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Volumn 62, Issue 1, 2015, Pages 198-207

Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: Molecular networks and biological concepts

Author keywords

Cancer stem cells; Cholangiocarcinoma; Tumour associated macrophages; Tumour microenvironment

Indexed keywords

BETA CATENIN; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; SONIC HEDGEHOG PROTEIN; STAT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 84918543521     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.09.007     Document Type: Review
Times cited : (68)

References (123)
  • 1
    • 80052874605 scopus 로고    scopus 로고
    • Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: One step closer to personalized medicine?
    • M. Kumar, X. Zhao, and X.W. Wang Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine? Cell Biosci 1 2011 5
    • (2011) Cell Biosci , vol.1 , pp. 5
    • Kumar, M.1    Zhao, X.2    Wang, X.W.3
  • 3
    • 84900992727 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma
    • J. Bridgewater, P.R. Galle, S.A. Khan, J.M. Llovet, J.W. Park, and T. Patel Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma J Hepatol 60 2014 1268 1289
    • (2014) J Hepatol , vol.60 , pp. 1268-1289
    • Bridgewater, J.1    Galle, P.R.2    Khan, S.A.3    Llovet, J.M.4    Park, J.W.5    Patel, T.6
  • 4
    • 84888250929 scopus 로고    scopus 로고
    • Pathogenesis, diagnosis, and management of cholangiocarcinoma
    • S. Rizvi, and G.J. Gores Pathogenesis, diagnosis, and management of cholangiocarcinoma Gastroenterology 145 2013 1215 1229
    • (2013) Gastroenterology , vol.145 , pp. 1215-1229
    • Rizvi, S.1    Gores, G.J.2
  • 5
    • 84873868525 scopus 로고    scopus 로고
    • Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity
    • V. Cardinale, G. Carpino, L. Reid, E. Gaudio, and D. Alvaro Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity World J Gastrointest Oncol 4 2012 94 102
    • (2012) World J Gastrointest Oncol , vol.4 , pp. 94-102
    • Cardinale, V.1    Carpino, G.2    Reid, L.3    Gaudio, E.4    Alvaro, D.5
  • 6
    • 84867163971 scopus 로고    scopus 로고
    • Cholangiocarcinoma: A cancer in search of the right classification
    • V. Cardinale, G. Carpino, L.M. Reid, E. Gaudio, and D. Alvaro Cholangiocarcinoma: a cancer in search of the right classification Hepatology 56 2012 1585 1586
    • (2012) Hepatology , vol.56 , pp. 1585-1586
    • Cardinale, V.1    Carpino, G.2    Reid, L.M.3    Gaudio, E.4    Alvaro, D.5
  • 7
    • 84861552732 scopus 로고    scopus 로고
    • Mucin-producing cholangiocarcinoma might derive from biliary tree stem/progenitor cells located in peribiliary glands
    • V. Cardinale, Y. Wang, G. Carpino, L.M. Reid, E. Gaudio, and D. Alvaro Mucin-producing cholangiocarcinoma might derive from biliary tree stem/progenitor cells located in peribiliary glands Hepatology 55 2012 2041 2042
    • (2012) Hepatology , vol.55 , pp. 2041-2042
    • Cardinale, V.1    Wang, Y.2    Carpino, G.3    Reid, L.M.4    Gaudio, E.5    Alvaro, D.6
  • 8
    • 84859927304 scopus 로고    scopus 로고
    • Genetic profiling of intrahepatic cholangiocarcinoma
    • J.B. Andersen, and S.S. Thorgeirsson Genetic profiling of intrahepatic cholangiocarcinoma Curr Opin Gastroenterol 28 2012 266 272
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 266-272
    • Andersen, J.B.1    Thorgeirsson, S.S.2
  • 9
    • 84875237481 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma: Pathogenesis and rationale for molecular therapies
    • D. Sia, V. Tovar, A. Moeini, and J.M. Llovet Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies Oncogene 32 2013 4861 4870
    • (2013) Oncogene , vol.32 , pp. 4861-4870
    • Sia, D.1    Tovar, V.2    Moeini, A.3    Llovet, J.M.4
  • 10
    • 84859441690 scopus 로고    scopus 로고
    • Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors
    • J.B. Andersen, B. Spee, B.R. Blechacz, I. Avital, M. Komuta, and A. Barbour Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors Gastroenterology 142 2012 e1015
    • (2012) Gastroenterology , vol.142 , pp. 1015
    • Andersen, J.B.1    Spee, B.2    Blechacz, B.R.3    Avital, I.4    Komuta, M.5    Barbour, A.6
  • 11
    • 84875244110 scopus 로고    scopus 로고
    • Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes
    • D. Sia, Y. Hoshida, A. Villanueva, S. Roayaie, J. Ferrer, and B. Tabak Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes Gastroenterology 144 2013 829 840
    • (2013) Gastroenterology , vol.144 , pp. 829-840
    • Sia, D.1    Hoshida, Y.2    Villanueva, A.3    Roayaie, S.4    Ferrer, J.5    Tabak, B.6
  • 12
    • 0001432874 scopus 로고
    • Combined liver cell and bile duct carcinoma
    • R.A. Allen, and J.R. Lisa Combined liver cell and bile duct carcinoma Am J Pathol 25 1949 647 655
    • (1949) Am J Pathol , vol.25 , pp. 647-655
    • Allen, R.A.1    Lisa, J.R.2
  • 13
    • 43949123310 scopus 로고    scopus 로고
    • Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin
    • M. Komuta, B. Spee, S. Vander Borght, R. De Vos, C. Verslype, and R. Aerts Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin Hepatology 47 2008 1544 1556
    • (2008) Hepatology , vol.47 , pp. 1544-1556
    • Komuta, M.1    Spee, B.2    Vander Borght, S.3    De Vos, R.4    Verslype, C.5    Aerts, R.6
  • 14
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • J.S. Lee, J. Heo, L. Libbrecht, I.S. Chu, P. Kaposi-Novak, and D.F. Calvisi A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells Nat Med 12 2006 410 416
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3    Chu, I.S.4    Kaposi-Novak, P.5    Calvisi, D.F.6
  • 15
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • J.S. Lee, and S.S. Thorgeirsson Comparative and integrative functional genomics of HCC Oncogene 25 2006 3801 3809
    • (2006) Oncogene , vol.25 , pp. 3801-3809
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 16
    • 2942585417 scopus 로고    scopus 로고
    • The molecular pathogenesis of cholangiocarcinoma
    • E.P. Berthiaume, and J. Wands The molecular pathogenesis of cholangiocarcinoma Semin Liver Dis 24 2004 127 137
    • (2004) Semin Liver Dis , vol.24 , pp. 127-137
    • Berthiaume, E.P.1    Wands, J.2
  • 17
    • 77949487850 scopus 로고    scopus 로고
    • Hepatitis B virus-Associated intrahepatic cholangiocarcinoma and hepatocellular carcinoma may hold common disease process for carcinogenesis
    • H. Zhou, H. Wang, D. Zhou, Q. Wang, S. Zou, and Q. Tu Hepatitis B virus-Associated intrahepatic cholangiocarcinoma and hepatocellular carcinoma may hold common disease process for carcinogenesis Eur J Cancer 46 2010 1056 1061
    • (2010) Eur J Cancer , vol.46 , pp. 1056-1061
    • Zhou, H.1    Wang, H.2    Zhou, D.3    Wang, Q.4    Zou, S.5    Tu, Q.6
  • 18
    • 31144432170 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype
    • K. Nomoto, K. Tsuneyama, C. Cheng, H. Takahashi, R. Hori, and Y. Murai Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype Pathol Res Pract 202 2006 71 76
    • (2006) Pathol Res Pract , vol.202 , pp. 71-76
    • Nomoto, K.1    Tsuneyama, K.2    Cheng, C.3    Takahashi, H.4    Hori, R.5    Murai, Y.6
  • 19
    • 33744941608 scopus 로고    scopus 로고
    • Different types of liver progenitor cells and their niches
    • T. Roskams Different types of liver progenitor cells and their niches J Hepatol 45 2006 1 4
    • (2006) J Hepatol , vol.45 , pp. 1-4
    • Roskams, T.1
  • 20
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • T. Roskams Liver stem cells and their implication in hepatocellular and cholangiocarcinoma Oncogene 25 2006 3818 3822
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 21
    • 84881052522 scopus 로고    scopus 로고
    • Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signalling
    • M. Kitade, V.M. Factor, J.B. Andersen, A. Tomokuni, K. Kaji, and H. Akita Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signalling Genes Dev 27 2013 1706 1717
    • (2013) Genes Dev , vol.27 , pp. 1706-1717
    • Kitade, M.1    Factor, V.M.2    Andersen, J.B.3    Tomokuni, A.4    Kaji, K.5    Akita, H.6
  • 22
    • 1642532389 scopus 로고    scopus 로고
    • Primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype
    • H. Kim, C. Park, K.H. Han, J. Choi, Y.B. Kim, and J.K. Kim Primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype J Hepatol 40 2004 298 304
    • (2004) J Hepatol , vol.40 , pp. 298-304
    • Kim, H.1    Park, C.2    Han, K.H.3    Choi, J.4    Kim, Y.B.5    Kim, J.K.6
  • 23
    • 77951037177 scopus 로고    scopus 로고
    • Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma
    • H.G. Woo, J.H. Lee, J.H. Yoon, C.Y. Kim, H.S. Lee, and J.J. Jang Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma Cancer Res 70 2010 3034 3041
    • (2010) Cancer Res , vol.70 , pp. 3034-3041
    • Woo, H.G.1    Lee, J.H.2    Yoon, J.H.3    Kim, C.Y.4    Lee, H.S.5    Jang, J.J.6
  • 24
    • 42249087302 scopus 로고    scopus 로고
    • Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma
    • H.G. Woo, E.S. Park, J.H. Cheon, J.H. Kim, J.S. Lee, and B.J. Park Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma Clin Cancer Res 14 2008 2056 2064
    • (2008) Clin Cancer Res , vol.14 , pp. 2056-2064
    • Woo, H.G.1    Park, E.S.2    Cheon, J.H.3    Kim, J.H.4    Lee, J.S.5    Park, B.J.6
  • 25
    • 84861560298 scopus 로고    scopus 로고
    • A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition
    • J.Y. Seok, D.C. Na, H.G. Woo, M. Roncalli, S.M. Kwon, and J.E. Yoo A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition Hepatology 55 2012 1776 1786
    • (2012) Hepatology , vol.55 , pp. 1776-1786
    • Seok, J.Y.1    Na, D.C.2    Woo, H.G.3    Roncalli, M.4    Kwon, S.M.5    Yoo, J.E.6
  • 28
    • 0035153640 scopus 로고    scopus 로고
    • Combined hepatocellular/cholangiocellular carcinoma with sarcomatoid features: Genetic analysis for histogenesis
    • M. Murata, Y. Miyoshi, K. Iwao, H. Wada, K. Shibata, and H. Tateishi Combined hepatocellular/cholangiocellular carcinoma with sarcomatoid features: genetic analysis for histogenesis Hepatol Res 21 2001 220 227
    • (2001) Hepatol Res , vol.21 , pp. 220-227
    • Murata, M.1    Miyoshi, Y.2    Iwao, K.3    Wada, H.4    Shibata, K.5    Tateishi, H.6
  • 29
    • 84855417413 scopus 로고    scopus 로고
    • Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: An anatomical in situ study yielding evidence of maturational lineages
    • G. Carpino, V. Cardinale, P. Onori, A. Franchitto, P.B. Berloco, and M. Rossi Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages J Anat 220 2012 186 199
    • (2012) J Anat , vol.220 , pp. 186-199
    • Carpino, G.1    Cardinale, V.2    Onori, P.3    Franchitto, A.4    Berloco, P.B.5    Rossi, M.6
  • 30
    • 84877921803 scopus 로고    scopus 로고
    • Notch-driven carcinogenesis: The merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype
    • N. Razumilava, and G.J. Gores Notch-driven carcinogenesis: the merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype J Hepatol 58 2013 1244 1245
    • (2013) J Hepatol , vol.58 , pp. 1244-1245
    • Razumilava, N.1    Gores, G.J.2
  • 31
    • 84879487740 scopus 로고    scopus 로고
    • Primary liver carcinomas can originate from different cell types: A new level of complexity in hepatocarcinogenesis
    • J. Zucman-Rossi, J.C. Nault, and L. Zender Primary liver carcinomas can originate from different cell types: a new level of complexity in hepatocarcinogenesis Gastroenterology 145 2013 53 55
    • (2013) Gastroenterology , vol.145 , pp. 53-55
    • Zucman-Rossi, J.1    Nault, J.C.2    Zender, L.3
  • 34
    • 84868625552 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes
    • S. Sekiya, and A. Suzuki Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes J Clin Invest 122 2012 3914 3918
    • (2012) J Clin Invest , vol.122 , pp. 3914-3918
    • Sekiya, S.1    Suzuki, A.2
  • 36
    • 84903768676 scopus 로고    scopus 로고
    • Tackling the cancer stem cells - What challenges do they pose?
    • D.R. Pattabiraman, and R.A. Weinberg Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov 13 2014 497 512
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 497-512
    • Pattabiraman, D.R.1    Weinberg, R.A.2
  • 37
    • 80052031109 scopus 로고    scopus 로고
    • Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways
    • J.U. Marquardt, C. Raggi, J.B. Andersen, D. Seo, I. Avital, and D. Geller Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways Hepatology 54 2011 1031 1042
    • (2011) Hepatology , vol.54 , pp. 1031-1042
    • Marquardt, J.U.1    Raggi, C.2    Andersen, J.B.3    Seo, D.4    Avital, I.5    Geller, D.6
  • 38
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumourigenic liver cancer stem/progenitor cells
    • S. Ma, K.W. Chan, L. Hu, T.K. Lee, J.Y. Wo, and I.O. Ng Identification and characterization of tumourigenic liver cancer stem/progenitor cells Gastroenterology 132 2007 2542 2556
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6
  • 40
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • T. Yamashita, M. Forgues, W. Wang, J.W. Kim, Q. Ye, and H. Jia EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma Cancer Res 68 2008 1451 1461
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3    Kim, J.W.4    Ye, Q.5    Jia, H.6
  • 41
    • 84872185005 scopus 로고    scopus 로고
    • Recent advances in cancer stem cell research for cholangiocarcinoma
    • T. Kokuryo, Y. Yokoyama, and M. Nagino Recent advances in cancer stem cell research for cholangiocarcinoma J Hepatobiliary Pancreat Sci 19 2012 606 613
    • (2012) J Hepatobiliary Pancreat Sci , vol.19 , pp. 606-613
    • Kokuryo, T.1    Yokoyama, Y.2    Nagino, M.3
  • 42
    • 79960852832 scopus 로고    scopus 로고
    • CD133: A potential indicator for differentiation and prognosis of human cholangiocarcinoma
    • L. Fan, F. He, H. Liu, J. Zhu, Y. Liu, and Z. Yin CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma BMC Cancer 11 2011 320
    • (2011) BMC Cancer , vol.11 , pp. 320
    • Fan, L.1    He, F.2    Liu, H.3    Zhu, J.4    Liu, Y.5    Yin, Z.6
  • 44
    • 84918501018 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma
    • L. Sulpice, M. Rayar, B. Turlin, E. Boucher, P. Bellaud, and M. Desille Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma J Surg Res 192 2014 117 123
    • (2014) J Surg Res , vol.192 , pp. 117-123
    • Sulpice, L.1    Rayar, M.2    Turlin, B.3    Boucher, E.4    Bellaud, P.5    Desille, M.6
  • 45
    • 79951996059 scopus 로고    scopus 로고
    • CD133 and ALDH may be the molecular markers of cholangiocarcinoma stem cells
    • M. Wang, J. Xiao, J. Jiang, and R. Qin CD133 and ALDH may be the molecular markers of cholangiocarcinoma stem cells Int J Cancer 128 2011 1996 1997
    • (2011) Int J Cancer , vol.128 , pp. 1996-1997
    • Wang, M.1    Xiao, J.2    Jiang, J.3    Qin, R.4
  • 46
    • 37549021879 scopus 로고    scopus 로고
    • Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: Immunohistochemical and double-fluorescence immunostaining evidence
    • F. Zhang, X.P. Chen, W. Zhang, H.H. Dong, S. Xiang, and W.G. Zhang Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence Histopathology 52 2008 224 232
    • (2008) Histopathology , vol.52 , pp. 224-232
    • Zhang, F.1    Chen, X.P.2    Zhang, W.3    Dong, H.H.4    Xiang, S.5    Zhang, W.G.6
  • 47
    • 84859383549 scopus 로고    scopus 로고
    • Second-line therapies in hepatocellular carcinoma: Emergence of resistance to sorafenib
    • A. Villanueva, and J.M. Llovet Second-line therapies in hepatocellular carcinoma: emergence of resistance to sorafenib Clin Cancer Res 18 2012 1824 1826
    • (2012) Clin Cancer Res , vol.18 , pp. 1824-1826
    • Villanueva, A.1    Llovet, J.M.2
  • 48
    • 84896398914 scopus 로고    scopus 로고
    • Notch signalling and new therapeutic options in liver disease
    • C.M. Morell, and M. Strazzabosco Notch signalling and new therapeutic options in liver disease J Hepatol 60 2014 885 890
    • (2014) J Hepatol , vol.60 , pp. 885-890
    • Morell, C.M.1    Strazzabosco, M.2
  • 49
    • 84886292825 scopus 로고    scopus 로고
    • Molecular mechanisms of liver and bile duct development
    • Y. Zong, and B.Z. Stanger Molecular mechanisms of liver and bile duct development Wiley Interdiscip Rev Dev Biol 1 2012 643 655
    • (2012) Wiley Interdiscip Rev Dev Biol , vol.1 , pp. 643-655
    • Zong, Y.1    Stanger, B.Z.2
  • 50
    • 38049150094 scopus 로고    scopus 로고
    • Deregulated expression of Notch receptors in human hepatocellular carcinoma
    • J. Gao, Z. Song, Y. Chen, L. Xia, J. Wang, and R. Fan Deregulated expression of Notch receptors in human hepatocellular carcinoma Dig Liver Dis 40 2008 114 121
    • (2008) Dig Liver Dis , vol.40 , pp. 114-121
    • Gao, J.1    Song, Z.2    Chen, Y.3    Xia, L.4    Wang, J.5    Fan, R.6
  • 51
    • 84878985394 scopus 로고    scopus 로고
    • A critical role for notch signalling in the formation of cholangiocellular carcinomas
    • S. Zender, I. Nickeleit, T. Wuestefeld, I. Sorensen, D. Dauch, and P. Bozko A critical role for notch signalling in the formation of cholangiocellular carcinomas Cancer Cell 23 2013 784 795
    • (2013) Cancer Cell , vol.23 , pp. 784-795
    • Zender, S.1    Nickeleit, I.2    Wuestefeld, T.3    Sorensen, I.4    Dauch, D.5    Bozko, P.6
  • 52
    • 84901621666 scopus 로고    scopus 로고
    • Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting
    • A.E. Sirica, and G.J. Gores Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting Hepatology 59 2014 2397 2402
    • (2014) Hepatology , vol.59 , pp. 2397-2402
    • Sirica, A.E.1    Gores, G.J.2
  • 53
    • 84856623009 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • S. Mikhail, and A.R. He Liver cancer stem cells Int J Hepatol 2011 2011 486954
    • (2011) Int J Hepatol , vol.2011 , pp. 486954
    • Mikhail, S.1    He, A.R.2
  • 55
    • 50249151525 scopus 로고    scopus 로고
    • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
    • A. Omenetti, Y. Popov, Y. Jung, S.S. Choi, R.P. Witek, and L. Yang The hedgehog pathway regulates remodelling responses to biliary obstruction in rats Gut 57 2008 1275 1282
    • (2008) Gut , vol.57 , pp. 1275-1282
    • Omenetti, A.1    Popov, Y.2    Jung, Y.3    Choi, S.S.4    Witek, R.P.5    Yang, L.6
  • 56
    • 33749418946 scopus 로고    scopus 로고
    • Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
    • L. Panman, A. Galli, N. Lagarde, O. Michos, G. Soete, and A. Zuniga Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling Development 133 2006 3419 3428
    • (2006) Development , vol.133 , pp. 3419-3428
    • Panman, L.1    Galli, A.2    Lagarde, N.3    Michos, O.4    Soete, G.5    Zuniga, A.6
  • 58
    • 67649618708 scopus 로고    scopus 로고
    • Regulation of organ size: Insights from the Drosophila Hippo signalling pathway
    • M. Kango-Singh, and A. Singh Regulation of organ size: insights from the Drosophila Hippo signalling pathway Dev Dyn 238 2009 1627 1637
    • (2009) Dev Dyn , vol.238 , pp. 1627-1637
    • Kango-Singh, M.1    Singh, A.2
  • 59
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signalling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    • J. Huang, S. Wu, J. Barrera, K. Matthews, and D. Pan The Hippo signalling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP Cell 122 2005 421 434
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 60
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • I. Lian, J. Kim, H. Okazawa, J. Zhao, B. Zhao, and J. Yu The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation Genes Dev 24 2010 1106 1118
    • (2010) Genes Dev , vol.24 , pp. 1106-1118
    • Lian, I.1    Kim, J.2    Okazawa, H.3    Zhao, J.4    Zhao, B.5    Yu, J.6
  • 61
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signalling is a potent in vivo growth and tumour suppressor pathway in the mammalian liver
    • L. Lu, Y. Li, S.M. Kim, W. Bossuyt, P. Liu, and Q. Qiu Hippo signalling is a potent in vivo growth and tumour suppressor pathway in the mammalian liver Proc Natl Acad Sci U S A 107 2010 1437 1442
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1437-1442
    • Lu, L.1    Li, Y.2    Kim, S.M.3    Bossuyt, W.4    Liu, P.5    Qiu, Q.6
  • 62
    • 84884560531 scopus 로고    scopus 로고
    • Increased expression of Yes-Associated protein 1 in hepatocellular carcinoma with stemness and combined hepatocellular-cholangiocarcinoma
    • G.J. Kim, H. Kim, and Y.N. Park Increased expression of Yes-Associated protein 1 in hepatocellular carcinoma with stemness and combined hepatocellular-cholangiocarcinoma PLoS One 8 2013 e75449
    • (2013) PLoS One , vol.8 , pp. 75449
    • Kim, G.J.1    Kim, H.2    Park, Y.N.3
  • 63
    • 77952336576 scopus 로고    scopus 로고
    • The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumourigenesis
    • K.P. Lee, J.H. Lee, T.S. Kim, T.H. Kim, H.D. Park, and J.S. Byun The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumourigenesis Proc Natl Acad Sci U S A 107 2010 8248 8253
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8248-8253
    • Lee, K.P.1    Lee, J.H.2    Kim, T.S.3    Kim, T.H.4    Park, H.D.5    Byun, J.S.6
  • 64
    • 38549177597 scopus 로고    scopus 로고
    • Activation of stem cells in hepatic diseases
    • T.G. Bird, S. Lorenzini, and S.J. Forbes Activation of stem cells in hepatic diseases Cell Tissue Res 331 2008 283 300
    • (2008) Cell Tissue Res , vol.331 , pp. 283-300
    • Bird, T.G.1    Lorenzini, S.2    Forbes, S.J.3
  • 65
    • 61949261267 scopus 로고    scopus 로고
    • Inflammatory pathways in liver homeostasis and liver injury
    • F. Tacke, T. Luedde, and C. Trautwein Inflammatory pathways in liver homeostasis and liver injury Clin Rev Allergy Immunol 36 2009 4 12
    • (2009) Clin Rev Allergy Immunol , vol.36 , pp. 4-12
    • Tacke, F.1    Luedde, T.2    Trautwein, C.3
  • 68
    • 33745220772 scopus 로고    scopus 로고
    • Origin of hepatocellular carcinoma: Role of stem cells
    • X.Z. Wu, and D. Chen Origin of hepatocellular carcinoma: role of stem cells J Gastroenterol Hepatol 21 2006 1093 1098
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 1093-1098
    • Wu, X.Z.1    Chen, D.2
  • 69
    • 0024312850 scopus 로고
    • Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma
    • S. Sell, and H.A. Dunsford Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma Am J Pathol 134 1989 1347 1363
    • (1989) Am J Pathol , vol.134 , pp. 1347-1363
    • Sell, S.1    Dunsford, H.A.2
  • 70
    • 84903783722 scopus 로고    scopus 로고
    • Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation
    • J. Li, N. Razumilava, G.J. Gores, S. Walters, T. Mizuochi, and R. Mourya Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation J Clin Invest 124 2014 3241 3251
    • (2014) J Clin Invest , vol.124 , pp. 3241-3251
    • Li, J.1    Razumilava, N.2    Gores, G.J.3    Walters, S.4    Mizuochi, T.5    Mourya, R.6
  • 71
    • 84904436891 scopus 로고    scopus 로고
    • A perspective on molecular therapy in cholangiocarcinoma: Present status and future directions
    • J.B. Andersen, and S.S. Thorgeirsson A perspective on molecular therapy in cholangiocarcinoma: present status and future directions Hepat Oncol 1 2014 143 157
    • (2014) Hepat Oncol , vol.1 , pp. 143-157
    • Andersen, J.B.1    Thorgeirsson, S.S.2
  • 72
    • 84862764922 scopus 로고    scopus 로고
    • TGF-beta control of stem cell differentiation genes
    • J. Massague, and Q. Xi TGF-beta control of stem cell differentiation genes FEBS Lett 586 2012 1953 1958
    • (2012) FEBS Lett , vol.586 , pp. 1953-1958
    • Massague, J.1    Xi, Q.2
  • 73
    • 84904460051 scopus 로고    scopus 로고
    • Roles of TGF-beta family signals in the fate determination of pluripotent stem cells
    • F. Itoh, T. Watabe, and K. Miyazono Roles of TGF-beta family signals in the fate determination of pluripotent stem cells Semin Cell Dev Biol 32C 2014 98 106
    • (2014) Semin Cell Dev Biol , vol.32 C , pp. 98-106
    • Itoh, F.1    Watabe, T.2    Miyazono, K.3
  • 74
    • 77954586069 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma
    • Y. Sato, K. Harada, K. Itatsu, H. Ikeda, Y. Kakuda, and S. Shimomura Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma Am J Pathol 177 2010 141 152
    • (2010) Am J Pathol , vol.177 , pp. 141-152
    • Sato, Y.1    Harada, K.2    Itatsu, K.3    Ikeda, H.4    Kakuda, Y.5    Shimomura, S.6
  • 75
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • H. Isomoto, S. Kobayashi, N.W. Werneburg, S.F. Bronk, M.E. Guicciardi, and D.A. Frank Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells Hepatology 42 2005 1329 1338
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6
  • 76
    • 84896694682 scopus 로고    scopus 로고
    • Gankyrin promotes tumour growth and metastasis through activation of IL-6/STAT3 signalling in human cholangiocarcinoma
    • T. Zheng, X. Hong, J. Wang, T. Pei, Y. Liang, and D. Yin Gankyrin promotes tumour growth and metastasis through activation of IL-6/STAT3 signalling in human cholangiocarcinoma Hepatology 59 2014 935 946
    • (2014) Hepatology , vol.59 , pp. 935-946
    • Zheng, T.1    Hong, X.2    Wang, J.3    Pei, T.4    Liang, Y.5    Yin, D.6
  • 77
    • 79959283388 scopus 로고    scopus 로고
    • Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers
    • T. Bekaii-Saab, M.A. Phelps, X. Li, M. Saji, L. Goff, and J.S. Kauh Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers J Clin Oncol 29 2011 2357 2363
    • (2011) J Clin Oncol , vol.29 , pp. 2357-2363
    • Bekaii-Saab, T.1    Phelps, M.A.2    Li, X.3    Saji, M.4    Goff, L.5    Kauh, J.S.6
  • 78
    • 27144523155 scopus 로고    scopus 로고
    • Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    • G.Y. Gwak, J.H. Yoon, C.M. Shin, Y.J. Ahn, J.K. Chung, and Y.A. Kim Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas J Cancer Res Clin Oncol 131 2005 649 652
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 649-652
    • Gwak, G.Y.1    Yoon, J.H.2    Shin, C.M.3    Ahn, Y.J.4    Chung, J.K.5    Kim, Y.A.6
  • 80
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • W.W. Lin, and M. Karin A cytokine-mediated link between innate immunity, inflammation, and cancer J Clin Invest 117 2007 1175 1183
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 81
    • 84883150093 scopus 로고    scopus 로고
    • Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
    • J.E. Eaton, J.A. Talwalkar, K.N. Lazaridis, G.J. Gores, and K.D. Lindor Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management Gastroenterology 145 2013 521 536
    • (2013) Gastroenterology , vol.145 , pp. 521-536
    • Eaton, J.E.1    Talwalkar, J.A.2    Lazaridis, K.N.3    Gores, G.J.4    Lindor, K.D.5
  • 82
    • 78650859531 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 - Key players in liver inflammation and cancer
    • G. He, and M. Karin NF-kappaB and STAT3 - key players in liver inflammation and cancer Cell Res 21 2011 159 168
    • (2011) Cell Res , vol.21 , pp. 159-168
    • He, G.1    Karin, M.2
  • 83
    • 84899483261 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in liver homeostasis and pathology
    • A. Sica, P. Invernizzi, and A. Mantovani Macrophage plasticity and polarization in liver homeostasis and pathology Hepatology 59 2014 2034 2042
    • (2014) Hepatology , vol.59 , pp. 2034-2042
    • Sica, A.1    Invernizzi, P.2    Mantovani, A.3
  • 84
    • 84856527774 scopus 로고    scopus 로고
    • Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice
    • M. Anson, A.M. Crain-Denoyelle, V. Baud, F. Chereau, A. Gougelet, and B. Terris Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice J Clin Invest 122 2012 586 599
    • (2012) J Clin Invest , vol.122 , pp. 586-599
    • Anson, M.1    Crain-Denoyelle, A.M.2    Baud, V.3    Chereau, F.4    Gougelet, A.5    Terris, B.6
  • 85
    • 84880646407 scopus 로고    scopus 로고
    • Isolation and characterization of biliary epithelial and stromal cells from resected human cholangiocarcinoma: A novel in vitro model to study tumour-stroma interactions
    • M. Massani, T. Stecca, L. Fabris, E. Caratozzolo, C. Ruffolo, and A. Furlanetto Isolation and characterization of biliary epithelial and stromal cells from resected human cholangiocarcinoma: a novel in vitro model to study tumour-stroma interactions Oncol Rep 30 2013 1143 1148
    • (2013) Oncol Rep , vol.30 , pp. 1143-1148
    • Massani, M.1    Stecca, T.2    Fabris, L.3    Caratozzolo, E.4    Ruffolo, C.5    Furlanetto, A.6
  • 86
    • 84874100938 scopus 로고    scopus 로고
    • Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells
    • A. Techasen, W. Loilome, N. Namwat, H. Dokduang, J. Jongthawin, and P. Yongvanit Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells Asian Pac J Cancer Prev 13 2012 115 118
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 115-118
    • Techasen, A.1    Loilome, W.2    Namwat, N.3    Dokduang, H.4    Jongthawin, J.5    Yongvanit, P.6
  • 87
    • 80051976226 scopus 로고    scopus 로고
    • Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization
    • L. Fabris, M. Cadamuro, L. Moserle, J. Dziura, X. Cong, and L. Sambado Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization Hepatology 54 2011 890 899
    • (2011) Hepatology , vol.54 , pp. 890-899
    • Fabris, L.1    Cadamuro, M.2    Moserle, L.3    Dziura, J.4    Cong, X.5    Sambado, L.6
  • 88
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signalling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • K.P. Olive, M.A. Jacobetz, C.J. Davidson, A. Gopinathan, D. McIntyre, and D. Honess Inhibition of Hedgehog signalling enhances delivery of chemotherapy in a mouse model of pancreatic cancer Science 324 2009 1457 1461
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 89
    • 67449098972 scopus 로고    scopus 로고
    • Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma
    • C. Chuaysri, P. Thuwajit, A. Paupairoj, S. Chau-In, T. Suthiphongchai, and C. Thuwajit Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma Oncol Rep 21 2009 957 969
    • (2009) Oncol Rep , vol.21 , pp. 957-969
    • Chuaysri, C.1    Thuwajit, P.2    Paupairoj, A.3    Chau-In, S.4    Suthiphongchai, T.5    Thuwajit, C.6
  • 90
    • 72749094687 scopus 로고    scopus 로고
    • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
    • S.S. Choi, A. Omenetti, R.P. Witek, C.A. Moylan, W.K. Syn, and Y. Jung Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis Am J Physiol Gastrointest Liver Physiol 297 2009 G1093 G1106
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , pp. 1093-G1106
    • Choi, S.S.1    Omenetti, A.2    Witek, R.P.3    Moylan, C.A.4    Syn, W.K.5    Jung, Y.6
  • 92
    • 82455210969 scopus 로고    scopus 로고
    • Myofibroblast-derived PDGF-BB promotes Hedgehog survival signalling in cholangiocarcinoma cells
    • C.D. Fingas, S.F. Bronk, N.W. Werneburg, J.L. Mott, M.E. Guicciardi, and S.C. Cazanave Myofibroblast-derived PDGF-BB promotes Hedgehog survival signalling in cholangiocarcinoma cells Hepatology 54 2011 2076 2088
    • (2011) Hepatology , vol.54 , pp. 2076-2088
    • Fingas, C.D.1    Bronk, S.F.2    Werneburg, N.W.3    Mott, J.L.4    Guicciardi, M.E.5    Cazanave, S.C.6
  • 94
    • 84883252924 scopus 로고    scopus 로고
    • Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-Associated fibroblasts in cholangiocarcinoma
    • M. Cadamuro, G. Nardo, S. Indraccolo, L. Dall'olmo, L. Sambado, and L. Moserle Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-Associated fibroblasts in cholangiocarcinoma Hepatology 58 2013 1042 1053
    • (2013) Hepatology , vol.58 , pp. 1042-1053
    • Cadamuro, M.1    Nardo, G.2    Indraccolo, S.3    Dall'Olmo, L.4    Sambado, L.5    Moserle, L.6
  • 96
    • 84905993872 scopus 로고    scopus 로고
    • Platelet-derived growth factor primes cancer-Associated fibroblasts for apoptosis
    • S. Rizvi, J.C. Mertens, S.F. Bronk, P. Hirsova, H. Dai, and L.R. Roberts Platelet-derived growth factor primes cancer-Associated fibroblasts for apoptosis J Biol Chem 289 2014 22835 22849
    • (2014) J Biol Chem , vol.289 , pp. 22835-22849
    • Rizvi, S.1    Mertens, J.C.2    Bronk, S.F.3    Hirsova, P.4    Dai, H.5    Roberts, L.R.6
  • 97
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumour microenvironment
    • B. Ruffell, N.I. Affara, and L.M. Coussens Differential macrophage programming in the tumour microenvironment Trends Immunol 33 2012 119 126
    • (2012) Trends Immunol , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3
  • 98
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumour-Associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • A. Mantovani, S. Sozzani, M. Locati, P. Allavena, and A. Sica Macrophage polarization: tumour-Associated macrophages as a paradigm for polarized M2 mononuclear phagocytes Trends Immunol 23 2002 549 555
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 99
    • 77956212940 scopus 로고    scopus 로고
    • Tumour-conditioned macrophages secrete migration-stimulating factor: A new marker for M2-polarization, influencing tumour cell motility
    • G. Solinas, S. Schiarea, M. Liguori, M. Fabbri, S. Pesce, and L. Zammataro Tumour-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumour cell motility J Immunol 185 2010 642 652
    • (2010) J Immunol , vol.185 , pp. 642-652
    • Solinas, G.1    Schiarea, S.2    Liguori, M.3    Fabbri, M.4    Pesce, S.5    Zammataro, L.6
  • 100
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • A. Mantovani, and A. Sica Macrophages, innate immunity and cancer: balance, tolerance, and diversity Curr Opin Immunol 22 2010 231 237
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 101
    • 80052138920 scopus 로고    scopus 로고
    • Cancer-promoting tumour-Associated macrophages: New vistas and open questions
    • A. Mantovani, G. Germano, F. Marchesi, M. Locatelli, and S.K. Biswas Cancer-promoting tumour-Associated macrophages: new vistas and open questions Eur J Immunol 41 2011 2522 2525
    • (2011) Eur J Immunol , vol.41 , pp. 2522-2525
    • Mantovani, A.1    Germano, G.2    Marchesi, F.3    Locatelli, M.4    Biswas, S.K.5
  • 102
    • 77954855351 scopus 로고    scopus 로고
    • Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma
    • H. Hasita, Y. Komohara, H. Okabe, T. Masuda, K. Ohnishi, and X.F. Lei Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma Cancer Sci 101 2010 1913 1919
    • (2010) Cancer Sci , vol.101 , pp. 1913-1919
    • Hasita, H.1    Komohara, Y.2    Okabe, H.3    Masuda, T.4    Ohnishi, K.5    Lei, X.F.6
  • 103
    • 33745104992 scopus 로고    scopus 로고
    • Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma
    • S. Ohira, K. Itatsu, M. Sasaki, K. Harada, Y. Sato, and Y. Zen Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma Pathol Int 56 2006 381 389
    • (2006) Pathol Int , vol.56 , pp. 381-389
    • Ohira, S.1    Itatsu, K.2    Sasaki, M.3    Harada, K.4    Sato, Y.5    Zen, Y.6
  • 104
    • 33645458005 scopus 로고    scopus 로고
    • Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumour necrosis factor-Alpha and stromal-derived factor-1 released in stroma
    • S. Ohira, M. Sasaki, K. Harada, Y. Sato, Y. Zen, and K. Isse Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumour necrosis factor-Alpha and stromal-derived factor-1 released in stroma Am J Pathol 168 2006 1155 1168
    • (2006) Am J Pathol , vol.168 , pp. 1155-1168
    • Ohira, S.1    Sasaki, M.2    Harada, K.3    Sato, Y.4    Zen, Y.5    Isse, K.6
  • 105
    • 84880260044 scopus 로고    scopus 로고
    • Tumour necrosis factor-Alpha (TNF-Alpha) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma
    • A. Techasen, N. Namwat, W. Loilome, P. Bungkanjana, N. Khuntikeo, and A. Puapairoj Tumour necrosis factor-Alpha (TNF-Alpha) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma Med Oncol 29 2012 3083 3091
    • (2012) Med Oncol , vol.29 , pp. 3083-3091
    • Techasen, A.1    Namwat, N.2    Loilome, W.3    Bungkanjana, P.4    Khuntikeo, N.5    Puapairoj, A.6
  • 107
    • 84878515954 scopus 로고    scopus 로고
    • Prognostic roles of cross-talk between peritumoural hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoural VEGF-C, VEGFR-1, and VEGFR-3
    • P.Y. Zhuang, J. Shen, X.D. Zhu, L. Lu, L. Wang, and Z.Y. Tang Prognostic roles of cross-talk between peritumoural hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoural VEGF-C, VEGFR-1, and VEGFR-3 PLoS One 8 2013 e64598
    • (2013) PLoS One , vol.8 , pp. 64598
    • Zhuang, P.Y.1    Shen, J.2    Zhu, X.D.3    Lu, L.4    Wang, L.5    Tang, Z.Y.6
  • 108
    • 84885350856 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases
    • A. Franchitto, P. Onori, A. Renzi, G. Carpino, R. Mancinelli, and D. Alvaro Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases Hepatobiliary Surg Nutr 2 2013 68 77
    • (2013) Hepatobiliary Surg Nutr , vol.2 , pp. 68-77
    • Franchitto, A.1    Onori, P.2    Renzi, A.3    Carpino, G.4    Mancinelli, R.5    Alvaro, D.6
  • 110
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots
    • H. Korkaya, S. Liu, and M.S. Wicha Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots Clin Cancer Res 17 2011 6125 6129
    • (2011) Clin Cancer Res , vol.17 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 111
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • P. Lu, V.M. Weaver, and Z. Werb The extracellular matrix: a dynamic niche in cancer progression J Cell Biol 196 2012 395 406
    • (2012) J Cell Biol , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 112
    • 79953736762 scopus 로고    scopus 로고
    • Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
    • J. Schrader, T.T. Gordon-Walker, R.L. Aucott, M. van Deemter, A. Quaas, and S. Walsh Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells Hepatology 53 2011 1192 1205
    • (2011) Hepatology , vol.53 , pp. 1192-1205
    • Schrader, J.1    Gordon-Walker, T.T.2    Aucott, R.L.3    Van Deemter, M.4    Quaas, A.5    Walsh, S.6
  • 113
    • 77958610661 scopus 로고    scopus 로고
    • An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer
    • J.B. Andersen, V.M. Factor, J.U. Marquardt, C. Raggi, Y.H. Lee, and D. Seo An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer Sci Transl Med 2 2010 54ra77
    • (2010) Sci Transl Med , vol.2 , pp. 54ra77
    • Andersen, J.B.1    Factor, V.M.2    Marquardt, J.U.3    Raggi, C.4    Lee, Y.H.5    Seo, D.6
  • 114
    • 79961074770 scopus 로고    scopus 로고
    • Tumour-Associated macrophages regulate tumourigenicity and anticancer drug responses of cancer stem/initiating cells
    • M. Jinushi, S. Chiba, H. Yoshiyama, K. Masutomi, I. Kinoshita, and H. Dosaka-Akita Tumour-Associated macrophages regulate tumourigenicity and anticancer drug responses of cancer stem/initiating cells Proc Natl Acad Sci U S A 108 2011 12425 12430
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12425-12430
    • Jinushi, M.1    Chiba, S.2    Yoshiyama, H.3    Masutomi, K.4    Kinoshita, I.5    Dosaka-Akita, H.6
  • 115
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumour-infiltrating macrophages decreases tumour-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • J.B. Mitchem, D.J. Brennan, B.L. Knolhoff, B.A. Belt, Y. Zhu, and D.E. Sanford Targeting tumour-infiltrating macrophages decreases tumour-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses Cancer Res 73 2013 1128 1141
    • (2013) Cancer Res , vol.73 , pp. 1128-1141
    • Mitchem, J.B.1    Brennan, D.J.2    Knolhoff, B.L.3    Belt, B.A.4    Zhu, Y.5    Sanford, D.E.6
  • 116
    • 84859614232 scopus 로고    scopus 로고
    • Macrophage-derived Wnt opposes Notch signalling to specify hepatic progenitor cell fate in chronic liver disease
    • L. Boulter, O. Govaere, T.G. Bird, S. Radulescu, P. Ramachandran, and A. Pellicoro Macrophage-derived Wnt opposes Notch signalling to specify hepatic progenitor cell fate in chronic liver disease Nat Med 18 2012 572 579
    • (2012) Nat Med , vol.18 , pp. 572-579
    • Boulter, L.1    Govaere, O.2    Bird, T.G.3    Radulescu, S.4    Ramachandran, P.5    Pellicoro, A.6
  • 117
    • 0034835564 scopus 로고    scopus 로고
    • Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma
    • K. Sugimachi, K. Taguchi, S. Aishima, S. Tanaka, M. Shimada, and K. Kajiyama Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma Mod Pathol 14 2001 900 905
    • (2001) Mod Pathol , vol.14 , pp. 900-905
    • Sugimachi, K.1    Taguchi, K.2    Aishima, S.3    Tanaka, S.4    Shimada, M.5    Kajiyama, K.6
  • 118
    • 33644831221 scopus 로고    scopus 로고
    • Immunohistochemical and mutational analyses of Wnt signalling components and target genes in intrahepatic cholangiocarcinomas
    • N. Tokumoto, S. Ikeda, Y. Ishizaki, T. Kurihara, S. Ozaki, and M. Iseki Immunohistochemical and mutational analyses of Wnt signalling components and target genes in intrahepatic cholangiocarcinomas Int J Oncol 27 2005 973 980
    • (2005) Int J Oncol , vol.27 , pp. 973-980
    • Tokumoto, N.1    Ikeda, S.2    Ishizaki, Y.3    Kurihara, T.4    Ozaki, S.5    Iseki, M.6
  • 119
    • 84896457874 scopus 로고    scopus 로고
    • New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing
    • J.S. Ross, K. Wang, L. Gay, R. Al-Rohil, J.V. Rand, and D.M. Jones New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing Oncologist 19 2014 235 242
    • (2014) Oncologist , vol.19 , pp. 235-242
    • Ross, J.S.1    Wang, K.2    Gay, L.3    Al-Rohil, R.4    Rand, J.V.5    Jones, D.M.6
  • 121
    • 84896492774 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma
    • Y. Arai, Y. Totoki, F. Hosoda, T. Shirota, N. Hama, and H. Nakamura Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma Hepatology 59 2014 1427 1434
    • (2014) Hepatology , vol.59 , pp. 1427-1434
    • Arai, Y.1    Totoki, Y.2    Hosoda, F.3    Shirota, T.4    Hama, N.5    Nakamura, H.6
  • 122
    • 84901742112 scopus 로고    scopus 로고
    • Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma
    • M.J. Borad, M.D. Champion, J.B. Egan, W.S. Liang, R. Fonseca, and A.H. Bryce Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma PLoS Genet 10 2014 e1004135
    • (2014) PLoS Genet , vol.10 , pp. 1004135
    • Borad, M.J.1    Champion, M.D.2    Egan, J.B.3    Liang, W.S.4    Fonseca, R.5    Bryce, A.H.6
  • 123
    • 84907033777 scopus 로고    scopus 로고
    • Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer
    • S.K. Saha, C.A. Parachoniak, K.S. Ghanta, J. Fitamant, K.N. Ross, and M.S. Najem Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer Nature 513 2014 110 114
    • (2014) Nature , vol.513 , pp. 110-114
    • Saha, S.K.1    Parachoniak, C.A.2    Ghanta, K.S.3    Fitamant, J.4    Ross, K.N.5    Najem, M.S.6


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