol.20 , pp. 340-352
    • Beckman, R.A.1
  • 99
    • 48249112190 scopus 로고    scopus 로고
    • A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors
    • (page 1-11)
    • Li SC, Loudon WG: A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors. Cancer Cell Int 2008, 8:9 (page 1-11).
    • (2008) Cancer Cell Int , vol.8 , pp. 9
    • Li, S.C.1    Loudon, W.G.2
  • 100
    • 84879996851 scopus 로고    scopus 로고
    • The new cancer dream teams, why amassing a huge cast of PhDs and funding them lavishly might just beat the tumors
    • Saporito B: The new cancer dream teams, why amassing a huge cast of PhDs and funding them lavishly might just beat the tumors. TIME 2013, 181(12):30-38.
    • (2013) TIME , vol.181 , Issue.12 , pp. 30-38
    • Saporito, B.1
  • 103
    • 84876454638 scopus 로고    scopus 로고
    • Study of molecule variations in renal tumor based on confocal micro-Raman spectroscopy
    • Zhuang Z, Li N, Guo Z, Zhu M, Xiong K, Chen S: Study of molecule variations in renal tumor based on confocal micro-Raman spectroscopy. J Biomed Opt 2013, 18:31103.
    • (2013) J Biomed Opt , vol.18 , pp. 31103
    • Zhuang, Z.1    Li, N.2    Guo, Z.3    Zhu, M.4    Xiong, K.5    Chen, S.6
  • 104
    • 84878004585 scopus 로고    scopus 로고
    • Raman imaging at biological interfaces: applications in breast cancer diagnosis
    • Surmacki J, Musial J, Kordek R, Abramczyk H: Raman imaging at biological interfaces: applications in breast cancer diagnosis. Mol Cancer 2013, 12:48.
    • (2013) Mol Cancer , vol.12 , pp. 48
    • Surmacki, J.1    Musial, J.2    Kordek, R.3    Abramczyk, H.4
  • 105
    • 84878100042 scopus 로고    scopus 로고
    • Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique
    • Wu L, Wang Z, Zong S, Chen H, Wang C, Xu S, Cui Y: Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique. Analyst 2013, 138(12):3450-3456.
    • (2013) Analyst , vol.138 , Issue.12 , pp. 3450-3456
    • Wu, L.1    Wang, Z.2    Zong, S.3    Chen, H.4    Wang, C.5    Xu, S.6    Cui, Y.7
  • 107
    • 84922220725 scopus 로고    scopus 로고
    • Sensitive multiplex detection of serological liver cancer biomarkers using SERS-active photonic crystal fiber probe
    • Dinish US, Balasundaram G, Chang YT, Olivo M: Sensitive multiplex detection of serological liver cancer biomarkers using SERS-active photonic crystal fiber probe. J Biophotonics 2013, doi: 10.1002/jbio.201300084.
    • (2013) J Biophotonics
    • Dinish, U.S.1    Balasundaram, G.2    Chang, Y.T.3    Olivo, M.4
  • 108
    • 84864048684 scopus 로고    scopus 로고
    • Towards big data science in the decade ahead from ten years of InCoB and the 1st ISCB-Asia Joint Conference
    • Ranganathan S, Schonbach C, Kelso J, Rost B, Nathan S, Tan TW: Towards big data science in the decade ahead from ten years of InCoB and the 1st ISCB-Asia Joint Conference. BMC Bioinformatics 2013, 12(Suppl 13):S1.
    • (2013) BMC Bioinformatics , vol.12 , pp. S1
    • Ranganathan, S.1    Schonbach, C.2    Kelso, J.3    Rost, B.4    Nathan, S.5    Tan, T.W.6
  • 109
    • 77955868506 scopus 로고    scopus 로고
    • Computational solutions to large-scale data management and analysis
    • Schadt EE, Linderman MD, Sorenson J, Lee L, Nolan GP: Computational solutions to large-scale data management and analysis. Nat Rev Genet 2010, 11(9):647-657.
    • (2010) Nat Rev Genet , vol.11 , Issue.9 , pp. 647-657
    • Schadt, E.E.1    Linderman, M.D.2    Sorenson, J.3    Lee, L.4    Nolan, G.P.5
  • 112
    • 77951702343 scopus 로고    scopus 로고
    • Genetic heterogeneity in human disease
    • McClellan J, King MC: Genetic heterogeneity in human disease. Cell 2013, 141:210-217.
    • (2013) Cell , vol.141 , pp. 210-217
    • McClellan, J.1    King, M.C.2
  • 114
    • 77953867567 scopus 로고    scopus 로고
    • Genomic analysis of mental illness: a changing landscape
    • McClellan J, King MC: Genomic analysis of mental illness: a changing landscape. JAMA 2013, 303:2523-2524.
    • (2013) JAMA , vol.303 , pp. 2523-2524
    • McClellan, J.1    King, M.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.